• Core-binding factor (CBF) is a heterodimeric transcription factor composed by the CBFβ and RUNX subunits (the latter is encoded by RUNX1, RUNX2, or RUNX3 genes). (wikipedia.org)
  • The discovery of AI-10-49 provides additional evidence that transcription factor drivers of cancer can be directly targeted. (wikipedia.org)
  • runx1 expression in the lateral plate mesoderm co-localizes with the hematopoietic transcription factor scl , and expression of runx1 is markedly reduced in the zebrafish mutants spadetail and cloche . (biologists.com)
  • The AML1-CBFbeta transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most frequent target of chromosomal rearrangements in human leukemia. (embl-heidelberg.de)
  • The Runt-related transcription factor 2, Runx2, is an important determinant of bone metastasis in breast cancer. (biomedcentral.com)
  • Runx1 is a sequence-specific DNA-binding protein, that along with its homologues Runx2 and Runx3 and their shared non-DNA binding subunit CBFbeta, constitute a small family of transcription factors called core-binding factors (CBFs). (ox.ac.uk)
  • The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
  • Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
  • AI-10-49 allosterically binds to CBFβ-SMMHC and disrupts protein-protein interaction between CBFβ-SMMHC and tumor suppressor RUNX1. (wikipedia.org)
  • CBFβ-SMMHC outcompetes CBFβ for binding to RUNX1 by direct protein-protein interaction. (wikipedia.org)
  • Genetic studies have identified a number of transcription factors and signaling molecules that act at the onset of hematopoiesis, and have begun to delineate the molecular mechanisms underlying the formation of HSCs. (ox.ac.uk)
  • Ectopic expression of AML1-MTG8 in L-G murine myeloid progenitor cells inhibits differentiation to mature neutrophils and induces cell proliferation in response to granulocyte colony-stimulating factor (G-CSF). (embl-heidelberg.de)
  • The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). (embl-heidelberg.de)
  • Molecular cloning of cDNA indicated that the AML1-MTG8-binding protein (MTGR1) is highly related to MTG8 and similar to Drosophila Nervy. (embl-heidelberg.de)
  • A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
  • The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)
  • A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)
  • Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)
  • This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
  • In this review, we highlight the main signals and transcription factors and how they are integrated at the level of chromatin programming and gene expression control. (amegroups.org)
  • The activity of these elements is controlled by transcription factors (TFs) which bind to DNA wrapped into chromatin, leading to the modification of the chromatin landscape, and the assembly of the transcription machinery. (amegroups.org)
  • Chromatin assembly factor 1. (lookformedical.com)
  • This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
  • We also show that a Runx-binding enhancer in the Rorc gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression. (life-science-alliance.org)
  • We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)
  • The TAF homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and whereof the core ~75-80 residues occur in TAF proteins. (embl-heidelberg.de)
  • Proteins which bind to DNA. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
  • Moreover, transcription factors and their target genes form vast interacting gene regulatory networks which can be exquisitely stable. (amegroups.org)
  • We also identified the osteoclast activators IL-11 and granulocyte-macrophage colony-stimulating factor (GM-CSF) as new target genes of Runx2/CBFβ in metastatic breast cancer cells. (biomedcentral.com)
  • Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103 + CD11b + cDC2s and alters characteristics of CD103 − CD11b + cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt + Th17 cells and type 3 Rorγt + regulatory T cells. (life-science-alliance.org)
  • We have previously demonstrated that Runx2 requires the co-activator core binding factor beta (CBFβ) to regulate gene expression in breast cancer cells. (biomedcentral.com)
  • Members of the transforming growth factor beta (TGFβ) family also contribute to inhibition of osteoblast differentiation by metastatic breast cancer cells [ 6 , 7 ]. (biomedcentral.com)
  • If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. (ox.ac.uk)
  • e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens. (lookformedical.com)
  • AI-10-49 allosterically binds to CBFβ-SMMHC and disrupts protein-protein interaction between CBFβ-SMMHC and tumor suppressor RUNX1. (wikipedia.org)
  • 17. CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium. (nih.gov)
  • RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (nih.gov)
  • The CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). (medlineplus.gov)
  • Mr. Hajra submitted a fabricated nucleotide sequence in computer data base entry U22149, ~Human leukemia-associated core binding factor subunit CBFbeta (CBFB) gene, promoter region and partial CDs. (nih.gov)
  • 6. Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia. (nih.gov)
  • KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 rearrangement. (cdc.gov)
  • Relationship between RAD51-g135C and XRCC3-C241T polymorphisms and prognosis of inv (16)/ t(16;16) (CBFbeta-MYH11) acute myeloid leukemia]. (cdc.gov)
  • The protein produced from the fusion gene, called CBFβ-MYH11, can still bind to RUNX1 to form CBF. (medlineplus.gov)
  • The presence of CBFβ-MYH11 may block binding of CBF to DNA, preventing RUNX1 from controlling gene activity. (medlineplus.gov)
  • These genomic rearrangements are characterized by disruption of the AML1 ( CBFalpha2 ) gene at 21q22 and the CBFbeta gene at 16q22, respectively. (medscape.com)
  • 4. Core Binding Factor-β Knockdown Alters Ovarian Gene Expression and Function in the Mouse. (nih.gov)
  • 16. Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancer. (nih.gov)
  • Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia. (cdc.gov)
  • Tumorigenic mutations frequently occur in a 35-residue domain of VHL responsible for ElonginC binding. (embl-heidelberg.de)
  • Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
  • These protein complexes bind to specific regions of DNA and help turn on (activate) certain genes. (medlineplus.gov)
  • Both genes encode a subunit of core binding factor (CBF), a regulator of normal hematopoiesis. (medscape.com)
  • At the molecular level, t(8;21)(q22;q22) and inv(16)(p13q22) result in creation of novel fusion genes, AML1/ETO and CBFbeta/MYH11 , which encode for fusion transcripts readily detected by reverse-transcription polymerase chain reaction and are used for assessment of minimal residual disease during complete remission. (medscape.com)
  • These genomic aberrations are characterized at the molecular level by disruption of genes encoding subunits of core binding factor (CBF) and are generally associated with the most favorable prognosis. (medscape.com)
  • 10. Core binding factor genes and human leukemia. (nih.gov)
  • 3. The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. (nih.gov)
  • A mutational patch on a separate domain of VHL indicates a second macromolecular binding site. (embl-heidelberg.de)
  • The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. (nih.gov)
  • 7. Core-binding factor beta interacts with Runx2 and is required for skeletal development. (nih.gov)
  • CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. (nih.gov)
  • Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. (embl-heidelberg.de)
  • Because the genetic changes affect CBF, the condition is classified as core binding factor AML (CBF-AML). (medlineplus.gov)
  • The "core binding factor AML" (CBF AML) [WHO classification] is the most common group of AML, including groups with the chromosome rearrangements inv(16)(p13q22) and t(8;21)(q22;q22). (wikipedia.org)