• Elevated expression levels of CCL2/MCP-1, CCL5/RANTES and CCL17/TARC which result in chemoattracted CD4+ and CD8+ T cell populations to the surrounding area may be responsible for exerting a downmodulatory effect on the AchE and CHRM3 expressions. (wikipedia.org)
  • Corticosteroid inhibits the expressions of CCL2/MCP-1, CCL5/RANTES and CCL17/TARC. (wikipedia.org)
  • This further support the notion that CCL2/MCP-1, CCL5/RANTES and CCL17/TARC play a crucial role. (wikipedia.org)
  • Here, we identified the impact of TNF-α and IL-1β on the inflammatory phenotype of CAFs and MSCs by determining the expression of inflammatory chemokines that are well-characterized as pro-tumorigenic in breast cancer: CCL2 (MCP-1), CXCL8 (IL-8) and CCL5 (RANTES). (nih.gov)
  • TNF-α (and IL-1β) induced the release of CCL2, CXCL8 and CCL5 by MSCs and CAFs generated by prolonged stimulation of MSCs with Tumor CM of MDA-MB-231 and MCF-7 cells. (nih.gov)
  • Patient-derived CAFs expressed CCL2 and CXCL8, and secreted CCL5 following TNF-α (and IL-1β) stimulation. (nih.gov)
  • RESULTS: Following in vivo SSC-injury loading, young rats exhibited increased concentrations of the chemokine proteins RANTES/CCL5 approximately 5 Fold (164.2 + 21.5 vs. 31.1 + 7.6 pg/ml, p (cdc.gov)
  • CCL5, also known as RANTES, is a member of the CC family of chemokines. (biolegend.com)
  • In addition to inducing potent and sustained production of the cytokines/chemokines IL-6, IL-8, CCL2 (MCP-1), CCL3 (MIP-1alpha), CCL4 (MIP-1beta) and CCL5 (RANTES) in microglia, B. burgdorferi also affected important inflammatory signaling pathways in these cells. (tulane.edu)
  • The C-C chemokine receptor types 2 and 5 (CCR2 and CCR5), and their respective ligands, C-C chemokine ligand types 2 (CCL2/MCP-1) and 5 (CCL5/RANTES) play an important role in polarizing monocytes to M1 macrophages [ 12 ]. (biomedcentral.com)
  • At tumor sites, monocytes differentiate into tumor-associated macrophages capable of producing growth factors, proteases, angiogenic mediators, cytokines, and chemokines such as CCL2 (MCP-1), CCL5 (RANTES). (creative-proteomics.com)
  • In the independent pathway, the induction of IFNβ and IFN inducible proteins such as monocyte chemoattractant protein 1 (MCP-1 also known as CCL2), IFNγ-induced protein (IP10 also known as CXCL10) and RANTES (also known and CCL5) are triggered 5 . (heart.org)
  • Subsequently, to SB225002 evaluate the anti-inflammatory effect of high-quality SVF, an in vitro study was performed to assess the expression patterns of inflammatory cytokines including prostaglandin E2 (PGE2), IL-6, and CXCL8/IL-8, COX2, TNF, IFN, CCL2/MCP-1 and CCL5/RANTES in co-culture with synoviocytes derived from the synovial fluid in SB225002 the TMJ-OA patients. (skinmicrobiomecongressca.com)
  • Multiplex protein analysis further showed elevated expression of IP-10/CXCL10, a potent downstream effector of IFN-γ, as well as RANTES/CCL5, eotaxin/CCL11 and IL-10, prior to symptomatic onset in Npc1 −/− /App −/− cerebella, compared with Npc1 −/− /App +/+ mice. (biomedcentral.com)
  • Interestingly, the SARS-CoV infected DCs showed low expression of antiviral cytokines (IFN-α, IFN-β, IFN-γ and IL-12p40), moderate upregulation of proinflammatory cytokines (TNF-α and IL-6) but significant upregulation of inflammatory chemokines (macrophage inflammatory protein (MIP)-1α/CCL3, regulated upon activation, normal T cell expressed and secreted (RANTES)/CCL-5, interferon-inducible protein of 10 kD (IP-10)/CXCL10 and monocyte chemotactic protein (MCP)-1/CCL2. (biomedcentral.com)
  • The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted. (lookformedical.com)
  • Liver tissues exhibited increased presence of CD68+ and TCD8+ cells as well as high expression of MMP-9, TNF-a, RANTES, VEGFR-2 mediators. (bvsalud.org)
  • Exposure of MSCs to TNF-α led to potent CCL2-induced migration of monocytic cells, a process that may yield pro-cancerous myeloid infiltrates in breast tumors. (nih.gov)
  • Additionally, the expression of RANTES, VEGFR-2 and VCAM-1 were observed. (bvsalud.org)
  • CCL2 was expressed in CAFs residing in proximity to breast tumor cells in biopsies of patients diagnosed with invasive ductal carcinoma. (nih.gov)
  • 3. Chemokine MCP1/CCL2 gene polymorphism influences Henoch-Schönlein purpura susceptibility in Iranian Azeri-Turkish patients. (nih.gov)
  • 4. Association of the polymorphisms of chemokine genes (IL8, RANTES, MIG, IP10, MCP1 and IL16) with the pathogenesis of autoimmune thyroid diseases. (nih.gov)
  • c-c motif chemokine ligand 2 (CCL2, also known as monocyte chemoattractant protein-1 [MCP-1]) is particularly important for its chemotactic activities in RA [ 7 ]. (ijbs.com)
  • MCP-1, also called chemokine (C-C motif) ligand 2 (CCL2), is a pain-related inflammatory cytokine that recruits several types of immune cells to the sites of inflammation in the condition of tissue injury or infection [ 9 ]. (biomedcentral.com)
  • The combination synergistically suppresses release of proinflammatory mediators, including tumour necrosis factor-α, IL-6, chemokine (C-C motif) ligand 5 (RANTES), matrix metalloproteinase-9, and others, from human peripheral blood mononuclear cells and mouse macrophages. (biomedcentral.com)
  • The previous studies focused on the changes of the pain-related inflammatory cytokines such as interleukin (IL)-1, IL-6,12 IL-8, spinal macrophage inflammatory protein (MIP), MCP-1, vascular endothelial growth factor (VEGF), and regulated on activation, normal T expressed and secreted (RANTES) before and after cataract surgery of the first eye, however the neuropeptide SP has not been identified. (biomedcentral.com)
  • Epidural cytokine levels were not detectable in most samples, except for scattered marginally elevated levels in a few cytokines such as MCP-1, RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) and interleukin-1b. (elsevierpure.com)
  • 2. Association of ACE, VEGF and CCL2 gene polymorphisms with Henoch-Schönlein purpura and an evaluation of the possible interaction effects of these loci in HSP patients. (nih.gov)
  • 12. Polymorphisms in the promoter region of RANTES and the regulatory region of monocyte chemoattractant protein-1 among Chinese children with systemic lupus erythematosus. (nih.gov)
  • Monocyte chemotactic protein-1 (MCP-1/CCL2), showing affinity to CCR2 receptor, constitutes one of the principal monocyte/macrophage chemokines [ 6 , 7 ]. (hindawi.com)
  • Nesfatin-1-induced stimulation of CCL2 expression and monocyte migration involved the MEK/ERK, p38, and NF-κB signaling pathways. (ijbs.com)
  • MCP-1 (CCL2) is a chemokine produced by vascular cells that stimulates monocytes/macrophage activation and migration, with actions mediated via the chemokine (C-C motif) receptor. (medscape.com)
  • Notably, nesfatin-1-induced increases in CCL2 expression favored M1 macrophage polarization, which increased the expression of proinflammatory cytokines IL-1β, IL-6, and TNF-α. (ijbs.com)
  • found a correlation among improved RANTES expression and tumor lymphocytic response in lung cancer individuals the macrophage inflammatory protein 1B levels are drastically reduce in individuals with skin toxicity compared towards the amounts in sufferers without any skin toxicity. (gp120-inhibitors.com)
  • In assays analyzing IL-12p40 and CCL2 (MCP-1), glial cells were not stimulated in vitro by either PrPres purified from infected mouse brains or prion protein amyloid fibrils produced in vitro. (nih.gov)
  • As a result, patients with higher systemic irritation, as represented by RANTES, could knowledge significant gen eral fatigue and shorter survival time. (gp120-inhibitors.com)
  • There were no significant differences between the two groups in aortic plasma concentrations or transcoronary concentration gradients of MCP-1, RANTES, and hsCRP. (nih.gov)
  • Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased. (nih.gov)
  • In our study, large level of plasma RANTES at diagnosis was connected together with the se verity of general fatigue. (gp120-inhibitors.com)
  • Very low amount of plasma RANTES at diagnosis was drastically associated with long term survival. (gp120-inhibitors.com)