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  • CDC27
  • Here, in normal murine mammary gland epithelial cells (NMuMG), CDC27 expression is controlled posttranscriptionally through the RNA binding protein poly(rC) binding protein 1 (PCBP1)/heterogeneous nuclear ribonucleoprotein E1 (HNRNP E1). (aacrjournals.org)
  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. (wikipedia.org)
  • subunits
  • In order for Cdc20 to bind the APC/C, specific APC/C subunits must be phosphorylated by Cdk1 (among other Cdks). (wikipedia.org)
  • In addition to the catalytic subunits, other core proteins of the APC are composed multiple repeat motifs with the main purpose of providing molecular scaffold support. (wikipedia.org)
  • SCF contains three core subunits, and a number of less critical components: F-box protein (e.g. (wikipedia.org)
  • regulatory
  • CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. (abnova.com)
  • Cell cycle regulatory proteins and checkpoints are downstream elements of cellular signaling cascades crucial for cell proliferation. (biomedcentral.com)
  • Because eukaryotic cell cycle involves a variety of proteins and regulatory interactions, dynamical systems approach can be taken to simplify a complex biological circuit into a general framework for better analysis. (wikipedia.org)
  • BUB1B
  • Representative image of Proximity Ligation Assay of protein-protein interactions between CDC20 and BUB1B. (abnova.com)
  • HeLa cells were stained with anti-CDC20 rabbit purified polyclonal antibody 1:1200 and anti-BUB1B mouse monoclonal antibody 1:50. (abnova.com)
  • chromosomes
  • Premature activation of the mitotic APC/C-CDC20 leads to missegregation of chromosomes and significantly contributes to chromosomal instability ( 7-9 ). (aacrjournals.org)
  • Her research group recently created haploid yeast cells containing extra copies of chromosomes and discovered that these aneuploid strains elicit phenotypes independent of the identity of the additional chromosome such as defects in cell cycle progression, increased energy demands, and interference with protein biosynthesis. (wikipedia.org)
  • regulates
  • The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. (uniprot.org)
  • Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. (wikipedia.org)