Toll-Like ReceMoleculeProteinsTarget antigenTumorChemokineAntibodyPreferentiallyProteinLymphocyteHematopoietic stemExpressionMiceViralComplexesInflammationEpithelialEndothelialGlycoproteinBindsCellularImmune systemCellsSurfaceMeaslesClinicalOrgan-specificDeficiencyAutoimmune diseasesLigandActivationMembrane-boundHumanTransplantationTypeSignalsMajor
Toll-Like Rece1
- On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)
Molecule3
- The majority of our de novo radiotracer development focuses on small molecule organic chemistry, and our antibody radiotracer development programs involves new bioconjugation chemistry, and defining and exploiting the biological mechanisms that underwrite the aberrant expression of cell surface receptors in cancer. (ucsf.edu)
- The virus CD46 molecule is the cellular receptor. (bestessaywriters.com)
- CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 ( SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes . (wikidoc.org)
Proteins6
- Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
- Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
- Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
- The team has developed two prostate cancer vaccines, which activate the immune system against two prostate cancer associated proteins - the androgen receptor (AR), and prostatic acid phosphatase (PAP). (pcf.org)
- OBJECTIVES: This study aimed to evaluate the expression pattern of complement regulatory proteins (CRPs) CD46, CD59, and CD55 in HPV-positive (HPV+) & negative (HPV-) cervical cancer cell lines in search of a reliable differential biomarker. (bvsalud.org)
- Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
Target antigen1
- The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
Tumor10
- Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. (biomedcentral.com)
- Meanwhile, these non-engineered viruses sometimes inevitably infect and spread to normal tissues, indiscriminately killed both tumor and normal cells, causing a series of unpredicted side effects. (biomedcentral.com)
- By the genetic recombination the viruses were conferred with high specificity against tumor cells without targeting normal tissues. (biomedcentral.com)
- However all the cell lines established so far were grown in medium containing at least 10% serum, and it has been shown that primary cell lines cultured under these conditions lose their ability to differentiate, acquire gene expression profiles that differ from that of tissue specific stem cells or the primary tumor they derive from, and in some cases are neither clonogenic nor tumorigenic. (biomedcentral.com)
- Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
- A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)
- It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. (childrensmercy.org)
- This graph shows the total number of publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in this website by year, and whether "Receptors, Tumor Necrosis Factor, Type I" was a major or minor topic of these publications. (childrensmercy.org)
- Below are the most recent publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in Profiles. (childrensmercy.org)
- The LG.3A10 antibody reacts with CD27, a 45 - 55 kDa member of the tumor necrosis factor receptor superfamily. (stemcell.com)
Chemokine4
- Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
- C-X-C chemokine receptor type 4 ( CXCR-4 ) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene . (wikidoc.org)
- CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells . (wikidoc.org)
- Until recently, SDF-1 and CXCR4 were believed to be a relatively monogamous ligand-receptor pair (other chemokines are promiscuous, tending to use several different chemokine receptors). (wikidoc.org)
Antibody3
- For example, production of autoantibodies that bind to and stimulate the thyroid-stimulating hormone (TSH) receptor cause the thyrotoxicosis of Graves' Disease, and anti-thyroid peroxidase antibody in Graves' and Hashimoto's thyroiditis is thought to inhibit thyroid function and promote complement deposition and thyroid destruction ( 2 ). (silverchair.com)
- 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
- Antibody FMC7 ( F linder M edical C entre) appears to recognise a conformational variant of CD20 [10] [11] also known as the FMC7 antigen. (wikidoc.org)
Preferentially2
- The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
- However, flow cytometry-based experiments revealed that CD46 was preferentially expressed more in HPV 16-positive SiHa cells followed by HPV 18-positive HeLa cells when compared to HPV- C33a cells. (bvsalud.org)
Protein6
- Searching for more direct proof to implicate thymic myoid and/or epithelial cells in the response, we now have looked for symptoms of go with attack in it and for appearance from the complement-regulatory protein CD46, Compact disc55, and Compact disc59. (kentlandsinitiative.org)
- The H protein targets the cellular receptors of the CD46 and CD150. (bestessaywriters.com)
- Factor I, with cofactors including membrane cofactor protein (CD46), inactivates C3b and C4b. (msdmanuals.com)
- Members of this nascent protein family are characterized by common structural features and similar intron / exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. (wikidoc.org)
- The protein has no known natural ligand [4] and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikidoc.org)
- This Human PEA ELISA Kit was designed for the quantitative measurement of Human PEA protein in serum, saliva, tissue homogenates. (cusabio.com)
Lymphocyte2
- The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
- B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
Hematopoietic stem1
- Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells . (wikidoc.org)
Expression7
- Using RNA sequencing (RNA-seq) data from primary and xenograft SCLC samples, we identified seizure-related homolog 6 (SEZ6) as a surface-expressed SCLC target with broad expression in SCLC and minimal normal tissue expression by both RNA-seq and IHC. (aacrjournals.org)
- Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
- Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
- However, as TRIM7 is not immune regulated and has restricted tissue expression, its natural function may not be as a viral restriction factor. (mdpi.com)
- While CXCR4's expression is low or absent in many healthy tissues, it was demonstrated to be expressed in over 23 types of cancer, including breast cancer, ovarian cancer, melanoma, and prostate cancer. (wikidoc.org)
- Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikidoc.org)
- Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy. (edu.pl)
Mice4
- To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)
- Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
- CD27 is found on peripheral T cells, memory B cells, and NK cells and in mice has been found on most thymocytes, except CD46-CD8- precursors. (stemcell.com)
- This study aimed to investigate the role of LTα in MOG 35-55 -induced EAE using mice deficient in LTα or its membrane receptor, LTβR. (rusimmun.ru)
Viral3
- These noninvasive visualization systems provide real-time follow-up of viral progression within the cancer tissue by the ability of engineered oncolytic viruses (OVs) to encode reporter transgenes based on recombinant technology. (biomedcentral.com)
- Virus-receptor interactions determine viral host range and tissue tropism. (bvsalud.org)
- Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com)
Complexes1
- Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
Inflammation2
- In contrast, regulatory T cells (Tregs) play a cardinal role in protecting against autoimmune diseases, inflammation and tissue damage 13 through secretion of IL-10 (ref. 14 ) and other mechanisms. (nature.com)
- Her study in Immunology concentrates on Complement, Inflammation, Complement receptor, Classical complement pathway and Complement membrane attack complex. (research.com)
Epithelial1
- Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
Endothelial2
- The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
- This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue. (wikidoc.org)
Glycoprotein2
- This type 1 integral membrane glycoprotein is a normal part of human tissue but may be overexpressed on some cancer cell types. (wikipedia.org)
- The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
Binds1
- Binds to VLA1 (Very Late Antigen-1) and α4β1 integrins. (goconqr.com)
Cellular3
- The human CD46 antigen is known to be the functional cellular receptor for Measles virus. (wikipedia.org)
- The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
- They have a wide cellular and tissue distribution, and play a major role in the mediation of biological responses. (medscape.com)
Immune system4
- The fetal tissues including the placenta must be protected from activation of the maternal immune system. (frontiersin.org)
- On the other hand, the placental tissue sheds into the maternal circulation and must be adequately identified and phagocytized by the maternal immune system. (frontiersin.org)
- Patients will be evaluated for safety, clinical responses, immune system responses against the vaccine antigens (PAP and AR), as well as immune system changes that correlate with clinical responses. (pcf.org)
- Her Innate immune system research focuses on Classical complement pathway and how it connects with T cell, Complement receptor and Acquired immune system. (research.com)
Cells10
- Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
- At 8 weeks of gestation, the trophoblast cells invade from the placenta into the maternal tissue and into the uterine arteries. (frontiersin.org)
- CD4 + T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD + ) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4 + IFNγ + IL-10 + T cells and reverses disease progression by restoring tissue integrity via remyelination and neuroregeneration. (nature.com)
- Studies have shown that Th1 IFN-γ-producing cells that co-produce IL-10 have immunosuppressive properties and can protect from tissue damage 21 , 22 . (nature.com)
- This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
- In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)
- Moreover, HSV engineered in gH of a scFv targeting the cancer-specific HER2 receptor, scFv-HER2-gH chimera, can enter, replicate and kill cancer cells efficiently [ 14 ]. (biomedcentral.com)
- SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. (wikidoc.org)
- PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue: White blood cells normally do not interact with the endothelium of blood vessels. (wikidoc.org)
- Immunohistochemistry can be used to determine the presence of CD20 on cells in histological tissue sections. (wikidoc.org)
Surface2
- Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)
- CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst , a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation . (wikidoc.org)
Measles1
- This imaging technique is an improvement over initial efforts to engineer a Measles virus to carry the soluble marker human carcinoembryonic antigen (CEA). (wikipedia.org)
Clinical3
- Strategies and Components Clinical Materials With up to date consent and moral committee acceptance, we researched thymic tissue through the same 11 adult age-matched handles (mostly going through thyroid or parathyroid medical procedures in Wrzburg25) as well as the same 67 sufferers with generalized MG such as Leite and co-workers25 (comprehensive in Supplemental Desk at 0.05, ** 0.01, *** 0.001). (kentlandsinitiative.org)
- Her Tissue homeostasis research includes elements of Risk analysis, Clinical trial, Complement and Drug discovery. (research.com)
- Plerixafor (AMD3100) is a drug, approved for routine clinical use, [7] which directly blocks the CXCR4 receptor. (wikidoc.org)
Organ-specific1
- These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. (silverchair.com)
Deficiency1
- Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)
Autoimmune diseases1
- Autoimmune diseases represent a failure of self-identification leading to an immune-mediated assault on host tissues. (frontiersin.org)
Ligand1
- CXCL12 (over-)expressing cancers might not sense the CXCL12 gradient released from the metastasis target tissues since the receptor, CXCR4, is saturated with the ligand produced in an autocrine manner. (wikidoc.org)
Activation3
- [ 2 ] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
- The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
- SARS CoV-2 may lead to the activation of persistent herpesviruses in heart tissue. (hhv-6foundation.org)
Membrane-bound1
- Complex immunobiology of lymphotoxin (LTα) is due to multiple modalities of signal transduction, involving a soluble homotrimer and membrane-bound heterotrimers that engage at least three different receptors. (rusimmun.ru)
Human3
- The virus was isolated in 1954 in monkey and human kidney tissue by Enders and Peebles. (bestessaywriters.com)
- Xenotransplantation involves the transplantation of nonhuman tissues or organs into human recipients. (medscape.com)
- CD55 and human neonatal Fc receptor (FcRn) were found to be the binding and uncoating receptors for some of the echovirus-related enterovirus species B serotypes in our previous study. (bvsalud.org)
Transplantation1
- The motivation for using animal sources for organ or tissue transplantation is driven by supply and demand. (medscape.com)
Type1
- anti-Mullerian hormone receptor type 2. (gsea-msigdb.org)
Signals1
- The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)
Major2
- CR1/CD35 and CR2/CD21 are major receptors for activated fragments of C3. (medscape.com)
- [15] In cases of obesity , the presence of fatty tissues surrounding the body's major organ systems results in cell necrosis and insulin desensitivity along the boundary between them. (wikidoc.org)