• HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells. (nih.gov)
  • Our contributions to elucidate the tumor suppressor-like functions of C/EBPδ in mammary epithelial cells include the findings that C/EBPδ augments cyclin D1 protein degradation by the APC/Ccdc27 pathway (Pawar et al. (cancer.gov)
  • FBXW7α is a substrate-binding subunit of the SCF polyubiquitination complex and a bona fide tumor suppressor for several epithelial cancers because it targets a number of oncoproteins for degradation. (cancer.gov)
  • In addition, we discovered two degradation pathways that downregulate C/EBPδ protein levels: the pro-oncogenic SIAH2 ubiquitin ligase pathway and a pathway requiring the tumor suppressor SCF-FBXW7 ubiquitin ligase (Sarkar et al. (cancer.gov)
  • Limiting supply of nutrients and oxygen in growing tumor cells disrupts the protein folding homeostasis resulting in activation of the unfolded protein response (UPR). (aacrjournals.org)
  • TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. (semanticscholar.org)
  • Mechanistically, we have correlated CEBPD's prometastatic activity to inhibition of the F-box protein FBXW7, a bona fide tumor suppressor, which leads to hypoxia adaptation and proinflammatory signaling. (nih.gov)
  • Peroxisome proliferator-activated receptor delta promotes colonic inflammation and tumor growth. (mayo.edu)
  • Chapter 4: Protein concentrations of proliferating cell nuclear antigen are tissue specific and variably heat responsive. (pdx.edu)
  • The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. (wikipedia.org)
  • A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium. (labome.org)
  • Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. (genscript.com)
  • Because the Jak/Stat pathway is involved in regulation of cellular responses to cytokines and growth factors, it has been hypothesized that dysregulation and/or chronic activation of Jak/Stat proteins could play a key role in malignant transformation of cells. (pnas.org)
  • In this review, we summarize research to date from mouse and human studies on the role of the SOCS proteins in determining the phenotype and function of macrophages. (frontiersin.org)
  • The Ad-Nogo-B-treated mice also had less severe lung injury, less alveolar protein exudation, and a higher number of macrophages but less neutrophil infiltration compared with Ad-RFP-treated mice. (onearray.com.cn)
  • Induction of PRL mRNA and secreted protein by NR4A2 was confirmed in subsequent experiments, with increases of 300-fold and 18-fold respectively. (biomedcentral.com)
  • Chapter 3: The heat-induced nuclear translocation of C/EBP-delta--as determined by immunohistochemistry--appears to be time, tissue and species specific with spleen, heart and retinae being particularly responsive in certain situations. (pdx.edu)
  • The full-length protein is 30,603 daltons in mass and has been noted to be nuclear. (biocompare.com)
  • The increase of nuclear C/EBPbeta protein was dependent on p38. (genscript.com)
  • The suppressor of cytokine signaling (SOCS) proteins play a key role in regulating macrophage phenotype. (frontiersin.org)
  • Furthermore, insulin-like growth factor-I (IGF-I) in combination with its principle binding protein (IGFBP-3) equilibrates proto anti-inflammatory cytokine ratios and improves homeostasis of severely burned pediatric patients. (biomedcentral.com)
  • 3 4 5 6 7 Retinoschisin is almost entirely composed of a highly conserved discoidin domain frequently found in a wide range of membrane and extracellular proteins and most likely mediating cell adhesion and cellular signaling processes. (arvojournals.org)
  • The inner mitochondrial membrane of BAs contains uncoupling protein 1 (UCP1). (biomedcentral.com)
  • White muscle tissue contains the highest C/EBP-delta concentration, which is further increased in response to sublethal heat stress at 2.0 or 4.0°C. This response is mostly acute and transitory, but a lesser upregulation was observed in fishes held for one month at 4.0°C. (pdx.edu)
  • In leukemic cell lines expressing the fusion product Bcr/Abl, Stat proteins were found to be constitutively activated ( 12 , 13 ), and recently, two studies reported on dysregulation of Jak/Stat signaling in malignant and/or nonmalignant cells obtained from peripheral blood cells from patients with acute lymphoblastic leukemia, acute myeloid leukemia, Sézary syndrome, and/or anaplastic large T cell lymphoma ( 14 , 15 ). (pnas.org)
  • Despite their inability to upregulate heat shock proteins, recent studies have demonstrated a capacity for heat response in these animals. (pdx.edu)
  • 2 It encodes a 24-kDa protein, termed retinoschisin, which is mainly secreted from photoreceptors as a homo-oligomeric complex. (arvojournals.org)