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Chemokine CCL21Chemokine CCL2Chemokine CCL19Chemokine CCL20Chemokine CCL5Chemokine CCL3Chemokine CCL22Chemokine CCL17Chemokine CCL7Chemokine CCL1Chemokine CCL27Chemokine CCL24Chemokines, CCChemokine CCL11Chemokine CCL4Carbon TetrachlorideChemokine CCL8Carbon Tetrachloride PoisoningReceptors, ChemokineChemokinesReceptors, CCR2Receptors, CCR10Receptors, CCR7Receptors, CCR1Receptors, CCRMacrophage Inflammatory ProteinsReceptors, CCR6Drug-Induced Liver InjuryLiver Cirrhosis, ExperimentalChemotaxis, LeukocyteReceptors, CCR3Mice, Inbred C57BLChemotaxisReceptors, CCR4Monocyte Chemoattractant ProteinsReceptors, CCR8Cells, CulturedCell MovementChemokine CXCL10Receptors, CCR5Mice, KnockoutCytokinesChemokines, CXCAspartate AminotransferasesLiverDendritic CellsMonocytesMacrophagesAlanine TransaminaseGene Expression RegulationRNA, MessengerChemokine CXCL13Mice, Inbred BALB CDisease Models, AnimalInflammationChlordeconeReverse Transcriptase Polymerase Chain ReactionEnzyme-Linked Immunosorbent AssayUp-RegulationLiver CirrhosisSignal TransductionHepatic Stellate CellsInflammation MediatorsEosinophilsLungT-LymphocytesTumor Necrosis Factor-alphaFlow CytometryNF-kappa BChemokine CXCL9Cell LineGene ExpressionCell Line, TumorTh2 CellsImmunohistochemistryLigandsEndothelium, LymphaticProtective AgentsMice, TransgenicInterferon-gammaLiver DiseasesChemokine CXCL12Rats, Sprague-DawleyDermatitis, AtopicAntigens, CD11bSkinGene Expression ProfilingLymph NodesEpithelial CellsPlant ExtractsLiver RegenerationChemokine CX3CL1Time FactorsReal-Time Polymerase Chain ReactionInterleukin-1betaMirexHydroxyprolineLymphoid TissueReceptors, CXCR3Interleukin-13
CCL11HumanExpressionEosinophilsProteinDataTarget
CCL112
  • This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). (cancerindex.org)
  • The effect of Mast cell Tryptase to the Expression of Eotaxin-1/CCL11, Eotaxin-2/CCL24 and Eotaxin-3/CCL26 by Conjunctival Fibroblasts. (nii.ac.jp)
Human1
Expression1
  • Based on the ADEPT study data set, we report that airway mucosal expression of CCL26 was a robust discriminator of type 2 inflammation from healthy nonatopic subjects. (cusabio.com)
Eosinophils2
  • Increased CCL24/eotaxin-2 with postnatal ozone exposure in allergen-sensitized infant monkeys is not associated with recruitment of eosinophils to airway mucosa. (nih.gov)
  • In ozone+HDM animal groups, CCL24 mRNA and immunofluorescence increased along with CCR3 mRNA, but did not correlate with airway mucosa eosinophils. (nih.gov)
Protein1
  • In an oral presentation by Ilan Vaknin , PhD, Chemomab's Vice President of R&D, analysis of serum samples from patients with primary sclerosing cholangitis (PSC) provided further evidence that the soluble protein CCL24 is associated with key inflammatory and fibrotic pathways implicated in the liver damage characterizing PSC. (chemomab.com)
Data2
  • These new data using advanced proteomic analytic tools add to the extensive body of evidence that CCL24 is a major driver of fibrotic and inflammatory processes underlying PSC and other fibrotic liver diseases,' said Adi Mor , PhD, co-founder, Chief Executive Officer and Chief Scientific Officer of Chemomab. (chemomab.com)
  • These data also confirm that key features of PSC are uniquely associated with high levels of CCL24. (chemomab.com)
Target1
  • The study also indicated that CM-101 has a strong and specific target engagement profile for CCL24. (chemomab.com)