Of interest, MM-derived MVs were enriched with the biologically active form of CD147, a transmembrane molecule previously shown by us to be crucial for MM cell proliferation. (oncotarget.com)
Sequence analysis showed that Compact disc147 is normally a single-chain type?We transmembrane (TM) proteins and an associate from the immunoglobulin superfamily (IgSF). (tech-strategy.org)
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. (cancer-genetics.org)
This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (cancer-genetics.org)
[4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
Basigin5
CD147 , also known as Basigin (BSG) , or extracellular matrix metalloproteinase inducer (EMMPRIN) . (proteinkinase.biz)
The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. (proteinkinase.biz)
A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. (proteinkinase.biz)
As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. (proteinkinase.biz)
Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins. (proteinkinase.biz)
EMMPRIN1
Recombinant Human CD147 /EMMPRIN Protein (rhCD147), His Tag (CD7-H5222) is expressed from human 293 cells (HEK293). (proteinkinase.biz)
Glycoprotein2
BSG is a membrane glycoprotein receptor, member of the immunoglobulin family, involved in several pathologies such as cancer and Alzheimer's disease. (wikipedia.org)
Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. (cusabio.com)
Antibody6
human liver tissue were subjected to SDS PAGE followed by western blot with 11989-1-AP (CD147 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. (ptglab.com)
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11989-1-AP (CD147 antibody) at dilution of 1:200 (under 10x lens. (ptglab.com)
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11989-1-AP (CD147 antibody) at dilution of 1:200 (under 40x lens. (ptglab.com)
Based on immunoelectrophoresis, the antibody reacts with the Fc portion of rat IgG heavy chain but not with the Fab portion of rat immunoglobulins. (srgroupchemical.com)
No antibody was detected against rat IgM or against non-immunoglobulin serum proteins. (srgroupchemical.com)
This cytokine is a ligand for receptors TNFRSF13B /TACI, TNFRSF17 /BCMA, and TNFRSF13C /BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. (wikidoc.org)
Membrane2
CD147 modulates the synthesis and activity of soluble and membrane-bound [membrane-type MMPs (MT-MMPs)] in various contexts via homophilic/heterophilic cell relationships vesicular dropping or cell-autonomous processes. (tech-strategy.org)
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. (cusabio.com)
Protein7
It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. (wikipedia.org)
Much of this response focused on researching the mechanisms of SARS-CoV-2 entry into host cells, in particular, how the receptor-binding domain (RBD) of the spike (S) protein binds to its receptor, angiotensin-converting enzyme 2 (ACE2). (carahealth.com)
SARS-CoV-2 S protein binds to its host-cell receptor ACE2 protein through its RBD, therefore, both RBD and ACE2 are therapeutic targets to prevent SARS-CoV-2 and treat C-19 disease (4). (carahealth.com)
Proteins with these characteristics have been shown to oligomerize into multi-protein complexes and are often involved in cell signalling events such as immune cell receptor complexes [31]. (tech-strategy.org)
Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. (embl.de)
B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
All these ligands act as homotrimers (i.e. three of the same molecule) interacting with homotrimeric receptors, [6] although BAFF has been known to be active as either a hetero- or homotrimer (can aggregate into 60-mer depending on the primary structure of the protein). (wikidoc.org)
Tumor4
Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)
This graph shows the total number of publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in this website by year, and whether "Receptors, Tumor Necrosis Factor, Type I" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in Profiles. (childrensmercy.org)
Internalization2
Using MVs isolated from HMCLs stably transfected with a CD147-GFP fusion construct (CD147 GFP ), we observed binding and internalization of MV-derived CD147 with HMCLs. (oncotarget.com)
Cells with greater CD147 GFP internalization proliferated at a higher rate than did cells with less CD147 GFP association. (oncotarget.com)
ACE22
As mentioned in previous articles, SARS-CoV-2 uses host cell receptor ACE2 to overcome the barrier and bind to host cells in the alveoli, thus ACE2 is a therapeutic target to treat C-19 (26). (carahealth.com)
The major green tea polyphenol epigallocatechin gallate (EGCG) effectively blocks viral attachment of SARS-CoV-2 and new variants to host cells by inhibiting S binding to ACE2 receptor (12). (carahealth.com)
FOLD1
The immunoglobulin variable (IgV) domain of D 1 adopts an immunoglobulin-like β-sandwich fold with seven β-strands in 2 β-sheets, in a Greek key topology . (wikidoc.org)
Intercellular1
In summary, this study demonstrates the significance of MV shedding and MV-mediated intercellular communication on malignant plasma cell proliferation, and identifies the role of MV-enriched CD147 in this process. (oncotarget.com)
Member1
Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily . (wikidoc.org)
BINDING2
BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. (wikidoc.org)
[12] The binding to CD4 creates a shift in the conformation of gp120 allowing HIV-1 to bind to a co-receptor expressed on the host cell. (wikidoc.org)
Domain2
Cell surface receptors containing an immunoglobin domain. (embl.de)
The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)
Gene1
This variance has been attributed to differential glycosylation at three conserved asparagine (mice pass away around the time of initial blastocyst implantation though different unfamiliar modifier regions surrounding the CD147 gene may attenuate this death rate [64 65 In the rare event that an embryo effectively implants the offspring are little and usually expire before a month due to problems in breathing supplementary to interstitial pneumonia. (tech-strategy.org)
Lymphocytes1
These receptors are expressed mainly on mature B lymphocytes and their expression varies in dependence of B cell maturation (TACI is also found on a subset of T-cells and BCMA on plasma cells ). (wikidoc.org)
Cells2
Inadequate level of BAFF will fail to activate B cells to produce enough immunoglobulin and will lead to immunodeficiency. (wikidoc.org)
CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells . (wikidoc.org)
Processes1
CD147 also participates in swelling nutrient and drug transporter activity microbial pathology and developmental processes. (tech-strategy.org)
CEA and related genes make up the CEA family belonging to the immunoglobulin superfamily. (wikidoc.org)
Domains2
D 1 and D 3 resemble immunoglobulin variable (IgV) domains. (wikidoc.org)
D 2 and D 4 resemble immunoglobulin constant (IgC) domains. (wikidoc.org)
Structure1
The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. (embl.de)
Active1
Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). (cancer-genetics.org)