BACKGROUND AND AIMS: Trefoil factor family (TFF) peptides and the chromosome 11p15.5 mucin glycoproteins are expressed and secreted in a site specific fashion along the length of the gastrointestinal tract. (embl.de)
Matricellular proteins1
CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, particularly in the context of wound repair. (wikipedia.org)
Extracellular4
CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). (wikipedia.org)
A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. (bvsalud.org)
A family of extracellular matrix glycoproteins that is structurally similar to LATENT TGF-BETA BINDING PROTEINS , but contain additional TGF-beta binding domains, in addition to unique domains at their N and C-terminals. (nih.gov)
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)
Superfamily Proteins3
TGF-beta Superfamily Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "TGF-beta Superfamily Proteins" by people in this website by year, and whether "TGF-beta Superfamily Proteins" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "TGF-beta Superfamily Proteins" by people in Profiles. (wakehealth.edu)
Amino acids2
The first exon encodes 5'-UTR sequence and the first several amino acids in the secretory signal peptide. (wikipedia.org)
Full-length CYR61 protein contains 381 amino acids with an N-terminal secretory signal peptide followed by four structurally distinct domains. (wikipedia.org)
NEPHROBLASTOMA OVEREXPRESSED PROTEIN3
Nephroblastoma Overexpressed Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
This graph shows the total number of publications written about "Nephroblastoma Overexpressed Protein" by people in this website by year, and whether "Nephroblastoma Overexpressed Protein" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Nephroblastoma Overexpressed Protein" by people in Profiles. (childrensmercy.org)
Structurally related2
A large family of cell regulatory proteins which are structurally related to TRANSFORMING GROWTH FACTOR BETA . (nih.gov)
A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE. (lookformedical.com)
PATHWAYS1
They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)
Glycoproteins1
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. (ouhsc.edu)
Connective tissue1
The CCN acronym is derived from the first three members of the family identified, namely CYR61 (CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). (wikipedia.org)
Transcriptional1
The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN. (ouhsc.edu)
Kinase3
locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner. (umassmed.edu)
No tumor-specific expression levels of protein kinase C isoenzymes and of c-fos in human breast cancer cell cultures. (shengsci.com)
Moderate to large variations of protein levels of three protein kinase C (PKC) isoenzymes (alpha, delta and epsil. (shengsci.com)
Ligands1
Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. (embl.de)
Cell4
Longobardi L, Torello M, Buckway C, O'Rear L, Horton WA, Hwa V, Roberts CT, Chiarelli F, Rosenfeld RG, Spagnoli A. A novel insulin-like growth factor (IGF)-independent role for IGF binding protein-3 in mesenchymal chondroprogenitor cell apoptosis. (rush.edu)
CHD8 is an independent prognostic indicator that regulates Wnt/ß-catenin signaling and the cell cycle in gastric cancer. (ouhsc.edu)
Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/ß-catenin signaling pathway. (ouhsc.edu)
A family of cell-surface proteins found on ANTIGEN-PRESENTING CELLS. (jefferson.edu)
Fibroblasts2
CYR61 was first identified as a protein encoded by a serum-inducible gene in mouse fibroblasts. (wikipedia.org)
Furthermore, we observed that synovial CD64 protein levels in source tissue for OAS-CM significantly associated with the OAS-CM-induced expression of MMP1, MMP3 and especially ADAMTS4 in cultured fibroblasts, but not chondrocytes. (bvsalud.org)
Peptide1
Both of these peptide families have important local actions in maintaining tissue homeostasis and repair after injury, and when mechanisms governing their regulation are disrupted they may contribute to disease progression. (embl.de)
Found1
A CCN protein family member found at high levels in NEPHROBLASTOMA cells. (childrensmercy.org)
Crucial1
Transforming growth factor-ß (TGF-ß) signaling via SMAD2/3 is crucial for blocking hypertrophy. (bvsalud.org)
Dependent2
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/ß-Catenin Signaling. (ouhsc.edu)
Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. (musc.edu)
Member2
Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. (wikipedia.org)
This review will focus on the structure of BTC and the various biological effects ascribed to this member of the EGF family. (embl.de)
Function1
The post-translational modifications of these SMAD proteins in the linker domain regulate their function and these can be triggered by inflammation through the activation of kinases or phosphatases. (bvsalud.org)
Alpha1
The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
Members1
These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six members of the family in vertebrates and have been renamed CCN1-6 in order of their discovery by international consensus. (wikipedia.org)
Cells2
CYR61 activates Akt signaling in thymic epithelial cells, promoting their proliferation and thus thymic size growth. (wikipedia.org)
The proteins are lost or reduced when these cells undergo viral or chemical transformation. (musc.edu)
Domain1
The four CYR61 domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, von Willebrand type C repeats (vWC) domain, thrombospondin type 1 repeat domain (TSR), and the C-terminal (CT) domain that contains a cysteine-knot motif. (wikipedia.org)
Expression1
CD64 protein expression and localization was evaluated using immunohistochemistry and immunofluorescence and quantified using flow cytometry. (bvsalud.org)