• Results show that the thrombospondin 1 (TSP1) and its receptor CD47 (CD47) axis selectively regulates NADPH oxidase 1 (Nox1) in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level. (cusabio.com)
  • Chimeric antigen receptor T cells in refractory B-cell lymphomas. (nature.com)
  • Beatty, G. L. & O'Hara, M. Chimeric antigen receptor-modified T cells for the treatment of solid tumors: defining the challenges and next steps. (nature.com)
  • Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody-antigen immune complexes and immunoproteins or Fc receptor expressing immune effector cells. (frontiersin.org)
  • The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators. (frontiersin.org)
  • Fc receptor-dependent antibody functions are also involved in activation of downstream adaptive immune responses by facilitating antigen presentation or by stimulating the secretion of inflammatory mediators ( 12 , 13 ). (frontiersin.org)
  • Dozens of BCMA-targeting therapies, such as antibody-drug conjugate, Bi-specific antibodies, and chimeric antigen receptor T (CAR-T) cells are presently being created and tested clinically. (news-medical.net)
  • The researchers found that anti-CD47 antibodies, which can block the "don't-eat-me" signal and enable macrophages to engulf cancer cells, eliminated or inhibited the growth of various blood cancers and solid tumors. (stanford.edu)
  • It was completely unexpected that CD8+ T cells would be mobilized when macrophages engulfed the cancer cells in the presence of CD47-blocking antibodies," said MD/PhD student Diane Tseng, the lead author of the study. (stanford.edu)
  • Because T cells are sensitized to attack a patient's particular cancer, the administration of CD47-blocking antibodies in a sense could act as a personalized vaccination against that cancer," Tseng added. (stanford.edu)
  • and virus infection, iron overload, and donor-specific anti-human leukocyte antigen antibodies to insects. (bvsalud.org)
  • Individuals lacking a specific Kell antigen may develop antibodies against Kell antigens when transfused with blood containing that antigen. (wikidoc.org)
  • Both AIHA and HDN may be severe when caused by anti-Kell antibodies, [10] as they are the most immunogenic antigens after those of the ABO and Rhesus blood group systems . (wikidoc.org)
  • When T cells are activated, they will express more immune checkpoint receptors, such as programmed cell death protein 1 (PD-1) or cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) [ 2 ] [ 3 ] . (encyclopedia.pub)
  • Phagocytes engulf foreign cells but not 'self' in part because self cells express CD47 as a ligand for signal regulatory protein SIRPalpha, which inhibits phagocytosis. (nih.gov)
  • Brooke G, Holbrook JD, Brown MH, Barclay AN: Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. (exbio.cz)
  • Current approaches to developing the vaccines rely on using immune cells called dendritic cells to introduce cancer protein fragments to T cells - a process known as antigen presentation. (stanford.edu)
  • To respond to coronavirus pandemic, ACROBiosystems has developed SARS-CoV-2 antigens specifically designed and optimized for serological test kits, including Spike-derived antigen S1, RBD and Nucleocapsid protein. (news-medical.net)
  • [1] [2] The Kell antigens are peptides found within the Kell protein , a 93- kilodalton transmembrane zinc -dependent endopeptidase which is responsible for cleaving endothelin-3 . (wikidoc.org)
  • The Kell glycoprotein links via a single disulfide bond to the XK membrane protein [6] that carries the Kx antigen . (wikidoc.org)
  • Absence of the XK protein (such as through genetic deletion or through a single point mutation within the coding region of the XK gene [8] ), leads to marked reduction of the Kell antigens on the red blood cell surface. (wikidoc.org)
  • Using immunoglobulin (IgG)-opsonized particles with varying levels of either human- or mouse-CD47, the effective inhibition constants K(i) for blocking phagocytosis are then determined with both human- and mouse-derived macrophages. (nih.gov)
  • CAR macrophages (CAR-Ms) demonstrated antigen-specific phagocytosis and tumor clearance in vitro. (nature.com)
  • Characterization of CAR-M activity showed that CAR-Ms expressed pro-inflammatory cytokines and chemokines, converted bystander M2 macrophages to M1, upregulated antigen presentation machinery, recruited and presented antigen to T cells and resisted the effects of immunosuppressive cytokines. (nature.com)
  • Importantly, we identified a subpopulation of M1 macrophages present in periodontally affected tissues which expressed high levels of CD47, a glycoprotein of the immunoglobulin family that plays a critical role in self-recognition and impairment of phagocytosis. (nih.gov)
  • Irving Weissman , MD, professor of pathology and of developmental biology , and his team previously showed that nearly all cancers use the molecule CD47 as a "don't-eat-me" signal to escape from being eaten and eliminated by macrophages. (stanford.edu)
  • The research revives interest in an aspect of macrophages that has been neglected for decades: their role in presenting antigens to T cells. (stanford.edu)
  • For many years, researchers have focused on the dendritic cell as the main antigen-presenting cell, and have generally believed that macrophages specialize in degrading antigens rather presenting them. (stanford.edu)
  • This research shows that macrophages can be effective at antigen presentation and are powerful initiators of the CD8+T cell response. (stanford.edu)
  • Development of reagents against leukocyte differentiation antigens in veterinary immunology is slower compared to humans and mice. (ox.ac.uk)
  • The KEL gene encodes a type II transmembrane glycoprotein [5] that is the highly polymorphic Kell blood group antigen. (wikidoc.org)
  • T cells can recognize differentiation antigens and other non-mutated self-antigens that are overexpressed by cancer cells in the context of sufficient inflammatory signals, which result from the release of damage-associated molecular pattern (DAMP) molecules [ 1 , 2 ]. (biomedcentral.com)
  • Its extracellular ligand is CD47. (exbio.cz)
  • The mouse monoclonal antibody SE5A5 recognizes a common extracellular epitope on human CD172a and CD172b antigens (approx. (exbio.cz)
  • The fact that T cells become involved in fighting cancer as a result of CD47-blocking antibody therapy could have important clinical implications. (stanford.edu)
  • In total, we profiled the transcriptome and antigen levels of 7,097 cells using CITE-seq, with a median of 819 expressed genes and 3,235 antibody-derived tag (ADT) unique molecular identifiers (UMIs) per cell. (biorxiv.org)
  • Individuals without K antigens(K 0 ) who have formed an antibody to a K antigen, must be transfused with blood from donors who are also K 0 to prevent hemolysis. (wikidoc.org)
  • Autoimmune hemolytic anemia (AIHA) occurs when the body produces an antibody against a blood group antigen on its own red blood cells. (wikidoc.org)
  • Quantitative analyses here prompt more complete characterizations of both CD47 levels and SIRPalpha polymorphisms when attempting to study in vivo effects of these key proteins in innate immunity. (nih.gov)
  • Here, we discuss how the principles of antigen presentation favor the presentation of peptides that are derived from newly synthesized proteins in irradiated cells. (biomedcentral.com)
  • High CD47 expression is associated with the increase in the ability of surviving breast cancer cells to evade innate and adaptive immunity. (cusabio.com)
  • Motivated by reports of upregulation of CD47 on both normal and cancerous stem cells [1: Jaiswal et al. (nih.gov)
  • The Kell antigen system (also known as Kell-Cellano system ) is a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. (wikidoc.org)
  • Active immunotherapy directly induces the autoimmune system so that it can recognize specific antigens on cancer cells and attack tumors. (encyclopedia.pub)
  • This examine discovered that the overexpression of CD47 on AML cells was at the. (forsker.net)
  • The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. (biomedcentral.com)
  • Antigens, CD43" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • This graph shows the total number of publications written about "Antigens, CD43" by people in UAMS Profiles by year, and whether "Antigens, CD43" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Antigens, CD43" by people in Profiles over the past ten years. (uams.edu)
  • in comparison, a common mouse polymorph of SIRPalpha binds with similar affinity to human and mouse CD47 (K(d) approximately 0.22 microM). (nih.gov)
  • Only human phagocytes show significant differences in man versus mouse K(i)'s and only at CD47 levels below normal densities for RBCs. (nih.gov)
  • The Stanford group plans to start human clinical trials of the anti-CD47 cancer therapy in 2014. (stanford.edu)
  • CD47 expression is decreased on the surface of erythrocytes in obese subjects. (cusabio.com)
  • These changes in CD47 expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity. (cusabio.com)
  • The XK appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface. (wikidoc.org)
  • Kell antigens are important in transfusion medicine , autoimmune hemolytic anemia and hemolytic disease of the newborn (anti-Kell) . (wikidoc.org)
  • 2007], we show here that inhibition of engulfment correlates with affinity of CD47 for SIRPalpha - but only at low levels of CD47. (nih.gov)
  • To bridge this gap, we developed an approach for enriching mIHC histology slides with single-cell RNA-seq data, building upon recent experimental procedures for augmenting single-cell transcriptomes with concurrent antigen measurements 7 , 8 . (biorxiv.org)
  • This is particularly true for the "K" antigen which shows a relatively high antigenicity and moderately low frequency (~9%) in Caucasian populations. (wikidoc.org)