Finally, our data reveal that, independent of inflammation, murine colon macrophages act as a major source of Ccl7 and Ccl8 chemokines that trigger further recruitment of their pro-inflammatory monocyte precursors. (frontiersin.org)
We found that inhalation of GMA-SS welding fume was associated with activation of complement (C2, C3, C1QA-C, C4B), type 1 interferon pathways and increased expression of monocyte and lymphocyte chemotactic genes such as CCL2, CCL7 and CCL8. (cdc.gov)
Fluorescent polarization and native mass spectrometry approaches showed that BK1.1 binds CCL8, CCL7 and CCL18, and disrupts CCL8 homodimerization. (ox.ac.uk)
We show that a BK1.1 derivative, BK1.3, has substantially improved ability to disrupt P672 binding to CCL8, CCL2 and CCL3 in an AlphaScreen assay. (ox.ac.uk)
BK1.3 also has substantially improved ability to inhibit CCL8, CCL7, CCL2 and CCL3 chemotactic function in vitro. (ox.ac.uk)
CCL31
With occult O. volvulus infection, serum levels of pro-inflammatory chemokines MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, MPIF-1/CCL23 and CXCL8/IL-8 enhanced and approached higher concentrations as determined in infection-free controls, whilst regulatory and Th2-type cytokines and chemokines MCP-4/CCL13, MIP-1δ/CCL15, TARC/CCL17 and IL-13 lessened. (nih.gov)
CCL51
This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). (cancerindex.org)
Chemokines5
In contrast to most chemokines, CCL7 exists in a general monomeric form, differing from the dimer formed in a highly concentrated solution. (wikipedia.org)
During inflammation or infection, classical monocytes are mobilized from bone marrow reserves in response to chemokines that bind to the CCR2 receptor, such as CCL2 and CCL7 ( Shi and Pamer, 2011 ). (frontiersin.org)
Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. (whispermovie.com)
Further, we found that FGF9 induces expression of Ccl2 and Ccl7, two pro-inflammatory chemokines that contribute to recruitment of microglia and macrophages into multiple sclerosis lesions. (gla.ac.uk)
At 3 days post-initial ivermectin treatment, MCP-1/CCL2, MCP-4/CCL13, MPIF-1/CCL23 and Eotaxin-2/CCL24 were strongly enhanced, suggesting that monocytes and eosinophil granulocytes have mediated Mf clearance. (nih.gov)
Chemokine7
Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3). (wikipedia.org)
CCL7 is a small protein that belongs to the CC chemokine family and is most closely related to CCL2 (previously called MCP1). (wikipedia.org)
In the human genome, CCL7 is encoded by the CCL7 gene which is one of the several chemokine genes clustered on chromosome 17q11.2-q12. (wikipedia.org)
It was also reported, that CCL7 can also induce neutrophil migration to the inflammatory site by increasing intracellular Ca2+ flux, which is more typical for the CXC chemokine family members. (wikipedia.org)
CCL7 is a multipotent chemokine involved in anti-bacterial, anti-viral and anti-fungal immune responses. (wikipedia.org)
For example, CCL7-mediated stimulation of CCR2 chemokine receptors on monocytes is participating in the elimination of Listeria monocytogenes infections by the recruitment of monocytes and TNF/iNOS-producing dendritic cells (TipDCs). (wikipedia.org)
Levels of Eotaxin-2/CCL24, MCP-3/CCL7 and BCA-1/CXCL13 remained unchanged. (nih.gov)
Monocyte1
The positive effect of CCL7 is mainly observed in monocyte mobilization from bone marrow to blood circulation and in the recruitment of monocytes to sites of inflammation. (wikipedia.org)
Chemotactic1
Thus, chemotactic factor CCL7 recruits leukocytes to infected tissues to mediate the immune response. (wikipedia.org)
Genes1
IL-1beta, AIM2, CCL2, and CCL7 genes were all dramatically up-regulated in monocytes during the 72 hrs of infection. (pcom.edu)
CCL7 has been shown to interact with MMP2 by binding CCR2 receptor. (wikipedia.org)
Fibroblasts1
CCL7 is expressed in many types of cells, including stromal cells, keratinocytes, airway smooth muscle cells, parenchymal cells, fibroblasts and leukocytes and also in tumor cells. (wikipedia.org)
Protein1
Recombinant Human CCL7 protein( Gln 24 - Leu 99), fused with His tag, was expressed in HEK293. (creativebiomart.net)
Gene1
The CCL7 gene has been given the locus symbol SCYA7. (wikipedia.org)
Expression2
In T lymphocytes the expression of CCL7 occurs after 3-5 days after the stimulation. (wikipedia.org)
It seems, that the expression of CCL7 can activate an antitumor immune response. (wikipedia.org)
Mouse1
Next, the role of the CCL7 was also observed in the mouse infected by West Nile Virus. (wikipedia.org)
Ccl132
Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). (nih.gov)
CCR2, also known as CD192, is a 38 kDa 7-TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. (bio-techne.com)
Ligand1
Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3). (wikipedia.org)
CXCL12
Multiplex immunoassay revealed significantly higher levels of pro-inflammatory cytokines IL-1alpha and TNF-alpha, but reduced expression of chemokine proteins including CCL2-5, CCL7, CCL11, CXCL1, and CXCL10 in IL-6Ralpha Amyeloid mouse skin relative to littermate control following irritant exposure. (cdc.gov)
IL-1 CXCL1 (KC) CCL2(MCP-1) CXCL2(MIP-2) CCL7(MCP-3) and CCL20(MIP-3A)] aswell as matrix metalloproteases (MMPs) to permit turned on T cells to penetrate extracellular matrix. (immune-source.com)
Receptor2
CCL7 has been shown to interact with MMP2 by binding CCR2 receptor. (wikipedia.org)
We selected most pathways CCL7 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. (creativebiomart.net)
Proteins1
Also, other proteins which involved in the same pathway with CCL7 were listed below. (creativebiomart.net)
Chemokine receptors1
For example, CCL7-mediated stimulation of CCR2 chemokine receptors on monocytes is participating in the elimination of Listeria monocytogenes infections by the recruitment of monocytes and TNF/iNOS-producing dendritic cells (TipDCs). (wikipedia.org)
MCP11
CCL7 is a small protein that belongs to the CC chemokine family and is most closely related to CCL2 (previously called MCP1). (wikipedia.org)
Glioma4
CCL2 in Cancers Vaccination with CCL2-transfected glioma cells did not reduce the tumor size in nude mice. (medscape.com)
2. CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells. (nih.gov)
13. Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy. (nih.gov)
17. A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis. (nih.gov)
Tumor3
CCL7 is expressed in many types of cells, including stromal cells, keratinocytes, airway smooth muscle cells, parenchymal cells, fibroblasts and leukocytes and also in tumor cells. (wikipedia.org)
[ 116 ] The role of CCL2 in tumor-development and progression is controversial. (medscape.com)
By contrast to above studies, expression of exogenous CCL2 by adenocarcinoma cells augmented the metastatic potential by modulating tumor-associated angiogenesis. (medscape.com)
Mediates1
Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). (nih.gov)
Migration1
It was also reported, that CCL7 can also induce neutrophil migration to the inflammatory site by increasing intracellular Ca2+ flux, which is more typical for the CXC chemokine family members. (wikipedia.org)
Pathway1
12. CCL2/CCR2 signaling pathway in glioblastoma multiforme. (nih.gov)
Immune2
CCL7 is a multipotent chemokine involved in anti-bacterial, anti-viral and anti-fungal immune responses. (wikipedia.org)
It seems, that the expression of CCL7 can activate an antitumor immune response. (wikipedia.org)
CCL7 consists of 99 amino acids, which contains 23-amino acid signal peptide. (wikipedia.org)
Induction1
Early induction of CCL7 downstream of TLR9 signaling also promotes the development of robust immunity to cryptococcal infections. (wikipedia.org)
Human1
[ 114 ] Tumorigenicity and growth rates of CCL2-producing H69/VP cells (MDR human small-cell lung cancer expressing P-glycoprotein) in nude mice were also similar to those of parental cells. (medscape.com)