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  • subtypes
  • a 2013 review identified the following characteristics: specific cell morphology shown by hematoxylin, demyelination shown by Luxol fast blue, macrophage appearance by KiM1P or CD68, damage to the axons shown by Bielschowsky stain, astrocytopathy shown by glial fibrillary acidic protein, and different lymphocyte subtypes, reacting to CD3, CD4, CD8, CD20 and CD138. (wikipedia.org)
  • immune
  • November 11, 1926 - July 25, 2017) was a professor emerita of anatomy at the University of California, Berkeley who had published research into the neuroanatomy of the forebrain, notably the discovery of the impact of the surrounding environment on brain development, differences between the cerebral cortex of male and female rats, and the link between positive thinking and immune health. (wikipedia.org)
  • Patients
  • Methods This retrospective study reviewed clinical records of 883 positive patients, who reported for treatment at the Suntreso Hospital for the first time within January 2010 to December 2011. (bmj.com)
  • Further study is needed to determine the causes for late presenting at the HIV clinic and address them, since this may account for high mortality among HIV positive patients accessing care. (bmj.com)
  • In patients with type 2 diabetes, lymphocyte content in adipose tissue biopsies significantly correlated with waist circumference, a marker of IR. (ahajournals.org)
  • role
  • 5 Furthermore, the role of adipose T-lymphocytes as early contributors of obesity-mediated IR and their relationship to adipose tissue macrophage invasion has not yet been studied. (ahajournals.org)
  • Models
  • SInger A, Adoro S, Park JH: Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. (wikipedia.org)
  • cytotoxic T lymphocyt
  • The nelipepimut-S sequence stimulates specific CD8+ cytotoxic T lymphocytes (CTLs) following binding to HLA-A2/A3 molecules on antigen presenting cells (APCs). (her2support.org)
  • Granulysin is present in cytolytic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. (wikipedia.org)
  • It triggers a vigorous cytotoxic T lymphocytes(CTL) response and thus, it is cleared rapidly by the host. (wikipedia.org)
  • Their key experiment involved harvesting of splenocytes containing LCMV-specific cytotoxic T lymphocytes(CTL) from an infected mouse strain A. These were then mixed in vitro with virus infected fibroblasts or macrophages from two different mouse strains, A and B. By the method of Cr-release cytotoxicity assay, thereby tagging the CTL with chromium-51 (Cr-51), the CTL destruction of infected cells was quantified by release of Cr-51. (wikipedia.org)
  • cytoplasmic
  • We are interested in the structure of the TCR on the surface of T lymphocytes, the cytoplasmic signaling proteins that convey the signal to the nucleus and how new genes get turned on by TCR signals. (openwetware.org)
  • The short cytoplasmic/intracellular tail (C) of CD4 contains a special sequence of amino acids that allow it to recruit and interact with the tyrosine kinase Lck. (wikipedia.org)
  • The resulting close proximity between the TCR complex and CD4 (extracellular and intracellular) allows the tyrosine kinase Lck bound to the cytoplasmic tail of CD4 to tyrosine-phosphorylate the Immunoreceptor tyrosine activation motifs (ITAM) on the cytoplasmic domains of CD3 to amplify the signal generated by the TCR. (wikipedia.org)
  • antibody
  • HIV antibody tests exceed the performance of most other infectious disease tests in both sensitivity (the ability of the screening test to give a positive finding when the person tested truly has the disease) and specificity (the ability of the test to give a negative finding when the subjects tested are free of the disease under study). (wikipedia.org)
  • It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. (wikipedia.org)
  • human
  • Repeated exposure to immature monocyte-derived human DCs secreting IL-10 has been shown to induce IL-10 and TGF-β-secreting CD4 Tr1 ( 7 ). (jimmunol.org)
  • AIDS
  • While this virus is the underlying cause of AIDS, not all HIV-positive individuals have AIDS, as HIV can remain in a latent state for many years. (wikipedia.org)
  • tumors
  • Recombinant 9 kD granulysin is broadly cytolytic against tumors and microbes, including gram positive and gram negative bacteria, fungi/yeast and parasites. (wikipedia.org)
  • high
  • On the other hand, its positive predictive value is high enough for it to be regarded as a pathognomonic sign of Hodgkin lymphoma. (wikipedia.org)
  • response
  • in response to environmental and pathogenic antigen challenge, lymphocytes clonally expand and are selected in a highly specific manner. (beds.ac.uk)
  • virus
  • Apparently, they test positive to something else than the virus. (newmediaexplorer.org)
  • The RNA-dependent, RNA-polymerase brought along with the virus initially binds to a promoter on the L and S segments and begins transcription from negative-stranded to a positive-stranded mRNA. (wikipedia.org)
  • types
  • There are two major types of Hodgkin lymphoma: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. (wikipedia.org)
  • diagnose
  • When clinical appearance alone is used to diagnose OHL, there is a false positive rate of 17% compared to more objective methods. (wikipedia.org)
  • level
  • The date of first reporting and the level of first CD4 counts were recorded. (bmj.com)