Ccl21 and ccl19 receptor. Medical search. Frequent questions

CCR7 is a highly important receptor with a role in trafficking of B and T lymphocytes and dendritic cells to and across high endothelial venules and positioning those cells correctly in T cell zones of secondary lymphoid organs. (wikipedia.org)
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. (biolegend.com)
The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels. (biolegend.com)
Once in the lymph node, the cells experience a second chemokine, (C-C motif) ligand19 (CCL19), which interacts with the same receptor (C-C chemokine receptor 7, CCR7) but interacts only weakly with sugars. (nature.com)
ACKR4 plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. (lsbio.com)
We reported previously that the production of IL-23 is impaired in DCs from mice that lack expression of the chemokines CCL19 and CCL21, which share the receptor CCR7, suggesting that these chemokines are required for IL-23 expression. (listlabs.com)
We found that CCL19 and CCL21 stimulated DCs through CCR7 and induced transcription of IL-23p19 mRNA and IL-23 production in splenic and BMDC. (listlabs.com)
The chemokine receptor CCR7 drives leukocyte migration into and within lymph nodes (LNs). (aai.org)
CCR7-dependent navigation is determined by the distribution of extracellular CCL19 and CCL21, which form concentration gradients at specific microanatomical locations. (aai.org)
In this article, we have incorporated multiple biochemical processes describing the CCL19-CCL21-CCR7-ACKR4 network into our model of LN fluid flow to establish a computational model to investigate intranodal chemokine gradients. (aai.org)
The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). (ku.dk)
We also identify a molecular switch in the top of TM7 important for keeping CCR7 in an inactive conformation (Tyr312), as introduction of the chemokine receptor-conserved Glu (or Ala) induces high constitutive activity. (ku.dk)
The rat monoclonal antibody 4B12 recognizes murine CD197 / CCR7 (chemokine receptor 7), a 43 kDa Gproteincoupled receptor for chemokines CCL19 and CCL21. (arigobio.com)
CCR7 Receptor Expression in Mono-MAC-1 Cells: Modulation by Liver X Receptor α Activation and Prostaglandin E 2. (monocyte.eu)
Cell migration via chemokine receptor CCR7 expression is an essential function of the immune system. (monocyte.eu)
Here, we explore the role of the liver X receptor α (LXRα) activation on CCR7 expression in Mono-Mac-1 (MM-1) cells in the presence of PGE2. (monocyte.eu)
CCR7 function was analyzed using migration assays in response to CCL19/CCL21, which are natural ligands for CCR7. (monocyte.eu)
Our results show that agonist-mediated activation of LXRα in the presence of PGE2 increases CCR7 mRNA transcription and MM-1 cell migratory capacity in response to CCL19/21. (monocyte.eu)
In addition, our results demonstrate that engagement of the E-prostanoids 2 and 4 (EP2/EP4) receptors present on MM-1 cells is responsible for the observed increase in CCR7 mRNA expression and function during LXRα activation. (monocyte.eu)
Binds to chemokine receptor CCR7. (cusabio.com)
CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. (creativebiomart.net)

CCR1 was the first CC chemokine receptor identified and binds multiple inflammatory/inducible (see inducible gene) CC chemokines (including CCL4, CCL5, CCL6, CCL14, CCL15, CCL16 and CCL23). (wikipedia.org)
CCR3 is a receptor for multiple inflammatory/inducible CC chemokines, including CCL11, CCL26, CCL7, CCL13, CCL15, CCL24 and CCL5 that attract eosinophils, and CCL28 that attracts B and T lymphocytes to mucosal tissues. (wikipedia.org)
The CC chemokines CCL3, CCL5, CCL17 and CCL22 signal through this receptor. (wikipedia.org)
Its ligands include the related chemokines CCL19 and CCL21, (previously called ELC and SLC). (wikipedia.org)
This molecule was originally designated CCR11 due to its ability to bind several CC chemokines (including CCL19, CCL21 and CCL25) and its structural similarity to chemokine receptors. (wikipedia.org)
However, due to the inability of this molecule (also known as CCRL1 and CCX CKR) to generate a signal following ligand interaction, it has been suggested that it is a scavenger receptor for chemokines and not a bona fide chemokine receptor. (wikipedia.org)
Beyond chemokines our approach is broadly applicable to alternative systems of chemo- and haptotaxis such as cells migrating along gradients of adhesion receptor ligands vs. any soluble cue. (nature.com)
a2,3) Both DCs and T cells interact with FRCs and their secreted chemokines (CCL19, CCL21), as well as cytokines (IL-6, IL-7), which promote their migration and survival. (weizmann.ac.il)
It is activated by chemokines CCL19 and CCL21, which are scavenged by the atypical chemokine receptor ACKR4. (aai.org)
This is largely orchestrated by chemokines, which are sensed by heptahelical G protein-coupled chemokine receptors on leukocytes ( 1 , 2 ). (aai.org)
Chemokines interact with their receptors in a stepwise manner with ultimate docking of their N-terminus into the main binding pocket. (ku.dk)
Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. (lookformedical.com)

The ligands for this receptor are CCL1 and CCL16 CCR9 was previously called orphan receptor GPR 9-6 and is very highly expressed in thymus (on both immature and mature T-cells) while low in lymph nodes and spleen. (wikipedia.org)
In activating cells, NF-κB signaling is activated through a series of signaling cascades, following the ligation of various cell surface receptors with paired ligands. (xiahepublishing.com)

However, some reports suggest a role for this receptor also in trafficking of dendritic cells. (wikipedia.org)
CCR6, a receptor for CCL20, is expressed on unactivated memory T-cells and some dendritic cells. (wikipedia.org)
We tracked migration of dendritic cells towards immobilized gradients of the chemokine CCL21 and varying superimposed soluble gradients of CCL19. (nature.com)
Using mature human dendritic cells (DCs), we show that CCL19 is more potent than CCL21 in inducing 3D chemotaxis. (ku.dk)
The mouse monoclonal antibody T21/8 recognizes the Nteminus of CD195, an approximately 45 kDa Gprotein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells. (arigobio.com)

The specific ligand of this receptor is CCL25 To note, the chemokine binding protein D6 had previously been named CCR9, but this molecule is a scavenger receptor not a true (signaling) chemokine receptor. (wikipedia.org)
CC chemokine ligand 20 (CCL20) attracts CC chemokine receptor 6 (CCR6)-expressing cells. (nih.gov)
Atypical chemokine receptor 4 (ACKR4) controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. (lsbio.com)
In various proinflammatory cytokine-stimulated cells, ligand-receptor interactions initially activate TAK1. (xiahepublishing.com)
Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. (creativebiomart.net)

Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. (cusabio.com)
TGF-α is related to EGF and binds to the EGF receptor, whereas TGF-β is structurally distinct from TGF-α. (antibodies-online.cn)

Chemokine receptor, G protein-coupled receptors (GPCR), seven transmembrane receptor. (biolegend.com)
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)

The mouse monoclonal antibody 5E8 recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils. (arigobio.com)

CCL19 mRNA and protein levels, as well as CCL21 mRNA levels, were also measured. (nih.gov)
Comparison of wild-type and deficient mice suggested that MZ macrophage population loss is dependent on interferon gamma (IFN-γ) receptor but independent of T cells or tumor necrosis factor alpha receptor 1 (TNF-αR1) signaling pathways and is not correlated to an alteration of CCL19, CCL21, and CXCL13 chemokine mRNA expression. (unamur.be)

After having captured antigen in non-lymphoid tissues, DCs migrate along immobilized gradients of the high affinity sugar-binding chemokine (C-C motif) ligand21 (CCL21) towards lymphatic vessels, from where they are flushed into the sinus of lymph nodes. (nature.com)

Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. (cusabio.com)

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. (wikipedia.org)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
They are grouped into one family because the receptor complex of each cytokine contains two (IL-6 and IL-11) or one molecule (all others cytokines) of the signaling receptor subunit gp130. (antibodies-online.cn)
In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used. (antibodies-online.cn)

CXCL12, CXCL10, CCL21, CCL19 manifestation (= 5 and 6 for WT and Tg, respectively) were compared to CXCL13 (= 17 and 21 for SR 144528 WT and Tg, respectively). (districsides.com)

They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. (wikipedia.org)
The receptors are members of the seven-transmembrane G protein-coupled receptor family. (lookformedical.com)

The dsRNA acts like a trigger for the production of interferon (via Toll Like Receptor 3 ( TLR 3 ) a pattern recognition receptor of the innate immune system which leads to activation of the transcription factor IRF3 and late phase NF kappa Beta). (wikidoc.org)

The model indicates that lymph flow shapes intranodal CCL21 gradients, and that CCL19 is functionally important at the boundary between B cell follicles and the T cell area. (aai.org)

It also predicts that ACKR4 in LNs prevents CCL19/CCL21 accumulation in efferent lymph, but does not control intranodal gradients. (aai.org)
Instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ackr4 -deficient LNs to ACKR4 loss upstream. (aai.org)

PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)

PAMP will be recognized by a receptor called PRR (pattern recognition receptor). (freezingblue.com)

This indicates that future selective pharmacological targeting of CCL19 versus CCL21 should focus on a differential targeting of the main receptor pocket, while selective targeting of tailless-CCL21 versus CCL21 and CCL19 requires targeting of the glycosaminoglycan (GAG) interaction. (ku.dk)

In humans, this receptor can be found on peripheral blood lymphocytes and monocytes. (wikipedia.org)

a1) T cells can also interact with, and be activated by, DCs presenting via MHC/HLA a specific antigen matching the T-cell receptor, and accompanied by co-stimulatory (CD80/CD86 DCs, and CD28 T cells) and adhesive molecules (ICAM-1/LFA-3 DCs, and LFA-1/CD2 T cells). (weizmann.ac.il)

CCR10 is receptor for CCL27 and CCL28 that was originally called orphan receptor GPR2. (wikipedia.org)
A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)

Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)

It has been shown in vitro that the directionality of DCs migrating on homogenously immobilized CCL21 can be biased by gradients of soluble CCL19 10 . (nature.com)
Importantly, the model recapitulates CCL21 gradients observed experimentally in B cell follicles and interfollicular regions, building confidence in its ability to accurately predict intranodal chemokine distribution. (aai.org)

Human derived T lymphocytes engineered to express chimeric antigen receptors, which are expanded in vitro culture and then infused into patients exerting robust cytotoxicity after tumor antigen recognition and subsequent activation. (biomedcentral.com)

In contrast, tailless-CCL21 displays increased potency in DC chemotaxis compared with native CCL21. (ku.dk)
Using standard laboratory cell lines, we observe low potency of both CCL21 and tailless-CCL21 in G protein activation and β-arrestin recruitment compared with CCL19, indicating that the tail itself does not improve receptor interaction. (ku.dk)

We selected most pathways Ccl21a participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. (creativebiomart.net)

It has specificity for CCR2 RECEPTORS. (lookformedical.com)

We assessed host immune responses and the prevalence of TLR1 (toll-like receptor 1)-1805GG polymorphism to gain insights into the pathophysiology of these conditions. (cdc.gov)
The canonical pathway is activated by signals from various immune-related receptors. (xiahepublishing.com)

All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor ( IFNAR ) that consists of IFNAR1 and IFNAR2 chains. (wikidoc.org)

Using a CCL21-specific antibody, we show that CCL21, but not tailless-CCL21, accumulates at the cell surface. (ku.dk)

CCR receptors with specificity for CHEMOKINE CCL27. (lookformedical.com)

There is some suggestion that this chemokine receptor is restricted to memory T-cells within the lymphocyte pool. (wikipedia.org)
Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. (biolegend.com)
In 2012, two siblings who were homozygous for a mutation that created a stop codon in the Ras homolog gene family member H ( RHOH ) gene exhibited an epidermodysplasia verruciformis phenotype and their T cells exhibited impaired T-cell receptor (TCR) signaling. (medscape.com)
Fig. 1 Canonical and noncanonical NF-κB signaling pathways in resting vs. receptor-stimulated cells. (xiahepublishing.com)
CXCL13 functions especially like a B-cell chemoattractant, as B cells express high levels of its receptor CXCR5 [2]. (districsides.com)

Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor . (wikidoc.org)

CCR4 is expressed on Th2 T lymphocytes and is up-regulated by T cell receptor activation. (wikipedia.org)

Intriguingly, CCL21 induces prolonged and more efficient ERK1/2 activation compared with CCL19 and a C-terminal truncated (tailless) CCL21 in DCs. (ku.dk)
In addition, removal of sialic acid from the cell surface by neuraminidase treatment impairs ERK1/2 activation by CCL21, but not by CCL19 or tailless-CCL21. (ku.dk)
After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)

We show that both CD1c(+) and CD14(+) dDC subsets were infected, but viral load greatly increased in CD14(+) dDCs upon IL-4 stimulation, which correlated with upregulation of virus-binding lectins Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Nonintegrin (DC-SIGN/CD209) and mannose receptor (CD206). (cnrs.fr)

The gene for CCL21 is located on human chromosome 9. (creativebiomart.net)

Does staining at room temperature or even at 37°C help for checking chemokine receptors expression? (biolegend.com)
CCL19 and CCL21 expression levels were comparable in the H. pylori-infected and the uninfected groups. (nih.gov)
HA binding receptor, CD44 and LYVE-1 expression were also upregulated in the CsA groups, and were localized to the area of fibrosis and the peritubular capillaries of the cortex. (mmp-signal.com)

STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)

A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)

Anatomy48

Organisms17

Diseases25

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes34

Disciplines and Occupations1

Information Science2

Health Care1

CCR721

Chemokines15

Ligands2

Dendritic cells5

Ligand5

Binds2

Protein-coupled receptors2

Extracellular1

MRNA2

Motif1

Potent1

Cytokines4

CXCL121

Seven transmembrane2

Interferon1

Functionally1

ACKR42

Neutrophils1

Pattern recognit1

Differential1

Monocytes1

Molecules1

CCR102

CCR32

Gradients2

Antigen1

Potency2

Cytokine1

CCR21

Immune2

IFNAR11

Antibody1

CCL271

Cells5

Interleukin1

Lymphocytes1

Activation3

Adhesion1

Gene1

Expression3

Cell1

THYMUS1