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Cyclin D1Cyclin ACyclin ECyclin BCyclin B1Cyclin D3Cyclin D2Cyclin A1Cyclin DCyclin A2Cyclin-Dependent KinasesCyclinsCyclin-Dependent Kinase 2Cyclin GCyclin-Dependent Kinase 4Cyclin G1Cyclin CCDC2-CDC28 KinasesCDC2 Protein KinaseCyclin TCell CycleCyclin B2Cyclin HG1 PhaseCyclin-Dependent Kinase 5Cyclin G2Cell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent Kinase 6S PhaseProtein-Serine-Threonine KinasesPhosphorylationMitosisCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase 9Cyclin IRetinoblastoma ProteinOncogene ProteinsGenes, bcl-1Cell DivisionG2 PhaseTumor Suppressor ProteinsCell ProliferationCyclin-Dependent Kinase 8Proto-Oncogene ProteinsCell Line, Tumorcdc25 PhosphatasesCyclin-Dependent Kinase Inhibitor p16Microtubule-Associated ProteinsMolecular Sequence DataE2F Transcription FactorsProtein BindingPurinesCell LineRNA, MessengerCell NucleusTumor Cells, CulturedHeLa CellsNuclear ProteinsG0 PhaseCyclin-Dependent Kinase 3Cyclin-Dependent Kinase Inhibitor ProteinsBlotting, WesternTransfectionProliferating Cell Nuclear AntigenApoptosisGene Expression Regulation, NeoplasticProtamine KinaseDown-RegulationTranscription FactorsCyclin-Dependent Kinase Inhibitor p18Amino Acid SequenceSignal TransductionEnzyme InhibitorsTranscription Factor DP1F-Box ProteinsProtein KinasesEnzyme ActivationTranscription, GeneticE2F1 Transcription FactorCells, CulturedMutationCDC28 Protein Kinase, S cerevisiaeDNA-Binding ProteinsGene Expression RegulationTumor Suppressor Protein p53Retinoblastoma-Binding Protein 1Promoter Regions, GeneticRecombinant Fusion Proteins3T3 CellsBase SequenceMaturation-Promoting FactorKinetinThreonineStarfishRNA, Small InterferingXenopus ProteinsPositive Transcriptional Elongation Factor BS-Phase Kinase-Associated ProteinsUbiquitin-Protein Ligase Complexes
CDK2CDKsKinasesComplexesInteractsCDK7InhibitorsGerm cellsE2F1DependentEncoded by this geneMeiosisTransitionDistinctCellComplexSizeDependent kinaseCdk4CDC2Kinase activityCCNB1CCNA1MitoticRegulatesBindsPhosphorylationMitosisProteinBiolInhibitorInhibits1999ProteinsDegradationInducesNuclearMRNAVitroAccumulation
CDK212
  • The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
  • This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. (wikipedia.org)
  • Fig. 2: p38γ compensates for the loss of CDK1 or CDK2. (nature.com)
  • Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (proteopedia.org)
  • NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. (proteopedia.org)
  • Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)
  • The profiling of compound 51 against a panel of 339 kinases revealed high selectivity for CDKs, with preference for CDK2 and CDK5 over CDK9, CDK1, CDK4, and CDK6. (proteopedia.org)
  • Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (proteopedia.org)
  • CDK2/Cyclin A2-H00A-Wuxi Biortus Biosciences Co. Ltd. (wuxibiortus.com)
  • Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. (wuxibiortus.com)
  • The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (wuxibiortus.com)
  • In HCMV-infected cells, particular subsets of CDK-cyclin complexes are downregulated/suppressed (CDK4-cyclin D, CDK6-cyclin D, CDK2-cyclin A) or upregulated/turned on (CDK1-cyclin B, CDK2-cyclin E), leading to an early on S stage arrest termed pseudomitosis [11] eventually. (niepokorny.org)
CDKs4
  • Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). (wikipedia.org)
  • Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (proteopedia.org)
  • CDKs are cyclin-dependent serine-/threonine-specific proteins kinases, the experience of which depends upon cyclin binding. (niepokorny.org)
  • In addition with their main function in the legislation of cell routine progression, particular types of CDKs and cyclins get excited about transcription also, splicing, epigenetic legislation, neuronal features, stem cell regeneration, spermatogenesis, and differentiation [10]. (niepokorny.org)
Kinases2
Complexes1
  • Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. (nature.com)
Interacts1
CDK71
  • Along with CDK1 and -2, CDK7 and -9 are necessary for effective HCMV replication and had been discovered upregulated in HCMV-infected cells [3,12,13,14,15]. (niepokorny.org)
Inhibitors1
  • Current scientific trials are looking into cyclin-dependent kinase (CDK) inhibitors, such as for example roscovitine, an inhibitor of CDK1, -2, -5, -7, and -9, that lowers viral DNA synthesis, creation of late protein and infectious pathogen particles [4]. (niepokorny.org)
Germ cells1
E2F11
  • This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins. (wikipedia.org)
Dependent2
Encoded by this gene1
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. (wikipedia.org)
Meiosis2
  • Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. (wikipedia.org)
  • controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)
Transition1
Distinct1
  • Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. (wikipedia.org)
Cell1
  • Increased foam cell formation results from lack of VDR-SERCA2b interaction, causing SERCA dysfunction, activation of ER stress-CaMKII-JNKp-PPARγ signaling, and induction of the scavenger receptors CD36 and SR-A1. (regenerativemedicine.net)
Complex1
  • After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)
Size1
Dependent kinase9
  • A well-studied actor of cell cycle is cyclin dependent kinase 1 (cdk1) (Malumbres, 2014). (biologists.com)
  • The secondary endpoints were to decipher the mutation types across breast cancer subtype, menopausal status, and time to treatment failure after everolimus (an mTOR inhibitor) or cyclin-dependent kinase 4/6 (CDK4/6) inhibitor treatment. (bvsalud.org)
  • Present study was aimed to find out whether RO-3306, specific cyclin dependent kinase 1 (Cdk1) inhibitor could protect against postovulatory aging-mediated spontaneous exit from M-II arrest in rat eggs cultured in vitro. (cgrpreceptor.com)
  • It is a heterodimer protein containing cyclin dependent kinase 1 (Cdk1) as a catalytic subunit and cyclin B1 as a regulatory subunit [1,5,6]. (cgrpreceptor.com)
  • Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe . (sdbonline.org)
  • 1999). Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. (sdbonline.org)
  • cyclin dependent kinase 1 [Source:H. (gsea-msigdb.org)
  • OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11 , which binds to CDK11 B with a K d of 40 nM. (medchemexpress.com)
  • Vanicoside B targets cyclin-dependent kinase 8 ( CDK8 ) and exhibits anti-tumor activity. (medchemexpress.com)
Cdk44
  • [ 70 ] The first cyclins to be expressed following mitogenic or growth factor stimulation are the D-type cyclins (D1, D2 and D3), which form active holoenzymes with CDK4 and CDK6 and allow cells to leave from G0 phase to enter into the G1 phase. (medscape.com)
  • Cell cycle G2/M phase-related genes were altered by BBR treatment: the expression of cyclin A1, cyclin B1, and Cdk1 were down-regulated, while Cdk4, p21, and p53 were up-regulated. (elsevierpure.com)
  • [3] Mitogenic signals received throughout G1-phase cause gradual accumulation of cyclin D, which complexes with CDK4/6. (wikipedia.org)
  • [3] Active cyclin D-CDK4/6 complex induces release of E2F transcription factor, which in turn initiates expression of S-phase genes. (wikipedia.org)
CDC26
  • In late G2 and early M, cyclin A forms complexes with CDK1/CDC2 to facilitate entry into M phase. (medscape.com)
  • Cyclin B is subsequently expressed in late S phase and G2, and through interaction with CDK1/CDC2 further regulates M phase. (medscape.com)
  • also called Cdc2) cyclin-dependent protein kinase. (nih.gov)
  • A30: Cdc2 (Cdk1), in association with either Cyclin B or Cyclin A, phosphorylates ORC2. (nih.gov)
  • Cyclin A:Cdc2 binds ORC and phosphorylates ORC2p in Xenopus (PMID: 10660590). (nih.gov)
  • Cdk1 is the same as Cdc2. (nih.gov)
Kinase activity2
  • [ 74 ] While p21 WAF1/CIP1 and p27 KIP1 act as both promoters and inhibitors of cyclin/CDK kinase activity, p21 WAF1/CIP1 is the only CDKI that is capable of binding to all the cyclin/CDK complexes involved in cell cycle progression. (medscape.com)
  • On the other hand, RO-3306 protected postovulatory aging-induced changes in specific phosphorylation of Cdk1, cyclin B1 level, inhibited the kinase activity and prevented spontaneous exit from M-II arrest. (cgrpreceptor.com)
CCNB11
CCNA12
  • Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. (wikipedia.org)
  • also called CCNA1) cyclin A, a cell cycle inducible protein, prominent in S-phase, which activates cdks. (nih.gov)
Mitotic2
  • However, it is not well known if the mitotic transitions are strictly controlled by Cdk1 or coupled actions of various enzymes. (biologists.com)
  • 2000). CPEB, Maskin, and Cyclin B1 mRNA at the mitotic apparatus: Implications for local translational control of cell division. (sdbonline.org)
Regulates3
Binds1
  • They include contrary activation at the thesis transcription and Subsequently, can activate taken into 19 binds( Subfamily A1-19) increased on a receptor-related checkpoint( Joost cell and Methner A, 2002). (erik-mill.de)
Phosphorylation7
  • Besides cyclin binding, CDK activity is additionally regulated by phosphorylation and dephosphorylation on conserved threonine and tyrosine residues. (medscape.com)
  • controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)
  • The morphological changes, percentage of spontaneous exit from M-II arrest, total and specific phosphorylation status of Cdk1, cyclin B1 level and Cdk1 activity were analyzed. (cgrpreceptor.com)
  • Conclusions: Our results suggest that postovulatory aging destabilizes MPF by modulating specific phosphorylation of Cdk1 and cyclin B1 level. (cgrpreceptor.com)
  • MPF destabiliza- tion may also be due to series of phosphorylation at Thr14/ Tyr15 and dephosphorylation at Thr161 of Cdk1 thereby modulates meiotic cell cycle progression [3,4,13]. (cgrpreceptor.com)
  • 1995). Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. (sdbonline.org)
  • 3) chemical inducers primarily phosphatase inhibitors such as okadaic acidity calyculin A and fostreicin.14-18 In the second option case activation from the maturation/mitosis promoting element (MPF) is an integral mediator of PCC while Cdk1 (p34cdc2) bound Caudatin to cyclin B1 is activated by tyrosine dephosphorylation by cdc25c.19 Cdc25 itself is controlled by auto-phosphorylation and dephosphorylation by protein phosphatases PP2A or PP1. (monossabios.com)
Mitosis4
Protein5
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. (wikipedia.org)
  • see Figure 4C legend) were treated with the indicated peptide-coupled beads and immunoblotted for cyclin A1 or 14-3-3 protein (right). (bioz.com)
  • Activated Cdk1 modulates several biochemical and morphological events by triggering the specific phosphorylations of various protein substrates [16,17]. (cgrpreceptor.com)
  • a protein kinase that inhibits Cdk1. (nih.gov)
  • After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)
Biol1
  • The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A. J Mol Biol. (proteopedia.org)
Inhibitor2
  • This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins. (wikipedia.org)
  • Previous studies suggest that RO-3306 (an ATP competi- tive Cdk1 inhibitor) specifically inhibits Cdk1 activity and thereby cell cycle progression in human cancer cell line [16,23,24]. (cgrpreceptor.com)
Inhibits1
  • 13. Knockdown of Annexin A1 Enhances Radioresistance and Inhibits Apoptosis in Nasopharyngeal Carcinoma. (nih.gov)
19991
  • 1999). Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. (sdbonline.org)
Proteins3
  • [ 68 , 71-73 ] The integrity of CDKI-cyclins/CDK-Rb pocket proteins-E2F family cascade is thought to be a major determinant in regulating cell fate. (medscape.com)
  • C) GST-Cdc25A proteins (phosphorylated or not by Chk1) and egg extracts (equivalent to 10 eggs) were both prepared as in (B) (GST-Cdc25A proteins being eluted from glutathione beads), mixed together, and incubated for 1 h at 4°C. GST-Cdc25A proteins were then immunoprecipitated with anti-Cdc25A antibody (IP) and analyzed by immunoblotting using anti-GST or anti-cyclin A1 antibodies. (bioz.com)
  • Members of the NAP/SET family of proteins interact specifically with B-type cyclins. (sdbonline.org)
Degradation2
  • Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. (wikipedia.org)
  • MPF stabilization requires association of cyclin B1 with Cdk1 [3,5,7], while dissociation of cyclin B1 from MPF heterodimer and its degradation destabilizes MPF and triggers meiotic resumption from diplotene as well as metaphase-II (M-II) arrest [3-5,7-13]. (cgrpreceptor.com)
Induces1
Nuclear1
  • To test if this sensitive enzyme is indeed Cdk1, the authors characterize Cdk1 activity at different temperatures during nuclear cycle 11. (biologists.com)
MRNA1
Vitro2
  • Postovulatory aging increased Thr14/Tyr15 phosphorylated Cdk1 level, decreased Thr161 phosphorylated Cdk1 as well as cyclin B1 levels and increased Cdk1 activity in aged eggs cultured in vitro. (cgrpreceptor.com)
  • Cdk1 activity increases during meiotic resumption from diplotene arrest in oocytes cultured in vitro [18-22]. (cgrpreceptor.com)
Accumulation1
  • Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila. (sdbonline.org)