Cd4 immunoadhesin. Medical search. Frequent questions

CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region, similarly known as immunoglobulin. (wikipedia.org)
Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. (bvsalud.org)

Immunoadhesins: principles and applications Steven M. Chamow and Avi Ashkenazi The prototypic immunoadhesin is an antibody-like molecule that fuses the Fc region of an immunoglobulin molecule. (coek.info)
Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)

The protein has also inspired the development of other immunoadhesin molecules, such as CD4-IgG2 and CD4-mimetic compounds, which are being investigated as potential therapies for HIV/AIDS. (wikipedia.org)
The extracellular domain of CD4 contains four immunoglobulin-like domains (D1-D4), which are responsible for binding to the major histocompatibility complex (MHC) class II molecules on antigen-presenting cells. (wikipedia.org)
CD4-Ig binds to MHC class II molecules on antigen-presenting cells, thereby preventing the activation of T-helper cells that are specific for self-antigens. (wikipedia.org)

While natural anti-gp120 antibodies exhibit a response towards uninfected CD4-expressing cells that have a soluble gp120 bound to the CD4 on the cell surface, CD4 immunoadhesin, however, will not exhibit a response. (wikipedia.org)
Its structure, which consists of the extracellular domain of CD4 and the Fc region of IgG1, allows for soluble circulation throughout the body. (wikipedia.org)
Moléculas quiméricas resultantes de la fusión de CD4 soluble recombinante con la porción Fc de las inmunoglobulinas. (bvsalud.org)

CD4 immunoadhesin was first developed in the mid-1990s as a potential therapeutic agent and treatment for HIV/AIDS. (wikipedia.org)
Despite its potential as a therapeutic agent, the development of CD4 immunoadhesin has faced several challenges. (wikipedia.org)

CD4 is a surface receptor for human immunodeficiency virus (HIV). (wikipedia.org)
The protein is a fusion of the extracellular domain of the CD4 receptor and the Fc domain of human immunoglobulin G (IgG), the most abundant antibody isotype in the human body. (wikipedia.org)
The development of CD4 immunoadhesin stems from the observation that the CD4 receptor plays a critical role in the entry of HIV into human cells. (wikipedia.org)
The CD4 receptor is used as a primary receptor by HIV to attach to the surface of target cells. (wikipedia.org)
The ability of CD4 immunoadhesin to block the interaction between the CD4 receptor and HIV was intended to prevent HIV from entering and infecting human cells. (wikipedia.org)
HIV infects T-helper cells by binding to the CD4 receptor and the co-receptor CCR5 or CXCR4. (wikipedia.org)
By binding to gp120, CD4-Ig prevents the virus from binding to the CD4 receptor on T-helper cells, thus preventing infection. (wikipedia.org)
Tienen un empleo potencial en el tratamiento del SIDA ya que poseen propiedades de unión a gp120 y de bloqueo del VIH de rCD4 así como una gran semivida plasmática y funcioones de unión al receptor Fc de la inmunoglobulina. (bvsalud.org)

CD4 immunoadhesin has been extensively studied in preclinical and clinical trials as a potential treatment for HIV/AIDS. (wikipedia.org)
In addition to its antiviral activity, CD4 immunoadhesin has also been investigated for its potential immunomodulatory effects. (wikipedia.org)
Additionally, the need for frequent dosing and the potential for immune responses against the fusion protein have also limited the clinical application of CD4 immunoadhesin. (wikipedia.org)
CD4-Ig has also been investigated as a potential treatment for other diseases that involve immune dysregulation, such as multiple sclerosis and rheumatoid arthritis. (wikipedia.org)

Specifically, CD4 immunoadhesin plays a role in antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells. (wikipedia.org)
CD4 immunoadhesin is a bifunctional protein that has the ability to block HIV infection, inhibit autoreactive T-cell activation, and potentially modulate immune responses. (wikipedia.org)
In addition to its role in blocking HIV infection and inhibiting autoreactive T-cell activation, CD4-Ig may also have immunomodulatory effects. (wikipedia.org)
the immunoadhesin polypeptides are assembled and secreted into the cell culture medium. (coek.info)

Nevertheless, knowledge on the function of CD4 immunoadhesin has contributed to increased understanding of the biology of HIV and the mechanisms of viral entry. (wikipedia.org)

The CD4 immunoadhesin molecular fusion allow the protein to possess key functions from each independent subunit. (wikipedia.org)

The protein is a fusion of the extracellular domain of the CD4 receptor and the Fc domain of human immunoglobulin G (IgG), the most abundant antibody isotype in the human body. (wikipedia.org)
The extracellular domain of CD4 contains four immunoglobulin-like domains (D1-D4), which are responsible for binding to the major histocompatibility complex (MHC) class II molecules on antigen-presenting cells. (wikipedia.org)

Specifically, CD4 immunoadhesin plays a role in antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells. (wikipedia.org)
Protuberance-into-cavity and wild-type CH3 variants were compared in their ability to direct the formation of a humanized antibody-immunoadhesin chimera (Ab / Ia) anti-CD3 / CD4-IgG. (patsnap.com)
0177] Thus, mutations were constructed in the CH3 domain of the humanized anti-CD3 antibody heavy chain and in CD4-IgG by site-directed mutagenesis using mismatched oligonucleotides (Kunkel et al. (patsnap.com)
9. A humanized, bispecific immunoadhesin-antibody that retargets CD3+ effectors to kill HIV-1-infected cells. (nih.gov)

CD4-Ig has also been investigated as a potential treatment for other diseases that involve immune dysregulation, such as multiple sclerosis and rheumatoid arthritis. (wikipedia.org)
In these diseases, CD4-Ig may work by inhibiting the activation of autoreactive T-cells. (wikipedia.org)

CD4-Ig works by mimicking the binding of CD4 to HIV, thereby preventing the virus from infecting T-helper cells. (wikipedia.org)

CD4 immunoadhesin is a bifunctional protein that has the ability to block HIV infection, inhibit autoreactive T-cell activation, and potentially modulate immune responses. (wikipedia.org)