• Pembrolizumab (Keytruda) showed activity in previously treated patients with advanced programmed cell death ligand 1 (PD-L1)-positive endometrial cancer in a cohort of the phase Ib KEYNOTE-028 study. (ascopost.com)
  • Together, our data show that a combination of DNA and MVA immunization induced robust, durable, multifunctional CD4(+) and CD8(+) responses in baboons targeting multiple HIV epitopes that may home to mucosal sites. (curehunter.com)
  • Immunohistochemistry ( PD-L1 , CD8, Foxp3, E-cadherin, and p53), PD-L1 mRNA in situ hybridization (ISH), microsatellite instability (MSI), and EBV ISH were performed in 392 stage II/III GCs treated with curative surgery and fluoropyrimidine-based adjuvant chemotherapy, and two public genome databases were analyzed for validation. (oncotarget.com)
  • These findings support the close relationship between PD-L1/CD8 status based immune types and EBV + , MSI-H GCs, and their prognostic significance in stage II/III GCs. (oncotarget.com)
  • The results indicated that provided the amount of exercise is constant for a given period, then exercise distribution is not a critical variable in the alteration of lymphocyte subpopulations that may occur in response to overload training. (biomedsearch.com)
  • PD-L1 + /CD8 High type accounted for majority of EBV + and MSI-high (MSI-H) GCs (92.0% and 66.7%, respectively), and genome analysis from public datasets demonstrated similar pattern. (oncotarget.com)
  • Binding of an immunomagnetically separated L-selectin- positive subpopulation of PBL to PLNs was also efficiently blocked by mAb 1B2 pretreatment (Fig. 3 C). Therefore, we determined whether L-selectin, although not necessary for lymphocyte binding to VAP-1, can also function as a receptor of VAP-1. (nih.gov)
  • Sera of eight donors were all positive on the particle agglutination (PA) test, but only of the four of the eight were positive on the immunofluorescence (IF) test. (alliedacademies.org)