CD1d is the only member of the group 2 CD1 molecules. (wikipedia.org)
CD1d tetramers are protein constructs composed of four CD1d molecules joined together and usually fluorescently labelled, used to identify NKT cells or other CD1d-reactive cells. (wikipedia.org)
The 1B1 monoclonal antibody specifically binds to mouse CD1d, a 48-kDa glycoprotein with structural homology to major histocompatibility complex (MHC) class I molecules. (bdbiosciences.com)
Invariant natural killer T (iNKT) cells recognize endogenous and exogenous lipids in the context of CD1d molecules, and through the activation and maturation of dendritic cells and B cells, can significantly enhance priming of antigen-specific T and B cell responses. (ox.ac.uk)
Recent findings have provided important insights into the recognition of several novel endogenous lipids by iNKT cells, and into the mechanisms controlling their generation and loading onto CD1d molecules. (ox.ac.uk)
2011 A unifying feature of αGC analogs that induce predominantly Th2 cell-associated cytokines is that they are more polar than KRN7000 and can load directly onto CD1d molecules on the cell surface (Im et?al. (biotech-angels.com)
2012 However other studies yielded different conclusions identifying pharmacokinetic properties of the glycolipids or localization of CD1d molecules containing bound glycolipids to different membrane microdomains as major determinants of cytokine skewing in the response to iNKT cell activation (Im et?al. (biotech-angels.com)
The adipocyte was reported as an antigen-presenting cell (APC) which expresses CD1d and MHC class I and II molecules. (frontiersin.org)
NKT cells recognize lipid antigen presented in the context of CD1d molecules. (umaryland.edu)
Intestinal epithelial cells1
However, CD1d expression was not detectable via flow cytometry on intestinal epithelial cells in studies using the anti-CD1d mAbs 3C11, 1B1, and 9C7. (bdbiosciences.com)
By visualizing glycolipid antigen presentation directly with monoclonal antibodies specific for complexes of αGC bound to CD1d we showed that the CD8α+DEC-205+ subset of dendritic cells was the major APC in the spleen for a range of αGC analogs irrespective of their chemical structures and cytokine biasing activities. (biotech-angels.com)
Glycolipid6
The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. (ox.ac.uk)
Many hematopoietic cell types express CD1d and so are with the capacity of presenting glycolipid antigens to invariant natural killer T?cells (iNKT cells). (biotech-angels.com)
Graphical Abstract Introduction Natural killer T?cells with invariant T?cell receptor α chains (iNKT cells) are a conserved population that recognizes KM 11060 glycolipid antigens bound to CD1d a lipid antigen-presenting molecule with structural similarities to major histocompatibility complex (MHC) class I proteins (Brennan et?al. (biotech-angels.com)
Alternatively, the adjuvant activity of CD1d-restricted invariant NKT cells (iNKT) on the innate and adaptive immunity is well demonstrated, and several CD1d glycolipid ligands are under pre-clinical and clinical evaluation. (biomedcentral.com)
In addition to TLR ligands, CD1d-restricted invariant NKT (iNKT) cells have been shown to efficiently promote the transactivation of DCs through the CD40L-CD40 interaction upon recognition of the CD1d-glycolipid antigen complex by their semi-invariant TCR. (biomedcentral.com)
iNKT cells have been traditionally defined by the expression of an invariant TCR α-chain (Vα14-Jα18 in mice or Vα24-Jα18 in humans) and their capacity to recognise the glycolipid antigen α-galactosylceramide (αGalCer) presented on CD1d. (elifesciences.org)
Immunity2
No. 559871, for the purified antibody), suggesting a possible role for CD1d in mucosal immunity. (bdbiosciences.com)
Specifically, a previously unknown role for ILC3s on CD1d-dependent immunity was discovered. (europa.eu)
Lipid antigens3
CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes. (wikipedia.org)
Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. (msdmanuals.com)
Cd1a1
Expanded Vδ3 T cells recognized CD1d but not CD1a, CD1b, or CD1c. (manchester.ac.uk)
Lipids2
We also present the CD1d structure without lipid, which has a more open conformation of the binding groove, suggesting a dual conformation of CD1d in which the 'open' conformation is more able to load lipids. (ox.ac.uk)
NKT cells, through TCR recognition of self- or commensal-derived lipids presented by CD1d, contribute to establish immune homeostasis and to anti-microbial, anti-tumour and autoimmune responses (10,11). (europa.eu)
INKT2
Activation and tumor targeting of iNKT cells via recombinant α-galactosylceramide (αGC)-loaded CD1d-anti-HER2 fusion protein (CD1d-antitumor) is combined or not with OVA peptide/CpG vaccine. (biomedcentral.com)
The combined CD1d/iNKT antitumor therapy and CpG/peptide-based immunization leads to optimized expansion of NK and OVA-specific CD8 T cells (CTLs), likely resulting from the maturation of highly pro-inflammatory DCs as seen by a synergistic increase in serum IL-12. (biomedcentral.com)
Ligands2
CD1d is also known as R3G1 Some of the known ligands for CD1d are: α-galactosylceramide (α-GalCer), a compound originally derived from the marine sponge Agelas mauritanius with no physiological role but great research utility. (wikipedia.org)
Importantly, additive or even synergistic effects have been shown upon combined CD1d/NKT agonists and TLR ligands. (biomedcentral.com)
Antitumor1
Altogether, our study in mice demonstrates that αGC/CD1d-antitumor fusion protein greatly increases the efficacy of a therapeutic CpG-based cancer vaccine, first as an adjuvant during T cell priming and second, as a therapeutic agent to redirect immune responses to the tumor site. (biomedcentral.com)
Intracellular1
2011 In contrast glycolipids that induce responses that are biased toward Th1 cell cytokines are more hydrophobic and require intracellular loading onto CD1d for presentation (Arora et?al. (biotech-angels.com)
Pentamers1
Although they are the most widely used of CD1d oligomers, sometimes CD1d dimers (two units) or pentamers (five units) are used instead. (wikipedia.org)
Subset1
Introduction Natural killer T (NKT) cells are a unique subset of CD1d-restricted T cells that provide a link between innate and adaptive immune responses. (sicollaborative.org)
Recognize1
It appears to recognize CD1d only in association with β2m. (bdbiosciences.com)
Expression1
Flow cytometric analysis of CD1d expression on mouse thymocytes. (bdbiosciences.com)
Dendritic2
MAb 1B1 detects CD1d at varying levels on most types of bone marrow and peripheral leukocytes and on epithelial, dendritic, and lymphoid cells in the thymus. (bdbiosciences.com)
Activated clones were able to kill CD1d-bearing dendritic or target cells. (ox.ac.uk)
Lysis2
Invariant NKT Cells From Donor Lymphocyte Infusions (DLI-iNKTs) Promote ex vivo Lysis of Leukemic Blasts in a CD1d-Dependent Manner. (pharmas-eu.org)
We suggest that one mechanism by which CD1d-restricted NKT cells can exert a regulatory role is by containing the proliferation of activated T cells, possibly through timely lysis of APCs or activated T cells bearing CD1d. (ox.ac.uk)
Antibody2
No. 553988, dashed line histogram) or with the FITC Rat Anti-Mouse CD1d antibody (Cat. (bdbiosciences.com)
Rat anti Mouse CD1d antibody, clone 1B1 ( MCA4700 ) used for immunofluorescence staining of mouse tissues. (bio-rad-antibodies.com)
Alterations1
Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses. (umaryland.edu)
Mice2
A. Representative spleen sections from 3 mo old B6.TC (left) and B6 (right) mice stained with Moma-1-FITC, CD1d-PE and B220-PB. (bio-rad-antibodies.com)
Representative spleen sections from 10 mo old B6.TC (left) and B6 (right) mice stained with CD4-FITC, CD1d-PE and B220-PB. (bio-rad-antibodies.com)
Immune1
Vα24 invariant (Vα24i) CD1d-restricted NKT cells are widely regarded to have immune regulatory properties. (ox.ac.uk)
Activation1
Dr. Webb is a leading immunologist and research scientist who is recognized for her studies focused on the modulation of CD1d-mediated NKT cell activation for cancer immunotherapy using natural and artificial platforms. (umaryland.edu)
Human5
CD1D is the human gene that encodes the protein CD1d, a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. (wikipedia.org)
The crystal structure of human CD1d with and without alpha-galactosylceramide. (ox.ac.uk)
Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sphingosine chain bound in the C' pocket and the longer acyl chain anchored in the A' pocket. (ox.ac.uk)
We first observed, using EBV/MHC I tetrameric complexes, that expansion of Ag-specific cells in human PBMCs was reduced when CD1d-restricted NKT cells were concomitantly activated. (ox.ac.uk)
2009 Because most cells of hematopoietic origin express CD1d (Brossay et?al. (biotech-angels.com)
Presence1
Linear regression model demonstrated significantly higher correlation between FKBP5 and cytoplasmic GR than the CD1D presence of MDD itself or phosphorylation of nuclear GR at S226. (healthdisparitiesks.org)