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  • regulates
  • Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function. (harvard.edu)
  • Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. (springer.com)
  • Proteins that localize to sites of DNA damage in the G2 phase initiate a signaling cascade that regulates wee1 and cdc25 activity, therefore controlling mitotic entry via cdc2-cyclin B. Delay in mitotic entry is important for cells to repair any DNA damage that may have accumulated after S phase. (wikipedia.org)
  • family kinases
  • Recent genetic studies indicate that mutations of Cdkl family kinases are associated with neurodevelopmental and neuropsychiatric disorders in humans. (frontiersin.org)
  • Inhibitor
  • This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). (abcam.com)
  • nuclear
  • 2000). The 110 kDa isoform localises to nuclear speckles and binds to the RNPS1 RNA binding protein (Loyer et al. (biologists.org)
  • Asada A, Yamamoto N, Gohda M, Saito T, Hayashi N, Hisanaga S. Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes. (springer.com)
  • regulators
  • cdc2) are key regulators of the eukaryotic cell cycle. (uofk.edu)
  • Cyclin A1 was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. (abcam.com)
  • This effect is dependent on the presence of wee1 and cdc25, which places chk1 upstream of these direct regulators of cyclin-dependent kinase. (wikipedia.org)