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  • septin
  • In particular, septin-associated protein kinases couple cell cycle progression with cellular morphogenesis. (frontiersin.org)
  • This review summarizes what we currently understand about how the action of septin-associated protein kinases and their substrates control information flow to drive the cell cycle into and out of mitosis, to regulate bud growth, and especially to direct timely and efficient execution of cytokinesis and cell abscission. (frontiersin.org)
  • In addition, and importantly, the activities of certain septin-associated protein kinases also regulate the state of organization of the septins themselves, creating a complex feedback loop. (frontiersin.org)
  • Budding yeast ( S. cerevisiae ) has served as a path-finding model eukaryote in which to explore the structure, function, and regulation of septins and septin-associated proteins. (frontiersin.org)
  • In particular, as discussed here, septin-based structures recruit, and thereby localize (and, in some cases, regulate the activity of) a multiplicity of protein kinases that integrate multiple inputs into signaling pathways and ultimately initiate ensuing biological responses (Figure 1 ). (frontiersin.org)
  • GEFs
  • The binding of GEFs to their GTPase substrates catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place. (wikipedia.org)
  • However, there are some similarities in how different GEFs alter the conformation of the G protein nucleotide-binding site. (wikipedia.org)
  • Though this general scheme is common among GEFs, the specific interactions between the regions of the GTPase and GEF vary among individual proteins. (wikipedia.org)
  • Calcium
  • The conventional PKCs are activated by calcium binding to the C2 domain and diacylglycerol binding to the C1 domain. (asm.org)
  • The C2 domain of the novel PKCs does not bind calcium but they are activated by diacylglycerol. (asm.org)
  • indirectly
  • Several common GTPase families like Rac and Rho promote microtubule assembly indirectly by facilitating GDP/GTP exchange on regulatory members that effect assembly and disassembly of tubulin dimers. (antibodies-online.com)
  • small
  • WASp is a product of the WASp, and mutations in the WASp can lead to Wiskott-Aldrich syndrome (an X-linked disease that mainly affects males with symptoms that include thrombocytopenia, eczema, recurrent infections, and small-sized platelets) in these patients the protein is usually significantly reduced or absent. (wikipedia.org)
  • Pathway
  • It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. (antibodies-online.com)
  • nucleus
  • For example, the Ran GEF, RCC1, is present in the nucleus while the Ran GAP is present in the cytosol, modulating nuclear import and export of proteins. (wikipedia.org)
  • different
  • Results indicated that all isolates represent genetically different S. cerevisiae var. (bioportfolio.com)
  • Extracellular Wnts bind a variety of different receptors, and initiate signaling in several distinct pathways. (antibodies-online.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)