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AntibodiesAntibody SpecificityAntibodies, ViralAntibodies, MonoclonalAntibodies, BacterialAntibody FormationAntibodies, NeutralizingAntibody AffinityCyclin D1Fluorescent Antibody TechniqueCyclin-Dependent KinasesAntibodies, Anti-IdiotypicBinding Sites, AntibodyHIV AntibodiesAntibodies, AntinuclearEpitopesCyclin-Dependent Kinase 4Antibodies, NeoplasmCyclin-Dependent Kinase 5Antibodies, ProtozoanCyclin-Dependent Kinase 2Cyclin D2Molecular Sequence DataCross ReactionsImmunoglobulin MCyclin DCyclinsAmino Acid SequenceAutoantibodiesAntibodies, FungalImmunoglobulin GMice, Inbred BALB CAntigen-Antibody ReactionsNeutralization TestsCDC2-CDC28 KinasesCyclin D3Antibodies, BispecificImmunoglobulin Fab FragmentsCyclin-Dependent Kinase 6Antigen-Antibody ComplexSingle-Chain AntibodiesAntibodies, BlockingRabbitsCell CycleCDC2 Protein KinaseAntibodies, HeterophileCell LineImmunoglobulin AAntibodies, CatalyticEnzyme-Linked Immunosorbent AssayBlotting, WesternImmunohistochemistryCells, CulturedFluorescent Antibody Technique, IndirectBase SequenceAntibodies, Monoclonal, HumanizedRecombinant ProteinsImmunoenzyme TechniquesCell Line, TumorHybridomasImmune SeraPhosphorylationEpitope MappingAntibodies, AntiphospholipidImmunizationAntigens, SurfaceAntigensB-LymphocytesCyclin-Dependent Kinase 9ImmunoblottingCell Cycle ProteinsGenes, bcl-1Antigens, BacterialMolecular WeightElectrophoresis, Polyacrylamide GelRNA, MessengerRadioimmunoassayImmunization, PassiveG1 PhaseT-LymphocytesGene AmplificationModels, MolecularTime FactorsHepatitis C AntibodiesFlow CytometryProtein-Serine-Threonine KinasesImmunoassayChromosomes, Human, Pair 11Immunoglobulin FragmentsCyclin-Dependent Kinase Inhibitor p27DNAProtein BindingTumor Cells, CulturedCyclin ECattleTropaeolaceaeCell ProliferationAntigens, ViralMice, Inbred C57BLKinetics

Monoclonal AntibodyOverexpressionRegulatory subunitCDK4CyclinChromosome 11MantleLymphomaVivoCellEffect

Monoclonal Antibody1

• The following product was used in this experiment: Cyclin D1 Monoclonal Antibody (3D8) from Thermo Fisher Scientific, catalog # MA5-15650, RRID AB_10978307. (thermofisher.com)

Overexpression2

• Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30-50%) pancreatic carcinomas (25%) bladder cancer (15%) pituitary adenomas (49-54%) breast carcinoma (13%) Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. (wikipedia.org)
• 5. cdk6 overexpression resulted from microRNA‑320d downregulation promotes cell proliferation in diffuse large B‑cell lymphoma . (nih.gov)

Regulatory subunit2

• Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (thermofisher.com)
• Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)

CDK42

• Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. (thermofisher.com)
• Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. (thermofisher.com)

Cyclin4

• In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11. (thermofisher.com)
• Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. (wikipedia.org)
• The CCND1 gene encodes the cyclin D1 protein. (wikipedia.org)
• Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. (wikipedia.org)

Chromosome 111

• The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). (wikipedia.org)

Mantle1

• 12. microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting cdk6 in mantle cell lymphoma . (nih.gov)

Lymphoma4

• 1. Targeted inhibitors and antibody immunotherapies: Novel therapies for paediatric leukaemia and lymphoma . (nih.gov)
• 3. Genome-wide CRISPR screen identifies cdk6 as a therapeutic target in adult T-cell leukemia/ lymphoma . (nih.gov)
• 4. [Expression of cdk6 and FOXM1 in peripheral T-cell lymphoma and their significance]. (nih.gov)
• 7. In vitro and in vivo anti-primary effusion lymphoma activities of fucoidan extracted from Cladosiphon okamuranus Tokida. (nih.gov)

Vivo1

• Anti-proliferation effect of ZNF831 was verified in vivo. (bvsalud.org)

Cell1

• Furthermore, ZNF831 could ameliorate the anti-proliferation effect of capecitabine and gemcitabine in breast cancer cell lines. (bvsalud.org)

Effect1

• Recent studies have prompted an anti-tumor effect of aspirin. (oncotarget.com)