Cd31 and vascular endothelial. Medical search. Frequent questions

The role of vascular endothelial growth factor (VEGF) in differential vWF expression was investigated using cultured human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)
In a case-control study, 24 tissue specimens from the patients with primary moderate pterygium (cases) and 15 specimens excised from the nasal bulbar region in healthy counterparts (controls) were compared in terms of the count of mast cells (inflammation), as well as the status of Cd31/vascular Endothelial Growth Factor (VEGF) expression (angiogenesis) in Tabriz Nikookari and Sina Teaching Hospitals. (scialert.net)
YAP expression increased following laser exposure, in accordance with vascular endothelial growth factor (VEGF) expression. (molvis.org)
Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
Its receptor binding site is VEGF-A, which is known to promote vascular generation and leakage and to cause nAMD. (molvis.org)
The scaffold consists of an outer PLLA scaffold and an inner porous PLLA biomimetic membrane combined with heparin (Hep), peptide Gly-Gly-Gly-Arg-Glu-Asp-Val (GGG-REDV), and vascular endothelial growth factor (VEGF). (gentaurpub.com)

CD34 antigen is a vascular endothelial cell marker that does not react with lymphatic endothelial cells. (wikipedia.org)
Vascular markers (CD31 and CD34), vascular endothelial growth factor receptor-3 (VEGFR-3), and lymphatic markers (D2-40 and PROX1) on the neoplastic cells suggest they may be derived from the endothelial cells of lymphatic vessels. (medscape.com)
Angiosarcomas can typically express CD31, CD34, D2-40 and ERG. (medicaljournals.se)
Malformed vascular endothelial cells expressed CD31, CD34 and ERG. (bvsalud.org)
Immunohistochemical analysis that demonstrates the endothelial nature of the neoplasm is frequently positive for specific vascular markers (CD31, CD34, factor VIII), and keratin 1,2,5,6 . (bvsalud.org)

It was consistent with the change of the CD31-positive staining areas representing angiogenesis of the injured patellar tendons. (hindawi.com)
CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. (thermofisher.com)
Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
While both processes result in new blood vessel formation, vasculogenesis occurs mainly during embryonic development and is facilitated by EPCs, while angiogenesis takes place via "sprouting" of endothelial cells , which allows new blood vessels to take shape from already existing blood vessels. (naturalnews.com)
The increased bone vascularization in Serpinf1 (−/−) mice correlated with increased number of CD31(+)/Endomucin(+) endothelial cells, which are involved in the coupling angiogenesis and osteogenesis. (northwestern.edu)
PECAM-1 is known to have various roles in vascular biology including angiogenesis, platelet function, and thrombosis. (bio-rad-antibodies.com)
Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway. (biomedcentral.com)

This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on leukocytes and platelets. (thermofisher.com)

In their previous study, the researchers found that epimedin C could induce endothelial-like (but not osteogenic) differentiation of C3H/10T1/2 cells in vitro. (naturalnews.com)
Based on these results, the researchers concluded that epimedin C effectively promotes vascularization both in the BMP2-dependent bone formation model and in the 4T1 mammary tumor-bearing model by inducing the endothelial-like differentiation of C3H/10T1/2 in vivo. (naturalnews.com)
now reveal that differentiation of USCs generates ECs with robust endothelial function in vitro and endothelial potential in vivo, thereby suggesting this approach as a non-invasive, simple, and low-cost method [5] to produce sufficient autologous ECs for applications in tissue-engineered vascular regeneration or the repair of endothelial dysfunction [6]. (stemcellsportal.com)
Differentiation of USCs in endothelial medium generated EC-like cells by day 14 that displayed endothelial characteristics at the morphological, ultrastructural (tight junction formation), and functional marker expression levels (e.g. (stemcellsportal.com)
Human Urine-Derived Stem Cell Differentiation to Endothelial Cells with Barrier Function and Nitric Oxide Production. (stemcellsportal.com)
No features of vascular differentiation, for example intracytoplasmic lumina or areas of conventional angiosarcoma, were observed. (medscape.com)
Malignant proliferation showing large monomorphic cells with some epithelioid (A1E/AE3) or angiocentric aspects without clear vascular differentiation. (medscape.com)
ERG and CD31 immunoexpression prove endothelial differentiation. (medscape.com)
Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
In the present study, an electrospinning poly (L)-lactic acid (PLLA) bilayered scaffold is developed to prevent thrombosis after implantation by promoting the capture and differentiation of endothelial colony-forming cells (ECFCs). (gentaurpub.com)

CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. (thermofisher.com)
The expression on endothelial cells is concentrated at junctions between adjacent cells. (bio-rad-antibodies.com)

Two-color flow cytometric analysis of CD31 expression on BALC/c mouse bone marrow cells. (bdbiosciences.com)
Two-color flow cytometric dot plots show the correlated expression patterns of CD31 (or Ig Isotype control staining) versus CD45R/B220 for gated events with the forward and side light-scatter characteristics of viable bone marrow cells. (bdbiosciences.com)
Mechanistic studies revealed that this progression was mediated by suppressed TNFα levels, both locally and systemically, resulting in reduced expression of tumor endothelial adhesion molecules, particularly intercellular adhesion molecule-1 (ICAM-1) and a subsequent decrease in the number of activated and effector CD8 + T cells in the tumor. (aacrjournals.org)
During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)
Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
We investigated whether atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells. (plos.org)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
Low PDCD4 level was associated with reduced proliferation but not apoptosis or phosphorylation of endothelial nitric oxide synthase caused by pulsatile shear stress to help maintain the homeostasis of endothelial cells. (plos.org)
However, the action of PDCD4 in endothelial cells is unclear. (plos.org)
Vascular endothelial cells, as a monolayer in direct contact with the flowing blood, bear the most of the wall shear stresses and have important homeostatic functions in response to stress [16] . (plos.org)
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
vWF is produced exclusively by endothelial cells and megakaryocytes. (biomedcentral.com)
Histopathology with immunochemistry showed extensive infiltration of the dermis by atypical cells positive for CD31 and negative on pan-cytokeratin and human herpesvirus-8 staining. (medicaljournals.se)
d) Immunochemistry, ×10 magnification: infiltration of dermis by CD31 + cells. (medicaljournals.se)
Antibodies against endothelial cells are the stain of choice (4). (medicaljournals.se)
The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)
Additionally, after laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells. (molvis.org)
This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
Urine-derived Stem Cells: An Exciting New Source of Autologous Endothelial Cells? (stemcellsportal.com)
The endothelial cells in the wall of abnormal lumen were flat or absent. (bvsalud.org)
Diagnosis is made with a biopsy showing malignant cells associated with vascular structures. (orthobullets.com)
CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1) , is a 140 kDa type I integral membrane glycoprotein that is expressed at high levels on early and mature endothelial cells, platelets, and most leukocyte subpopulations. (bio-rad-antibodies.com)
Thomas RA et al (2009) Detection and characterization of circulating endothelial progenitor cells in normal rat blood. (bio-rad-antibodies.com)
a Large dilated vascular structures lined by endothelial cells filled with red blood cells. (biomedcentral.com)
c Microscopy showing large dilated vascular structure lined by endothelial cells. (biomedcentral.com)
For knocking down proteins of interest, endothelial cells were transfected with siRNAs. (biomedcentral.com)
These include efficient drug delivery, infiltration of immune cells by reducing the heterogeneity of intratumoral blood flow, and increased vascular permeability caused by tight associations between endothelial cells and perivascular cells [ 9 , 10 ]. (biomedcentral.com)
Here, we describe the isolation, characterization, and expansion of human saphenous vein endothelial cells (hSVECs). (gentaurpub.com)
Cells isolated by collagenase digestion display the typical cobblestone morphology and express endothelial cell markers CD31 and VE-cadherin. (gentaurpub.com)
Endothelial cells' F-actin pattern and nitric oxide (NO) secretion are modulated accordingly by the arterial stretch. (gentaurpub.com)
A small-diameter vascular graft immobilized peptides for capturing endothelial colony-forming cells. (gentaurpub.com)
2277 related Products with: A small-diameter vascular graft immobilized peptides for capturing endothelial colony-forming cells. (gentaurpub.com)
Defects in vein valve PROX1/FOXC2 antithrombotic pathway in endothelial cells drive the hypercoagulable state induced by trauma and critical illness. (gentaurpub.com)
Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. (bvsalud.org)
The histologic hallmark of AE is represented by the presence of sheets and groups of atypical endothelial cells with prominent epithelioid morphologies. (bvsalud.org)

The purpose of this report is to describe the features of angiosarcoma arising in mucinous tumor that was misinterpreted as a benign vascular proliferation during the intraoperative consultation. (hindawi.com)
However, many disease-predisposing factors and/or contributing factors have been identified, including inflammation, endothelial cell dysfunction, aberrant vascular wall cell proliferation and mutations in the bone morphogenetic protein-receptor type 2 ( Bmpr2 ) gene [ 1 - 3 ]. (ersjournals.com)
Epithelioid angiosarcoma (EA) is a rare variant of angiosarcoma, which is characterized by a high-grade malignant neoplasm, which consists of an atypical, multilayered, or solid endothelial proliferation and vasoformative architecture, presenting necrosis and an area of hemorrhage 1-5 . (bvsalud.org)

The MEC13.3 antibody specifically recognizes CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1). (bdbiosciences.com)
Description: The WM59 monoclonal antibody reacts with human CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa. (thermofisher.com)
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. (thermofisher.com)
Finally, the researchers reported that the mRNA levels of endothelial markers - namely, the platelet endothelial adhesive factor-1 (CD31), the endothelial cell-specific molecule-1 (ESM-1), and the vascular von Willebrand factor (vWF) in mouse 4T1 mammary tumor tissue - significantly increased after epimedin C treatment. (naturalnews.com)
D) A 3-dimensional reconstruction of (A). CD31: an endothelial marker, also known as anti-platelet/endothelial cell adhesion molecule-1 (PECAM). (pancreapedia.org)

The immunohistologic and ultrastructural results listed below can be utilized to confirm that the tumor is derived from blood vessels: Antibodies against factor VIII-related antigen are endothelial cell markers. (wikipedia.org)
This case shows that vascular markers should be done in front of an aggressive sellar lesion with unexpected histologic features. (medscape.com)
Vascular markers allowed us in this case to make the unusual diagnosis of primary epithelioid angiosarcoma. (medscape.com)

Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
Overall, the authors provide substantial evidence that non-invasively collected USCs represent an exciting new source of autologous ECs for applications in tissue-engineered vascular regeneration or repair of endothelial dysfunction. (stemcellsportal.com)
Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. (ersjournals.com)

Histologically, Stewart-Treves syndrome displays networks of proliferating vascular channels that dissect the dermal collagen. (medicaljournals.se)
Following in vitro exposure to CTX, hBMSCs showed decreased cell growth in a dose- and time-dependent manner, accompanied by increased expressions of collagen-I/III, and CD31. (ijbs.com)

Recently, we have shown that blood flow patterns at vein valves induce oscillatory stress genes, which maintain an anticoagulant endothelial phenotype that inhibits spontaneous clotting at vein valves and sinuses, is lost in the presence of DVT in human pathological samples, and is dependent on expression of the transcription factor FOXC2. (gentaurpub.com)

BALB/c aortas (H-2(d)) transplanted into α-TFPI-transgenic (Tg) mice (H-2(b)) regenerated a quiescent endothelium in contrast to progressive IH seen in C57BL/6 wild-type (WT) mice even though both developed aggressive anti-H-2(d) alloresponses, indicating similar vascular injuries. (nih.gov)
Normally, the endothelium forms an integral cellular barrier to regulate vascular homeostasis. (surrey.ac.uk)
YAP was localized in the vascular endothelium within the CNV site. (molvis.org)
The abrupt increase of hemodynamic stress associated with the graft arterialization results in vascular damage, especially the endothelium, that may influence the low patency of the saphenous vein graft (SVG). (gentaurpub.com)

Whether or not these new conveyors of biological information contribute to the acquisition and/or maintenance of the altered endothelial phenotype is unexplored in PH and requires further study. (ersjournals.com)
In summary, we present a detailed method to isolate hSVECs to study the influence of hemodynamic mechanical stress on an endothelial phenotype. (gentaurpub.com)

c) Coloration haematoxylin phloxine saffron stain (HPS), ×10 magnification: section of a cutaneous papule from the chest revealing a normal epithelium and a dermis infiltrated by irregular anastomosing vascular channels. (medicaljournals.se)
Magnification of ×400 with (A) hematoxylin and eosin stain, (B) ERG immunostaining, and (C) CD31 and ×200 magnification with (D) pan-keratin AE1/AE3 immunostainings. (medscape.com)

Lymphatic blockage may encourage neoplastic transformation due to local immunodeficiency, which could promote vascular oncogenesis (2). (medicaljournals.se)

This malignant vascular tumour can develop in cases of long-standing chronic lymphoedema. (medicaljournals.se)
Angiosarcoma is a rare malignant vascular neoplasm which constitutes less than 1% of all sarcomas. (bvsalud.org)

Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)

Left Panel) or BD Horizon™ BV510 Rat Anti-Mouse CD31 antibody (Cat. (bdbiosciences.com)
The following product was used in this experiment: CD31 (PECAM-1) Monoclonal Antibody (WM-59 (WM59)), Functional Grade, eBioscience™ from Thermo Fisher Scientific, catalog # 16-0319-82, RRID AB_468934. (thermofisher.com)

A diagnosis of tufted angiomas is classically suspected in an infant or young child presenting with a red or violet vascular lesion with ill-defined borders present on the trunk or extremities. (medscape.com)
However, there are times when a biopsy carries more risk than benefit and is deferred, such as when the lesion is highly vascular and/or the patient also presents with thrombocytopenia and coagulopathy. (medscape.com)
Angiography reveals a highly vascular lesion with vessels oriented parallel to one another. (medscape.com)

b Microarray analysis shows that vascular related genes, among which are Col4a1 and Col4a2 , show the highest significance in late chick lung development. (biomedcentral.com)

The coadministration of cisplatin with PCNs induced a synergistic suppression of tumor growth by improving drug delivery as evidenced by increased blood prefusion and decreased vascular permeability. (biomedcentral.com)

These small, round, calcified densities occur within organizing thrombi within the vascular structures of hemangiomas, as in the image below. (medscape.com)
The diagnosis of hemangioma may be made with MRI when these signal characteristics are present and when the serpentine pattern of the vascular structures is depicted, usually with interposed fat as well. (medscape.com)
The signal characteristics are similar to those of intramuscular hemangiomas (increased signal on T1 and T2, and depiction of vascular structures). (medscape.com)

The presence of endothelial atypia provides further support for the diagnosis. (hindawi.com)

The application of tissue-engineered vascular grafts constructed with autologous ECs in combination with suitable scaffolds may avoid many of the problems associated with revascularization approaches employing autologous vessels or allogenic/synthetic vascular grafts. (stemcellsportal.com)
Combining synthetic polymers and biomacromolecules prevents the occurrence of thrombogenicity and intimal hyperplasia in small-diameter vascular grafts (SDVGs). (gentaurpub.com)

It is a mechanosensor of endothelial cell response to fluid shear stress and it is involved in the regulation of leukocyte migration through venular walls. (bio-rad-antibodies.com)
Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch. (gentaurpub.com)

In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia. (biomedcentral.com)

CD31 is a 130 kDa integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. (bdbiosciences.com)
The cytoprotective and anti-inflammatory activity of APC is mediated through binding to its receptor, endothelial cell protein C receptor (EPCR). (biomedcentral.com)

PCNs induced PAR-1/PAR-3 heterodimerization through EPCR occupation and PAR-1 activation, which resulted in Gα13-RhoA-mediated-Tie2 activation and stabilized vascular tight junctions via the Akt-FoxO3a signaling pathway. (biomedcentral.com)

Homotypic interaction of CD31 is important in adhesion, cell-cell and cell-matrix interaction, and signal transduction. (thermofisher.com)
N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. (thermofisher.com)
CD31 is also expressed on a major population of macrophage/dendritic cell precursors in the bone marrow. (bio-rad-antibodies.com)

To overcome this limitation, we developed nanoparticles with antiseptic activity that target tumor vascular abnormalities. (biomedcentral.com)

It is one of key regulatory molecules in vascular system. (thermofisher.com)

Pulmonary hypertension (PH) is a fatal disease with no treatment options, characterised by elevated pulmonary vascular resistanzce and secondary right ventricular failure. (ersjournals.com)
Pulmonary hypertension (PH) is characterised by widespread obstruction and obliteration of pulmonary arterioles, leading to a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. (ersjournals.com)

Mutations in Col4a1 derived from the vascular component were sufficient to cause defects in vascular development and the BGB. (biomedcentral.com)

While the antithrombotic activity of APC is based on its ability to inactivate clotting factors Va and VIIIa, leading to adverse bleeding, the cytoprotective effect is based on its anti-inflammatory, antiapoptotic, and endothelial barrier stabilization activities [ 12 , 14 ]. (biomedcentral.com)

The lung is a complex, precisely structured organ in which the vascular network is intimately associated with epithelial-lined tubes and sacs for the prime purpose of gas exchange. (biomedcentral.com)

Anatomy39

Organisms12

Diseases6

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes37

Disciplines and Occupations1

Information Science3

Health Care1

VEGF6

CD345

Angiogenesis7

Expressed by endothelial cells1

Differentiation10

Junctions between adjacent cells2

Cells40

Proliferation3

Platelet5

Markers3

Marker1

Dysfunction3

Collagen2

Induce1

Endothelium4

Phenotype2

Magnification2

Lymphatic1

Malignant vascular2

Antigen1

Antibody2

Lesion3

Shows that vascular1

Permeability1

Structures3

Atypia1

Grafts2

Shear stress2

Growth1

Protein2

Signaling pathway1

Cell3

Tumor1

Molecules1

Pulmonary2

Mutations1

Barrier1

Lung1