• Podocalyxin-like protein 1 is a protein that in humans is encoded by the PODXL gene. (wikipedia.org)
  • Molecular cloning and characterization of human podocalyxin-like protein. (wikipedia.org)
  • Endoglycan, also named Podocalyxin-like 2 protein, is a type I transmembrane glycoprotein. (rndsystems.com)
  • It belongs to the CD34/Podocalyxin family of sialomucins that share structural similarity and sequence homology. (rndsystems.com)
  • CD34, also known as gp105-120, is a type I monomeric sialomucin-like glycophosphoprotein with an approximate molecular weight of 105-120 kD. (biolegend.com)
  • Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoietic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. (wikipedia.org)
  • This single-chain, 105-120 kDa, heavily O-glycosylated protein is expressed on hematopoietic progenitor cells, vascular endothelium, bone marrow stromal cells and embryonic fibroblasts. (bdbiosciences.com)
  • In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
  • His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
  • In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
  • Selectively expressed on the majority of hematopoietic stem/progenitor cells, bone marrow stromal cells, capillary endothelial cells, embryonic fibroblasts, and some nervous tissue, CD34 is a commonly used marker to identify human hematopoietic stem/progenitor cells. (biolegend.com)
  • According to antibody-based profiling, the protein is present in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus and seminal vesicle and according to RNA expression analysis, the PODXL transcripts are present in all analysed human tissues. (wikipedia.org)
  • The 581 monoclonal antibody specifically binds to CD34, a sialomucin-like type I transmembrane glycoprotein. (bdbiosciences.com)
  • The 581 antibody blocks reactivity of another anti-CD34 monoclonal antibody, 8G12. (bdbiosciences.com)
  • is to generate an antibody-like molecule by combining framework sequences from a human mAb with sequences from a human protein that carries a target-recognition function. (coek.info)
  • CD34 may also play a role as an adhesion molecule since it binds to CD62E and CD62L. (bdbiosciences.com)
  • Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)
  • The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
  • This gene encodes a member of the CD34 sialomucin protein family. (wikipedia.org)
  • What started as a series of microscopic observations in different animal model systems has since evolved into studies of gene expression and regulation, and subsequent protein-protein interactions, cell surface protein expression profiling, and functional mapping of cell fates. (biomedcentral.com)
  • There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
  • The expression and localisation of PODXL in human cells, tissues and organs have been investigated by the Human Protein Atlas consortium. (wikipedia.org)
  • Human KG-1a cells (blue) and mouse EL4 T cells (red) stained with 148Nd-anti-CD34 (581). (biolegend.com)
  • Approach and Results: Patients with stable coronary artery disease were enrolled in a prospective study enumerating CPCs as CD (cluster of differentiation)-34-expressing mononuclear cells (CD34+) and inflammation as levels of IL (interleukin)-6 and high-sensitivity CRP (C-reactive protein) levels. (bvsalud.org)
  • In this review, we summarize the many examples of immunoadhesins in the literature, and discuss some essential structural and functional features of this expanding fanuly of recombinant proteins. (coek.info)
  • CD34 and VE-cadherin expression was detected using immunofluorescence. (silverchair.com)
  • In this issue of Bioscience Reports (volume 42, issue 1), Caliskan and Hill provide a detailed view into the emerging roles of cardiovirus 2A protein, which is the primary factor for virulence during infections. (silverchair.com)
  • Podocalyxin-like protein 1 is a protein that in humans is encoded by the PODXL gene. (wikipedia.org)
  • The expression and localisation of PODXL in human cells, tissues and organs have been investigated by the Human Protein Atlas consortium. (wikipedia.org)
  • According to antibody-based profiling, the protein is present in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus and seminal vesicle and according to RNA expression analysis, the PODXL transcripts are present in all analysed human tissues. (wikipedia.org)
  • Podocalyxin-like protein (PODXL) is a member of the CD34 family of transmembrane sialomucins. (medscape.com)
  • Podocalyxin, also known as Podocalyxin-like protein-1 (PCLP1 or PODXL), is a type I transmembrane glycoprotein. (novusbio.com)
  • However, CD34 is differentially expressed on endothelial cells in different organs and in pathological conditions. (bvsalud.org)
  • Expression of CD34 is also strongly regulated in-vitro in endothelial cell models, including human umbilical vein endothelial cells (HUVEC) and endothelial colony forming cells (ECFC). (bvsalud.org)
  • These results suggest that CD34 expression by endothelial cells in-vitro associates with their ability to proliferate and with an immunogenic ability that favours the tolerogenic response. (bvsalud.org)
  • Little is known about regulation of endothelial CD34 expression or function. (bvsalud.org)
  • The encoded protein was originally identified as an important component of glomerular podocytes. (wikipedia.org)
  • Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoietic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. (wikipedia.org)
  • A sialic acid-rich protein and an integral cell membrane mucin. (uams.edu)