EpilepsyTypes of myoclonusReflex myoclonusDystoniaType of myoclonusHistory of progressive myoclonus epilepsiesNeurologySeizuresOpsoclonus-myoclonusEpilepticTremorAtaxiaOccurSymptomsJerksPathologicHypnic myoclonusAction myoclonusCortical myoclonusDiagnose myoclonusMovementsPhysiologicSuddenContractionPalatalReticularCerebellarMyoclonicSpinalBenignPropriospinalMusclesTypicallyOccursSyndromePhysiologicalClinicalRigidityDisordersGeneSymptomSecondaryProgressiveEssentialSpontaneousHiccups
Epilepsy24
- Cortical reflex myoclonus is thought to be a type of epilepsy that originates in the cerebral cortex - the outer layer, or "gray matter", of the brain, responsible for much of the information processing that takes place in the brain. (wikipedia.org)
- Essential myoclonus occurs in the absence of epilepsy or other apparent abnormalities in the brain or nerves. (wikipedia.org)
- Some scientists speculate that some forms of essential myoclonus may be a type of epilepsy with no known cause. (wikipedia.org)
- Progressive myoclonus epilepsy (PME) is a group of diseases characterized by myoclonus, epileptic seizures, tonic-clonic seizures, and other serious symptoms such as trouble walking or speaking. (wikipedia.org)
- We performed a 5-year clinical and electrophysiologic follow-up study on two sibling cases with myoclonus epilepsy with ragged-red fibers. (nih.gov)
- Benign adult familial myoclonus epilepsy (BAFME): an autosomal dominant form not linked to the dentatorubral pallidoluysian atrophy (DRPLA) gene. (bmj.com)
- The genetic differences between two types of dominant inherited myoclonus epilepsy, dentatorubral pallidoluysian atrophy (DRPLA) and benign adult familial myoclonus epilepsy (BAFME), have been reported. (bmj.com)
- OBJECTIVES: Early onset ataxia (EOA) concerns a heterogeneous disease group, often presenting with other comorbid phenotypes such as myoclonus and epilepsy. (lu.se)
- The aim of this study is to investigate the key pathological mechanisms in EOA with myoclonus and/or epilepsy. (lu.se)
- EOA phenotypes with comorbid myoclonus and myoclonus/epilepsy were specifically associated with abnormalities in the cerebello-thalamo-cortical network. (lu.se)
- EOA, myoclonus and epilepsy genes shared enriched pathways involved in neurotransmission and neurodevelopment both in the in silico and clinical genes. (lu.se)
- EOA gene subgroups with myoclonus and epilepsy showed specific enrichment for lysosomal and lipid processes. (lu.se)
- Mutations in EOA, epilepsy and myoclonus associated genes can all cause heterogeneous ataxia phenotypes, which supports exome sequencing with a movement disorder panel over conventional single gene panel testing in the clinical setting. (lu.se)
- [Genton and Guerrini, 1990] Genton P., Guerrini R. Antimyoclonic effects of alcohol in progressive myoclonus epilepsy. (jle.com)
- Minassian B.A., Striano P., Avanzini G. Progressive myoclonus epilepsy: the gene-empowered era. (jle.com)
- [Pranzatelli and Tate, 2001] Pranzatelli M.R., Tate E.D. Chloral hydrate for progressive myoclonus epilepsy: a new look at an old drug. (jle.com)
- Cortical myoclonus is associated with cerebral cortex damage or epilepsy. (msdmanuals.com)
- 2013). Most of the traditional medications used to treat myoclonus are also used to treat epilepsy, which suggests that cannabis, already demonstrating effective for epilepsy, may also prove beneficial for myoclonus. (qualifyingconditions.com)
- Epileptic myoclonus is the presence of myoclonus in people living with epilepsy. (medlink.com)
- Myoclonus can occur as the only seizure manifestation, as one component of a seizure, or one of multiple types of seizures within an epilepsy syndrome. (medlink.com)
- Gly144Trp) was reported as a novel cause of Progressive Myoclonus Epilepsy (PME) with early-onset ataxia. (rug.nl)
- abstract = "Myoclonus is a possible manifestation of mitochondrial disorders, and its presence is considered, in association with epilepsy and the ragged red fibers, pivotal for the syndromic diagnosis of MERRF (myoclonic epilepsy with ragged red fibers). (unicatt.it)
- Finally, myoclonus is not inextricably linked to epilepsy in MERRF patients, but more to cerebellar ataxia. (unicatt.it)
- Finally, this study reinforces the notion that myoclonus is not inextricably linked to epilepsy in MERRF patients, and therefore the term {"}myoclonic epilepsy{"} seems inadequate and potentially misleading. (unicatt.it)
Types of myoclonus4
- [ 6 ] Although some types of myoclonus are relatively well understood from a physiologic basis, the underlying etiology of benign neonatal sleep myoclonus remains unknown. (medscape.com)
- Propriospinal myoclonus is characterized by slowly propagated movements that spare the face, often with a burst duration incompatible with other types of myoclonus. (msdmanuals.com)
- The types of myoclonus can be classified as physiological, essential, epileptic, or symptomatic (secondary). (qualifyingconditions.com)
- Types of myoclonus. (medlink.com)
Reflex myoclonus3
- Cortical reflex myoclonus can be intensified when patients attempt to move in a certain way or perceive a particular sensation. (wikipedia.org)
- Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus. (bmj.com)
- Cortical reflex myoclonus originates in the cerebral cortex (the outer layer of the brain that is largely responsible for information processing). (medlink.com)
Dystonia3
- A second group of PME diseases belonging to the class of cerebral storage diseases usually involves myoclonus, visual problems, dementia, and dystonia (sustained muscle contractions that cause twisting movements or abnormal postures). (wikipedia.org)
- OBJECTIVE: Myoclonus-dystonia (M-D) is a hyperkinetic movement disorder, typically alcohol-responsive upper body myoclonus and dystonia. (cardiff.ac.uk)
- In some families there is an association of essential myoclonus with essential tremor or a form of dystonia (myoclonus-dystonia). (medlink.com)
Type of myoclonus3
- In this type of myoclonus, jerks usually involve only a few muscles in one part of the body, but jerks involving many muscles may occur. (wikipedia.org)
- This type of myoclonus can severely impair speech and gait. (msdmanuals.com)
- It's apparent on MBSS when someone has this type of myoclonus because they have repetitive and rhythmic movements of the pharynx and palate. (patheoushealth.com)
History of progressive myoclonus epilepsies1
Neurology1
- "Myoclonus After 5 Hydroxytryptophan In Rats With Lesions Of Indoleamine Neurons In The Central Nervous System" Neurology . (erowid.org)
Seizures7
- These myoclonic twitches, jerks, or seizures are usually caused by sudden muscle contractions (positive myoclonus) or brief lapses of contraction (negative myoclonus). (wikipedia.org)
- Lafora disease is characterized by myoclonus, epileptic seizures, and dementia (progressive loss of memory and other intellectual functions). (wikipedia.org)
- Severe seizures or myoclonus can be life-threatening. (medlineplus.gov)
- Pathologic myoclonus in the newborn is typically associated with manifestations of encephalopathy, seizures, or both. (medscape.com)
- RESULTS: The core clinical features of NSPME are early-onset ataxia, myoclonus and seizures, with additionally areflexia and scoliosis. (rug.nl)
- In addition, we conducted an interview focused on factors influencing myoclonus severity.RESULTS: The core clinical features of NSPME are early-onset ataxia, myoclonus and seizures, with additionally areflexia and scoliosis. (rug.nl)
- But I also have myoclonus, which in my case is uncontrollable movements that can look like full body seizures, or involve just my limbs, sometimes with mild movements like trembles, sometimes severe movements like I'm being thrown about. (livingwithfibro.org)
Opsoclonus-myoclonus19
- A retrospective data collection was performed on 29 children diagnosed with neuroblastoma and opsoclonus-myoclonus between 1983-1993 from Pediatric Oncology Group institutions. (nih.gov)
- The aim was to describe neurologic outcome in children with neuroblastoma and opsoclonus-myoclonus. (nih.gov)
- The duration of opsoclonus-myoclonus symptoms prior to the diagnosis of neuroblastoma ranged from 6 days to 17 months (median duration, 6 weeks). (nih.gov)
- Treatment for opsoclonus-myoclonus ranged varied. (nih.gov)
- Six children received no treatment for opsoclonus-myoclonus. (nih.gov)
- Eighteen of 29 children (62%) had resolution of opsoclonus-myoclonus symptoms. (nih.gov)
- Of the 9 children who had complete recovery of opsoclonus-myoclonus without neurologic sequelae, age at diagnosis and duration of symptoms were not different from the entire group. (nih.gov)
- In conclusion, persistent neurologic deficits are characteristic for children with neuroblastoma and opsoclonus-myoclonus. (nih.gov)
- Opsoclonus myoclonus may occur in association with tumors or viral infections. (vaccineinjuryhelpcenter.com)
- Vaccines are linked to Opsoclonus-Myoclonus Syndrome. (vaccineinjuryhelpcenter.com)
- Opsoclonus-myoclonus syndrome is a combination of involuntary, arrhythmic, conjugate saccadic eye movements with myoclonus. (bmj.com)
- After 2 days, he developed opsoclonus-myoclonus, and then bronchorrhoea and bradycardia, raising suspicion of organophosphate poisoning. (bmj.com)
- Opsoclonus- myoclonus syndrome is also called OMS or dancing eyes-dancing feet syndrome. (osmosis.org)
- Opsoclonus- myoclonus syndrome (OMS) is a rare condition, characterized by rapid, uncontrolled eye movements (opsoclonus) and sudden twitching or jerking of muscles (myoclonus). (osmosis.org)
- The opsoclonus, myoclonus, and ataxia disappeared without treatment. (org.sa)
- However, 6 weeks later she presented again with classic opsoclonus-myoclonus syndrome. (org.sa)
- This case illustrates that transient opsoclonus-myoclonus may occur with neuroblastoma and should not be assumed to be due to viral cause. (org.sa)
- Thus, a thorough search for occult neuroblastoma should be initiated even if opsoclonus-myoclonus resolves spontaneously. (org.sa)
- Acute cerebellar ataxia, acute cerebellitis, and opsoclonus- myoclonus syndrome. (bvsalud.org)
Epileptic3
- It's not uncommon for multiple sclerosis, Parkinson's disease, Alzheimer's disease, or epileptic patients to develop myoclonus. (qualifyingconditions.com)
- Epileptic myoclonus occurs in association with an epileptic disorder. (qualifyingconditions.com)
- The article presents the main definitions, classification, and electroclinical characteristics of epileptic myoclonus. (epilepsia.su)
Tremor4
- This Modified Monday features palato-pharyngo-laryngeal myoclonus (a diagnosis related to palatal tremor, but even less prevalent). (patheoushealth.com)
- An apparent increase in the number of persons with tremor, myoclonus, and parkinsonism between 4 mo and 1 y is reflective of detection of these movement disorders in persons who were initially flaccid/immobile, nonambulatory, or too functionally impaired to assess. (cdc.gov)
- Our purpose was to: (1) characterize the tremor patterns, (2) characterize the myoclonus physiology, (3) determine whether electrophysiology can detect abnormalities in asymptomatic cases. (elsevierpure.com)
- Caviness, JN , Tsuboi, Y & Wszolek, ZK 2003, ' Clinical-electrophysiological correlation of tremor and myoclonus in a kindred with the N279K tau mutation ', Parkinsonism and Related Disorders , vol. 9, no. 3, pp. 151-157. (elsevierpure.com)
Ataxia4
- Methods: We describe an Italian family in which three sisters were affected by ataxia with postural/intentional myoclonus and involuntary movements at onset, which persisted during the disease. (uni-koeln.de)
- Don't fight Myoclonus cerebellar ataxia deafness alone. (rareguru.com)
- Connect with other caregivers and patients with Myoclonus cerebellar ataxia deafness and get the support you need. (rareguru.com)
- This syndrome is characterised by the association of myoclonus, cerebellar ataxia and sensorineural hearing loss. (rareguru.com)
Occur2
- Physiologic myoclonus may occur when a person is falling asleep and during early sleep phases (called hypnic myoclonus). (msdmanuals.com)
- Myoclonus refers to involuntary rapid, jerking movements that suddenly occur without preemptive notice. (broadviewhealthcentre.com)
Symptoms7
- CJD symptoms include dementia, myoclonus, and other central nervous. (msdmanuals.com)
- Essential myoclonus occurs on its own, unrelated to an underlying illness and typically without other symptoms. (qualifyingconditions.com)
- In the cases where the underlying condition can be fixed, such as changing the medication that causes jerking, myoclonus symptoms can be eliminated. (qualifyingconditions.com)
- However, most underlying causes cannot be cured or eliminated, so treatment efforts focus on easing myoclonus symptoms with anticonvulsant or tranquilizer medications. (qualifyingconditions.com)
- The diagnosis of OMS is also often based on symptoms like opsoclonus and myoclonus which can appear abruptly, progressing over days to weeks. (osmosis.org)
- While we don't want to encourage self-diagnosis, the above signs and symptoms can help make sense of what you are experiencing with a myoclonus. (broadviewhealthcentre.com)
- If you are experience myoclonus symptoms that are regularly occurring and for extended durations, it's a good idea to see a professional to make a proper diagnosis and potential treatment plan - it's important to diagnose properly as there are several movement disorders with similar symptoms. (broadviewhealthcentre.com)
Jerks4
- Eventually, the tremors worsen to become myoclonic jerks, which can be triggered by voluntary movements or the intention to move (action myoclonus). (medlineplus.gov)
- Myoclonus describes lightening-like limb movements or limb jerks, that can also be more tremulous. (osmosis.org)
- Myoclonus is more commonly defined as muscle jerks (contraction of groups of muscles) and it is a clinical sign and not the disease itself. (broadviewhealthcentre.com)
- OBJECTIVE: Propriospinal myoclonus (PSM) is a rare disorder with repetitive, usually flexor arrhythmic brief jerks of the trunk, hips, and knees in a fixed pattern. (ox.ac.uk)
Pathologic2
- Other causes of pathologic myoclonus include degenerative disorders affecting the basal ganglia and some dementias. (msdmanuals.com)
- Pathologic myoclonus may involve persistent, shock-like contractions in a group of muscles and is more widespread in general. (medlink.com)
Hypnic myoclonus2
- Hypnic myoclonus can be focal, multifocal, segmental, or generalized (see below) and may resemble a startle reaction. (msdmanuals.com)
- Sleep myoclonus (also known as hypnic myoclonus) occurs during sleep and sleep transitions, often as one is drifting off to sleep. (medlink.com)
Action myoclonus2
- Action myoclonus is triggered by voluntary movement or even the intention to move. (medlink.com)
- It becomes more intense when a person attempts to move in a certain way (action myoclonus) or perceives a particular sensation. (medlink.com)
Cortical myoclonus3
- Its effects are similar to those of cortical myoclonus. (msdmanuals.com)
- Cortical myoclonus: an insight into the organization of normal movement in man. (ox.ac.uk)
- The study of cortical myoclonus affords an insight into both the spatiotemporal organization of the human sensorimotor cortex and the nature of descending motor signals. (ox.ac.uk)
Diagnose myoclonus2
- This descriptive wording can be used on SLP reports since we cannot diagnose myoclonus. (patheoushealth.com)
- At Broadview Spine & Health Centre in Ottawa, we have the expertise and experience to correctly diagnose myoclonus and help in developing a treatment. (broadviewhealthcentre.com)
Movements1
- Myoclonus is characterized by quick, shock-like jerking movements. (healthline.com)
Physiologic2
- Another type of physiologic myoclonus is hiccuping (diaphragmatic myoclonus). (msdmanuals.com)
- Physiologic myoclonus involves quick muscle twitches followed by relaxation. (medlink.com)
Sudden3
- Myoclonus is the sudden involuntary contraction or relaxation of a muscle or group of muscles. (luriechildrens.org)
- Myoclonus is a symptom characterized by a sudden, involuntary muscle jerk. (qualifyingconditions.com)
- Myoclonus refers to sudden, brief involuntary twitching or jerking of a muscle or group of muscles. (medlink.com)
Contraction1
- Myoclonus is a brief, shocklike contraction of a muscle or group of muscles. (msdmanuals.com)
Palatal3
- Palatal myoclonus--its remote influence. (bmj.com)
- It has to be distinguished from other conditions such as palatal myoclonus or typewriter tinnitus, as well as eustachian tube disorders. (topdoctors.co.uk)
- Palatal myoclonus is a neurological condition that can cause a clicking sound in the ears, and is often present all the time, instead of coming and going. (topdoctors.co.uk)
Reticular1
Cerebellar1
- The patient in this Modified Monday had palato-pharyngo-laryngeal myoclonus which occurred after a cerebellar stroke 10 years ago. (patheoushealth.com)
Myoclonic1
- In a myoclonic patient, evidences of mitochondrial dysfunction must be investigated, even though myoclonus is not a common sign of mitochondriopathy. (unicatt.it)
Spinal6
- Anatomically, myoclonus may originate from lesions of the cortex, subcortex or spinal cord. (wikipedia.org)
- Myoclonus is not a disease but a sign of several diseases or conditions that affect the brain or spinal cord. (luriechildrens.org)
- Segmental myoclonus includes spinal segmental and propriospinal myoclonus. (msdmanuals.com)
- Spinal segmental myoclonus refers to myoclonus in spinal muscles of one or several contiguous segments of the spinal cord. (msdmanuals.com)
- The most common form of myoclonus is symptomatic, which occurs as a result of some underlying condition, such as a neurological disorder, a reaction to a medication, prolonged oxygen deprivation, kidney or liver failure, infection, head or spinal cord injury, or a metabolic condition. (qualifyingconditions.com)
- Surgery may be necessary when myoclonus is caused by a tumor or lesion on the brain or spinal cord. (qualifyingconditions.com)
Benign2
- A retrospective study (1996-2011) of 15 consecutive Japanese infants with benign neonatal sleep myoclonus, including 3 paired familial cases, suggests there may be an association with migraine. (medscape.com)
- [ 17 ] However, benign neonatal sleep myoclonus is generally reported in otherwise healthy newborns without signs of neurologic compromise. (medscape.com)
Propriospinal1
- Propriospinal myoclonus: clinical reappraisal and review of literature. (ox.ac.uk)
Muscles2
- Myoclonus is a brief, involuntary, irregular (lacking rhythm) twitching of a muscle, a joint, or a group of muscles, different from clonus, which is rhythmic or regular. (wikipedia.org)
- In some cases, myoclonus can cause a person to experience persistent, shock-like contractions in a group of muscles. (qualifyingconditions.com)
Typically1
- Myoclonus is typically treated with barbiturates, which slow down the action of the central nervous system. (luriechildrens.org)
Occurs3
- Botox injections can be helpful in treating myoclonus when it occurs in a single area. (qualifyingconditions.com)
- Essential myoclonus occurs on its own and is not influenced by abnormalities in the brain or nerves. (medlink.com)
- It is almost always not severe enough that it needs medical attention, however, if the myoclonus is ongoing and frequently occurs, then is might be of some concern. (broadviewhealthcentre.com)
Syndrome1
Physiological1
- Healthy individuals experience physiological myoclonus, such as hiccups or jerking suddenly just before falling asleep, and do not need to be treated. (qualifyingconditions.com)
Clinical4
- Myoclonus is not a disease itself, rather it describes a clinical sign. (medlink.com)
- The aims of this study are the evaluation of the prevalence of myoclonus in a big cohort of mitochondrial patients and the clinical characterization of these subjects. (unicatt.it)
- Based on the database of the {"}Nation-wide Italian Collaborative Network of Mitochondrial Diseases,{"} we reviewed the clinical and molecular data of mitochondrial patients with myoclonus among their clinical features. (unicatt.it)
- Myoclonus is a rather uncommon clinical feature of mitochondrial diseases (3.6% of 1,086 patients registered in our database). (unicatt.it)
Rigidity1
- Progressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies. (ox.ac.uk)
Disorders3
- Subcortical myoclonus is associated with disorders that affect the basal ganglia or other subcortical structures. (msdmanuals.com)
- According to the National Institute of Neurological Disorders and Stroke, most myoclonus is caused by a disturbance of the central nervous system. (qualifyingconditions.com)
- Two subjects had similar movement disorders characterized by myoclonus. (cdc.gov)
Gene1
- Because the same genotype was described in six cases from a Tunisian family with a typical AOA2 without myoclonus, we speculate this latter feature is associated with a second mutated gene, namely AFG3L2 (p.Gly116Arg variant). (uni-koeln.de)
Symptom1
- While some people may not be troubled by this or need treatment, others may require treatment where myoclonus may be a symptom of a more complex and disturbing sleep disorder. (medlink.com)
Secondary3
- We performed a chart review of 3 patients with myoclonus secondary to ciprofloxacin and reviewed the literature for similar cases. (bvsalud.org)
- We describe 3 cases of myoclonus secondary to ciprofloxacin , 2 males and a female aged 61, 26, and 48 years, respectively. (bvsalud.org)
- Although ciprofloxacin is widely prescribed for different infections , only 13 cases were reported to develop myoclonus secondary to ciprofloxacin . (bvsalud.org)
Progressive1
- The history of the progressive myoclonus epilepsies (PMEs) spans more than a century. (elsevierpure.com)
Essential2
- Essential myoclonus tends to be stable without increasing in severity over time. (wikipedia.org)
- In addition, palate-pharyngo-laryngeal myoclonus can have no known cause as well (essential tremors). (patheoushealth.com)
Spontaneous1
Hiccups1
- A common example of myoclonus is experiencing hiccups - and with all forms of myoclonus, the twitching cannot be stopped or controlled. (broadviewhealthcentre.com)