AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
T-LymphocytesLymphocytesAntigens, CD3Lymphocyte ActivationAntigens, CD8CD4-Positive T-LymphocytesCD4-CD8 RatioCD40 LigandAntigens, CD40Antigens, CD28Antigens, CD44Antigens, CD34Antigens, CDCD8-Positive T-LymphocytesT-Lymphocytes, CytotoxicAntigens, CD14Antigens, CD38Lymphocyte CountAntigens, CD2B-LymphocytesAntigens, CD80Flow CytometryAntigens, CD1Antigens, CD95Lymphocyte SubsetsAntigens, CD19Cytotoxicity, ImmunologicT-Lymphocyte SubsetsAntigens, CD5Antigens, CD86Antigens, Differentiation, T-LymphocyteInterleukin-2SpleenAntigens, CD56ImmunophenotypingAntigens, CD18Receptors, Antigen, T-CellCD4 Lymphocyte CountCells, CulturedAntigens, CD30Thymus GlandAntigens, CD43Lymphocytes, Tumor-InfiltratingAntigens, CD24Mice, Inbred C57BLAntigens, CD20Antibodies, MonoclonalAntigens, CD36Antigens, CD7Antigens, CD9Interferon-gammaAntigens, CD11Clone CellsAntigens, SurfaceT-Lymphocytes, RegulatoryCytokinesAntigens, CD57Receptors, Antigen, T-Cell, alpha-betaMice, Inbred BALB CT-Lymphocytes, Helper-InducerAntigens, CD59Antigens, CD70Dendritic CellsAntigens, CD47Cell SeparationLymph NodesCell LineMolecular Sequence DataAntigens, DifferentiationAntigens, CD46PhytohemagglutininsAntigens, CD11bReceptors, Interleukin-2Lymphocyte Culture Test, MixedImmunologic MemoryAntigens, CD81HIV-1HLA-DR AntigensMice, TransgenicKiller Cells, NaturalAntigens, CD137Immunity, CellularAntigens, CD58Jurkat CellsImmunohistochemistryLeukocyte CountAntigens, CD11cAntigens, CD31Antigens, CD45Lymphocyte DepletionConcanavalin AMacrophagesCell DivisionAntigens, CD4Histocompatibility Antigens Class IIInterleukin-4Amino Acid SequenceCytotoxicity Tests, ImmunologicLichenoid EruptionsAntigens, CD55
SubsetsTumor-infiltratinInfiltrationMacrophagesPeripheral blood lymphocyteNumbers of lymphocytesTILsCD25NeutrophilsAntigenProliferationDepletionReceptorCellsPredominantlyAntibodiesMicroenvironmentThymicCounts and percentagesCancersCytometricHaematologicalPercentageAntibodyPercentagesPrognosticResponsesClinicalCell ratioMonocytesNeoplasticImmuneLocalizationSuppressorProportionInfectionCountTumorsMoleculesProteinEtiologySurvivalParticipantsFlowExpressionThyroidLevelsLymphomaNormalSignificantly lowerActivation
Subsets11
  • The level of The infants with PEM were enrolled in T-lymphocyte subsets in peripheral blood the study after fulfilling a set of inclusion provide information about the development criteria. (who.int)
  • The mechanism was perhaps related to inhibiting lymphocyte apoptosis and promoting the balance of Th1/Th2 cell subsets. (hindawi.com)
  • It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
  • This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)
  • Serum from145 iGCTs patients were collected and lymphocyte subsets were analyzed by flow cytometry. (researchsquare.com)
  • Dynamic monitoring of serum lymphocyte subsets can be used as an auxiliary indicator for prognosis judgment. (researchsquare.com)
  • Flow cytometric results showing development of Jin Li, Bo-An Li, and Yuan-Li Mao1 peripheral blood lymphocyte subsets during the disease course were divided into 3 groups on the basis of time of We analyzed changes in immunologic values over time illness onset until date of blood sample collection: 1-3, for 28 hospitalized patients with pandemic (H1N1) 2009. (cdc.gov)
  • With the advent of the human immunodeficiency virus (HIV) pandemic, there has been a tendency to overlook the role of malnutrition in immunodeficiency, and indeed, only a handful of studies have investigated the CD4 + and CD8 + lymphocyte subsets in severely malnourished children [ 3 , 4 ]. (biomedcentral.com)
  • The objective of this study was to report the clinical features, haematological findings and CD4 + and CD8 + lymphocyte subsets of severely malnourished children with regard to their HIV status. (biomedcentral.com)
  • In addition, the distribution of major conventional and regulatory T-cell subsets was analyzed in the same peripheral lymphocyte compartments. (ac.rs)
  • ii) enhanced cell proliferation across all thymocyte subsets and (iii) reduced apoptosis of cells within the CD4 + CD8 + thymocyte subset. (ac.rs)
Tumor-infiltratin8
Infiltration4
  • Histological examination was performed to evaluate lymphocyte infiltration, presence of immune cells (T and B cells, plasma cells, dendritic cells and macrophages) and immune activation markers. (bmj.com)
  • Notch1 expression in B16 melanoma cells inhibited the infiltration of CD8+ cytotoxic T lymphocytes and NK cells and reduced IFN-γ release in tumor tissue. (biomedcentral.com)
  • Results: Patients with MMR-D showed a higher T-bet/CD4 ratio ( p = 0.02), a higher rate of CD80 expression and CD8 lymphocyte infiltration compared to those with no MMR-D. Moreover, in the MMR-D group, the Treg marker FoxP-3 was not expressed ( p = 0.05). (oncotarget.com)
  • Lymphocyte infiltration in breast cancer: a key prognostic factor that should not be ignored. (tilsinbreastcancer.org)
Macrophages8
  • Kupffer cells, hepatic stellate cells and sinusoidal endothelium) and infiltrating leukocytes (e.g., monocytes, monocyte-derived macrophages, neutrophils and lymphocytes). (mdpi.com)
  • Scattered T gamma-delta and B lymphocytes, macrophages and NK cells were observed among the cells of the dermal infiltrate of vulvar condylomata. (medicaljournals.se)
  • In the lymphoid aggregate, 20% macrophages are seen, while 30% B-L or plasma cells and remainder T-L (with a ratio of CD4: CD8 = up to 4: 1). (labpedia.net)
  • We also collected macrophages and CD8 + T cells from the peripheral blood of patients with IDD for co-cultures with NP cells. (medsci.org)
  • And macrophages and CD8 + T cells were harvested for apoptosis analysis by FCM after 2 days of co-cultures. (medsci.org)
  • FCM analysis found that human NP cells with increased FasL expression resulted in significantly increased apoptosis ratio of macrophages and CD8 + T cells. (medsci.org)
  • The presence of PAS-positive granules containing macrophages is not pathognomonic. (medscape.com)
  • Intestinal lamina propria of AIDS patients with concomitant Mycobacterium avium-intracellulare complex (MAC) infection may be packed with PAS-positive granules containing macrophages, but the intracellular bacilli are acid fast. (medscape.com)
Peripheral blood lymphocyte2
  • Flow cytometric analysis of peripheral blood lymphocyte understanding of disease pathogenesis. (cdc.gov)
  • This is a normal peripheral blood lymphocyte population with no indication of a neoplastic process. (labce.com)
Numbers of lymphocytes2
  • BAL samples of patients with ACPA-positive, but not ACPA-negative, RA had significantly higher relative numbers of lymphocytes and expressed higher levels of activation markers compared with controls. (bmj.com)
  • Based on the studies of survival, behavior of hematograms, and numbers of lymphocytes, whole body following irradiation, it was demonstrated that Vitamin c was an effective radioprotector. (biomedgrid.com)
TILs2
  • In addition, a deeper characterization of immune infiltrates, including the presence of a high number of cytotoxic (CD8 + ) TILs or a high CD8 + /FOXP3 + ratio, is able to define TNBC patients with a better prognosis following neoadjuvant chemotherapy [ 6 ]. (biomedcentral.com)
  • Tumour infiltrating lymphocytes (TILs) in breast cancer during pregnancy. (tilsinbreastcancer.org)
CD256
  • Median survival was 45.81 months and patients of increased Tc cells, activated T helper cells(CD4 + CD25 + T cells or activated Th cells), activated Tc cells and normal CD4 + /CD8 + ratio presented encouraging outcomes (p = 0.007;0.016;0.028;0.016 respectively). (researchsquare.com)
  • CD25 is expressed by early progenitors of T and B lineage as well as by activated mature T and B lymphocytes. (thermofisher.com)
  • CD25 plays a role in lymphocyte differentiating and activation/proliferation. (thermofisher.com)
  • CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
  • The ratios of CD3 + CD8 + cytotoxic T cells, CD49b + NK cells, CD4 + CD25 + FoxP3 + Tregs and Gr1 + CD11b + MDSCs in tumor-DLN or spleen were examined by flow cytometry. (biomedcentral.com)
  • T cells, especially CD8 T cells, showed an enhanced expression of late activation marker CD25 and exhaustion marker PD-1. (medrxiv.org)
Neutrophils1
Antigen3
  • Those condylomata with moderate to severe mononuclear infiltrate showed leucocyte function antigen 1 positive T cells forming small clusters in the lower epithelial half around the ICAM-1 positive keratinocytes. (medicaljournals.se)
  • Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
  • In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
Proliferation3
  • A recent study suggests that this may be related to a loss of function of regulatory T lymphocytes in such individuals, which may result in unchecked proliferation of lymphocytes that are normally restrained by these regulatory cells. (medscape.com)
  • After the co-culture of B16 cells and CD8 + T cells, the effects of Notch1 on the proliferation and activation of T cells were assessed by CCK8 assay, CFSE dilution and Chromium-release test. (biomedcentral.com)
  • It could also enhance B16 cell-mediated inhibition of T cell proliferation and activation, and upregulate PD-1 expression on CD4 + and CD8 + T cells. (biomedcentral.com)
Depletion5
  • Progressive depletion of CD4+ T-lymphocytes is associated with an increased likelihood of clinical complications (9,10). (cdc.gov)
  • In contrast, increased CD4 + T lymphocyte depletion depended on only two protein interaction surfaces in Nef that mediate either downregulation of cell surface CD4 or interaction with the NAKC signalosome. (biomedcentral.com)
  • Our findings suggest that Nef facilitates depletion of CD4 + T lymphocytes in HIV-1-infected lymphoid tissue ex vivo by increasing the pool of productively infected cells and by sensitizing bystander cells for killing. (biomedcentral.com)
  • The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of lymphocyte B depletion and hypogammaglobulinaemia is known as Good's syndrome and may affect up to 5% of patients with thymoma. (ecancer.org)
  • HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
Receptor3
  • Triple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast carcinomas and is associated with earlier age of onset, aggressive clinical course, and dismal prognosis compared to hormone receptor- and HER2-positive breast carcinomas [ 1 ]. (biomedcentral.com)
  • Description: The RPA-T8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). (thermofisher.com)
  • The pathogenesis of acquired immunodeficiency syndrome (AIDS) is largely attributable to the decrease in T-lymphocytes that bear the CD4 receptor (4-8). (cdc.gov)
Cells34
  • In conclusion, 10 d of IT resulted in a significant reduction in the number of circulating T cells independent of the training mode and a reduction in the CD4+/CD8+ ratio for ITRT but not for ITCT. (nih.gov)
  • CD4 helper T-cells which alert the immune the studied infants were from low socio- system to an attack by a pathogen and the economic status families according to the CD8 suppressor T-cells which destroy cells classification of Park and Park [11]. (who.int)
  • Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. (hindawi.com)
  • CD1a positive Langerhans' cells were also observed in dermis of condylomata, suggesting an abnormal epithelial traffic of dendritic cells. (medicaljournals.se)
  • T lymphocytes with a mean CD4/CD8 ratio of 0.25 and a mean density of 267 +/- 59 cells/mm2 of epithelial section were the main cellular infiltrate in vulvar papillomavirus infection. (medicaljournals.se)
  • Germinal centres, B cells and plasma cells were only found in ACPA-positive patients. (bmj.com)
  • The frequency of T cells in bronchial biopsies of patients with ACPA-positive RA was positively associated with expression of immune activation markers. (bmj.com)
  • Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. (bmj.com)
  • Results We discovered that T lymphocytes induce galectin-9 secretion in various types of human cancer cells derived from solid malignant tumors. (bmj.com)
  • The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
  • Another study showed a decrease data result from samples or information obtained on the in CD4, CD8, and B cells 2 days of symptom onset in day of hospitalization or when the patient was experiencing patients with pandemic (H1N1) 2009 than in healthy the acute phase of infection. (cdc.gov)
  • A muscle biopsy illustrated two processes: an inflammatory myopathy with prominent endomysial and perimysial infiltrations (mainly CD4-lymphocytes, some multinucleated giant cells and epitheloid cells) and pronounced neurogenic changes (grouplike atrophy of muscle fibers and florid disintegration of muscle fibers). (biomedcentral.com)
  • Cells in the lymphocyte gate were used for analysis. (thermofisher.com)
  • CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. (thermofisher.com)
  • CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. (thermofisher.com)
  • Therefore, there is good representation of both T helper and cytotoxic T cells (a neoplastic process could have predominantly one or the other or dual positive CD4 and CD8). (labce.com)
  • The B cells that are present, though a small percentage of the total lymphocytes, have no abnormal markers. (labce.com)
  • Most lymphocytes in this sample are T cells, which are also normal. (labce.com)
  • In addition, tumor infiltrating mononuclear cells (TIMC) and T cell subpopulations (CD4, CD8, T-bet and FoxP-3) were quantified. (oncotarget.com)
  • Accurate and reliable measures of CD4+ T-lymphocytes (CD4+ T-cells) are essential to the assessment of the immune system of human immunodeficiency virus (HIV)-infected persons (1-3). (cdc.gov)
  • and the percentage of lymphocytes that are CD4+ T-cells. (cdc.gov)
  • In comparison to HD, the lymphocyte percentage was slightly decreased, the percentages of CD4 and CD8 T cells in lymphocytes are similar, whereas B cell percentage increased in COVID-19 patients. (medrxiv.org)
  • ut of nave T cells as indicated by elevated levels of both CD4 + and CD8 + RTEs in peripheral blood and spleen. (ac.rs)
  • The augmented thymic output of naive T cells in Ovx rats most likely reflected an early disinhibition of thymocyte development followed by increased positive/reduced negative selection, at least partly, due to raised thymocyte surface Thy-1 expression. (ac.rs)
  • The increased thymic cellularity was accompanied by altered thymocyte differentiation/maturation culminating in increased thymic output of nave T cells as indicated by elevated levels of both CD4 + and CD8 + RTEs in peripheral blood and spleen. (ac.rs)
  • This review will recount the path to discovering the importance of resident memory CD8 T cells as they pertain to cancer immunity. (frontiersin.org)
  • Indeed a wealth of studies from humans and mouse models establishes a particularly potent role for CD8 T cells in controlling the outgrowth of malignancies ( 3 ). (frontiersin.org)
  • The recent success of T cell immune checkpoint inhibitor (ICI) therapies for cancer has revealed CD8 T cells as potent mediators of immunity against advanced cancers ( 4 , 5 ). (frontiersin.org)
  • In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
  • After administration of Vitamin c , enhanced CD4 and CD8 cells, numbers of NK cells and CD4 and CD8 cells in mice were found and lymphocytes numbers was higher than in irradiated control group. (biomedgrid.com)
  • Stimulated recovery of leukocyte, lymphocytes, and NK cells counts were observed in mice pre-treated with Vitamin c . (biomedgrid.com)
  • This procedure allows CDC to determine the distribution of CD4 cells in a random sample of HIV-positive individuals. (cdc.gov)
  • Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
  • CD4 and CD8 T lymphocytes directly target biliary epithelial cells. (msdmanuals.com)
Predominantly1
Antibodies1
  • Women who test positive for thyroid antibodies may be at increased risk of developing symptoms associated with postpartum depression than women without thyroid antibodies. (wikipedia.org)
Microenvironment1
  • Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
Thymic1
  • All enrolled thymic lymphocytes is widely accepted as infants were breastfed in addition to receiv- an indicator of the depression of thymus- ing some traditional foods, according to dependent immune competence associated their age. (who.int)
Counts and percentages1
  • In this paper, we report the complete results of the HIV tests as well as the CD4 + and CD8 + cell counts and percentages of the 315 children. (biomedcentral.com)
Cancers2
  • Occasionally positive in thyroid cancers. (labpedia.net)
  • Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2/neu oncogene. (tilsinbreastcancer.org)
Cytometric1
  • The publication of several sets of guidelines addressing aspects of the CD4+ T-lymphocyte testing process (e.g., quality control, quality assurance, and reagents for flow cytometric immunophenotyping of lymphocytes) has contributed to this standardization (29-32). (cdc.gov)
Haematological1
  • The aim of this study was to describe the clinical features, haematological findings and CD4 + and CD8 + cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection. (biomedcentral.com)
Percentage1
  • The last stage in the process of measuring the percentage of CD4+ T-lymphocytes in the whole-blood sample is referred to as 'immunophenotyping by flow cytometry' (22-28). (cdc.gov)
Antibody1
  • Whole EDTA anti-coagulated blood stored at -70°C from the 31 HIV antibody-positive participants from NHANES 1999-2004 and 34 age-matched controls were used. (cdc.gov)
Percentages1
  • The novel observation of this study is that the CD4 + percentages in both HIV-positive and HIV-negative children without oedema were lower that those in children with oedema. (biomedcentral.com)
Prognostic2
  • CD4+ T-lymphocyte levels also are used as prognostic indicators in patients who have HIV disease (17,18) and recently have been included as one of the criteria for initiating prophylaxis for several opportunistic infections that are sequelae of HIV infection (19,20). (cdc.gov)
  • Lymphocytes prognostic in breast cancer. (tilsinbreastcancer.org)
Responses2
  • Implement of comprehensive treatments led to positive responses. (researchsquare.com)
  • The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection. (ox.ac.uk)
Clinical3
  • Monocyte DNA methylation patterns associated with viral load, CD4 count, CD4/CD8 ratio, and longitudinal clinical phenotypes. (nih.gov)
  • Moreover, CD4+ T-lymphocyte levels are a criterion for categorizing HIV-related clinical conditions by CDC's classification system for HIV infection and surveillance case definition for AIDS among adults and adolescents (21). (cdc.gov)
  • The clinical manifestation of AIDS results from continuous replication of HIV in infected individuals that causes slow but steady decline of CD4 + T lymphocytes to levels that no longer control opportunistic infections [ 1 ]. (biomedcentral.com)
Cell ratio1
  • In addition, an increased CD4 + /CD8 + cell ratio was found in the spleen of Ovx rats. (ac.rs)
Monocytes2
  • We profiled longitudinal genome-wide DNA methylation in monocytes and CD4+ T lymphocytes from 22 participants in the RV254/SEARCH010 acute HIV infection (AHI) cohort that diagnoses infection within weeks after estimated exposure and immediately initiates ART. (nih.gov)
  • We identified monocytes harbored 22,697 differentially methylated CpGs associated with AHI compared to 294 in CD4+ T lymphocytes. (nih.gov)
Neoplastic1
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Immune3
  • Conclusions Signs of immune cell accumulation and activation are present both in the bronchial tissue and in BAL of untreated patients with early RA without concomitant lung disease, strengthening the role of the lung compartment as an important player in ACPA-positive RA. (bmj.com)
  • Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
  • Lymphocellular immune-competence was tested by CD4 and CD8 lymphocyte subtype count. (biomedcentral.com)
Localization1
  • Studies in infectious disease models have provided a wealth of information regarding memory CD8 T cell generation and localization. (frontiersin.org)
Suppressor1
  • A low ratio of CD4+ (helper) any chromosomal or hereditary disorder lymphocytes relative to CD8+ (suppressor) that caused the malnutrition. (who.int)
Proportion1
  • Defining lymphocyte-predominant breast cancer by the proportion of lymphocyte-rich stroma and its significance in routine histopathological diagnosis. (tilsinbreastcancer.org)
Infection1
  • The children showed a high prevalence of infections: pneumonia (68%), diarrhoea (38%), urinary tract infection (26%) and bacteraemia (18%), with no significant difference with regard to the HIV status (HIV-positive versus HIV-negative children). (biomedcentral.com)
Count5
Tumors1
  • Among the 900 patients evaluable for these exploratory analyses, most tumors that expressed PD-L1 were also positive for PD-L1 ICs. (cancertherapyadvisor.com)
Molecules1
  • LDH is a marker of parenchymal lung damage, and troponin and myoglobin are markers of myocardial and muscular involvement, while the remaining molecules belong to the group of positive acute-phase proteins (APP). (biomedcentral.com)
Protein1
Etiology1
  • The diagnosis is made by confirming hemolytic anemia and idiopathic thrombocytopenic purpura, but also a positive direct antiglobulin test (DAT) and an absence of any known underlying etiology. (standardofcare.com)
Survival2
  • A positive overall survival outcome was achieved only in PD-L1 + TNBC patients, suggesting a need to enrich the patient population more likely to benefit from an immunotherapeutic approach. (biomedcentral.com)
  • 11 ] demonstrated a substantial overall survival (OS) benefit in patients with PD-L1-positive (PD-L1 + ) metastatic or inoperable locally advanced TNBC through the addition of the anti-PD-L1 agent atezolizumab to first-line chemotherapy with nab-paclitaxel. (biomedcentral.com)
Participants1
  • Enumeration of CD4+ lymphocytes in HIV-positive participants and age-matched controls was performed on cryopreserved whole blood using the method reported by Fiebig et. (cdc.gov)
Flow1
  • The CDC guidelines concerning CD4+ T-cell determinations (33) were first published in the MMWR in 1992 to provide laboratorians with the most complete information about how to measure CD4+ T-lymphocytes in blood from HIV-infected persons by using flow cytometry. (cdc.gov)
Expression2
  • 8 Interestingly, increased expression of citrullinated proteins in RA was present in smokers as well as in ACPA-positive non-smokers, suggesting that factors other than smoking might also contribute to generation of citrullinated epitopes in the lungs. (bmj.com)
  • Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
Thyroid1
Levels1
  • Consequently, the Public Health Service (PHS) has recommended that CD4+ T-lymphocyte levels be monitored every 3-6 months in all HIV-infected persons (11). (cdc.gov)
Lymphoma3
  • 1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
  • 6 However, using a stricter definition requiring the presence of a prominent histiocytic component as a major feature and almost complete absence of small B lymphocytes, the unique character of this lymphoma has been demonstrated. (haematologica.org)
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Normal4
  • all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. (biomedcentral.com)
  • Electromyography showed spontaneous fibrillation and positive sharp waves with normal motor unit potentials. (biomedcentral.com)
  • There is a normal ratio of kappa to lambda. (labce.com)
  • results may be positive even in patients with normal chest radiographs. (medscape.com)
Significantly lower1
  • The CD4+/CD8+ ratio was significantly lower during ITRT compared with ITCT at D11. (nih.gov)
Activation1