• CD40/CD40L may participate in the development of coronary atherosclerosis and the triggering of acute coronary syndromes, while sCD40L seems to have a prognostic role not only in subjects with advanced atherosclerosis but also in the general population. (onlinejacc.org)
  • Although conventional cardiovascular medication such as antiplatelet therapy, statins, angiotensin-converting enzyme inhibitors, and many others have been shown to reduce both sCD40L and cardiovascular risk, it is still unclear whether specific treatments targeting the CD40/CD40L system will prove to be beneficial against atherothrombosis in the near future. (onlinejacc.org)
  • To examine the relationship between ultra-endurance exercise in trained athletes and levels of sCD40L and its natural ligand sCD40. (bmj.com)
  • Cloning of the human homologue of the murine flt3 ligand: a growth factor early hematopoietic progenitor cells," Blood , vol. 83, no. 10, pp. 2795-2801, 1994. (hindawi.com)
  • More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. (google.com.au)
  • That we had very few LCLs from XHIM B cells upon EBV infection led us to investigate whether CD40L and CD40 play a role in EBV infection and/or subsequent B cell transformation. (pnas.org)
  • The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes," Diabetologia , vol. 52, no. 6, pp. 1152-1163, 2009. (hindawi.com)
  • In accordance with the in situ and in vitro data obtained with human material, interruption of the CD40-CD40L signaling pathway in low density lipoprotein receptor-deficient hyperlipidemic mice substantially decreased expression of the enzyme within atherosclerotic plaques. (rupress.org)
  • CD40 ligand (CD40L) plays important roles in regulation of immune responses, including T cell-dependent activation of B cells and cytokine production by monocytes and dendritic cells. (ovid.com)
  • Early evidence for these effects were that in CD40 or CD154 deficient mice, there is little class switching or germinal centre formation, and immune responses are severely inhibited. (wikipedia.org)
  • CD40-CD40L interaction was essential for IL-12 production by DC. (nih.gov)
  • CD40-CD40L interaction is crucial to B cells for their proliferation, survival, Ig istotype switching, and germinal center reaction upon stimulation by activated T cells ( 4 ). (pnas.org)
  • CD40 and CD40L are members of the TNF family, and their interaction provides a potent signal for DC activation ( 11 ). (jimmunol.org)
  • Over the recent years, it has been well established that interactions between CD40 and its immunomodulating ligand (CD40L), expressed in a variety of cell types including platelets, vascular wall cells, and immune cells, are actively involved in atherogenetic and thrombotic mechanisms and may serve as a link between inflammation, atherosclerosis, and thrombosis ( 2 ). (onlinejacc.org)
  • The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells," Nature Immunology , vol. 3, no. 5, pp. 451-456, 2002. (hindawi.com)
  • For CD40 stimulation in LCL analysis, an agonistic mAb to CD40 (mAb89, Immunotech, Luminy, France) was used ( 9 ). (pnas.org)
  • To assess the linearity of the assay, samples containing and/or spiked with high concentrations of CD40 Ligand were serially diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay. (rndsystems.com)
  • These results suggest that EBV infection induces CD40L/CD40 signaling in host cells, which appears to play an essential role in its persistent infection and malignancies of lymphocytes. (pnas.org)
  • Mice null for CD40 or CD40L had severe defects not only in their Ig isotype switching, but also in germinal center formation and establishment of B cell memory ( 4 , 6 ). (pnas.org)
  • Aspects of the CD8 + -T-cell response are substantially modified in mice that lack B cells, CD4 + T cells, or the CD40 ligand (CD40L). (asm.org)
  • Monocytes are activated in patients with myelodysplastic syndromes and can contribute to bone marrow failure through CD40-CD40L interactions with T helper cells," Leukemia , vol. 21, no. 12, pp. 2411-2419, 2007. (hindawi.com)
  • As Assistant Professor at Columbia, Dr. Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function. (wikipedia.org)
  • FDA awarded TNX -102 SL "Breakthrough Therapy" (breakthrough therapy) designation for PTSD because its effects in military-related PTSD have the potential to be improvements over existing therapies As Assistant Professor at Columbia, Dr. Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function. (wikipedia.org)
  • however, it hardly transformed X-linked hyper IgM syndrome B cells, because of the dysfunctional gene of CD40 ligand (CD40L) of the patients. (pnas.org)
  • Results obtained using natural human CD40 Ligand showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. (rndsystems.com)
  • These results indicate that this kit can be used to determine relative mass values for naturally occurring human CD40 Ligand. (rndsystems.com)
  • Recent results suggest an activation of T-lymphocytes via the CD40L implying a dual function of this ligand involved in the activation of both B- and T-lymphocytes [1- (nih.gov)
  • The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. (reliatech.de)
  • XHIM is a rare genetic disease caused by mutations in the gene encoding CD40 ligand (CD154) and is characterized by hypogammaglobulinemia, opportunistic infections, and an increased risk of neoplastic disease. (knowcancer.com)
  • As a result, the macrophage expresses more CD40 and TNF receptors on its surface, which helps increase the level of activation. (wikipedia.org)
  • The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation," Blood , vol. 110, no. 1, pp. 193-200, 2007. (hindawi.com)
  • Despite the initial suggestion that CD40 exists as a dimer that is being trimerized after CD40L binding, recent studies described CD40 as a constitutional trimer complex on cell surface ( Fig. 1 )( 3 ). (onlinejacc.org)
  • The recovery of CD40 Ligand spiked to levels throughout the range of the assay in various matrices was evaluated. (rndsystems.com)