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  • FOXO1
  • Among them, FoxO1/3a proteins are the first identified transcription factors ( 11 ). (diabetesjournals.org)
  • Activated Akt subsequently phosphorylates FoxO1/3a at multiple sites including Ser 256 on FoxO1 and Ser 253 on FoxO3a, and the phosphorylated form of FoxO1/3a possesses higher binding affinity with chaperone protein 14-3-3ζ for the cytoplasmic retention and nuclear export of FoxO1/3a ( 20 ). (diabetesjournals.org)
  • mRNA
  • C/EBP alpha mRNA levels decrease 60 to 80% within 1 to 3 h after partial hepatectomy as the cells move from G0 to G1 and decrease further when cells progress into S phase. (asm.org)
  • EBPa
  • Der Transkriptionsfaktor CCAAT/Enhancer-Binding Protein alpha (C/EBPa) koordiniert Proliferationshemmung und Differenzierung von myeloiden VorlŠuferzellen und Adipozyten. (hu-berlin.de)
  • E2F reprimiert die transkriptionelle AktivitŠt von C/EBPa ohne Bindung an cis-regulatorischen Elemente, sondern durch direkte Protein-Protein Interaktionen, die die Bindung von C/EBPa an DNA verhindern. (hu-berlin.de)
  • Disturbed DNA binding of C/EBPa is often observed in AML patients suggesting a causative role in granulocytic disorders. (hu-berlin.de)
  • Thus, it would be of main interest to analyze whether E2F mediates disruption of C/EBPa''s DNA-binding in AML patients and whether therapies directed against E2F could restore granulocytic maturation. (hu-berlin.de)
  • This work demonstrates an association of C/EBPa to the RNA Pol I transcription factor UBF1, both proteins retained in large chromosomal foci. (hu-berlin.de)
  • demonstrate
  • These results demonstrate that FLT3-ITD mutant proteins are sufficient to induce a myeloproliferative disorder, but are insufficient to recapitulate the AML phenotype observed in humans. (jove.com)
  • thereby
  • Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. (atcgbio.com)