AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsHumanities
Corneal OpacityEyelashesTrichiasisCataractHair RemovalCorneaLecithin Acyltransferase DeficiencyCorneal DiseasesEntropionCorneal Dystrophies, HereditaryBlindnessSurgery, PlasticTrachomaEyelid DiseasesTattooingEye DiseasesCorneal StromaKeratoplasty, PenetratingKeratoconjunctivitisVisual AcuityCorneal KeratocytesPupil DisordersEye BurnsBurns, ChemicalPhotorefractive KeratectomyEstheticsMicroscopy, AcousticCorneal NeovascularizationKeratitisEye AbnormalitiesVision, LowKeratan SulfateAnterior Eye SegmentLens Nucleus, CrystallineKeratitis, HerpeticLasers, ExcimerLens Cortex, CrystallineCorneal TransplantationVision DisordersContact LensesEpithelium, CornealEyePhosphatidylcholine-Sterol O-Acyltransferase
OpacificationDystrophyEpitheliumAmerican Academy of OpCongenital corneal opacitiesBovine Corneal Opacity and PermeabilityTransplantationKeratitisNeovascularizationKeratoplastyEndothelialGlaucomaTransparencySevereCorneaBlindnessMacularTrachomaRisk of corneal opacityStromaRecurrent corneal erosions2019CataractInfectionProsthetic cornealConjunctivalDiagnosisRefractive surgeryAbnormalitiesConjunctivitisThicknessTransplantNebularCurvatureScarEdemaEpithelialVascularizationPediatricPatientsOcularDiagnosticKProOccurSymmetrical
Opacification5
  • Corneal opacification is a term used when the human cornea loses its transparency. (wikipedia.org)
  • The word corneal opacification literally means loss of normal transparency of cornea. (mdwiki.org)
  • prised: demographic details (e.g. name, age, Corneal opacification (traumatic, infec- sex and country of origin), best corrected tious or other) constituted one-fifth of visual visual acuity (VA), basic eye examination, impairment. (who.int)
  • Reis-Bücklers, formerly known as Granular corneal dystrophy type III or Corneal Dystrophy of Bowman's type I, typically present with normal corneas at birth but develop painful recurrent erosions, opacification, and progressive vision loss within the first decade of life (1). (uiowa.edu)
  • Brown SI, Kuwabara T. Peripheral corneal opacification and skeletal deformities. (medscape.com)
Dystrophy7
  • Alterations in the spacing of collagen fibrils in a variety of conditions including corneal edema, scars, and macular corneal dystrophy is clinically manifested as corneal opacity. (wikipedia.org)
  • Posterior polymorphous corneal dystrophy (PPMD, PPCD): PPCD, also known as Schlichting dystrophy, is an autosomal dominant disorder of the corneal endothelium and Descemet's membrane. (wikipedia.org)
  • Congenital hereditary stromal dystrophy (CHSD): CHSD is also known as Congenital stromal corneal dystrophy or Congenital stromal dystrophy of the cornea. (wikipedia.org)
  • To report potentially pathogenic mutations in the keratin 3 ( KRT3 ) and keratin 12 ( KRT12 ) genes in two individuals with clinically diagnosed Meesmann corneal dystrophy (MECD). (molvis.org)
  • The hyaline-like material consists of rod-like bodies ultrastructurally, which helps distinguish it from Thiel-Behnke corneal dystrophy (1, 2). (uiowa.edu)
  • Lattice corneal dystrophy (LCD) is the most common of the corneal epithelial-stromal dystrophies. (uiowa.edu)
  • Lattice corneal dystrophy: a source of confusion. (bmj.com)
Epithelium5
  • Corneal diameters were 12 mm for both eyes with normal corneal thickness, intact epithelium, and diffuse mid to posterior stromal haze. (paojournal.com)
  • TGFβI is located on chromosome 5q31 and codes for keratoepithelin, a protein secreted by corneal epithelium. (uiowa.edu)
  • The ocular irritation potential of formulations, products, ingredients, and chemicals can be evaluated using in vitro reconstructed human corneal epithelium (RhCE) models, such as the EpiOcular™ (MatTek Corp.) and SkinEthic HCE (EPISKIN) organotypic 3-D tissue constructs. (iivs.org)
  • Circulating antibodies against corneal epithelium and hookworm in patients with Mooren's ulcer from Sierra Leone. (bmj.com)
  • Following full-thickness corneal transplantation (Penatrating Keratoplasty, PK), rejection may involve any cellular layer of the cornea (epithelium, stroma or endothelium). (college-optometrists.org)
American Academy of Op1
  • HSK is listed by the American Academy of Ophthalmology as a relative contraindication to corneal refractive surgery, although specifics have not been further elucidated. (dovepress.com)
Congenital corneal opacities4
  • Available at: https://www.aao.org/topic-detail/congenital-corneal-opacities-europe. (cvs.com)
  • Birth prevalence and characteristics of congenital corneal opacities. (bvsalud.org)
  • To report the birth prevalence and natural history of congenital corneal opacities among a population -based cohort of children . (bvsalud.org)
  • In this 40-year cohort, congenital corneal opacities were relatively rare and the result of a variety of disorders. (bvsalud.org)
Bovine Corneal Opacity and Permeability1
  • The BCOP (Bovine Corneal Opacity and Permeability) assay is an in vitro eye irritation test method developed by Gautheron et al. (iivs.org)
Transplantation8
  • Experimental mice, i.e., wild-type, Col5a1 f/f and Kera-Cre/Col5a1 f/f ( Col5a1 ∆st/∆st , collagen V null in the corneal stroma) mice in a C57BL/6J genetic background, were subjected to a lamellar keratectomy, and treated with or without UMSC (10 4 cells/cornea) transplantation via an intrastromal injection or a fibrin plug. (molvis.org)
  • UMSC transplantation was successful in recovering some corneal transparency in injured corneas of wild-type, Col5a1 f/f and Col5a1 ∆st/∆st mice. (molvis.org)
  • Corneal transplantation is one of the common treatment to correct several corneal opacity which involves tissue from human donor. (medgadget.com)
  • However, the treatment fails in some cases, leading to development of keratoprosthesis which is used when corneal transplantation is not an option. (medgadget.com)
  • Increasing incidences of corneal blindness along with patients who have failed human corneal transplantation may create potential growth prospects of the keratoprosthesis market. (medgadget.com)
  • The patient requires a corneal transplantation procedure, preferably DMEK. (crstoday.com)
  • Diseases surgical technique developed since the start of the involving the corneal endothelium can be controlled twentieth century for the realization of corneal with endothelial or penetrating keratoplasties, and transplantation (CT). (bvsalud.org)
  • CT is the most common type those diseases that involve both the endothelium and of tissue transplantation made around the world, the corneal stroma generally require PK when there is substitution of all corneal layers (the (REINHART, 2011). (bvsalud.org)
Keratitis3
  • A 53 year old male presents corneal opacity after a mycotic keratitis in left eye. (ascrs.org)
  • Four patients had congenital glaucoma , 4 had limbal dermoids , 2 had sclerocornea, and 1 patient each had Descemet's tear from birth trauma , herpes simplex virus type 1 keratitis , corneal leukoma , and an undiagnosed scar . (bvsalud.org)
  • The incidence of herpes simplex keratitis (HSK) in patients following corneal refractive surgery is higher than in the general population, and several case reports of ocular morbidity in HSK infection following corneal refractive surgery have been published. (dovepress.com)
Neovascularization2
Keratoplasty2
  • PPMD patients with bilateral, corneal opacities that can affect vision, descemet's membrane endothelial keratoplasty or penetrating keratoplasty are the treatments of choice to improve vision and to avoid amblyopia. (wikipedia.org)
  • With the development of new surgical techniques, instrumentation and pharmacological advances, corneal transplant procedures can undergo changes directly in the clinical profile of patients with the indication for penetrating keratoplasty technique. (bvsalud.org)
Endothelial2
  • The 2015 International Committee for Classification of Corneal Dystrophies (IC3D) classification system has divided corneal dystrophies into 4 categories: epithelial and subepithelial dystrophies, epithelial-stromal dystrophies, stromal dystrophies, and endothelial dystrophies. (uiowa.edu)
  • This case presents a few challenges, including repositioning or replacing the IOL and addressing corneal endothelial decompensation and iris damage. (crstoday.com)
Glaucoma4
  • One of the major complication of adherent leucoma is Secondary glaucoma Corneoiridic scar: if iris tissue is incarcerated and incorporated within the scar tissue, as occurs in healing of a large sloughed corneal ulcer, it is called a corneoiridic scar. (wikipedia.org)
  • The appearance of the cornea is similar to that in congenital glaucoma but without increased corneal diameter and elevated intraocular pressure. (wikipedia.org)
  • Six (42.8%) patients required treatment for their underlying corneal opacity including the four patients with congenital glaucoma . (bvsalud.org)
  • The commonest causes of bilat- nessisthoughttobeduetochildhood Eyeexaminationincludesslit-lamp, eralblindnesswerecataract(20.0%), blindness[ 2 ].Indevelopingcountries, fundoscopy,retinoscopyandtonom- glaucoma(17.8%),retinaldisorders thecausesofchildhoodblindnesshave etrywhenneeded.Afterestablishing (13.3%) and corneal nontraumatic notbeenwidelystudied.Toplaneffec- thediagnosis,medicinesorglassesare opacities(13.3%)(Table2).Foruni- tiveinterventionandpreventionpro- prescribedasappropriate. (who.int)
Transparency5
  • The term corneal opacity is used particularly for the loss of transparency of cornea due to scarring. (wikipedia.org)
  • In vivo Heidelberg retinal tomograph (HRT II) confocal microscopy, second harmonic generated (SHG) confocal microscopy, histology, and immunofluorescence microscopy were used to assess the corneal transparency of the regenerated corneas. (molvis.org)
  • The production of collagen V by transplanted UMSCs may account for the regeneration of corneal transparency, as exemplified by better collagen fiber organization, as revealed with SHG signals. (molvis.org)
  • Cornea can loss its transparency due to various reasons and it majorly occurs due to some disorders of eye that eventually leads to corneal opacity. (krishnaeyecentre.com)
  • I have found that, in some cases, once the anatomy has been restored, corneal transparency returns, and DMEK is no longer necessary. (crstoday.com)
Severe3
  • Severe corneal damage in trachoma patients is due primarily to the constant rubbing of the cornea by errant, bristle-like lashes. (uiowa.edu)
  • In January 1992, FDA approved Boston KPro for patients suffering with severe corneal opacity. (medgadget.com)
  • 3 While many recover without permanent visual impairment, 15% will develop severe complications such as persistent pain, dry eye, corneal scarring, and vision loss. (dovepress.com)
Cornea7
  • A number of different presentations of leucomatous corneal opacity exist: Adherent leucoma: results when healing occurs after perforation of cornea with incarceration of iris. (wikipedia.org)
  • In this bilateral Snowflake, whitish opacities appear throughout the cornea. (wikipedia.org)
  • Corneal opacity is a disorder of the cornea that occur due to scarring or clouding of the normally clear and transparent cornea. (krishnaeyecentre.com)
  • Corneal clouding stops the light from passing through the cornea to the retina and therefore results in decreased vision. (krishnaeyecentre.com)
  • Corneal opacity is scarring of the cornea. (cvs.com)
  • Corneal epithelial-stromal and stromal dystrophies are a group of inherited disorders of the cornea that are caused by progressive accumulation of deposits within the layers of the cornea. (uiowa.edu)
  • The test method evaluates the cytotoxicity induced by a series of test chemical dilutions in a monolayer of rabbit corneal fibroblasts (Statens Seruminstitut Rabbit Cornea - SIRC) after a single five-minute exposure. (iivs.org)
Blindness6
Macular2
Trachoma2
  • Ocular trauma Corneal ulceration Xerophthalmia, caused by Vitamin A deficiency Trachoma Onchocerciasis Mucous membrane pemphigoid: Ocular form of mucous membrane pemphigoid may cause corneal opacity and loss of vision. (wikipedia.org)
  • This photo demonstrates the stigmata of established trachoma, i.e. trichiasis, pannus, and corneal scarring. (uiowa.edu)
Risk of corneal opacity1
  • The risk of corneal opacity rose with increasing exposure to total amines (OR=1.15, 95% CI= 1.02, 1.30). (cdc.gov)
Stroma8
  • Nebular corneal opacity is a faint opacity which results due to superficial scars involving Bowman's layer and superficial stroma. (wikipedia.org)
  • Leucomatous corneal opacity is a dense white opacity which results due to scarring of more than half of the stroma. (wikipedia.org)
  • Maintenance of a transparent corneal stroma is imperative for proper vision. (molvis.org)
  • The corneal stroma is composed of primarily collagen fibrils, small leucine-rich proteoglycans (SLRPs), as well as sparsely distributed cells called keratocytes. (molvis.org)
  • Being a small protein roughly the size of albumin, it has the capability to diffuse through the corneal stroma. (uiowa.edu)
  • Irregular, grey-white, geographic-like opacities are located in the Bowman layer and anterior stroma. (uiowa.edu)
  • In more advanced stages of the disease, the opacities can extend to the limbus and deeper stroma (2). (uiowa.edu)
  • It is characterized by lattice lines which are linear, radially oriented, branching refractile opacities described as 'glass like' located in the anterior stroma (See Figure 2A and 2B). (uiowa.edu)
Recurrent corneal erosions1
  • It is typically an autosomal dominant, bilateral disease that typically presents toward the end of the first decade of life with symptoms of recurrent corneal erosions and decreased vision. (uiowa.edu)
20191
  • En décembre 2019, la population de Wuhan, une grande ville chinoise de 11 millions d'habitants, est atteinte par une pneumonie virale extrêmement contagieuse due au coronavirus SARSCoV-2. (bvsalud.org)
Cataract1
  • Binocularblindnesswasdefinedasa cataract(34.8%),followedbytrauma- ofblindnessandthemagnitudeofthe correctedvisualacuityof3/60orbelow relatedcomplications(19.1%),corneal problemiscrucial. (who.int)
Infection2
  • Corneal opacity is caused by infection, injury, or swelling of the eye. (cvs.com)
  • The keratoprosthesis market is expected to grow exponentially over the forecast period due to increasing incidence of corneal infection. (medgadget.com)
Prosthetic corneal2
  • A variety of biologic materials are being considered for improving the prosthetic corneal implants. (medgadget.com)
  • KPro) is the most widely used prosthetic corneal transplant in the United States and the world [ 1 ]. (hindawi.com)
Conjunctival1
  • Lymphoid follicles on the tarsal plate or along the corneal limbus, linear conjunctival scarring, and corneal pannus are considered diagnostic in the appropriate clinical setting. (msdmanuals.com)
Diagnosis1
Refractive surgery2
  • This review summarizes the current literature regarding reactivation of HSK following corneal refractive surgery and provides a guideline for considering corneal refractive surgery in a patient with a previous history of HSK. (dovepress.com)
  • Based on the current literature, we recommend that corneal refractive surgery is appropriate for patients with a history of HSK without multiple recurrences who have had no evidence of disease for at least one year. (dovepress.com)
Abnormalities2
  • Other occasional abnormalities are relatively large big toe and corneal clouding. (paojournal.com)
  • Other features include hyperpigmented macules on the trunk, corneal opacities, other hematological abnormalities. (lu.se)
Conjunctivitis1
  • Case-patient 3 was a 45-year-old man from Kuyuwiniña with a 5-year history of TT, madarosis, blepharitis, conjunctivitis, and corneal opacity in both eyes. (cdc.gov)
Thickness2
  • The prevalence of increased corneal thickness in either eye increased with higher levels of exposure to total amines, as did both the mean and median changes in thickness. (cdc.gov)
  • Median corneal thickness increased with increasing grades of corneal opacity. (cdc.gov)
Transplant2
  • Corneal transplant rejection is the most common cause of transplant failure in the post-operative period. (college-optometrists.org)
  • In 'high-risk' corneal transplant recipients up to 70% fail within 10 years despite local or systemic immunosuppressive therapy. (college-optometrists.org)
Nebular1
Curvature1
  • Kerectasia: In this condition, corneal curvature is increased at the site of opacity (bulge due to weak scar). (wikipedia.org)
Scar1
  • Corneoiridic scar: If iris tissue is incarcerated and incorporated within the scar tissue, as occurs in healing of a large sloughed corneal ulcer, it is called a corneoiridic scar. (mdwiki.org)
Edema4
  • Examination shows inferior corneal edema and a dislocated three-piece IOL, with optic capture inferiorly and the inferior haptic in the anterior chamber (Figure). (crstoday.com)
  • Corneal edema inferiorly and optic capture of a three-piece IOL, the inferior haptic of which is in the anterior chamber. (crstoday.com)
  • Media opacity from focal corneal edema must also be considered. (crstoday.com)
  • I would prefer a superior approach to avoid constructing the wound in the area of corneal edema. (crstoday.com)
Epithelial1
  • The second proband demonstrated bilateral, diffusely distributed epithelial opacities that appeared gray-white on direct illumination and translucent on retroillumination. (molvis.org)
Vascularization1
  • Riboflavin is found essential for iron absorption, gastrointestinal development, neurogenesis, corneal vascularization and corneal opacity. (sigmaaldrich.com)
Pediatric1
  • Pediatric corneal opacities may be congenital or acquired. (wikipedia.org)
Patients4
  • Fourteen patients were diagnosed with a congenital corneal opacity during the 40-year study period for a birth prevalence of 1 in 5188 live births . (bvsalud.org)
  • Patients with refractive er- that of corneal opacities in our study group. (who.int)
  • The keratoprosthesis is intended to replace the damaged corneal tissue and restore vision of the patients with bilateral corneal disease. (medgadget.com)
  • Dès le début de la pandémie, l'établissement hospitalier et universitaire d'Oran (EHUO), centre de soins de première ligne, d'une capacité 780 lits desservant environ 2 millions d'habitants s'est complètement réorganisé, en aménageant principalement des circuits pour le tri des patients « suspects Covid 19 ¼. (bvsalud.org)
Ocular3
  • Ocular form of mucous membrane pemphigoid may cause corneal opacity and loss of vision. (mdwiki.org)
  • The Ocular Irritection Assay is an in chemico eye irritation assay that detects, ranks, and predicts the corneal irritation potential of a test material. (iivs.org)
  • 1992), which uses living bovine corneal tissue, obtained as a by-product from abattoirs, to evaluate the potential ocular irritancy of a test article. (iivs.org)
Diagnostic1
  • Corneal opacities--a diagnostic feature of the trisomy 8 mosaic syndrome. (bmj.com)
KPro2
  • Thirteen of these eyes had hypotony and/or retinal detachment in addition to corneal pathology and thus received KPro + PPV + SOI. (hindawi.com)
  • The addition of PPV and SOI to the KPro implantation in the eyes with corneal pathology, as well as hypotony and/or retinal detachment, is a safe and effective procedure for visual rehabilitation. (hindawi.com)
Occur2
  • Congenital opacities may occur as developmental anomalies or following birth trauma. (wikipedia.org)
  • As corneal keratins naturally occur as obligate K3/K12 heterodimers, gene mutations altering the encoded protein of either KRT3 or KRT12 are expected to negatively impact the K3/K12 heterodimer complex. (molvis.org)
Symmetrical1
  • Corneal topography showed symmetrical bow-tie astigmatism of -3.38D for the right eye and -3.00D for the left eye. (paojournal.com)