Loading...
  • OX40
  • Our previous studies have implicated signaling through the tumor necrosis family receptors OX40 and CD30 as critical for maintaining CD4 memory responses. (rupress.org)
  • However, in the combined absence of OX40 and CD30, FoxP3-deficient mice develop normally and breed successfully. (rupress.org)
  • Although the absence of OX40 plays the dominant role, FoxP3-deficient mice sufficient in CD30 but deficient in OX40 signals still eventually develop lethal disease. (rupress.org)
  • These observations identify OX40 and CD30 signals as essential for the development of clinically relevant CD4-dependent autoimmunity and suggest that combination therapies that abrogate these signals might be used to treat established human autoimmune diseases. (rupress.org)
  • We show in this paper that FoxP3 T reg cells are dispensable in mice deficient in OX40 and CD30 signals. (rupress.org)
  • FoxP3-deficient mice lacking OX40 and CD30 develop and grow normally, fail to develop clinically relevant autoimmune disease, and have a normal lifespan. (rupress.org)
  • We also show that blocking mAbs to OX40 and CD30 ligands abrogates development of FoxP3 KO disease. (rupress.org)
  • As expected, ∼50% of male offspring heterozygous for expression of OX40 and CD30 (dKO het ) were FoxP3 deficient and developed lethal autoimmune disease at ∼4 wk ( Fig. 1 A ), characterized by weight loss ( Fig. 1 B ) and scurfy phenotype ( Fig. 1 C ). Because OX40 and CD30 are linked genetically, offspring have a high probability of inheriting deficiency in both genes as a haplotype. (rupress.org)
  • INFLAMMATION
  • Fischer M, Harvima IT, Carvalho RF, Möller C, Naukkarinen A, Enblad G, Nilsson G: Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. (exbio.cz)
  • pathways
  • Wright CW, Rumble JM, Duckett CS: CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. (exbio.cz)
  • development
  • Interference of the CD30-CD30L pathway reduces atherosclerosis development. (harvard.edu)
  • Polte T, Behrendt AK, Hansen G: Direct evidence for a critical role of CD30 in the development of allergic asthma. (exbio.cz)
  • role
  • Kennedy MK, Willis CR, Armitage RJ: Deciphering CD30 ligand biology and its role in humoral immunity. (exbio.cz)
  • publication
  • This graph shows the total number of publications written about "CD30 Ligand" by people in Harvard Catalyst Profiles by year, and whether "CD30 Ligand" was a major or minor topic of these publication. (harvard.edu)