• CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. (wikipedia.org)
  • Unlike many of the antibody receptors, CD23 is a C-type lectin. (wikipedia.org)
  • CD23 is known to have a role of transportation in antibody feedback regulation. (wikipedia.org)
  • Bidirectional transport of IgE was measured across filter-grown cells, either normal cells or those transfected with antisense CD23 oligonucleotides, or in the presence of blocking antibody. (mcmaster.ca)
  • IgE was transported in both the basal-to-apical direction and the apical-to-basal direction across filter-grown epithelial cells, a process that was inhibited by transfection of cells with CD23 antisense oligonucleotides or pretreatment with nonspecific IgE or anti-CD23 antibody. (mcmaster.ca)
  • As CD23 is soluble, it can move freely and interact with cells in plasma. (wikipedia.org)
  • Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. (wikipedia.org)
  • CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. (angioproteomie.com)
  • In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. (angioproteomie.com)
  • Experimental Design: Bcl -6, CD10, and CD40 were chosen as markers for a germinal center phenotype, CD23 as a marker of pre/early germinal center origin, and CD138 as a marker for postgerminal center origin. (aacrjournals.org)
  • Alemtuzumab mediates the CD39 + T-regulatory cell response via CD23 + macrophages. (nih.gov)
  • Serum eosinophil cationic protein and CD23 in acute RSV bronchiolitis. (medscimonit.com)
  • IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor). (wikipedia.org)
  • CD23 is a 45 kD protein also known as low affinity IgE Fc receptor, FcεRII, BLAST-2, Ly-42, or B6. (biolegend.com)
  • CONCLUSIONS: These findings provide evidence that CD23 encodes a functional IgE receptor on human intestinal epithelial cells and that this epithelial receptor is likely to play an important role in food allergies. (mcmaster.ca)
  • The IgE response is in turn regulated by the B-cell co-receptor CD23, and CD23-deficient mice show exaggerated IgE responses and airway hyper-responsiveness. (ox.ac.uk)
  • Expression of the variant CD23 chain interferes with trimerisation of the receptor and has a dominant-negative effect leading to reduced IgE binding in crosses between NZB and other strains. (ox.ac.uk)
  • We previously reported that CD23/FcεRII (low-affinity IgE receptor) is expressed on human intestinal epithelial cells and is responsible for transepithelial transport of IgE. (mcmaster.ca)
  • CD57BL/6 mouse splenocytes were stained with CD23 (clone B3B4) FITC (solid line), or rat IgG2a, κ FITC (broken line). (biolegend.com)
  • CD23 and CD40 expression seems to be prognostically favorable in DLBCL. (aacrjournals.org)
  • The present study was designed to examine expression of CD23 by human epithelial cells, determine its isoform and regulation by interleukin (IL) 4, and identify the role of CD23 in transepithelial IgE transport. (mcmaster.ca)
  • METHODS: Epithelial expression of CD23 was studied in cell lines, ileal biopsy specimens, and explanted fetal intestine. (mcmaster.ca)
  • IL-4 up-regulated the expression of epithelial CD23. (mcmaster.ca)
  • In this report, we show that New Zealand black (NZB) mice express a variant CD23 allele, with mutations in both the C-lectin-binding domain and stalk region, which fails to bind IgE at high affinity and has reduced expression on the cell surface. (ox.ac.uk)
  • In this study, we compared the transport of IgE with that of immune complexes in both the apical-to-serosal and the serosal-to-apical directions across HT29 epithelial cell layers and examined the effects of two p38 MAPK inhibitors, SKF86002 and SB203580, on the expression and function of CD23. (mcmaster.ca)
  • Our study showed that both p38 MAPK inhibitors at 10 μM significantly inhibited constitutive and IL-4-upregulated CD23 protein expression in epithelial cells. (mcmaster.ca)
  • Our results indicate that CD23 expression in these human intestinal epithelial cells is mediated through the p38 MAPK pathway and that inhibition of p38 MAPK consequently interferes with the transport of IgE and immune complexes across the intestinal epithelial barrier. (mcmaster.ca)
  • further studies in CD23-/- mice provided evidence that CD23 is involved in protected transport of antigen into the body. (mcmaster.ca)
  • Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. (ox.ac.uk)
  • In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell lymphoma (CD23-negative). (wikipedia.org)
  • The IgE immune complexes that are formed bind to CD23 molecules on B cells, and are transported to the B cell follicles of the spleen. (wikipedia.org)
  • CD23 responds to high levels of IgE by downregulating IgE secretion. (biolegend.com)
  • In contrast to neoplastic mantle cells (which are negative for CD23), the resting cells of physiologic mantle zone express CD23. (wikipedia.org)
  • Reed - Sternberg cells are usually positive for CD23. (wikipedia.org)
  • Paradoxically, Lymphomas arising from the mantle zone are generally negative for CD23, while most B-cell chronic lymphomocytic leukaemias are positive, allowing immunohistochemistry to distinguish these conditions, which otherwise have a similar appearance. (wikipedia.org)
  • Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region. (angioproteomie.com)
  • CD23 was positive in 16% of the cases (all CD5 negative and all CD40 positive). (aacrjournals.org)
  • Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. (wikipedia.org)
  • The CD23 antibody recognizes a 45-kilodalton (kDa) type II membrane glycoprotein, which is a human B-lymphocyte differentiation antigen. (bdbiosciences.com)
  • The CD23 antigen is also known as the low affinity IgE receptor, Fc epsilon RII, and FcεRII. (bdbiosciences.com)
  • Gordon J, Rowe M, Walker L, Guy G. Ligation of the CD23,p45 (Blast-2, EBVCS) antigen triggers the cell-cycle progression of activated B lymphocytes. (bdbiosciences.com)
  • A B-cell- specific differentiation antigen, CD23, is a receptor for IgE (FcεR) on lymphocytes. (bdbiosciences.com)
  • Immunohistochemistry of paraffinembedded Human tonsil tissue with CD23 Monoclonal Antibody(Antigen repaired by EDTA). (neomedscientific.com)
  • CD23 antigen is an integral membrane glycoprotein, Mr. 45 kdaltons The CD23 antigen is present on approximately all pre-B lymphocytes, plasma cells CD25 positive Ki-1 cells and HLA-DR. CD23 antigen is also expressed on Lymphoma, T Cell Lymphomas and B-CLLs. (exalpha.com)
  • CD23 antigen is present on HodgkinÕs and Reed Sternberg cells). (exalpha.com)
  • The presence of BCGF during B cell activations was found to down‐regulate the expression of the CD23 antigen while the coating of activated cells with MHM6 antibody diminished their capacity to absorb BCGF activity. (consensus.app)
  • In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell lymphoma (CD23-negative). (wikipedia.org)
  • This will include CD5, CD19, and CD20 expression by the CLL cells typically also with CD23 expression, but CD23 negative cases may be included if there is an absence of t(11;14). (nih.gov)
  • Immunohistochemical analysis of paraffin-embedded normal human spleen using CD23 (E1R4G) Rabbit mAb (left) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (right). (cellsignal.com)
  • It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. (nih.gov)
  • Most of CLL / SLL are CD23 positive, while mantle cell lymphoma is usually CD23 negative. (neomedscientific.com)
  • Paradoxically, Lymphomas arising from the mantle zone are generally negative for CD23, while most B-cell chronic lymphomocytic leukaemias are positive, allowing immunohistochemistry to distinguish these conditions, which otherwise have a similar appearance. (wikipedia.org)
  • Experimental Design: Bcl -6, CD10, and CD40 were chosen as markers for a germinal center phenotype, CD23 as a marker of pre/early germinal center origin, and CD138 as a marker for postgerminal center origin. (aacrjournals.org)
  • CD23 was positive in 16% of the cases (all CD5 negative and all CD40 positive). (aacrjournals.org)
  • CD23 is overexpressed in allergic disease [ 57 ] and may therefore be involved in IgE overproduction, which can lead to mast-cell degranulation. (medscape.com)
  • It also has been shown that CD23 can preassociate trimeric or oligomeric form involving many allergic diseases. (ncl.edu.tw)
  • 1. CD23: a multi-lineage cell activation molecule with a split personality. (exalpha.com)
  • comparison with MAL, CD23, and other markers. (nih.gov)
  • Immunohistochemical analysis of paraffin-embedded human non-Hodgkin lymphoma using CD23 (E1R4G) Rabbit mAb. (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded human small cell carcinoma of the salivary gland using CD23 (E1R4G) Rabbit mAb. (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded normal human lymph node using CD23 (E1R4G) Rabbit mAb. (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded HDLM-2 cell pellet (left, positive) or NCI-H146 cell pellet (right, negative) using CD23 (E1R4G) Rabbit mAb. (cellsignal.com)
  • Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. (ox.ac.uk)
  • Utilizing fCD23 can elucidate the correlation between mouse CD23 and IgE. (ncl.edu.tw)
  • To construct fCD23, T4 phage fibritin sequence was ligated to mouse CD23 N-terminal, and then we successful induced large amount of fCD23 by E. coli. (ncl.edu.tw)
  • Réunion Island, an overseas department of France, Processus Infectieux en Milieu Insulaire Tropical, University of La where cases emerged in 2015 ( 6 , 7 ). (cdc.gov)
  • Genetic mapping shows that the variant CD23 leads to an exaggerated primary IgE response, which is independent of other strain-specific effects. (ox.ac.uk)