CD98HC has been shown to participate in integrin signaling, and most notably, has been implicated in tumor cell growth. (bmj.com)
CD98hc (SLC3a2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. (ucsd.edu)
Human3
Paraffin sections were co-stained with an anti-mouse CD31 antibody to visualize microvascular endothelial cells and an anti-human CD98HC antibody. (bmj.com)
Conclusions We have established a humanized B-hCD98HC mouse model that exhibits robust expression of human CD98HC, which can be used for preclinical studies to assess the efficacy of novel therapeutic agents. (bmj.com)
The cover for issue 13 of Oncotarget features Figure 6, "CGA analyses (expression, metastasis and prognosis) and possible CD98hc-independent cell-surface expression of LAT1 in human cells," by Hayashi, et al . (oncotarget.com)
Shown1
They have shown that CD98hc was present at the surface of sEVs, transferred and stabilized at the plasma membrane of recipient cells. (inserm-transfert.com)
SLC3A23
Here, through a proteomic-based approach, we identified a list of potential PTPRJ-interacting proteins and among them we focused on CD98hc, a type II glycosylated integral membrane protein encoded by SLC3A2, corresponding to the heavy chain of a heterodimeric transmembrane amino-acid transporter, including LAT1. (unina.it)
18. SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed. (nih.gov)
System Xc is composed of two subunits, the light chain (xCT) and the heavy chain (CD98hc, SLC3A2) and functions by cellular uptake of cysteine in exchange for glutamate in a 1:1 ratio (1,2). (novusbio.com)
Amino acid1
During this time, he worked on the structure-function characterisation of the heteromeric amino acid transport, LAT1-CD98hc, a membrane protein that is the focus of drug development for targeted drug delivery to tumours and blood-brain barrier. (crick.ac.uk)
Protein3
The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells. (unina.it)
We first validated PTPRJ-CD98hc interaction, then demonstrated that PTPRJ overexpression dramatically reduces CD98hc protein levels in A549 lung cancer cells. (unina.it)
Finally, the team discovered that interactions on the stem cell surfaces between HML-2 and another immune cell protein called CD98HC may restrain differentiation by triggering internal chemical reactions that are known to control cell growth and tumors. (nih.gov)
Interaction1
The decreased interaction of Env with CD98HC results in the inactivation of mTOR and LPCAT1 pathways, leading to decreased cell proliferation and the loss of stemness. (nih.gov)
Cell2
CD98hc is widely overexpressed in several types of cancers and contributes to the process of tumorigenesis by interfering with cell proliferation, adhesion, and migration. (unina.it)
Moreover, PTPRJ overexpression combined with CD98hc silencing consistently reduced cell proliferation and triggered apoptosis of lung cancer cells. (unina.it)