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  • antigen-specific
  • Moreover, during the contraction phase of an immune response where most antigen-specific CD8 + T cells disappear by apoptosis, IL-2 signals are able to rescue CD8 + T cells from cell death and provide a durable increase in memory CD8 + T-cell counts. (springer.com)
  • CD8 T cells, which have a crucial role in immunity to infection and cancer, are maintained in constant numbers, but on antigen stimulation undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific effector (T(E)) populations, followed by the persistence of long-lived memory (T(M)) cells. (nih.gov)
  • We show that mice with a T-cell-specific deletion of TRAF6 mount robust CD8 T(E)-cell responses, but have a profound defect in their ability to generate T(M) cells that is characterized by the disappearance of antigen-specific cells in the weeks after primary immunization. (nih.gov)
  • counts
  • In general, CD4 and CD8 counts decrease as the HIV disease progresses. (reference.com)
  • But my CD8 results are also climbing right along with the climb of CD4 counts. (thebody.com)
  • When reading information on CD8 I have read that if your meds are working effectively your CD4 counts should rise and the CD8 should drop. (thebody.com)
  • But, I thought CD8 was a predictor of how well your immune system was working to control HIV - so shouldn't it climb along with the CD4 counts? (thebody.com)
  • You will not see profound drops in CD8 counts with treatment. (thebody.com)
  • viral
  • CD4 50 CD8 350 and viral load 125,000 and CD4 600 CD8 1800 and viral load (thebody.com)
  • Once your HIV viral load becomes undetectable for a few months I suspect the CD8 will fall again. (thebody.com)
  • infection
  • A high CD4 or CD8 ratio would indicate that the disease is progressing slowly or that the infection is recent and the immune system is still strong. (reference.com)
  • Immunol
  • Orientation of the Ig domains of CD8 alpha beta relative to MHC class I". J Immunol . (wikidoc.org)
  • antigens
  • After the initial arrest, CD8 TE actively crawl along liver sinusoids and probe sub-sinusoidal hepatocytes for the presence of antigens by extending cytoplasmic protrusions through endothelial fenestrae. (nih.gov)
  • protein
  • His research indicated that there was a protein produced by CD8 lymphocyte s which conferred much greater HIV response strength to the immune system . (everything2.com)
  • It has become apparent in the past decade that there is probably more than one protein component to CD8, due to conflicting findings in several studies. (everything2.com)
  • chain
  • The most common form of CD8 is composed of a CD8-α and CD8-β chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. (wikidoc.org)
  • Product
  • Now another new product is disturbing my peace: the CD8 S ($10,000), which French manufacturer Metronome Technologie describes as an integrated player , in the same sense that many hundreds of electronics manufacturers describe their preamplifier-amplifier combinations as integrated amplifiers . (stereophile.com)