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  • cyclins
  • The idea that Cdc2 and cyclins play a key role in the control of the G2/M transition of the cell cycle came largely from genetic analysis of fission yeast and physiological studies of clam, frog, sea urchin and starfish eggs and oocytes. (biologists.org)
  • Fission yeast mutants that are prematurely advanced into mitosis and thus enter prophase at reduced size focused attention on Cdc2, but gave no clues about cyclins. (biologists.org)
  • cdc28
  • It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. (wikipedia.org)
  • molecular
  • View detailed Cdc2 Substrate specifications, including Cdc2 Substrate CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name. (scbt.com)
  • significantly
  • For example, an increase in expression of cyclin B1/cdc2 is significantly higher in breast tumor tissue and shown to increase lymph node metastasis in breast cancer. (wikipedia.org)
  • functional
  • We now report on the isolation of partial cdc2 pseudogenes from Picea engelmannii and Picea sitchensis, as well as partial functional cdc2 sequences from P. engelmannii, P. sitchensis and Pinus contorta. (deepdyve.com)
  • Phylogenetic analyses of pseudogene and functional cdc2 sequences, as well as the presence of shared insertions or deletions, support the division of most of the cdc2 pseudogenes into two subfamilies. (deepdyve.com)
  • expression
  • 4. Tsujioka Y, et al (1999) Localization and expression of cdc2 and cdk4 in Alzheimer brain tissue. (ihcworld.com)
  • The changes in the chromatin structure such as the appearance of DNase I hypersensitivity sites or the slteration of DNA methylation status were not observed in T-lymphocytes even after the induction of cdc2 mRNA expression by mitogenic stimuli. (nii.ac.jp)