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  • Lymphocyte
  • The genetic and functional abnormalities in a lymphocyte cell line from a patient with LAD have been corrected by retrovirus-mediated transduction of a functional CD18 gene. (sciencemag.org)
  • monocytes
  • The mean fluorescence of CD18 on lymphocytes and CD11c on monocytes of HIV-1-infected subjects was significantly higher than for the control group (P = .008 and .014, respectively). (antibodybeyond.com)
  • CD18 was shed primarily from intermediate CD14 ++ CD16 + monocytes, supporting the view that alterations in innate immunity can regulate the inflammatory processes in SpA. (biomedcentral.com)
  • mAbs
  • In addition, both transduction of ICAM-1 shRNA into gastric epithelial cells and treatment with neutralizing mAbs to CD18 significantly decreased OMV-mediated or OMV-CM-mediated release of ECP. (hindawi.com)
  • The CD11a/CD18 mAbs found positive in the sheep were reactive with all the cell populations tested. (antibodybeyond.com)
  • heterodimer
  • The non-covalent heterodimer of 150 kDa alpha X/CD11c and 95 kDa beta 2/CD18 integrin subunits is expressed on macrophages, dendritic cells and hairy cell leukemias, with lower amounts on other myeloid cells and activated B, NK and some cytotoxic T cells (1‑7). (novusbio.com)
  • mice
  • During irritant dermatitis induced by topical application of croton oil, the number of emigrated neutrophils in histological sections of dermis was 98% less in CD18-/- mutants than in WT mice. (nih.gov)
  • Dermal neutrophil emigration in WT and CD18−/− mice 6 h after topical application of 2% croton oil. (nih.gov)
  • Emigrated neutrophils were quantitated morphometrically and expressed as mean ± SEM standardized volume fractions for WT (closed bars) or CD18−/− (open bars) mice. (nih.gov)
  • In contrast, there was no increase in emigrated neutrophils in the dermis of CD18−/− mutant mice after 6 h of croton oil dermatitis (Fig. 2). (nih.gov)
  • Moreover, mice receiving EPCs that were treated with control isotype IgG exhibited significantly increased capillary density in the infarct border zone, reduced cardiac dilatation, ventricular wall thinning, and fibrosis when compared with myocardial infarction mice receiving PBS and CD18 blockade reversed the EPC-mediated improvements to the infarcted heart. (ahajournals.org)
  • complexes
  • Previously, we demonstrated that altered soluble CD18 (sCD18) complexes in the blood and synovial fluid of patients with arthritis have anti-inflammatory functions. (biomedcentral.com)
  • respectively
  • The number of emigrated neutrophils in lung sections during Escherichia coli pneumonia, or in peritoneal lavage fluid after 4 h of S. pneumoniae peritonitis, was not reduced in CD18-/- mutants, but rather was greater than the WT values (240 +/- 30 and 220 +/- 30% WT, respectively). (nih.gov)
  • functional
  • Thus, our results suggest an essential role of CD18 in mediating EPC recruitment and the subsequent functional effects on the infarcted heart. (ahajournals.org)
  • We further examined the functional involvement of ICAM-1/CD18 in EPC recruitment and repair of the infarcted myocardium. (ahajournals.org)