• The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. (thermofisher.com)
  • The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. (cytekbio.com)
  • Description: The OKT3 monoclonal antibody reacts with an epitope on the epsilon-subunit within the human CD3 complex. (thermofisher.cn)
  • CD3 epsilon subunit of T-cell rece. (gsea-msigdb.org)
  • CD3 gamma subunit of T-cell recept. (gsea-msigdb.org)
  • Epsilon subunit of the human CD3 complex Collagen IV alpha! (histoprime.com)
  • Clone 500A2 antibody is able to partially cross-block the 17A2 and 145-2C11 antibodies, indicating that all three of these anti-CD3 antibodies recognize distinct but overlapping epitopes. (biolegend.com)
  • The following product was used in this experiment: CD3 Monoclonal Antibody (17A2), Brilliant Violet™ 480, eBioscience™ from Thermo Fisher Scientific, catalog # 414-0032-82, RRID AB_2925604. (thermofisher.com)
  • C57BL/6 mouse splenocytes were stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and 0.25 µg of Rat IgG2b kappa Isotype Control, Brilliant Violet 480 (Product # 414-4031-81) (left) or 0.25 µg of CD3 Monoclonal Antibody, Brilliant Violet 480 (right). (thermofisher.com)
  • Description: The 17A2 monoclonal antibody reacts with the mouse CD3 complex. (thermofisher.com)
  • Whole blood was stained with BD Horizon™ BV421 Mouse Anti-Human CD3 antibody (Cat. (bdbiosciences.com)
  • The SK7 (Leu-4) monoclonal antibody specifically binds to the epsilon chain of the CD3 antigen/T-cell antigen receptor (TCR) complex. (bdbiosciences.com)
  • The following product was used in this experiment: CD3 Monoclonal Antibody (UCHT1), Brilliant Ultra Violet™ 805, eBioscience™ from Thermo Fisher Scientific, catalog # 368-0038-42, RRID AB_2896070. (thermofisher.com)
  • The antibody MEM-57 reacts with gamma-epsilon and delta-epsilon dimers of human CD3 complex, a part of a bigger multisubunit T cell receptor complex (CD3/TCR) expressed on peripheral blood T lymphocytes and mature thymocytes. (sigmaaldrich.com)
  • Xaluritamig is a novel humanized bispecific T cell recruiting antibody cross-reactive to human and nonhuman primate STEAP1 and CD3. (drugbank.com)
  • The following product was used in this experiment: CD3 Monoclonal Antibody (OKT3), NovaFluor™ Blue 510, eBioscience™ from Thermo Fisher Scientific, catalog # H030T03B01, RRID AB_2910767. (thermofisher.cn)
  • The polyclonal antibody E053 recognizes the cytoplasmic part of the epsilon subunits of the CD3 complex on thymocytes and on peripheral T lymphocytes and, in contrast to many monoclonal antibodies of the same specificity, is suitable for cryostat material and kerosene sections. (histoprime.com)
  • CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11. (wikipedia.org)
  • The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. (wikipedia.org)
  • The epsilon polypeptide plays an essential role in T-cell development. (wikipedia.org)
  • Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. (wikipedia.org)
  • T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. (thermofisher.cn)
  • The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. (thermofisher.cn)
  • The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T lymphoid lineage. (histoprime.com)
  • T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3EAP and NCK2. (wikipedia.org)
  • Recognizes the epsilon -chain of the CD3/T cell antigen receptor complex (McMichael, A.J. et al . (rndsystems.com)
  • CD3ε forms a TCR complex by associating with the CD3δ, γ and ζ chains, as well as the TCR α/β or γ/δ chains. (biolegend.com)
  • CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex. (biolegend.com)
  • Ig superfamily, forms CD3/TCR complex with CD3δ, γ and ζ subunits and TCR (α/β and γ/δ), 20 kD. (biolegend.com)
  • CD3 subunits gamma, delta and epsilon are required for proper assembly, trafficking and surface expression of the TCR complex. (thermofisher.com)
  • Along with the other CD3 subunits gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. (thermofisher.com)
  • Teplizumab targets the epsilon chain, which is part of the CD3 receptor protein complex. (yaledailynews.com)
  • The CD3 complex is a component of the T-cell membrane responsible for recognizing the respective targets of that T-cell, which is a type of immune cell. (yaledailynews.com)
  • The signal created when the CD3 complex encounters a viral antigen is much stronger than the signal from teplizumab reception. (yaledailynews.com)
  • The CD3 complex mediates signal transduction. (lu.se)
  • The TCR/CD3 complex of T lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. (lu.se)
  • CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. (prospecbio.com)
  • These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor - CD3 complex. (cytekbio.com)
  • The CD3 complex is experimented on the cell membrane of T lymphocytes. (histoprime.com)
  • The complex consists of several protein subunits (including gamma, delta, epsilon) associated with the T cell receptor (TCR). (histoprime.com)
  • The T cell receptor/CD3 complex: a dynamic protein ensemble. (histoprime.com)
  • Clevers H, Dunlap S and Terhorst C. The transmembrane orientation of the epsilon chain of the TcR/CD3 complex. (histoprime.com)
  • Studies reveal that chronic exposure of T cells to TNF uncouples TCR signal transduction pathways by impairing the assembly and stability of the TCR/CD3 complex at the cell surface. (biomedcentral.com)
  • When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. (bvsalud.org)
  • CD3ε is a 20 kD transmembrane protein, also known as CD3 or T3. (biolegend.com)
  • KACTUS Biosystems Human CD3E/CD3 epsilon Protein (CD3-HM20E) (catalog No. CD3-HM20E) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Asp23-Asp126(C119S, C122S). (ushelf.com)
  • 您现在的位置: 主页 / 其他重组蛋白 / Mouse CD3E&CD3D/CD3 epsilon&CD3 delta Protein, Accession: P2. (watson-bio.cn)
  • Recombinant Mouse CD3E&CD3D/CD3 epsilon&CD3 delta Protein is expressed from HEK293 with hFc tag at the C-terminal.It contains Asp23-Asp108(CD3E)&Phe22-Ala105(CD3D). (watson-bio.cn)
  • Prokaryotic fusion protein corresponding to the human CD3 epsilon chain. (histoprime.com)
  • Teplizumab binds to an epitope of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic response that is a key component of the disease. (science20.com)
  • [ 1 ] It is also important that flow cytometry antibodies against the CD3 epsilon chain be used, as immunohistochemical antibodies may detect the zeta chain of CD3, which lack specificity. (medscape.com)
  • T-cell surface glycoprotein CD3 zeta chain (CD247) is a member of the CD3Z/FCER1G family. (prospecbio.com)
  • ab52959 reacts with CD3 epsilon. (abcam.cn)
  • CD3 epsilon is one of at least four invariant proteins that associate with the variable antigen recognition chains of the T cell receptor and function in signal transduction. (rndsystems.com)
  • However, Ig alpha, Ig beta, and most of the other receptor chains that contain ITAMs, including CD3 epsilon, CD3 gamma, TCR zeta, and Fc epsilon Rl gamma, are found as components of multimeric and heterogeneous complexes. (nih.gov)
  • Complejo formado al menos por cinco polipéptidos de unión a la membrana de los linfocitos T maduros que se asocian de forma no covalente con otro y con el receptor del linfocito T (RECEPTORES DE ANTÍGENOS DE LOS LINFOCITOS T). El complejo CD3 incluye las cadenas (subunidades) gamma, delta, épsilon, zeta y eta. (bvsalud.org)
  • Cuando el antígeno se une al receptor del linfocito T, el complejo CD3 transduce las señales activadoras al citoplasma del linfocito T. Las cadenas (subunidades) gamma y delta del antígeno CD3 están separadas de las cadenas gamma/delta del receptor del linfocito T (CADENAS GAMMA-DELTA DE LOS RECEPTORES DE ANTÍGENOS DE LOS LINFOCITOS T) y no están relacionadas con ellas. (bvsalud.org)
  • The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA). (bvsalud.org)
  • The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. (wikipedia.org)
  • There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). (embl.de)
  • CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. (thermofisher.com)
  • Activation of human thymocytes via CD3 and CD2 molecules. (histoprime.com)
  • C57BL/6 mouse splenocytes were stained with CD19 FITC and CD3ε (clone 500A2) APC/Fire™ 750. (biolegend.com)
  • Binding of 17A2 to CD3 initiates the intracellular biochemical pathway resulting in cellular activation and proliferation. (thermofisher.com)
  • Synthetic peptide corresponding to Human CD3 epsilon aa 150-250. (abcam.cn)
  • Synthetic human epsilon-chain CD3 peptide (AS 156-168) was used to immunize rabbits after coupling to thyroglobulin. (histoprime.com)
  • No other peripheral cells experiment CD3 (except possibly Purkinje cells in the cerebellum). (histoprime.com)
  • These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. (thermofisher.cn)
  • CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. (cytekbio.com)
  • Chetty R and Gatter K. CD3: structure, function, and role of immunostaining in clinical practice. (histoprime.com)
  • Matched Description: … primate STEAP1 and CD3. (drugbank.com)