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  • immunology
  • He was a member of the Basel Institute for Immunology in Switzerland (1973-1996), director of Unité INSERM 373 at the René Descartes University in Paris, France and is Professor of Pathology at Harvard Medical School and the Faculty of Arts and Sciences of Harvard University, Cambridge and Chief of the Laboratory for Lymphocyte Biology at the Dana Farber Cancer Institute in Boston. (wikipedia.org)
  • subtypes
  • a 2013 review identified the following characteristics: specific cell morphology shown by hematoxylin, demyelination shown by Luxol fast blue, macrophage appearance by KiM1P or CD68, damage to the axons shown by Bielschowsky stain, astrocytopathy shown by glial fibrillary acidic protein, and different lymphocyte subtypes, reacting to CD3, CD4, CD8, CD20 and CD138. (wikipedia.org)
  • antibodies
  • Interestingly, in CD4+ cells, two types of surface immunoferritin labeling were observed, light or slightly heavy segmental in pattern, though CD8 + cells were always labeled in dense, heavy segmental fashion, when antibodies were applied to short term cultured fresh lymphocytes. (alliedacademies.org)
  • Women who test positive for thyroid antibodies may be at increased risk of developing symptoms associated with postpartum depression than women without thyroid antibodies. (wikipedia.org)
  • The classical laboratory finding is polyclonal hypergammaglobulinemia, and other immunoglobulin derangements are also seen, including hemolytic anemia with cold agglutinins, circulating immune complexes, anti-smooth muscle antibodies, and positive rheumatoid factor. (wikipedia.org)
  • proliferation
  • Simultaneous stimulation of cells with Con A and suppression with Dex resulted in decreased lymphocyte proliferation in dogs receiving both dietary antioxidants and cognitive enrichment, compared to dogs receiving dietary antioxidants or cognitive enrichment alone. (biomedsearch.com)
  • It is also known by the following terms: proliferation of large granular lymphocytes (LGLs), LGL leukemia, Tγ-lymphoproliferative disorder, and, in common with other T cell leukemias such as T-cell prolymphocytic leukemia, T-cell chronic lymphocytic leukemia. (wikipedia.org)
  • cells
  • In order to determine the fine structural differences and labeling by immunoferritin particles of CD4-positive (CD4+) and CD8 positive (CD8+) cells at the ultrastructural level, short term cultured lymphocytes from eight healthy donors seropositive for HTLV-I were examined and virus production was examined in vitro. (alliedacademies.org)
  • These findings demonstrated that labeling of CD4+ and CD8+ cells with each CD4 or CD8 antigen differed, as did the ultrastructural findings for these cells. (alliedacademies.org)
  • citation needed] Histopathologic examination of the pancreas reveals a characteristic lymphoplasmacytic infiltrate of CD4- or CD8-positive lymphocytes and IgG4-positive plasma cells, and exhibits interstitial fibrosis and acinar cell atrophy in later stages. (wikipedia.org)
  • It has been proposed that a cytologic smear primarily composed of acini rich in chronic inflammatory cells (lymphocytes, plasma cells), with rare ductal epithelial cells lacking atypia, favors the diagnosis of AIP. (wikipedia.org)
  • The foam cells of monocyte/macrophage origin are positive for KP1, HAM56, CD11b and CD68 as pointed out by Nakashiro et al. (wikipedia.org)
  • The primary function of thymocytes is the generation of T lymphocytes (T cells). (wikipedia.org)
  • Expression of both CD4 and CD8 makes them double positive, and matures into either CD4+ or CD8+ cells. (wikipedia.org)
  • The postulated cells of origin of T-LGLL leukemia are transformed CD8+ T-cell with clonal rearrangements of β chain T-cell receptor genes for the majority of cases and a CD8- T-cell with clonal rearrangements of γ chain T-cell receptor genes for a minority of cases. (wikipedia.org)
  • Questions concerned with the role of positive and negative selection of developing T cells by peptide-MHC complexes in the thymus in generating an effective and self-tolerant immune system were analyzed in TCR transgenic mice. (wikipedia.org)
  • von Boehmer, H., Hudson, L. and Sprent, J.: Collaboration of histo-incompatible T and B lymphocytes using cells from tetraparental bone manow chimeras. (wikipedia.org)
  • Allo-MHC-restricted CD4 and CD8 T cells in hemopoietic chimeras reveal plasticity of MHC-restricted antigen recognition. (wikipedia.org)
  • Markers
  • Further investigation of these differences is needed using other types of markers, such as those for chemokine receptors, and other methods to clearly determine the differences between the two types of lymphocytes in fine structure and how these relate to their functions. (alliedacademies.org)
  • Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV-infected individuals. (biomedsearch.com)
  • expression
  • Normally, after infectious insult, the immune system down-regulates by increasing Fas expression on activated B and T lymphocytes and Fas-ligand on activated T lymphocytes. (wikipedia.org)
  • 5% virtually pathognomonic for ALPS Mild elevations also found in other autoimmune diseases Thought to be cytotoxic T lymphocytes that have lost CD8 expression Unknown if driver of disease or epiphenomenon May be falsely elevated in setting of lymphopenia or falsely decreased with immunosuppressive treatment BiomarkersPolyclonal hypergammaglobulinemia Elevated serum FASL Elevated plasma IL-10 and/or IL-18 Elevated plasma or serum vitamin B12 Autoantibodies: Non-specific. (wikipedia.org)
  • Activation
  • OBJECTIVES: The aim of the study was to explore the relationships between lymphocyte and monocyte activation, inflammation, and subclinical vascular disease among HIV-1-infected patients on antiretroviral therapy (ART). (biomedsearch.com)
  • All subjects were adults on stable ART with evidence of heightened T-cell activation (CD8(+)CD38(+)HLA-DR(+) ≥ 19%) or increased inflammation (high-sensitivity C-reactive protein ≥ 2 mg/L). All had fasting low-density lipoprotein (LDL) cholesterol ≤ 130 mg/dL. (biomedsearch.com)
  • Upon this activation, the TCR co-receptor CD4 or CD8 binds to the MHC, activating the co-receptor associated tyrosine kinase Lck. (wikipedia.org)
  • thymocytes
  • Thymopoiesis is the process in the thymus by which thymocytes differentiate into mature T lymphocytes. (wikipedia.org)
  • They produce precursors of T lymphocytes, which seed the thymus (thus becoming thymocytes) and differentiate under influence of the Notch and its ligands. (wikipedia.org)
  • cases
  • The immunophenotype CD4+/CD8- is present in 60% of cases, the CD4+/CD8+ immunophenotype is present in 25%, and the CD4-/CD8+ immunophenotype is present in 15% of cases. (wikipedia.org)
  • RESULTS
  • There were no significant differences between the groups of dogs for percentages of CD4 and CD8 T-lymphocyte subpopulations before or after lymphocyte stimulation with Con A. These results support our hypothesis that both dietary antioxidants and behavioral enrichment enhance host defense mechanisms. (biomedsearch.com)
  • negative
  • The earliest thymocyte stage is the double negative stage (negative for both CD4 and CD8), which more recently has been better described as Lineage-negative, and which can be divided into four substages. (wikipedia.org)
  • proteins
  • The negative RNA strand, complementary to the necessary mRNA strand, indicates that it must first be transcribed into a positive mRNA strand before it can be translated into the required proteins. (wikipedia.org)
  • Lck is a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes. (wikipedia.org)
  • vitro
  • LHR2A antibody In vitro assay of secreting antibody in the lymphocyte supernatant (i.e., the ALS assay) is definitely capable of the detecting specific antibody response after oral vaccination having a killed Saquinavir whole-cell-plus-B-subunit cholera vaccine (WC-B) in healthy adults inside a phase I medical trial. (dansukyoshitsu-park.com)
  • specific
  • in response to environmental and pathogenic antigen challenge, lymphocytes clonally expand and are selected in a highly specific manner. (beds.ac.uk)
  • double negative
  • The earliest thymocyte stage is the double negative stage (negative for both CD4 and CD8), which more recently has been better described as Lineage-negative, and which can be divided into four substages. (wikipedia.org)
  • count
  • another LP was performed and revealed a protein level of 160 mg/dL, WBC count of 185/mm 3 , and RBC count of 1/mm 3 with 95% lymphocytes and 5% macrophages ( Table 1 ). (cdc.gov)
  • several
  • Further supporting this hypothesis, several studies have demonstrated a positive correlation between the diversity level of some HLA genes and the richness of environmental pathogens (Prugnolle et al. (springer.com)