Cdk1 in tumor. Medical search. Frequent questions

In the current study, Lu and her colleagues show that a protein complex named cyclin B1/cdk1, which is expressed at high levels in the cytoplasm of advanced melanomas, induces a pair of precise chemical modifications on iASPP to activate the protein. (medindia.net)
In ER+ cancer cells, PIP5K1α acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of target genes including cyclin D1 and CDK1. (lu.se)
The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. (bdbiosciences.com)
Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb), nucleolin and others. (bdbiosciences.com)
Cyclin A is involved in both S-phase and G2/M transitions of the cell cycle through its association with cdk2 and cdk1, respectively. (bdbiosciences.com)
CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. (ncats.io)
This effect is mediated by downregulation of the key cell cycle progression factors cyclin B1, cyclin D1, CDK1, CDK4, and survivin, the latter also constituting an essential inhibitor of apoptosis, underlying additionally the onset of apoptosis. (uandes.cl)
Inhibiting WEE1 abrogates G2 cell cycle arrest, resulting The tyrosine kinase WEE1 regulates cyclin-dependent kinase in premature entry into mitosis and leading to aberrantly 1 (CDK1), which drives cells from the G2 phase into mitosis, high CDK2 activity in S-phase cells, with the deregulated and CDK2, which drives cells into and through the S phase DNA replication resulting in replication stress [1, 5]. (sagepub.com)
Milciclib (PHA-848125AC) is a small molecule inhibitor of several cyclin dependent kinases such as CDK1, CDK4, CDK5 and CDK7. (covaipost.com)
Cyclin-dependent kinase 5 (CDK5) affects the tumor microenvironment, which may influence the efficacy of TKI+IO. (e-crt.org)
Second, CDC25B activates the mitotic kinase CDK1/cyclin B complicated in the cytoplasm to stimulate cell routine development [16]. (pkc-inhibitor.com)
Some studies have reported that the G2 M arrest induced by SP600125 may be due to inhibition of cyclin B Cdk1 kinase activity through an increase in p21 levels. (hsp90-inhibitors.com)
Thus, inhibition of JNK activity prevents dissociation between p21 and JNK, and then prevents inhibition of cyclin B Cdk1 activity, leading to induction of G2 M arrest. (hsp90-inhibitors.com)

Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. (nature.com)
Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
However, changes in the tumor immune microenvironment induced by lenvatinib are poorly understood. (bvsalud.org)
In addition, heterogeneity of the tumor microenvironment was explored, and distinct subtypes of immune cells and fibroblasts in PDAC were characterized. (biomedcentral.com)
Exploring highly expressed pathways in stromal components, such as fibroblasts, will delineate the underlying mechanisms that are pivotal for tumor microenvironment maintenance. (biomedcentral.com)
We demonstrated myeloid compartment was an interactive hub of tumor microenvironment (TME) essential for PDAC progression. (biomedcentral.com)

Phosphorylation at CDK1, CDK4, and CDK9 sites on, respectively, protein phosphatase 1alpha, retinoblastoma protein, and RNA polymerase II is inhibited in neuroblastoma SH-SY5Y cells exposed to meriolins. (rcsb.org)
Palbociclib targets the rapid division of tumor cells by inhibiting the activity of the enzymes CDK4 and CDK6, which help drive cell division and are upregulated in most cancers. (news-medical.net)

Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. (ncats.io)
In pediatric solid tumors and brain tumors, PLK1 inhibition leads to apoptosis in vitro and in tumor xenografts. (childrenscolorado.org)
ASncmtRNA knockdown with an antisense oligonucleotide induces massive apoptosis in tumor cell lines, without affecting healthy cells. (uandes.cl)
This work adds to the elucidation of the molecular mechanisms behind cell cycle arrest preceding tumor cell apoptosis induced by ASncmtRNA knockdown. (uandes.cl)
Depletion of HSP70-2 in MDA-MB-231 and MCF7 cells resulted in a significant reduction in cellular growth, motility, onset of apoptosis, senescence, cell cycle arrest as well as reduction of tumor growth in the xenograft model. (biomedcentral.com)

In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)

Further, such treatment significantly suppressed tumor growth in mice. (medindia.net)
The combination of BRD4 inhibitor and RT significantly suppressed tumor growth compared to RT alone. (preprints.org)

In all five HPV negative and HPV positive cell lines tested, roscovitine caused inhibition of CDK1 and 2. (oncotarget.com)
Proportion of M1 tumor-associated macrophages (TAMs) increased, and proportion of M2 TAMs decreased upon BRD4 inhibition. (preprints.org)
The novel PLK1 inhibitor, onvansertib, is the first available for oral administration and has shown tumor growth inhibition in hematologic tumors, osteosarcoma, ovarian carcinoma, breast cancer and colon adenocarcinoma cells. (childrenscolorado.org)
As proof-of-concept, we show that in vivo knockdown of ASncmtRNAs results in drastic inhibition of tumor growth in a xenograft model of MDA-MB-231 subcutaneous tumors, further supporting this approach for the development of new therapeutic strategies against breast cancer. (uandes.cl)
The tumor suppressor protein p53 is inhibition also exploits the G1 checkpoint deficiency seen involved in regulation of the G1 checkpoint. (sagepub.com)
Thus, WEE1 inhibition sensitizes cancers have loss-of-function TP53 mutations, meaning that tumor cells to DNA-damaging chemotherapy and can lead to they become more dependent on the G2/M- and S-phase unstable DNA replication, DNA damage and mitotic catas- checkpoints to halt progression of the cell cycle [3, 4]. (sagepub.com)

By examining samples taken from a patient through the course of her treatment with palbociclib, the team found that as the tumors became resistant, the cells more than doubled their expression of several cell-cycle-driving genes, including PLK1, TOP2A, CDK1, and BUB1. (news-medical.net)
Second, CDK1, PLK1, and AURKA were identified and verified to serve as pharmacological targets of proliferative ductal cells. (biomedcentral.com)

TP63 is a member of the tumour suppressor TP53 gene family, and ΔNp63α, a TP63 splicing variant, is constitutively expressed in the stem cell-containing basal layer of stratified epithelial tissues, including the mammary gland, where it plays a critical role in stemness and tissue development. (researchsquare.com)

Meriolin 3 potently inhibits tumor growth in two mouse xenograft cancer models, namely, Ewing's sarcoma and LS174T colorectal carcinoma. (rcsb.org)
The reduced tumor growth upon EHMT2 deficiency was reversed by recombinant DKK1 or LGK974, which also inhibits Wnt signaling. (elifesciences.org)
Following DNA damage, WEE1 inhibits CDK1, leading 1 Introduction to cell cycle arrest and allowing time for DNA repair [4]. (sagepub.com)
Farnesyltransferase inhibitor tipifarnib is well leurocristine tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic tumor survival pathways in patients with advanced multiple myeloma. (hsp90-inhibitors.com)

SncmtRNA is expressed in all proliferating cells, while ASncmtRNAs are expressed in normal proliferating cells, but is downregulated in tumor cells. (uandes.cl)

We can show Sox2 is very important for tumorigenesis, but it's difficult to have a Sox2 inhibitor," says Mayumi Fujita, M.D., Ph.D., an investigator at the CU Cancer Center and senior author of the current study, which found that CDK1 directly interacts with Sox2 to keep cancer cells "stemmy. (genengnews.com)
To do so, they treated melanoma cells with a panel of small molecules and identified JNJ-7706621 (JNJ) as the best inhibitor of cyclinB1/cdk1. (medindia.net)
Quite interestingly, we found that a CDK inhibitor, Far1, could regulate the Cln2-CDK1 activity partly by inhibiting the Cln2-substrate interaction, thus demonstrating that docking interactions can be targets of regulation. (umassmed.edu)
BACKGROUND: Lenvatinib, a multiple receptor tyrosine kinase inhibitor, might exert antitumor effects via tumor immune modulation. (bvsalud.org)
BRD4 inhibitor reduced the size of the unirradiated tumor indicating that it may induce systemic immune responses. (preprints.org)
Expression of HIF-1α and PD-L1 in tumor was significantly downregulated by the BRD4 inhibitor. (preprints.org)

That is, enhanced tumor-initiating capacities could come down to interactions between stem cell genes and seemingly unrelated regulatory mechanisms. (genengnews.com)
Tumor RNA was sequenced using the Oncomine® Immune Response panel which targets 395 genes related to immunological processes. (eurekalert.org)
CDK1, CCND1, RAF1, CDKN1B and BTRC were defined as the top 5 hub target genes, and patients with high expression of CDK1 showed poor prognosis. (biomedcentral.com)
Investigators used CRISPR-Cas9 screening to determine which genes were essential for medulloblastoma tumor growth. (childrenscolorado.org)
In recent decades, it has been confirmed that tumor progression of GC is a multi-step process that involves the activation of oncogenes and the inactivation of tumor suppressor genes at different stages ( 7 , 8 ). (jcancer.org)
Uncontrolled cell proliferation is the hallmark of cancer, and genes that directly regulate the cell cycle are typically damaged in tumor cells ( 10 ). (jcancer.org)
An analysis of expression of CDK1 and CDK1-associated genes in the NCI60 cell line database confirmed the broad association of these genes with chemotherapeutic responsiveness. (johnshopkins.edu)

Although the trial wasn't designed to test whether the combination is more effective against breast tumors than paclitaxel, the patients' responses were promising. (news-medical.net)
Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. (muni.cz)

Objective This open-label Phase Ib study (NCT02341456) investigated the safety, pharmacokinetics, and clinical activity of adavosertib in combination with carboplatin alone or paclitaxel plus carboplatin in Asian patients with advanced solid tumors and defined the recommended Phase II dose. (sagepub.com)
administered in combination with cisplatin, carboplatin, or gemcitabine in patients with advanced solid tumors in a * Yung-Jue Bang [email protected] Phase I study (NCT00648648, PN001) [6]. (sagepub.com)
Adavosertib 175 mg twice daily (bid) for 2.5 days (five Patients also had to have at least one measurable lesion that doses) in combination with carboplatin (AUC 5) alone or could be accurately assessed at baseline by computed tomog- paclitaxel (175 mg/m ) plus carboplatin was considered raphy or magnetic resonance imaging and Response Evalua- tolerable in Asian patients with advanced solid tumors. (sagepub.com)
tion Criteria in Solid Tumors (RECIST) v1.1. (sagepub.com)

Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene. (wikipedia.org)

Meriolins display better antiproliferative and proapoptotic properties in human tumor cell cultures than their parent molecules, meridianins and variolins. (rcsb.org)
Therefore, elimination of the checkpoint increases the sensitivity of human tumor cell lines to anticancer agents. (hsp90-inhibitors.com)

The MHC Class I-high cells also expressed high levels of CDK1, a "normal" molecule that regulates the cell cycle. (genengnews.com)
Instead, the CU scientists asked which factors could cause these cells to initiate tumor growth in the first place. (genengnews.com)
This finding, the scientists indicated, could help explain how cells of different subtypes within cancers show various tumor-initiating capacities. (genengnews.com)
Knockout of Sox2 in CDK1-overexpressing cells reduced CDK1-driven tumor-initiating capacity substantially. (genengnews.com)
Furthermore, GSEA analysis of CDK1-hi tumor cells identified a pathway signature common in all three cancer types, including E2F, G2M, MYC, and spermatogenesis, confirming a stem-like nature of CDK1-hi tumor cells. (genengnews.com)
Importantly, this signature of MHC Class 1, CDK1, and Sox2 was common across melanoma, colon, and pancreatic cancers, implying that cancer stem cells across cancer types may share common features. (genengnews.com)
Lab dish studies of tumor cells that develop resistance to palbociclib revealed similar changes. (news-medical.net)
One protein that keeps healthy cells from behaving this way is a tumor suppressor named p53. (medindia.net)
Since multiple signaling pathways drive the growth of tumor cells, Lu and her colleagues wondered if the restoration of p53 function could be used as a strategy to enhance existing cancer therapies that target parallel signaling pathways. (medindia.net)
The abnormally high number of centrosomes found in many human tumor cells can lead directly to aneuploidy and genomic instability through the formation of multipolar mitotic spindles. (umassmed.edu)
A low concentration arecoline can induce the proliferation and migration of HepG2 cells, with the potential mechanism of action linked to high levels of exosomal miR-21 and miR-1267, activation of the PI3K-AKT pathway, upregulation of CDK1 and CCND1, and downregulation of RAF1. (biomedcentral.com)
In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. (modellab.cn)
We also report that HSP70-2 plays an important role in cellular growth, migration and invasion of breast cancer cells and tumor growth of breast cancer xenograft. (biomedcentral.com)
In a preclinical study, Zotiraciclib (TG02) inhibited growth of FLT3-mutated acute myeloid leukemia cells in culture, resulted in complete tumor regression in cell line xenograft animal models ( PMID: 21860433 ). (jax.org)
TFDP1 may be the first example of a family of related transcription factors and may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells. (avivasysbio.com)
We previously reported that aberrant manifestation of CDC25B in ESCC tumor cells can induce CDC25B autoantibodies in sera of ESCC individuals, and antibodies against CDC25B had been. (pkc-inhibitor.com)
Further, we uncovered several ligand-receptor pairs lining tumor cells and macrophages. (biomedcentral.com)
The G2 M checkpoint is especially important in protecting normal cells from tumor formation driven by the accumulation of mutations. (hsp90-inhibitors.com)
They can inhibit the growth of tumor cells, kill them via phagocytosis, and promote anti-tumor immunity. (frontiersin.org)

The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. (phosphosite.org)
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. (modellab.cn)
This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. (modellab.cn)
ΔNp63α has been reported to transcriptionally inhibit the tumour suppression protein p53. (researchsquare.com)

Non-CPR patients showed an upregulation of proliferation, tumor marker, interferon signaling, housekeeping and tumor antigen pathways. (eurekalert.org)
Based on their results, Lu and her colleagues argue that the best strategy in such cases might be to use drug combinations that target multiple, parallel pathways involved in tumor development and maintenance. (medindia.net)

Recently, a series of studies revealed the diagnostic and prognostic value of CDKs (mainly CDK1-7) in different types of human cancer, including oral cancer, medulloblastoma, pancreatic cancer ( 11 - 14 ). (jcancer.org)

Detailed results appeared in the journal Cancer Research , in an article titled, " CDK1 interacts with Sox2 and promotes tumor initiation in human melanoma . (genengnews.com)
Hypoxia-induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R. (nih.gov)

This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (wikipedia.org)
We collected blood sample (n = 51) and tumor tissue (n, baseline/four weeks after treatment initiation/post-progression = 50/8/12). (bvsalud.org)
Recently, reduced expression of CDK10 has been observed in several cancerous human tissue, suggesting that CDK10 is a tumor suppressor gene. (jcancer.org)
HSP70-2 expression was examined in 154 tumor and 103 adjacent non-cancerous tissue (ANCT) specimens and breast cancer cell lines (MCF7, BT-474, SK-BR-3 and MDA-MB-231) by RT-PCR, quantitative-PCR, immunohistochemistry, Western blotting, flow cytometry and indirect immunofluorescence. (biomedcentral.com)

Two recent studies from Dr. Wenming Wu's group at the Department of General Surgery, Peking Union Medical College Hospital (PUMCH), applied single-cell RNA sequencing and whole-genome sequencing (WGS) to delineate heterogeneity of pancreatic tumors, including pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumor (PanNET). (biomedcentral.com)

Patients with HPV positive tumors possess a far better prognosis than those with HPV negative cancers. (oncotarget.com)

Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical fragment ion spectra (SWATH) mass spectrometry and establish key proteins for breast tumor classification. (muni.cz)
Proteins that contribute most strongly to the proteotype-based classification include INPP4B, CDK1, and ERBB2 and are associated with estrogen receptor (ER) status, tumor grade status, and HER2 status. (muni.cz)
Our results suggest that ASncmtRNA targeting blocks tumor cell proliferation through reduction of essential cell cycle proteins, mediated by mitochondrial and nuclear miRNAs. (uandes.cl)
Heat shock family of proteins (HSPs) is proposed to play pivotal role in breast tumor development owing to their intrinsic molecular chaperone properties [ 5 ]. (biomedcentral.com)

Tumor-associated macrophages (TAMs) orchestrate PDAC malignancy, but their dynamics during disease progression remains poorly understood. (biomedcentral.com)
In xenografts, the tumor volumes in the experimental group were significantly larger than those in the control group, and the proportion of M2 macrophages was significantly higher. (frontiersin.org)

Combining the new breast cancer drug palbociclib with paclitaxel (Taxol) shrank tumors in nearly half of patient with estrogen-receptor (ER) positive breast cancer, according to new research from the Perelman School of Medicine at the University of Pennsylvania. (news-medical.net)
There were no significant associations between CDK2AP1 expression and estrogen receptor status, tumour grade and tumour type. (cancerindex.org)

This finding provides new insight into understanding how distinct tumor types regulate their immune heterogeneity. (biomedcentral.com)

Treatment with Sorafenib induces autophagy, which may suppress tumor growth. (covaipost.com)

Blockade or knockdown of CDK1 resulted in reduced phosphorylation, nuclear localization, and transcriptional activity of Sox2," the article indicated. (genengnews.com)

Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)

RESULTS: Here we show that lenvatinib has similar anti-tumor efficacy with objective response rate and progression-free survival in both Immune-Hot and Immune-Cold subtypes. (bvsalud.org)
This is a single-arm, repeated-dose, 6-month duration study to evaluate safety, tolerability and anti-tumor activity of Milciclib in Sorafenib-refractory or -intolerant patients with unresectable or metastatic HCC. (covaipost.com)

Medulloblastoma, the most common malignant pediatric brain tumor , is a diverse and heterogenous disease with four major subgroups. (childrenscolorado.org)
With a total of 989,600 new cancer cases and 738,000 deaths worldwide in 2008, gastric cancer (GC) is the fourth most common malignant tumor and the second most common cause of cancer-related deaths, accounting for 10.4% of cancer-related deaths ( 1 , 2 ). (jcancer.org)

Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer. (medindia.net)
Tumor size was measured and in vivo imaging was performed to evaluate tumor growth. (preprints.org)
Plasmid driven short hairpin RNA approach was employed to validate the role of HSP70-2 in cellular proliferation, senescence, migration, invasion and tumor growth. (biomedcentral.com)

Background: Neuroendocrine tumors of the lung comprise typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine cancer (LCNEC) and small-cell lung cancer (SCLC). (oncotarget.com)

Therefore, there is a need to characterize a tumor-associated molecule for early detection of breast cancer and for identifying a novel therapeutic target for better cancer treatment. (biomedcentral.com)

The drug caused the woman's tumor to shrink, and her cancer remained progression-free for nearly three years, until a metastatic skin lesion was detected in 2013. (news-medical.net)
This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
solid tumor (excluding lymphoma), failure to respond to Key Points standard therapy, disease progression despite standard ther- apy, or cancers for which standard therapy did not exist. (sagepub.com)

Purvalanol is a purine-derived CDKI that binds with a high selectivity and competitively to the ATP binding side of CDK1/2 and leads to G2/M cell cycle arrest ( 4 ). (spandidos-publications.com)

Although CDK1 was highly expressed in tumor tissues, its loss from the cytoplasm unexpectedly predicted poor survival and conferred resistance to chemotherapy in multiple cell lines, especially microtubule-directed agents. (johnshopkins.edu)

Treatment with 2.5 µM arecoline increased the levels of miR-21-3p, miR-21-5p and miR-1267, upregulated the expression of PI3K-AKT pathway factors, CDK1, CCND1 but decreased RAF1 expression. (biomedcentral.com)

however, they also reveal varying heterogeneity within the conventional subtypes, with triple negative tumors being the most heterogeneous. (muni.cz)

With such treatment, advanced melanoma tumors in preclinical mouse models shrank by a full 75 percent after 28 days of treatment. (medindia.net)

Anti-angiogenic therapy blocks the formation of new blood vessels (angiogenesis) in the tumor, and this type of therapy might also impact the immune system. (bvsalud.org)

4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
Immune-inflamed tumors are called hot tumors, while the latter two are collectively referred to as cold tumors, and they respond poorly to immunotherapy. (nature.com)
Immunotherapy helps the patient's immune system to attack the tumor. (bvsalud.org)
Patient outcomes on lenvatinib did not depend on the immune features of the tumor before treatment. (bvsalud.org)
However, immune characteristics of the tumors did change after treatment, and this may mean these tumors become easier to treat with immunotherapies. (bvsalud.org)

This research is a continuation of the work I led in Sydney which identified tumour and blood markers and resulted in a phase I clinical trial of microRNA replacement therapy (NCT 02369198). (otago.ac.nz)
serum autoantibodies was in comparison to that of the tumor markers carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag) and cytokeratin 19 fragment antigen 21-1(CYFRA21-1). (pkc-inhibitor.com)
Few individuals examined positive for the tumor markers CEA Fairly, SCC-Ag and CYFRA21-1 (13.4%, 17.2%, and 32.1%, respectively). (pkc-inhibitor.com)
Conclusions Recognition of serum CDC25B-Abs can be more advanced than detection from the tumor markers CEA, CYFRA21-1 and SCC-Ag for analysis of ESCC, and CDC25B-Abs certainly are a potential prognostic serological marker for advanced ESCC. (pkc-inhibitor.com)
There's a developing have to determine useful natural markers for early therefore, noninvasive analysis of ESCC as well as for monitoring tumor development [4]. (pkc-inhibitor.com)
As well as the traditional tumor markers CEA, CYFRA21-1 and SCCA, autoantibodies against tumor-associated antigens were reported in sera from individuals with ESCC recently. (pkc-inhibitor.com)
Like the traditional tumor markers, these autoantibodies had CP-673451 supplier been been shown to be useful molecular markers for ESCC. (pkc-inhibitor.com)

BCL2 expression increased over BAX expression with increasing malignancy of the tumor from TC to SCLC. (oncotarget.com)

CONCLUSIONS: Our findings show the ability of lenvatinib to modulate tumor immunity in clinical samples of hepatocellular carcinoma. (bvsalud.org)

Single-cell sequencing is pivotal for exploring tumor heterogeneity and dissecting the tumor-related mechanism in detail. (biomedcentral.com)

Although the scientists could suppress these stem-cell-like characteristics by inhibiting of CDK1 with pharmacological agents, they couldn't see how CDK1's role as a cell cycle regulator could be relevant. (genengnews.com)

The concentration of CDC25B autoantibodies in serum was correlated with tumor stage ( em P /em 0 significantly.001). (pkc-inhibitor.com)

Overexpression of CDK1, the CU Cancer Center scientists found, increased the spheroid forming ability, tumorigenic potential, and tumor-initiating capacity of the curious cell type. (genengnews.com)

Anatomy11

Organisms9

Diseases83

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes50

Disciplines and Occupations1

Information Science4

Health Care8

Cyclin13

Microenvironment6

CDK42

Apoptosis5

Irradiated tumor cells1

Suppressed tumor growth2

Inhibition6

PLK12

TP531

Inhibits4

Downregulated in tumor cells1

Inhibitor6

Genes7

Breast tumors2

Solid tumors4

Kinase1

Human tumor cell2

Cells19

Protein4

Pathways2

CDKs1

Promotes tumor2

Tissue4

Pancreatic1

Prognosis1

Proteins4

Macrophages2

Estrogen-receptor2

Regulate1

Induces1

Phosphorylation1

Oncogenic1

Anti-tumor2

Common malignant2

Growth3

Neuroendocrine1

Molecule1

Progression3

Arrest1

Survival1

CCND11

Subtypes1

Shrank1

Angiogenesis1

Immune5

Markers7

BCL21

Immunity1

Heterogeneity1

Cell cycle1

Significantly1

Overexpression1