Cd55 complement activation antigens cd46. Medical search. Frequent questions

For example, production of autoantibodies that bind to and stimulate the thyroid-stimulating hormone (TSH) receptor cause the thyrotoxicosis of Graves' Disease, and anti-thyroid peroxidase antibody in Graves' and Hashimoto's thyroiditis is thought to inhibit thyroid function and promote complement deposition and thyroid destruction ( 2 ). (silverchair.com)
Due to the previous development of vaccine candidates against the related highly pathogenic coronaviruses SARS-CoV and MERS-CoV, the antigen that elicits immune protection is known: the surface spike protein of SARS-CoV-2 or specific domains encoded in that protein, e.g., the receptor binding domain. (bvsalud.org)
Her Innate immune system research focuses on Classical complement pathway and how it connects with T cell, Complement receptor and Acquired immune system. (research.com)
Her study in Immunology concentrates on Complement, Inflammation, Complement receptor, Classical complement pathway and Complement membrane attack complex. (research.com)
As a part of the same scientific study, she usually deals with the Cell biology, concentrating on Decay-accelerating factor and frequently concerns with Complement receptor 1. (research.com)

Our cell cultures were strongly positive for CD46, CD47, CD56 and CD63 and were also strongly positive for some markers never described before in mesothelioma cell lines, including CD55, CD90 and CD99. (biomedcentral.com)
Antigens, CD47" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Antigens, CD47" by people in this website by year, and whether "Antigens, CD47" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)

Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
[4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)

Her Immunology study focuses mostly on Inflammation and Complement. (research.com)
Endothelial injury can trigger activation of the complement system, promoting inflammation and the development of endothelial injury syndromes, ultimately leading to organ damage and failure. (biomedcentral.com)

Claire L. Harris spends much of her time researching Complement system, Factor H, Immunology, Innate immune system and Alternative complement pathway. (research.com)
Her primary areas of investigation include Immunology, Complement system, Factor H, Cell biology and Alternative complement pathway. (research.com)
Claire L. Harris has included themes like Odds ratio, Alternative complement pathway, Lysosome, Fibrinogen and Immunology in her Macular degeneration study. (research.com)

C3 cleavage may result in formation of the membrane attack complex (MAC), the cytotoxic component of the complement system. (msdmanuals.com)

Several complement inhibitors targeting various complement pathways are in clinical trials for the treatment of HSCT-TMA. (biomedcentral.com)

Factor I, with cofactors including membrane cofactor protein (CD46), inactivates C3b and C4b. (msdmanuals.com)
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. (wakehealth.edu)

Claire L. Harris combines subjects such as Molecular biology, Innate immune system, Disease and Macular degeneration with her study of Complement system. (research.com)

Pattern-recognition molecules such as mannose-binding lectin (MBL), collectins, and ficolins-collectively termed lectins-bind to DAMPs on injured host cells, forming activation complexes with MBL-associated serine proteases 1, 2, and 3 (MASP-1, MASP-2, and MASP-3). (biomedcentral.com)

The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
In particular, the lectin pathway of complement is activated by damage-associated molecular patterns (DAMPs) on the surface of injured endothelial cells. (biomedcentral.com)
Endothelial injury triggers activation of the complement system-significantly through the lectin pathway-via altered cell-surface patterns on injured endothelial cells, initiating an inflammatory response [ 7 ]. (biomedcentral.com)
Here we discuss evidence for the role of lectin pathway activation in endothelial injury-associated complications of HSCT and how targeting complement activity may provide therapeutic benefit for patients with HSCT-TMA. (biomedcentral.com)

These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. (silverchair.com)
PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)

Her Tissue homeostasis research includes elements of Risk analysis, Clinical trial, Complement and Drug discovery. (research.com)

Her biological study spans a wide range of topics, including Mutation, Molecular biology, Internal medicine and Complement factor B. (research.com)

Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)

Alternate pathway activation occurs when components of microbial cell surfaces (eg, yeast walls, bacterial cell wall lipopolysaccharide [endotoxin]) or immunoglobulin (eg, nephritic factor, aggregated IgA) cleave small amounts of C3. (msdmanuals.com)
Her Complement system research integrates issues from Proteases, Biochemistry, Binding site and Cell biology. (research.com)
Her primary areas of study are Complement system, Macular degeneration, Complement, Disease and Factor H. She has researched Complement system in several fields, including Clusterin, Endosome and Cell biology. (research.com)

Activation of the lectin pathway may also trigger the coagulation cascade via MASP-2 cleavage of prothrombin to thrombin. (biomedcentral.com)
In this article, we review the role of the complement system in HSCT-TMA pathogenesis, with a focus on the lectin pathway. (biomedcentral.com)

The complement system is an enzyme cascade that helps defend against infection. (msdmanuals.com)
Claire L. Harris focuses on Disease, Tissue homeostasis, Eculizumab, Complement system and Drug development. (research.com)
Claire L. Harris specializes in Complement system, namely Complement factor I. (research.com)

Complement, a target for therapy in inflammatory and degenerative diseases. (research.com)

This pathway is regulated by properdin, factor H, and decay-accelerating factor (CD55). (msdmanuals.com)
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome. (research.com)
Her Factor H study combines topics from a wide range of disciplines, such as Complement factor I, Complement factor B and CD46. (research.com)
CD46 is frequently linked to Factor H in her study. (research.com)
Her study in Factor H is interdisciplinary in nature, drawing from both Complement factor B and C4A. (research.com)

To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)

Together, activation of complement and the coagulation cascade lead to a procoagulant state that may result in development of HSCT-TMA. (biomedcentral.com)

CD46, CD55, and CD59 in uveal melanomas. (nih.gov)
These include genes encoding components of the complement activation pathway (CD46, CD55 and CD59), regulators of platelet coagulation (thrombomodulin, tissue factor pathway inhibitor and endothelial protein C receptor) and others with immune-quelling effects such as heme oxygenase-1 and CD47. (co.ke)

The presence of a functional BCR is necessary during antigen-dependent differentiation and for continued survival in the peripheral immune system. (wikidoc.org)

Fios Therapeutics is similarly working with TKO pigs, but with one key difference: in addition to the triple knockout, the company has incorporated a transgene encoding human CD46, a critical regulator of the complement system that contributes to both innate and adaptive immune responses after organ transplantation. (co.ke)
As a crucial regulator of the complement system, CD55 has been widely studied in autoimmune diseases. (oncotarget.com)

Another mechanism that may render MM refractory to rituximab is the possibility that MM cells express increased levels of complement-inhibiting proteins thus reducing the effectiveness of CDC. (medscape.com)
The complement system consists of a group of proteins that are activated in sequential steps, similarly to the coagulation cascade. (aacc.org)
Complement proteins are produced mainly in the liver, but also by macrophages, monocytes, and epithelial cells in the urogenital and gastrointestinal tracts. (aacc.org)
For each of the pathways, the recognition molecule that will trigger activation of complement is different, and so are some of the proteins involved in each of the cascades. (aacc.org)
Activation of these circulating complement proteins in response to an injurious or infectious challenge results in a self-amplifying cascade of proteolytic reactions through any one of four major identified pathways (Figure 1 ). (biomedcentral.com)

This pathway is regulated by properdin, factor H, and decay-accelerating factor (CD55). (msdmanuals.com)

Alternate pathway activation occurs when components of microbial cell surfaces (eg, yeast walls, bacterial cell wall lipopolysaccharide [endotoxin]) or immunoglobulin (eg, nephritic factor, aggregated IgA) cleave small amounts of C3. (msdmanuals.com)
Complement component 1q (C1q) is the recognition molecule of the classical pathway of the complement system that can bind to an array of closely spaced antigen-bound immunoglobulin G (IgG) and IgM antibodies. (explorationpub.com)
The DC-SIGN-C1q or SIGN-R1-C1q complex could mediate the immunoglobulin (Ig)-independent classical complement pathway against Streptococcus pneumoniae. (sagepub.com)
CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. (uams.edu)

Binding of carbohydrate antigens by mannose-binding lectin (MBL) or MBL-associated serine proteases (MASPs) initiates the 'lectin pathway' . (biomedcentral.com)

The classical pathway is activated by an antibody binding to a target antigen, forming a complex. (aacc.org)
The only FDA approved therapy is eculizumab, a humanized monoclonal antibody that prevents the cytolytic and proinflammatory effects of the terminal complement system by acting against the C5 component of the complement cascade [ 2 ]. (hindawi.com)
Up-regulation of an activation marker, CD69, on NK cells, particularly the CD56 dim subset, in the presence of both the antibody and target cells was much greater for the low-fucose antibodies. (aacrjournals.org)
Antibodies of the human IgG1 isotype are commonly used for therapeutic applications as they can mediate multiple effector functions including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and direct apoptosis induction (1-3) . (aacrjournals.org)
Recognition of antigen-antibody complexes by C1q initiates the 'classical pathway' . (biomedcentral.com)
It is of interest to note in this context that pathogen opsonisation and antibody ligation by C1q also provide a bridge to activation of the adaptive immune system, which includes an enhancement of antigen retention in lymphoid tissues, a decrease in the B cell activation threshold and increased memory B cell survival [ 22 - 24 ]. (biomedcentral.com)
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. (thermofisher.com)

11. Membrane-bound regulators of complement activation in uveal melanomas. (nih.gov)
Soluble and membrane-bound negative regulators of complement and their site of action are indicated in green . (biomedcentral.com)

Other issues like coagulation regulation and complement regulation - those are all downstream effects of the antibodies binding to the cell," he says. (co.ke)

C3 cleavage may result in formation of the membrane attack complex (MAC), the cytotoxic component of the complement system. (msdmanuals.com)
There is a surveillance role for the alternative pathway, mediated by continuous hydrolysis of one complement component called C3. (aacc.org)
The complement system, a major component of the innate immune system, is becoming increasingly recognised as a key participant in physiology and disease. (biomedcentral.com)
Autoantibodies and the key complement component C3b can often be detected at the basement membrane zone (BMZ) of the lesional skin of bullous pemphigoid patients [ 5 ]. (oncotarget.com)
In addition, it has been reported that complement component C5-deficient mice do not develop bullous pemphigoid following exposure to the pathogenic anti-BP180 IgG, which is used to induce this disease model. (oncotarget.com)
Complement component 1q (C1q) is the first recognition subcomponent of the complement (C) classical pathway [ 1 ]. (explorationpub.com)

18. Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) in posterior uveal melanoma: correlation with clinical and histological survival markers. (nih.gov)

Interestingly, CD55 depletion in HaCaT human keratinocytes enhanced autoantibody-mediated complement activation. (oncotarget.com)

IgM has the greatest ability to activate complement among all immunoglobulins. (aacc.org)
In the classical pathway, an immune complex formation exposes sites in the Fc fraction of immunoglobulins that will allow attachment of C1q, which is the first subcomponent of complement. (aacc.org)

A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. (childrensmercy.org)

In this report, we investigated the relationship between enhanced ADCC and antigen density on target cells using IgG1 antibodies with reduced fucose. (aacrjournals.org)

[ 17 ] The mechanism of action relies on the inhibition of CD40-CD40L interaction and activation as well as on ADCC. (medscape.com)
We further investigated IgG1 binding to natural killer (NK) cells and NK cell activation during ADCC induction to elucidate the mechanism by which low-fucose IgG1 induces ADCC upon target cells with low antigen expression. (aacrjournals.org)
Low-fucose IgG1s showed potent ADCC at low antigen densities at which their corresponding high-fucose counterparts could not induce measurable ADCC. (aacrjournals.org)
Our data showed that fucose removal from IgG1 could reduce the antigen amount required for ADCC induction via efficient recruitment and activation of NK cells. (aacrjournals.org)

CD40 is also expressed by BMSCs and upon activation it triggers the secretion of IL-6 and VEGF. (medscape.com)
The lectin pathway is analogous to the classical pathway, except that the triggers for its activation are bacteria containing mannose on its cellular membranes. (aacc.org)
Various studies have revealed particularly novel findings on the wide-ranging involvement of complement in neural development, synapse elimination and maturation of neural networks, as well as the progression of pathology in a range of chronic neurodegenerative disorders, and more recently, neurotraumatic events, where rapid disruption of neuronal homeostasis potently triggers complement activation. (biomedcentral.com)

Thus, CD55 deficiency is a crucial factor in bullous pemphigoid pathogenesis, suggesting that increasing CD55 levels may exert a therapeutic effect. (oncotarget.com)

Here, we investigated the involvement of CD55 in bullous pemphigoid, as little is known regarding its role in this disease. (oncotarget.com)

Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). (thermofisher.com)

Complement participates in innumerous autoimmune and infectious processes. (aacc.org)
Bullous pemphigoid is a common autoimmune blistering disease of the elderly associated with autoantibody-mediated complement activation, and complement dysregulation is critical for its pathogenesis. (oncotarget.com)
Bullous pemphigoid is the most common autoimmune subepidermal blistering disease and is characterized by the production of autoantibodies that directly target the bullous pemphigoid antigen 180 (BP180 or COL17A1) within the dermoepidermal junction (DEJ) [ 1 , 2 ]. (oncotarget.com)

Its reported functions in a range of biological processes including tissue remodelling, aging, neuronal synapse homeostasis, and immunomodulation, in addition to the classical pathway activation, are simply remarkable [ 2 , 3 ]. (explorationpub.com)

[ 12 ] The binding of CD40 to its natural ligand determines its functional activation that, in turn, induces diverse biologic events including MM cell proliferation and migration via the PI3K-AkT-NF-κB signaling pathway. (medscape.com)
IgG1 binding to NK cells was increased by ligating IgG1 with clustered antigen, especially for low-fucose IgG1. (aacrjournals.org)

The functional significance of certain activation steps is shown in red . (biomedcentral.com)

In addition, spontaneous activation from hydrolysis of C3 occurs and generates C3b. (aacc.org)

7. Expression of cancer-testis antigens (MAGE-A1, MAGE-A3/6, MAGE-A4, MAGE-C1 and NY-ESO-1) in primary human uveal and conjunctival melanoma. (nih.gov)
13. Human leukocyte antigen class I expression. (nih.gov)
As with human-to-human allotransplants, he thinks that cross-match methods and human leukocyte antigen (HLA) typing should be sufficient to allow successful xenotransplants from TKO pigs. (co.ke)

Notably, a significant increase in the expression of TNF-α and IFN-γ, administration of which downregulated CD55 levels in HaCaT cells, was observed in the sera of patients with bullous pemphigoid (n = 38) compared to that in healthy controls (n = 19). (oncotarget.com)

We found that CD55 levels were significantly lower in the lesions of patients with bullous pemphigoid (n = 8) compared to those in skin samples from healthy controls (n = 6). (oncotarget.com)
We found that ERK1/2 is involved in both TNF-α- and IFN-γ-induced CD55 downregulation. (oncotarget.com)

demonstrated that immunotherapy using either a plasmid DNA encoding mycobacterial 85A antigen or interleukin-12 (IL-12) DNA vaccine combined with conventional chemotherapy was highly effective for the prevention AZD6738 supplier of Mycobacterium tuberculosis (M. tb) reactivation and reinfection in mice [9]. (erksignal.com)

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Organisms7

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