The most common histiocyte disorders are Langerhans' cell histiocytosis and haemophagocytic lymphohistiocytosis. (wikipedia.org)
[ 2 ] For example, the entity now referred to as Langerhans cell histiocytosis (LCH) was initially divided into eosinophilic granuloma, Hand-Schüller-Christian disease, and Abt-Letterer-Siwe disease, depending on the sites and severity. (medscape.com)
Most recently, this designation was changed to Langerhans cell histiocytosis based on the suggestion by Nezelof that the Langerhans cell represented the primary cell involved in the pathophysiology of the disease. (medscape.com)
[ 5 , 6 ] Although several histiocytic disorders are briefly discussed in this article (see History ),the primary focus is on Langerhans cell histiocytosis. (medscape.com)
Each category of histiocytosis can be traced to reactive or neoplastic proliferation in one of these cell lineages. (medscape.com)
CD141
They express LCAs (leucocyte common antigens) CD45, CD14, CD33, and CD4 (also expressed by T helper cells). (wikipedia.org)
Differentiation1
Macrophages and dendritic cells are derived from common bone marrow precursor cells that have undergone different differentiation (as histiocytes) under the influence of various environmental (tissue location) and growth factors such as GM-CSF, TNF and IL-4. (wikipedia.org)
Antigens3
they express Factor XIIIa, CD1c, and Class II Human leukocyte antigens. (wikipedia.org)
The histiocyte is a tissue macrophage or a dendritic cell (histio, diminutive of histo, meaning tissue, and cyte, meaning cell). (wikipedia.org)
Costimulatory interaction (i.e., second signal) is between CD80(B7.1)/CD86(B7.2) on the dendritic cell, and CD28 on the T cells. (medscape.com)
Maturation1
We found that efficient gene transfer into pDC can be achieved with VSVG-pseudotyped lentiviral vectors (LV) under the control of phoshoglycerate kinase (PGK) and elongation factor-1 (EF1α) promoters (28% to 90% of E-GFP + cells, respectively) in the absence of phenotypic and functional maturation. (biomedcentral.com)
Macrophages are important cells in the host immune response in fungal infections. (bvsalud.org)
Lesions were characterized by inflammatory infiltrate of macrophages, lymphocytes, epithelioid and multinucleated giant cells with intense number of fungal forms. (bvsalud.org)
The histiocytoses encompass a group of diverse disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. (medscape.com)
Rheumatoid1
The term Histiocyte can also simply refer to a cell from monocyte origin outside the blood system, such as in a tissue (as in rheumatoid arthritis as palisading histiocytes surrounding fibrinoid necrosis of rheumatoid nodules). (wikipedia.org)
Spleen1
Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
Myeloid1
In humans, at least two subsets of DC are known in the blood, myeloid DC (also known as interstitial or dermal DC), and plasmacytoid DC (pDC) and Langerhans cells (LC) in the tissues [ 3 ]. (biomedcentral.com)
Eosinophilic1
Higher power demonstrating multinucleated giant cells with eosinophilic ground-glass cytoplasm. (medscape.com)
Histiocytes3
Histiocytes are derived from the bone marrow by multiplication from a stem cell. (wikipedia.org)
Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
Gene1
Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. (biomedcentral.com)
Helper1
[ 15 ] The surface of the APC contains 2 peptide-binding proteins (ie, major histocompatability complex [MHC] classes I and II), which can stimulate cytotoxic T (T C ) cells, regulatory T (Treg) cells, and helper T (T H ) cells. (medscape.com)
Mononuclear2
A histiocyte is a vertebrate cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system). (wikipedia.org)
reports exist of elevated counts of neutrophils or mononuclear cells. (medscape.com)
Occurs1
Such a description excludes diseases in which infiltration of these cells occurs in response to a primary pathology. (medscape.com)
Migrate1
The derived cells migrate from the bone marrow to the blood as monocytes. (wikipedia.org)
Cytoplasm2
Dendritic cells have an indented (bean-shaped) nucleus and cytoplasm with thin processes (dendritic). (wikipedia.org)
They also express S-100, and their cytoplasm contains tennis-racket like ultra-structural inclusions called Birbeck granules. (wikipedia.org)
Cytotoxic1
In order to contribute to the comprehension of immune mechanisms in JLD human lesions, we studied the cytotoxic immune response, focusing on TCD8+ and NK cells, and granzyme B. Forty skin biopsies of lower limbs were selected and an immunohistochemistry protocol was developed to detect CD8+ T cells, NK cells and Granzyme B. In order to compare the cellular populations, we also performed a protocol to visualize TCD4+ cells. (bvsalud.org)
Macrophage2
However, the term histiocyte has been used for multiple purposes in the past, and some cells called "histocytes" do not appear to derive from monocytic-macrophage lines. (wikipedia.org)
We could observe high number of cells expressing Arginase1, CD163 and c-MAF that correspond to elements of the M2 profile of macrophage, over iNOS and RBP-J (elements of the M1 profile). (bvsalud.org)
Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
The first signal may involve interaction between an MHC I-bound and/or MHC II-bound peptide on an APC with the T-cell receptor (TCRs) on the effector lymphocytes. (medscape.com)
Human2
Human pDC do not express lineage specific markers, but are characterized by the expression of HLA-DR, CD4, CD123, BDCA2 and BDCA4 [ 3 ]. (biomedcentral.com)
Here we have synthesized and investigated new variants of sp2-IGLs for their ability to suppress the activation of human monocyte-derived dendritic cells (DCs) by lipopolysaccharide (LPS) signaling through Toll-like receptor 4. (cnrs.fr)
Stem2
Committed stem cells can mature to become antigen-processing cells, with some possessing phagocytic capabilities. (medscape.com)
One study demonstrated aberrant expression of CD10 (a 90- to 110-kd cell surface zinc-dependent metalloprotease) in skin and synovial multinucleated giant cells in patients with MRH. (medscape.com)
Giant1
It is characterized by a granulomatous reaction with multinucleated giant cells and high number of fungal cells. (bvsalud.org)