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  • guanine nucleo
  • The enrichment of activated Cdc42 in SSeCKS- leading edge filopodia correlated with recruitment of the Cdc42-specific guanine nucleotide exchange factor, Frabin, likely recruited via multiple PIP2/3-binding domains. (nih.gov)
  • Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene. (wikipedia.org)
  • FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein that in humans is encoded by the FGD1 gene that lies on the X chromosome. (wikipedia.org)
  • RhoA
  • Baculorviruses containing coding regions of Cdc42, Rac1, or RhoA fused with glutathione S -transferase (GST) at their N termini (kindly provided by Kimberly Tolias and Christopher Carpenter, Beth Israel Hospital, Boston) were used to infect Sf9 cells at a density of 1 × 10 6 cells/ml. (pnas.org)
  • Left panel) Exchange activity of immunoprecipitates from FLAG-ECT2-expressing cells (open symbols) or FLAG-expressing cells (filled symbols) on RhoA (circles), Rac1 (squares), or Cdc42 (triangles). (nih.gov)
  • The ruffling of membranes is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. (wikipedia.org)
  • DLC1 expression is frequently lost in tumor cells, resulting in constitutive activation of the RhoGTPases RhoA and Cdc42. (wikipedia.org)
  • scaffold protein
  • During myoblast differentiation, the promyogenic cell surface receptor Cdo binds to the p38alpha/beta pathway scaffold protein JLP and, via JLP, p38alpha/beta itself. (nih.gov)
  • Other functions of WASP depend on its activity as a scaffold protein for assembly of effective signalling complexes downstream of antigen receptor or integrin engagement. (wikipedia.org)
  • regulatory
  • However, very little is known with regard to potential regulation by G-protein regulatory factors (e.g., the guanosine diphosphate-dissociation inhibitor [GDI]) of insulin secretion from the islet β-cell. (diabetesjournals.org)
  • Pseudopodia
  • Cdc42 overexpression significantly improved the ability of cervical cancer cells to migrate, possibly due to improved pseudopodia formation. (wikipedia.org)
  • When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. (wikipedia.org)
  • filopodia
  • Activated Rho leads to the formation of stress fibers, and activated Cdc42 causes filopodia to form ( 17 , 28 , 34 ). (asm.org)
  • SSeCKS loss induced chemotactic velocity and linear directionality, correlating with replacement of leading edge lamellipodia with fascin-enriched filopodia-like extensions, the formation of thickened longitudinal F-actin stress fibers reaching to filopodial tips, relative enrichments at the leading edge of phosphatidylinositol (3,4,5)P3 (PIP3), Akt, PKC-ζ, Cdc42-GTP and active Src (SrcpoY416), and a loss of Rac1. (nih.gov)
  • It was proposed that the overexpression of Cdc42 can promote filopodia formation in HeLa cells. (wikipedia.org)
  • downstream
  • These results reveal a previously unknown linkage between a cell surface receptor and downstream modulation of Cdc42 activity. (nih.gov)
  • The C1 domain - immediately downstream of the Ras binding domain - is a special zinc finger, rich in cysteines and stabilized by two zinc ions. (wikipedia.org)
  • Molecular
  • The core PCP proteins have been mapped to the Wnt/PCP pathway genetically, but the molecular mechanism of their action remains unknown. (biologists.org)
  • In molecular terms, citron-K depletion impaired the accumulation of 3 key proteins: Rho, Anillin and septins (specifically septin 6 and 7) in the intercellular bridge in mid-late telophase, which in previous stages early to mid-telophase was found to co-localize with them. (wikipedia.org)
  • stimulate
  • Rho family GTP-binding proteins also stimulate other signaling pathways that are important in both normal cellular function and transformation, including cell cycle progression, activation of the c-jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways, and regulation of transcription. (asm.org)
  • Phosphorylation
  • PAK2 kinase activity is stimulated by transforming growth factor β in fibroblasts, by proteinase inhibitor alpha2-macroglobulin binding to GRP78 in prostate cancer cells, by its phosphorylation by AMP-activated protein kinase in stem and cancer cells and eryptosis. (wikipedia.org)
  • induce
  • Recent data also suggest that constitutive active forms of Cdc42 can induce apoptosis through a mechanism requiring signaling through SAPK/JNK. (abcam.com)
  • novel
  • The C2 domain of the novel PKCs does not bind calcium but they are activated by diacylglycerol. (asm.org)
  • Antibodies
  • Both PS and anti-PSR antibodies stimulated membrane ruffling, vesicle formation, and "bystander" uptake of cells bound to the surface of the phagocyte. (nih.gov)
  • Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
  • This C-terminal repetitive region is designated as the immuno-dominant region since ligand binding can be blocked by monoclonal antibodies specific to this region. (wikipedia.org)