• Baseline Age, sex, CD4 count and viral load were extracted from the patient's database. (who.int)
  • The number of oocysts in all samples was small, independent of CD4 + T lymphocyte count, HIV plasma viral load, and presence of diarrhea. (scielo.br)
  • The objectives of this study were to assess the occurrence of cryptosporidiosis in HIV-infected individuals and its relationship with diarrhea, rural or urban zone origin, CD4 + and CD8 + T cell counts, HIV plasmatic viral load, and antiretroviral treatment. (scielo.br)
  • Patients without determined HIV plasmatic viral load or CD4 + and CD8 + T lymphocyte counts at least three months before or after feces sampling were excluded. (scielo.br)
  • We show here that IL-2R expression in HIV patients with high viral load (group 1 in the study) is greatly enhanced on B lymphocytes, CD8 T lymphocytes, and monocytes, but not on CD4 T lymphocytes, compared with noninfected individuals. (pnas.org)
  • In patients receiving triple combination therapy (TCT, two reverse transcriptase inhibitors and one protease inhibitor) that has triggered a drastic reduction in plasma viral load and an increase in CD4 counts (group 2 patients), IL-2R expression is significantly lower than in group 1 patients. (pnas.org)
  • Here we analyze the expression of the three IL-2R chains by CD4 T, CD8 T, B, and natural killer (NK) lymphocytes, as well as monocytes, of HIV-infected patients with high viral load. (pnas.org)
  • Recently, new antiretroviral therapies combining two inhibitors of HIV reverse transcriptase (RT) and one inhibitor of HIV protease, usually called triple combination therapy (TCT) or highly active antiretroviral therapy (HAART), have been successful in leading to a significant reduction of plasmatic viral load and an increase in CD4 counts ( 17 , 18 ). (pnas.org)
  • Interestingly, in CD4+ cells, two types of surface immunoferritin labeling were observed, light or slightly heavy segmental in pattern, though CD8 + cells were always labeled in dense, heavy segmental fashion, when antibodies were applied to short term cultured fresh lymphocytes. (alliedacademies.org)
  • Uninfected CD4 T cells undergo X4 Env-mediated autophagy, leading to their apoptosis, a mechanism now recognized as central to immunodeficiency. (cnrs.fr)
  • The objective is to assess CD4+ cell recovery in HIV+ patients with CD4 count below 200 cells/μl) at HAART initiation.Methods: this was a retrospective cohort study among 110 HIV+ patients with initial CD4 count (who.int)
  • P=0.than participants aged above 40 years (16.7%).Conclusion: HAART was associated with viremia suppression but many patients failed to achieve a CD4 count >200 cells/µl. (who.int)
  • Further investigation of these differences is needed using other types of markers, such as those for chemokine receptors, and other methods to clearly determine the differences between the two types of lymphocytes in fine structure and how these relate to their functions. (alliedacademies.org)
  • Cytotoxic T-lymphocyte (CTL) responses to E6 and E7 were previously shown to be more commonly detectable in human papillomavirus type 16 (HPV-16)-positive women without squamous intraepithelial neoplasia (SIL) than in HPV-16-positive women with SIL (M. Nakagawa, D. P. Stites, S. Farhat, J. R. Sisler, B. Moss, F. Kong, A. B. Moscicki, and J. M. Palefsky, J. Infect. (asm.org)
  • Dendritic cells (DCs) are the most potent antigen-presenting cells with respect to their ability to efficiently prime both CD4-positive and CD8-positive cytotoxic T cells. (hindawi.com)
  • Our results suggest that both CD4 and CD8 T lymphocytes contribute to HPV-16 E6- and E7-specific CTL responses although their relative contributions vary from individual to individual. (asm.org)
  • Therefore, CD4 cells could be preferentially stimulated and thus could have contributed solely to the observed CTL responses. (asm.org)
  • Together, our data show that a combination of DNA and MVA immunization induced robust, durable, multifunctional CD4(+) and CD8(+) responses in baboons targeting multiple HIV epitopes that may home to mucosal sites. (curehunter.com)
  • Vaccination of mice with P815 tumor lysate-pulsed CD4+ 8+ TID815 or TID198 and CD4+ 8- TID198 induced IFN-gamma-secreting Th1 and effective CTL responses leading to protective immunity against P815 tumor , whereas CD4- 8- TID815 stimulated IL-10-expressing Tr1 responses leading to immune suppression. (curehunter.com)
  • They similarly stimulate allogeneic T cell proliferation and have nitric oxide -mediated cytotoxicity to tumor cells with an exception of CD4- 8- TID815 with less efficiency. (curehunter.com)
  • However 2 weeks of overload training followed by 2 weeks of active recovery (baseline) training may induce an increase in the lymphocyte count. (biomedsearch.com)
  • 0.05) between the 6 day.week-1 programme and the 3 alternate day.week-1 programme in total lymphocyte count, CD3+, CD4+, CD8+, CD16+, or CD19+ cells, the CD4:CD8 ratio, HLA-DR+ (activated) T cells or plasma cortisol concentrations. (biomedsearch.com)
  • Experimental data suggested that these T-lymphocytes may also play a role in the development of IR during obesity. (ahajournals.org)
  • Transfer of CD4+ Tr1 cells obtained from CD4- 8- TID815-immunized wild-type, but not IL-10(-/-) mice, into CD4+ 8+ TID815 immunized mice abolished otherwise inevitable development of antitumor immunity. (curehunter.com)
  • Co-expression of CD4 and β2-AR was observed in spleens of both intact and CIA mice. (medscimonit.com)
  • The study determined the CD4 lymphocytes count levels of HIV positive patient at first presentation at STI/HIV Clinic at Suntreso Government Hospital in Kumasi, Ghana. (bmj.com)
  • 20.7% (183/883) reported with CD4 count less than 50 cell/mm3, 9.5% (84/883) with CD4 count of less than 100 cells/mm3, 24.7% (218/883) with CD4 count of less than 250 cells/mm3, 16.0% (141/883) with CD4 count of less than 350 cells/mm3, 10.3% (91/883) with CD4 count of less than 500. (bmj.com)
  • 70.9% came with CD4 count of less than 350 cells/mm3. (bmj.com)
  • However following both S1 and S2 (baseline training) there was a significant increase in total lymphocyte count, CD3+, CD4+ and CD8+ lymphocytes. (biomedsearch.com)
  • The CD4 count mean of this group was 303 per mm 3 (range: 14-924). (pnas.org)
  • At the same time, a mixed lymphocyte culture was set as a positive cytotoxicity control with an irradiated (40 Gy) allogeneic Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cell line (LCL) (10 6 cells/well) for stimulation. (asm.org)
  • In these cell types, HIV-1 entry is mediated by the binding of envelope glycoproteins (gp120 and gp41, Env) to the receptor CD4 and a coreceptor, principally CCR5 or CXCR4, depending on the viral strain (R5 or X4, respectively). (cnrs.fr)
  • METHODOLOGY/PRINCIPAL FINDINGS: We demonstrate here that autophagy and cell death are also induced in the uninfected CD4 T cells by HIV-1 R5 Env, while autophagy is inhibited in productively X4 or R5-infected CD4 T cells. (cnrs.fr)
  • Immunoelectron-microscopic study of CD4- and CD8- positive lymphocytes from healthy donors seropositive for human T-lymphotropic virus type I . Biomedical Research (India) , 18 (2), 83-88. (elsevier.com)
  • Furthermore, in vitro stimulation with this adenoviral chimeric vaccine rapidly expanded multiple antigen-specific human CD8(+) and CD4(+) T-cells from healthy virus carriers. (nih.gov)
  • The results indicated that provided the amount of exercise is constant for a given period, then exercise distribution is not a critical variable in the alteration of lymphocyte subpopulations that may occur in response to overload training. (biomedsearch.com)
  • In order to determine the fine structural differences and labeling by immunoferritin particles of CD4-positive (CD4+) and CD8 positive (CD8+) cells at the ultrastructural level, short term cultured lymphocytes from eight healthy donors seropositive for HTLV-I were examined and virus production was examined in vitro. (alliedacademies.org)
  • The objective of this study was to determine whether the HPV-specific effectors responsible for the CTL response were primarily CD4 T lymphocytes and whether natural killer (NK) cells contributed to the observed killing. (asm.org)
  • Tumor cells may overexpress the stress-inducible NKG2D ligands (NKG2DLs: MICA/B, ULBPs) and the NKG2D signaling has been shown to be involved in lymphocyte-mediated anti-tumor activity. (mendeley.com)
  • 7B2 IgG1 or A32 IgG1, each containing mutations to enhance Fc function, was administered passively to rhesus macaques but afforded no protection against productive clinical infection while the positive control antibody CH22 IgG1 prevented infection in 4 of 6 animals. (duke.edu)
  • Sera of eight donors were all positive on the particle agglutination (PA) test, but only of the four of the eight were positive on the immunofluorescence (IF) test. (alliedacademies.org)
  • Sera with high titer on the PA test, e. g., above 26, were likely to be positive on the IF test, as well. (alliedacademies.org)