• MDA-MB-468 cells overexpressing E-cadherin were more proliferative and less migratory in vitro, whereas E-cadherin knockdown (short hairpin CDH1 [shCDH cells were more migratory and invasive, less proliferative, and took longer to form tumors. (biomedcentral.com)
  • The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. (cusabio.com)
  • Complete loss of E-cadherin protein expression in 84% of lobular breast carcinomas. (wikipedia.org)
  • The present study aimed to characterize the immunohistochemical expression of vimentin (VIM), of E-cadherin (CDH1), and of cytokeratin 5 (CK5) in patients with invasive ductal carcinomas (IDCs). (scielo.br)
  • Several proteins such as SNAI1/SNAIL, ZFHX1B/SIP1, SNAI2/SLUG, TWIST1 and DeltaEF1 have been found to downregulate E-cadherin expression. (wikipedia.org)
  • CDH1 encodes E-cadherin, a glycoprotein that plays an important part in cell-cell interaction. (springer.com)
  • Cdh1 polymorphisms and low expression of e-cadherin and beta-catenin in colorectal cancer patients. (springer.com)
  • Association between e-cadherin (cdh1) polymorphisms and pancreatic cancer risk in Han Chinese population. (springer.com)
  • Homo sapiens cDNA FLJ78203 complete cds, highly similar to Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA. (embl.de)
  • Homo sapiens truncated E-cadherin (CDH1) mRNA, complete cds. (embl.de)
  • The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. (wikipedia.org)
  • During the time of APC/CCdc20 activity, Cdh1 is phosphorylated and cannot bind to the APC/C. After metaphase, however, S/M-Cdks are inactivated by APC/CCdc20, and Cdh1 can exist in a non-phosphorylated state and bind the APC/C. This enables the APC/C to continue to degrade S/M cyclins (and thus S/M Cdks) until they are needed again in the next S-phase. (wikipedia.org)
  • The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. (wikipedia.org)
  • This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. (wikipedia.org)
  • An example that reveals the interaction of the multiple negative and positive feedback loops is the activation of cyclin-dependent protein kinases, or Cdks14. (wikipedia.org)
  • The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. (wikipedia.org)
  • Region of homology to semaphorins (Sema domain), which includes the full α-chain and the N-terminal part of the β-chain Cysteine-rich MET-related sequence (MRS domain) Glycine-proline-rich repeats (G-P repeats) Four immunoglobulin-like structures (Ig domains), a typical protein-protein interaction region. (wikipedia.org)
  • overexpressed a human cDNA library in S. cerevisiae, and screened for genes that simultaneously affected cell cycle and cell polarity controls, inducing a filamentous yeast budding phenotype, and thus identified the HEF1 protein (Human Enhancer of Filamentation 1). (wikipedia.org)
  • Pei Y, Wang P, Liu H, He F, Ming L. Foxq1 promotes esophageal cancer proliferation and metastasis by negatively modulating cdh1. (springer.com)
  • Without Cdk1-Clb2 complexes to phosphorylate proteins that are involved in spindle dynamics such as Sli15, Ase1, and Ask1, spindle elongation and chromosomal segregation are promoted, facilitating mitotic exit. (wikipedia.org)
  • CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. (uniprot.org)
  • Methylation of CDH1 promotors can alter the expression of its protein and is also considered as a contributor to various cancers. (springer.com)
  • In this study, CDH1 methylation and expression profile as well as prognosis of 38 cases of eyelid SCC and the corresponding adjacent tissues were analyzed to clarify the role of CDH1 methylation in SCC carcinogenesis and prognosis. (springer.com)
  • Methylation was detected by PCR, and CDH1 expression was evaluated by immunohistochemistry. (springer.com)
  • We observed that CDH1 methylation is significantly correlated with decreased CDH1 protein expression in eyelid SCC patients. (springer.com)
  • Patients with methylation and low expression of CDH1 are significantly associated with advanced and aggressive phenotypes. (springer.com)
  • Therefore, CDH1 methylation and CDH1 expression are both independent prognostic factors for prognosis of eyelid SCC patients. (springer.com)
  • CDH1 promoter methylation in patients with cervical carcinoma: a systematic meta-analysis with trial sequential analysis. (nih.gov)
  • Activation of the APC requires its association with substoichiometric activating subunits termed Cdc20 and Hct1 (also known as Cdh1). (sdbonline.org)