CD95 receptors - also referred to as Fas - have gained the nickname 'death receptors' because they send a signal that causes cancer cells to 'self-destruct,' according to a press release from UC Davis. (rationalreview.com)
Indeed we show that CD8(+) T cells were able to activate macrophages through receptors that include CD95 (Fas). (ox.ac.uk)
Experts are hopeful that future cancer drugs could boost the activity of these CD95 receptors to create a new weapon against cancer tumors, which have been treated historically with surgery, chemotherapy and radiation. (newsrollup.com)
Key players in the controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR activated by its cognate ligand CD95L triggering programmed cell death. (researchgate.net)
Receptor6
The antibody LT95 reacts with an extracellular epitope on CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. (exbio.cz)
CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. (exbio.cz)
An epitope on CD95 receptor causes tumour cells to self-destruct and may prolong benefits of CAR T-cell therapy for solid tumours. (drugtargetreview.com)
Scientists at the UC Davis Comprehensive Cancer Center in Sacramento, California, have identified a protein on the CD95 receptor that can 'program' cancer cells to die, as detailed in a study published in the journal Cell Death & Differentiation last month. (rationalreview.com)
Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. (researchgate.net)
Stimulation of CD952
Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. (exbio.cz)
Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the transduction of either apoptotic or non‐apoptotic signals. (researchgate.net)
Monoclonal Antibody1
In this work, we isolate a dromedary camel V H H single-domain antibody (also known as nanobody) named D4 and a monoclonal antibody (mAb) named HM2 recognizing membrane-distal and membrane-proximal epitopes of GPC1, respectively. (nature.com)
Cytokine1
Park DR, Thomsen AR, Frevert CW, Pham U, Skerrett SJ, Kiener PA, Liles WC: Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. (exbio.cz)
Antibodies1
Examples of this exception are the elderly individuals infected during the 2009 pandemic season who made antibodies with broader epitope recognition and higher avidity than those made by younger individuals. (biomedcentral.com)
CD95L1
As a consequence, alterations in the CD95/CD95L pathway have been involved in several disease co. (researchgate.net)
CD861
Results Consistent with previous reports, SARD patients had increased proportions of activated B cells (CD86 + or CD95 + ) and in the SLE patient subset there were increased proportions of plasma cells/plasmablasts, as compared to ANA - controls. (bmj.com)
CD901
MSCs can be defined by their ability to adhere to tissue culture plastic, their expression of several cell surface molecular epitopes-cluster of differentiation CD73, CD90, and CD105, and others-as well as their lack of several surface markers, including CD45 [ 6 ]. (biomedcentral.com)
Flow cytometry2
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD95 (LT95) PE-DyLight® 594 antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
Separation of human CD95 positive T cells (red-filled) from CD95 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD95 (LT95) PE-DyLight® 594 antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
Motifs1
Estimating the fraction of the T-cell response directed against the single immunodominant epitope, we identify the sequence features of TCRs that define the high precursor frequency of the two major TCR motifs specific for this particular epitope. (elifesciences.org)
Recognizes1
It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule. (exbio.cz)
Therapeutic1
But now that we've identified this epitope (target), there could be a therapeutic path forward to target Fas in tumors,' Jogender Tushir-Singh, an associate professor in the Department of Medical Microbiology and Immunology and senior author of the study, said in the release. (rationalreview.com)
Cells2
This study demonstrates the potential of V H H-based CAR T for pancreatic cancer therapy and provides an engineering strategy for developing potent CAR T cells targeting membrane-distal epitopes. (nature.com)
Conclusions Tfh cells appear to play an important role in the development of a positive ANA and in the epitope spreading that may accompany disease progression, and therefore constitute a promising target for treatment of early disease. (bmj.com)
Target2
Thus, the design of CARs needs to consider both the epitope within the target and the nature and length of the spacer and TM regions. (nature.com)
Here we report that macrophages infected with Mycobacterium tuberculosis, rapidly process and present an early secreted antigenic target (ESAT-6)-specific HLA class I-restricted CD8(+) T cell epitope. (ox.ac.uk)
Type1
Brumatti G, Yon M, Castro FA, Bueno-da-Silva AE, Jacysyn JF, Brunner T, Amarante-Mendes GP: Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide. (exbio.cz)
Made1
Thus far, no CD95-boosting drugs have made it into clinical trials. (newsrollup.com)
CD692
Results In MS, GA diminished transitional B-cell and plasmablast frequency, downregulated CD69, CD25, and CD95 expression, and decreased TNF-α production, whereas IL-10 secretion and MHC Class II expression were increased. (neurology.org)
RESULTS: KTrs who developed ATN upon transplantation had significantly higher expression of CD25, CD69, and CD95 on CD8+ and lower expression of CD95 on CD4+ T lymphocytes than patients with stable graft function. (bvsalud.org)
Apoptosis3
12. Carboplatin induces Fas (APO-1/CD95)-dependent apoptosis of human tongue carcinoma cells: sensitization for apoptosis by upregulation of FADD expression. (nih.gov)
17. VEINCTR-N, an immunogenic epitope of Fas (CD95/Apo-I), and soluble Fas enhance T-cell apoptosis in vitro. (nih.gov)
Cytoflorymetric analysis of chosen markers of apoptosis CD95/CD95L (Fas/FasL) in thyroid tissues from young patients with Graves' disease and Hashimoto's thyroiditis. (edu.pl)
We should know a patient's Fas status - particularly the mutations around the discovered epitope - before even considering giving them CAR T," Tushir-Singh said. (medicine.news)
Dr Tushir-Singh said mutations to this epitope could be used as a marker to spot who should get CAR T-cell therapy. (patriotnewsorganization.com)
Tushir-Singh3
We have found the most critical epitope for cytotoxic Fas signaling, as well as CAR T-cell bystander anti-tumor function," Mr. Tushir-Singh said in a statement . (medicine.news)
But now that we've identified this epitope, there could be a therapeutic path forward to target Fas in tumors," Mr. Tushir-Singh said. (medicine.news)
Dr Tushir-Singh, one of the researchers, said: 'Now that we've identified this epitope, there could be a therapeutic path forward to target Fas in tumours. (patriotnewsorganization.com)
Antigen2
10. Functional consequences of APO-1/Fas (CD95) antigen expression by normal and neoplastic hematopoietic cells. (nih.gov)
To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58) diluted to 1X solution in water in a microwave at 100 degree Celsius for 10 minutes. (thermofisher.com)
Mutation2
2. Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells. (nih.gov)
Evasion of the host CTL response through mutation of key epitopes is a major challenge to natural or vaccine-induced immune control of HIV. (medscape.com)
Protein1
Cancer cells have cell membranes that contain protein receptors known as CD95 receptors. (medicine.news)
Molecules1
As these groups are most abundantly found within cells, as opposed to their surface, fixation and permeabilization are required, making these methods less suitable for barcoding before probing of fixation- or permeabilization-sensitive molecules or epitopes. (nature.com)
Expression1
Flow cytometric analysis of CD95 expression on human peripheral blood lymphocytes. (bdbiosciences.com)
Human2
Whole blood was stained with either PE-Cy™7 Mouse Anti-Human CD95 antibody (Cat. (bdbiosciences.com)
Recognizes an epitope (aa 1-200) present in both short (FLIP S ) and long (FLIP L ) splice variants of human and mouse FLIP. (adipogen.com)
Cell5
13. Soluble Fas (APO-1/CD95) isoform in adult T-cell leukemia. (nih.gov)
The research team was able to identify and activate a crucial epitope that signals a swift death of the cancer cell. (medicine.news)
With the advent of this latest epitope discovery, CAR T-cell therapies could become more effective against solid tumors in any part of the body. (medicine.news)
CD95 receptors, also known as Fas receptors, are located on the outside of cancer cell membranes. (patriotnewsorganization.com)
This results in cryptic T-cell epitopes, the degeneracy of T-cell receptors, and the disruption of immune tolerance [ 15 , 16 ]. (hindawi.com)
Patients1
AMA is a highly specific autoantibody found in about 90% of patients with PBC that reacts with an epitope on the E2 subunit of the pyruvate dehydrogenase enzyme complex (PDC-E2) [ 1 - 3 ]. (hindawi.com)
Production1
This study describes a form of partial agonism for a CD8+ CTL clone, S15, in which perforin-dependent killing and IFN-gamma production were lost but Fas (APO1 or CD95)-dependent cytotoxicity preserved. (ox.ac.uk)