• Human CD10 is a well known marker for common acute lymphoblastic leukemia antigen (CALLA). (adipogen.com)
  • Description: The eBioSN5c monoclonal antibody recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALLs). (cytekbio.com)
  • Neprilysin , also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. (assaysolution.com)
  • CD10 is a neutral endopeptidase and hydrolyzes peptide bonds on the amino side of hydrophobic amino acids. (adipogen.com)
  • Subsequently, CD10 was shown to be the same molecule as neutral endopeptidase (NEP), or KII-NA. (cytekbio.com)
  • CD10 expression is lost as the T and B lineage cells mature and only appears again on activated germinal center B cells. (adipogen.com)
  • In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and its expression has been reported on mature germinal center B cells. (cytekbio.com)
  • CD10 is intended for in vitro diagnostic use in the identification of cells expressing CD10 antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)
  • The common acute lymphoblastic leukemia antigen (CD10)--emancipation from a functional enigma. (bdbiosciences.com)
  • Compared with the polyclonal and monoclonal antibodies of MME, this MME recombinant antibody has the features of increased reproducibility and control, animal-free technology, high degree of monovalency, high batch-to-batch consistency, easier isotype conversion, etc. (cusabio.com)
  • Human CD10 Protein, hFc Tag on SDS-PAGE under reducing condition. (abeomics.com)
  • Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. (assaysolution.com)
  • These findings support the role of the stromal CD10 expression in breast cancer progression and dissemination, and suggest a relationship with cancer stem cells. (cusabio.com)
  • CD10 expression is also found on normal donor granulocytes and bone marrow stromal cells. (cytekbio.com)
  • Applications Reported: This eBioSN5c (SN5c L4-1A1) antibody has been reported for use in flow cytometric analysis. (cytekbio.com)
  • Applications Tested: This SN5c antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. (cytekbio.com)
  • CD10 is present on neutrophils. (adipogen.com)
  • CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils. (cytekbio.com)
  • Clinical significance of CD10 expression in childhood acute lymphoblastic leukemia. (bdbiosciences.com)
  • Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. (assaysolution.com)
  • CD10 expression varies in distinct cancer types. (cusabio.com)
  • CD10 is highly expressed in prostate cancer, melanomas, and papillary thyroid cancer, while its expression is declined in cervical carcinoma and adenocarcinoma of the gastrointestinal tract. (cusabio.com)
  • High expression of CD10 is associated with lymph node invasion in colorectal cancer. (cusabio.com)
  • CD10 is expressed on normal early B cells in bone marrow and is also on fetal thymocytes. (adipogen.com)
  • Xanthorrhizol (Xan) reduced 4-hydroxynonenal (HNE) levels on NEP proteins and preserved enzymatic activities of neprilysin (NEP) in HNE- or oligomeric Abeta42-treated cells. (cusabio.com)
  • MME, also called CD10, is a cell surface zinc metalloendopeptidase expressed in various normal and neoplastic lymphoid and nonlymphoid tissues including melanomas. (cusabio.com)
  • Zola H. CD10 Workshop Panel report. (bdbiosciences.com)
  • When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize any non-specific polymer interactions. (cytekbio.com)
  • The antibody reagent is stable until the expiration date shown on the label when stored at 2° to 8°C. Do not use after the expiration date. (bdbiosciences.com)
  • 8. Elevated hepatocyte paraffin 1 and neprilysin expression in hepatocellular carcinoma are correlated with longer survival. (nih.gov)
  • 14. The utility of hepatocyte paraffin 1 antibody in the immunohistological distinction of hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinoma. (nih.gov)
  • The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases . (wikidoc.org)
  • 10. Canalicular immunostaining of neprilysin (CD10) as a diagnostic marker for hepatocellular carcinomas. (nih.gov)
  • CD10 antibody LS-C300834 is a biotin-conjugated rabbit polyclonal antibody to CD10 (MME) (aa382-538) from human. (lsbio.com)
  • Human Neprilysin, Tag Free (orb257693) is expressed from human 293 cells (HEK293). (biorbyt.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
  • Anti-K is the next most common immune red cell antibody after those in the ABO and Rh system. (wikidoc.org)
  • Knockout of CD10 was achieved by CRISPR-Cas9 genome editing using LentiArray™ Lentiviral sgRNA (Product # A32042, Assay ID CRISPR1056041_LV) and LentiArray Cas9 Lentivirus (Product # A32064). (thermofisher.com)
  • Both AIHA and HDN may be severe when caused by anti-Kell antibodies, [10] as they are the most immunogenic antigens after those of the ABO and Rhesus blood group systems . (wikidoc.org)