• In contrast, when iron is scarce, Fep1 becomes inactive and php4 + is expressed to act as a regulatory subunit of the CCAAT-binding factor that is required to block pcl1 + , sdh4 + , and isa1 + gene transcription. (asm.org)
  • Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. (embl.de)
  • A DNA-binding domain and a subunit interaction domain are specified by two separate segments. (embl.de)
  • Both the DNA binding and subunit interaction functions of CBF-B have been examined by mutational analysis. (embl.de)
  • Carboxyl-terminal deletions of this segment (or mutations in arginine residues in this carboxyl-terminal part) abolish DNA binding, but do not alter subunit interactions between CBF-A and CBF-B. Mutations in hydrophobic amino acids within the amino-terminal part of the evolutionarily conserved sequence at positions 252-334 result in loss of both DNA binding and subunit interaction activities. (embl.de)
  • Overall, our study suggests that the myeloid specific factor C/EBPε is involved in systemic lipid metabolism and that silencing of C/EBPε could decrease the development of atherosclerosis. (oregonstate.edu)
  • However, compared with the massive knowledge about the transcriptome, we have surprisingly little knowledge about regulatory mechanisms underling transcriptomic diversity.Our analysis found that motifs bound by ELK1, E2F, NRF1 and NFY are potential regulatory motifs that positively correlate with malignant progression of breast cancer.The results suggest that these 4 motifs are principal regulatory motifs driving malignant progression of breast cancer. (nih.gov)
  • Our analysis found that motifs bound by ELK1, E2F, NRF1 and NFY are potential regulatory motifs that positively correlate with malignant progression of breast cancer. (nih.gov)
  • Furthermore, we demonstrated that soluble ATF6 binds directly to CCACG only when CCAAT exactly 9 bp upstream of CCACG is bound to NF-Y. Based on these and other findings, we concluded that specific and direct interactions between ATF6 and ERSE are critical for transcriptional induction not only of ER chaperones but also of CHOP and XBP-1. (asm.org)
  • Thus, it would be of main interest to analyze whether E2F mediates disruption of C/EBPa''s DNA-binding in AML patients and whether therapies directed against E2F could restore granulocytic maturation. (hu-berlin.de)
  • The genetic factor is linked to quantitative and/or qualitative defects in the insulin receptor (INSR) signaling pathway which regulates growth and metabolic responses to insulin, in insulin target cells and tissues [ 6 ]. (hindawi.com)