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  • CD207
  • Although CD1a and langerin (CD207) are used as specific markers to distinguish LCs from other DC subsets, their immunological functions have remained mostly unknown. (jci.org)
  • A - E ) Representative dot plots from a minimum of 3 independent donors show staining for CD1a along with ( A ) Langerin (CD207) , ( B ) DC-SIGN (CD209), ( C ) CD4, ( D ) CCR5, and ( E ) CXCR4. (jci.org)
  • cortical
  • Human amniotic fluid cells form functional gap junctions with cortical cells. (biomedsearch.com)
  • In this study, we show that AF cells express high levels of CX43 (GJA1) and are able to establish functional gap junctions with cortical cultures. (biomedsearch.com)
  • These findings suggest that CX43-mediated intercellular communication between AF cells and cortical astrocytes may contribute to the reconstruction of damaged tissue by mediating modulatory, homeostatic, and protective factors in the injured brain and hence warrants further investigation. (biomedsearch.com)
  • Monocytes
  • In a model of transendothelial trafficking, human peripheral blood monocytes, after initial transmigration on endothelial monolayer, migrate in basal-to-apical directions to become dendritic cells (DCs) 3 , whereas those that remain in the subendothelium mature into macrophages ( 2 , 3 ). (jimmunol.org)
  • PMNs are rapidly recruited to tissues upon injury or infection, where they likely encounter other cells, for instance local and/or recruited dendritic cells and monocytes/macrophages. (springeropen.com)
  • protein
  • P-selectin effects on enhancing CD14 + CD16 + DLC generation were completely abrogated by pretreatment of cells with the protein kinase C δ inhibitor rottlerin, but not by classical protein kinase C inhibitor Gö6976. (jimmunol.org)
  • Sera from three of eight vaccinated men contained new antibodies recognizing polypeptides of 26, 31, and 150 kDa in protein extracts from prostate cells. (aacrjournals.org)
  • epidermal
  • Although LCs were discovered in 1868 by gold chloride staining as a highly dendritic epidermal cell population, their lineage or function remained unknown until the 1960s and 1970s when appropriate LC "markers" were discovered. (jci.org)
  • epithelial
  • Because many such antigens may also be present in normal prostate epithelial cells as well as PCA cells, one major therapeutic challenge for induction of anti-PCA immune responses may be the need to overcome immune tolerance against normal prostate antigens. (aacrjournals.org)
  • subset
  • Although PLCH has generally been considered an acquired benign disorder, recent evidence suggests that at least a subset of these patients have a clonal proliferative disorder of mutated cells including the BRAF V600E mutation. (oncologynurseadvisor.com)
  • allogeneic
  • CD163 low DDC migrate toward CCL21, they activate allogeneic CD8 and CD4 T cells and, like their potential human lung counterpart, they skew CD4 T cells toward a Th17 profile. (jimmunol.org)
  • FACS analysis was used to assess expression of maturation markers, and functional studies were carried out using naïve allogeneic T-cells to assay for a Th1-promoting DC phenotype. (biomedcentral.com)
  • Functional end-points made by co-culture of allogeneic CD4 + T cells with the cocktail treated DCs, showed that five cocktails in particular could induce a classical Th1-phenotype with ability to secrete high amounts of the hall-mark cytokine IFNγ. (biomedcentral.com)
  • Functionally, DLCs generated by P-selectin in combination with M-CSF plus IL-4 primed naive allogeneic CD4 + T cells to produce significantly less IFN-γ than cells generated by BSA in the presence of M-CSF and IL-4. (jimmunol.org)
  • consistent
  • Reactive DTH site biopsies manifested infiltrates of effector cells consisting of CD45RO+ T-cells, and degranulating eosinophils consistent with activation of both Th1 and Th2 T-cell responses. (aacrjournals.org)
  • effector cells
  • Polymorfonuclear leukocytes (PMNs) or neutrophils, one of the first effector cells of the innate immune system against infection are the most abundant circulating leukocytes and were discovered by Paul Ehrlich. (springeropen.com)
  • outermost
  • To establish infection, HIV-1 must infect cells that support high-level replication, namely CD4+ T cells, which are absent from the outermost genital epithelium. (jci.org)
  • APCs
  • Unexpectedly, however, at later times (6 and 24 hours) NETs apparently triggered a cell death process in these APCs by a caspase- and Apoptosis induced factor (AIF)-dependent pathway, suggesting mitochondrial damage. (springeropen.com)
  • Our results would suggest that early in inflammation, NETs can activate the two main APCs (Mfs and cDCs), but as the process continues, NETs can then initiate apoptosis of these cells through mitochondrial harm. (springeropen.com)
  • tissue
  • Due to limited cell quantities, the CD1a + VEDCs in these plots are not all from the same tissue. (jci.org)
  • L and M ) Two independent Western blots of cell pellets from different vaginal tissue and skin donors. (jci.org)
  • The usage of stem cells is a promising strategy for the repair of damaged tissue in the injured brain. (biomedsearch.com)
  • subsequently
  • Following assembly with β2-microglobulin in the endoplasmic reticulum, all CD1 isoforms are transported to the cell surface but are subsequently delivered to distinct endosomal and/or lysosomal compartments. (jci.org)
  • therapeutic
  • Therefore, other stem cell sources, such as human amniotic fluid (AF) [ 11 - 13 ], are being considered for therapeutic applications. (biomedsearch.com)
  • vivo
  • Even though the E-selectin gene is silent in in vitro-cultured endothelial cells, low levels of E-selectin are expressed in most tissues in vivo and regulate leukocyte homeostasis together with constitutively expressed P-selectin ( 8 , 12 ). (jimmunol.org)
  • significantly
  • At 18 hours, 24 hours, and 48 hours, the CD1a + cells in the culture medium of the UVB-only group and the UVB + pimecrolimus group were significantly more than in the control group, while the CD1a + cells of the UVB + pimecrolimus group was less than of the UVB-only group. (dovepress.com)
  • gene
  • These data suggest that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines. (aacrjournals.org)
  • patients
  • BACKGROUND : Actinic cheilitis (AC) is a potentially malignant lesion diagnosed in the lip of patients chronically exposed to the sun that may give rise to a fully invasive lower lip squamous cell carcinoma (LLSCC). (up.ac.za)
  • necrosis
  • 2009 ). Upon activation, these neutrophil extracellular traps (NETs) are released as a result of a cell death process apparently different from apoptosis or necrosis, which was called Netosis. (springeropen.com)
  • immune cells
  • However, little is known about its composition in immune cells, and among them dendritic cells (DC), that are essential in the initiation of the immune response. (jimmunol.org)
  • However, the functional consequences of NETs interacting with other immune cells, either resident or recruited during early inflammation, have not been assessed. (springeropen.com)
  • Disorders
  • Dendritic cells (DCs) are central in the pathogenesis of immune disorders, where they respond towards environmental factors by regulating the adaptive immune system through activation and expansion of T cells. (biomedcentral.com)
  • present
  • Dendritic cells (DCs), present in mucosal epithelia, potentially facilitate HIV-1 acquisition. (jci.org)
  • Lymphoma, especially T cell lymphoblastic lymphoma, can present with superior mediastinal syndrome needing urgent empirical therapy without biopsy. (hindawi.com)