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  • antibodies
  • Recipients were intraperitoneally administrated anti-GITRL, anti-CD25 monoclonal antibodies (mAb), or control immunoglobulin (IgG). (arvojournals.org)
  • Of the 302 monoclonal antibodies included in the Third Workshop on Ruminant Leukocyte Antigens, 167 have been tested for their reactivity on uninfected and Salmonella-infected sheep lymph node leukocytes using FACS analysis. (univ-amu.fr)
  • On the other hand, the IgG3 hinge-truncated antibodies IgG3m15 and IgGm17 showed higher bactericidal activity than both IgG1 and IgG3 regardless of the target antigen. (asm.org)
  • By using monoclonal hapten (4-hydroxy-3-nitrophenacetyl [NP/NIP])-specific antibodies of all four IgG isotypes, we have demonstrated that IgG1 and IgG3 are best in inducing complement-mediated cellular lysis and IgG1 performs better than IgG3 when the antigen concentration on the target cells is high, while IgG3 performs better than IgG1 when the antigen concentration on the target cells is low ( 20 , 21 ). (asm.org)
  • In separate studies, IgG3 antibodies also showed higher SBA than IgG1 antibodies when the target antigen was sparsely expressed (as in the case of FHbp) ( 22 ), but IgG1 antibodies were more bactericidal than IgG3 antibodies when the target antigen was highly expressed, such as for PorA ( 23 ). (asm.org)
  • Now Offering Over 102,157 Antibodies & 44,722 Antigens! (avivasysbio.com)
  • CD59
  • Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. (genetex.com)
  • lymphocytes
  • Selective and specific delivery of transgenes into particular types of lymphocytes is highly desirable for immunotherapy and gene therapy. (bloodjournal.org)
  • This is shown by increased anti-CD3-induced proliferation of CD4 + spleen T lymphocytes in the presence of the Crry/p65-specific mAb P3D2. (jimmunol.org)
  • Another two molecules of wide cellular distribution, DAF (CD55) and MCP (CD46), are expressed by lymphocytes to inactivate C3b- and C4b-containing C convertases deposited on their cell surface (reviewed in Ref. 5 ). (jimmunol.org)
  • vitro
  • CD8-LV mediated stable in vitro and in vivo reporter gene transfer as well as efficient transfer of genes encoding TCRs recognizing the melanoma antigen tyrosinase. (bloodjournal.org)
  • In vitro, cornea pretreated with anti-GITRL mAb or control IgG was incubated with T cells, and destruction of corneal endothelial cells and the population of Foxp3 + CD25 + CD4 + T cells were assessed. (arvojournals.org)
  • Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non-self-antigens. (bloodjournal.org)
  • tumors
  • HER2 overexpressed and/or gene amplified tumors are generally regarded as biologically aggressive neoplasms. (pubmedcentralcanada.ca)
  • Exome-wide analyses have recently greatly contributed to a better understanding of the biology of human neoplasms through the identification of mutations and copy number variations in genes crucial for the development of human tumors. (pubmedcentralcanada.ca)
  • therapeutic
  • Although few attempts have been undertaken to retarget LVs to CD3 + T cells, 4 the transduction of subpopulations or even the transfer of therapeutic genes by such targeting vectors has not been described. (bloodjournal.org)
  • activation
  • This recognition leads to the expression of cytokines, chemokines and co-stimulatory molecules that eliminate pathogens like viruses for the activation of antigen presenting cells and for the activation of specific adaptive response [ 4 ]. (intechopen.com)
  • Chemotaxis of phagocytic cells by complement activation products C5a is also required for certain cancer immunotherapy such as combined β -glucan with anti-tumor mAb therapy. (springer.com)
  • vaccine
  • To characterize the safety and immunogenicity of a heptavalent antigen-keyhole limpet hemocyanin (KLH) plus QS21 vaccine construct in patients with epithelial ovarian, fallopian tube, or peritoneal cancer in second or greater complete clinical remission. (aacrjournals.org)
  • This heptavalent-KLH conjugate plus QS21 vaccine safely induced antibody responses against five of seven antigens. (aacrjournals.org)
  • cells
  • A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. (creativebiomart.net)
  • We describe here a novel vector (CD8-LV) derived from lentivirus, which delivers genes exclusively and specifically to CD8 + cells. (bloodjournal.org)
  • 1 ⇓ - 3 Failure to distinguish between subtypes of cells and thereby transferring genes to both target and nontarget cells is a limitation of vector systems currently in use. (bloodjournal.org)
  • Whereas TCR gene-modified T cells recognize peptide-major histocompatibility complex (pMHC), CAR recognize antigen in an MHC-independent fashion. (bloodjournal.org)
  • 10 The central part of the cornea, which is used as donor tissue, contains only a small population of major histocompatability complex (MHC) class II-expressing antigen-presenting cells (APCs). (arvojournals.org)
  • In normal cells, there are two copies of the gene per cell. (pubmedcentralcanada.ca)
  • 2 Importantly, IL-10 induces long-lasting antigen (Ag)-specific T-cell anergy and differentiation of type 1 regulatory T (Tr1) cells both in humans 3 and mice. (bloodjournal.org)
  • Simultaneous staining of C57BL/6 spleen cells with anti-NK1.1 mAb (PK136) and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells.Applications Reported: This DX5 antibody has been reported for use in flow cytometric analysis.Applications Tested: This DX5 antibody has been tested by flow cytometric analysis of mouse splenocytes. (fishersci.co.uk)
  • immunotherapy
  • CD8-LV represents a powerful novel vector for TCR gene therapy and other applications in immunotherapy and basic research requiring CD8 + cell-specific gene delivery. (bloodjournal.org)
  • ELISA
  • Serologic responses by ELISA were largely IgM against each antigen with the exception of Tn-MUC1 where both IgM and IgG responses were induced. (aacrjournals.org)
  • significantly
  • Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. (abnova.com)
  • receptors
  • Among the PRRs, there are Toll Like Receptors (TLRs) that can be either endosomal or extracellular [ 5 , 6 ] and retinoic acid-inducible gene- (RIG-)I/MDA5 (melanoma differentiation-associated gene) [ 7 ] known as RNA helicase-like receptors (RLRs). (intechopen.com)
  • product
  • IHC (Formalin-fixed paraffin-embedded sections) : This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. (genetex.com)
  • levels
  • The brain is immunologically privileged due to a physical blood brain barrier (BBB) and due to the absence of a lymphatic system and therefore displays low levels of molecules that are critical to antigen presentation. (hindawi.com)
  • Activity
  • Our developed microscale assays provided evidence that rag1 -/- fish do not possess serum IgM protein, that they do not achieve specific protection even after vaccination, and that they cannot induce antigen-specific CTL activity. (kyushu-u.ac.jp)
  • IgG1 showed higher bactericidal activity than IgG3 when directed against PorA (an abundant antigen), while IgG3 was more bactericidal than IgG1 when directed against FHbp (a sparsely and variably distributed antigen). (asm.org)