Integrins are heterodimeric proteins made up of alpha and beta subunits. (abbkine.com)
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)
Membrane receptors1
Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. (wikipedia.org)
Collagen1
This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. (wikipedia.org)
Dimers1
It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. (wikipedia.org)
ITGB11
Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. (wikipedia.org)
Distinct1
The strategy underlying these CD4 based therapies, i.e. blocking the interaction between gp120 and the CD4 receptor, encompasses advantages distinct from current HAART regimens. (justia.com)
Integrins2
Based on this association between extracellular signals and intracellular protein kinase activity, we have chosen to include integrins in the 'Catalytic receptors' section of the database until more stringent criteria from NC-IUPHAR allows precise definition of their classification. (guidetopharmacology.org)
Integrins are heterodimeric entities, composed of α and β subunits, each 1TM proteins, which bind components of the extracellular matrix or counter-receptors expressed on other cells. (guidetopharmacology.org)
Integrin alpha3
It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. (thermofisher.com)
This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. (wikipedia.org)
It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. (wikipedia.org)
Membrane2
Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. (nih.gov)
IL-4-mediated alternative macrophage activation is inhibited by siRNA-targeted deletion of galectin-3 or its membrane receptor CD98 and by inhibition of PI3K. (aai.org)