Cause of reye syndrome. Medical search. Frequent questions

Reye (or Reye's) syndrome most often affects kids 4 to 14 years old. (kidshealth.org)
Reye's syndrome primarily affects children and teenagers. (faqs.org)
Reye's syndrome is a rare disorder. (faqs.org)
The number of cases of Reye's syndrome rose slowly until 1980. (faqs.org)
Researchers had learned at that point that children who are given aspirin are at risk for Reye's syndrome. (faqs.org)
As a result of those warnings, the number of cases of Reye's syndrome began to fall. (faqs.org)
Reye's syndrome is sometimes confused with other nervous-system disorders. (faqs.org)
The reason for this confusion is that many doctors have never seen a case of Reye's syndrome. (faqs.org)
The actual number of cases of Reye's syndrome may therefore be somewhat higher than the official total. (faqs.org)
Reye's syndrome is a childhood disease that often occurs after chickenpox or the flu and seems to be related to taking aspirin. (webmd.com)
If caught early, children with Reye's syndrome can make a full recovery. (webmd.com)
To prevent Reye's syndrome, never give aspirin to a child unless directed to do so by a doctor. (webmd.com)
Follow the links below to find WebMD's comprehensive coverage about how Reye's syndrome is contracted, what it looks like, how to treat it, and much more. (webmd.com)
CASE REPORT: Reye's Syndrome in a 17-Year-Old Male: Is This Disease Really Disappearing? (springer.com)
Partin JC: Reye's syndrome. (springer.com)
Larsen SU: Reye's syndrome. (springer.com)
Belay ED, Bresee JS, Holman RC, Khan AS, Shahriari A, Schonberger LB: Reye's syndrome in the United States from 1981 through 1997. (springer.com)
Latham PS: Reye's syndrome: Are adults big children? (springer.com)
Meythaler JM, Varma RR: Reye's syndrome in adults. (springer.com)
Peters LJ, Wiener GJ, Gilliam J, Noord GV, Geisinger KR, Roach ES: Reye's syndrome in adults: A case report and review of the literature. (springer.com)
Chang CH, Uchawat F, Massalskis F, Arcinue E: Morphologic grading of hepatic mitochondrial alteration in Reye's syndrome: Potential prognostic implication. (springer.com)
Reye's syndrome is a rare disease that affects many children every year. (firstcry.com)
What is Reye's Syndrome? (firstcry.com)
Reye's syndrome is a rare but severe illness that can lead to brain swelling and damage to the liver and organs. (firstcry.com)
Reye's syndrome is often signalled by the sudden onset of symptoms and is most common in children between the ages of 4 and 12. (firstcry.com)
While it is not known precisely what brings about Reye's syndrome, its causes are frequently debated. (firstcry.com)
Usually, Reye's syndrome will begin when the blood sugar level of a child drops at the same time that the levels of ammonia and acidity in the blood rise. (firstcry.com)
Early diagnosis of Reye's syndrome is important to save the life of the child. (firstcry.com)
Early treatment is necessary to treat Reye's syndrome because of the sudden onset nature of its symptoms. (firstcry.com)
Glasgow JF, Middleton B, Moore R, Gray A, Hill J. The mechanism of inhibition of beta-oxidation by aspirin metabolites in skin fibroblasts from Reye's syndrome patients and controls. (medscape.com)
Reye's syndrome most often affects children and teenagers recovering from a viral infection, most commonly the flu or chickenpox. (npsk.org)
Early diagnosis and treatment of Reye's syndrome can save a child's life. (npsk.org)
Aspirin has been linked with Reye's syndrome, so use caution when giving aspirin to children or teenagers. (npsk.org)
In Reye's syndrome, a child's blood sugar level typically drops while the levels of ammonia and acidity in his or her blood rise. (npsk.org)
The signs and symptoms of Reye's syndrome typically appear about three to five days after the onset of a viral infection, such as the flu (influenza) or chickenpox, or an upper respiratory infection, such as a cold. (npsk.org)
If you suspect that your child has Reye's syndrome, it's important to act quickly. (npsk.org)
The exact cause of Reye's syndrome is unknown, although several factors may play a role in its development. (npsk.org)
Reye's syndrome seems to be triggered by using aspirin to treat a viral illness or infection - particularly flu (influenza) and chickenpox - in children and teenagers who have an underlying fatty acid oxidation disorder. (npsk.org)
In some cases, Reye's syndrome may be an underlying metabolic condition that's unmasked by a viral illness. (npsk.org)
Exposure to certain toxins - such as insecticides, herbicides and paint thinner - also may contribute to Reye's syndrome. (npsk.org)
Most children and teenagers who have Reye's syndrome survive, although varying degrees of permanent brain damage are possible. (npsk.org)
Without proper diagnosis and treatment, Reye's syndrome can be fatal within a few days. (npsk.org)
Reye's syndrome is often diagnosed in an emergency situation because of serious signs and symptoms, such as seizures or loss of consciousness. (npsk.org)
When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. (nih.gov)
Reye's Syndrome is a rare but serious condition, especially in children and young people. (vimfay.com)
In this article, we will discuss what Reye's Syndrome is, symptoms, causes and treatment methods. (vimfay.com)
Reye's syndrome can progress rapidly and, if not treated in time, can lead to permanent brain damage and even death. (vimfay.com)
Symptoms of Reye's Syndrome may resemble viral infections such as influenza or chickenpox in the initial stage of the disease. (vimfay.com)
The treatment of Reye's syndrome may vary depending on the severity of the disease and the intensity of the symptoms. (vimfay.com)
Reye's Syndrome causes sudden and severe deterioration in brain and liver function. (vimfay.com)
The diagnosis of Reye's Syndrome is made by excluding other possible conditions and the combination of the above-mentioned findings. (vimfay.com)
Reye's Syndrome can lead to serious complications, especially if not diagnosed and treated quickly. (vimfay.com)
Early diagnosis and effective treatment of Reye's syndrome plays an important role in preventing these complications. (vimfay.com)
A 2022 article notes an association between taking aspirin and the development of Reye's syndrome , which can be fatal. (medicalnewstoday.com)
Children and teenagers should not use this medicine for chicken pox or flu symptoms before a doctor is consulted about Reye's syndrome, a rare but serious illness reported to be associated with aspirin. (rxlist.com)
It can cause Reye's syndrome. (familydoctor.org)
Reye's syndrome or other encephalopathy. (drugs.com)
The use of prochlorperazine and other potential hepatotoxins should be avoided in children and adolescents whose signs and symptoms suggest Reye's syndrome. (drugs.com)
While rare, aspirin use in children or adolescents with viral infections can lead to Reye's syndrome. (wowio.com)
Never give aspirin to children because it can cause Reye's syndrome. (cdc.gov)
If you have Reye's syndrome. (aarppharmacy.com)
Examples include mesothelioma (environmental asbestos), aplastic anemia ( benzene ), bronchiolitis obliterans (artificial butter flavorings), Reye's syndrome (aspirin in children), and angiosarcoma of the liver (vinyl chloride). (cdc.gov)

The serious symptoms of Reye syndrome appear to result from damage to cellular mitochondria, at least in the liver, and there are a number of ways that aspirin could cause or exacerbate mitochondrial damage. (wikipedia.org)
Causes for similar symptoms include[citation needed] Various inborn metabolic disorders Viral encephalitis Drug overdose or poisoning Head trauma Liver failure due to other causes Meningitis Kidney failure Shaken baby syndrome Treatment is supportive. (wikipedia.org)
What Are the Signs & Symptoms Reye Syndrome? (kidshealth.org)
The signs and symptoms of Reye syndrome almost always follow the start of a viral illness, such as an upper respiratory tract infection ( a cold , the flu, etc.), a diarrheal illness, or chickenpox. (kidshealth.org)
Of course, many kids with viruses will have some of these symptoms, and most will not have Reye syndrome. (kidshealth.org)
The following are the most common symptoms of Reye syndrome. (childrenshospital.org)
Your child may have had a viral illness, such as a respiratory infection , chickenpox , or diarrhea before experiencing symptoms of Reye syndrome. (childrenshospital.org)
The diagnosis of Reye syndrome is made after the sudden onset of specific symptoms and after diagnostic testing. (childrenshospital.org)
The syndrome begins with the symptoms of a viral infection, such as an upper respiratory tract infection, influenza, or sometimes chickenpox. (msdmanuals.com)
The biochemical explanation for Reye-like symptoms is a generalized disturbance in mitochondrial metabolism, eventually resulting in metabolic failure in the liver and other tissues. (qxmd.com)
Thus, several infections and diseases might present clinically with Reye-like symptoms. (qxmd.com)
[ 2 ] Some have postulated that salicylates stimulate the expression of inducible nitric oxide synthase (iNOS) because of the findings of iNOS stimulation in African children with fatal malaria, a disease that causes symptoms similar to those of Reye syndrome and is often treated with aspirin. (medscape.com)
What is Reye Syndrome, What are the Symptoms and Treatment Methods? (vimfay.com)
The diagnosis of this syndrome is based on the patient's symptoms, clinical findings and some laboratory tests. (vimfay.com)
There is no specific treatment for Reye Syndrome, so treatment focuses on managing symptoms and preventing complications. (vimfay.com)
Antidepressants such as paroxetine should be tapered rather than stopped abruptly, to reduce the risk of developing a discontinuation syndrome and to allow time to assess the possible re-emergence of depressive symptoms. (bpac.org.nz)

There have been no cases of Reye syndrome following its use, and the measure is a precaution. (wikipedia.org)
Documented cases of Reye syndrome in adults are rare. (wikipedia.org)

Early diagnosis of the syndrome improves outcomes. (wikipedia.org)
The diagnosis of Reye syndrome greatly decreased in the 1980s, when genetic testing for inborn errors of metabolism was becoming available in industrialized countries. (wikipedia.org)
The outlook for children with Reye syndrome has improved thanks to earlier diagnosis and better treatment. (kidshealth.org)
But it's best to be sure because early diagnosis is the key to successful treatment of Reye syndrome. (kidshealth.org)
A dramatic decrease in the use of aspirin among children, in combination with the identification of medication reactions, toxins, and inborn errors of metabolism (IEMs) that present with Reye syndrome-like manifestations, have made the diagnosis of Reye syndrome exceedingly rare. (medscape.com)
With the recognition that Reye syndrome is rare, this condition should be considered in the differential diagnosis in any child with vomiting and altered mental status and classic laboratory findings. (medscape.com)
Given that manifestations of Reye syndrome are not unique to Reye syndrome but also are seen in a growing list of conditions, and given that no test is specific for Reye syndrome, the diagnosis must be one of exclusion. (medscape.com)
Having information about Reye Syndrome can positively affect the course of the disease with early diagnosis and correct treatment methods. (vimfay.com)
With early diagnosis and correct treatment methods, complete recovery from Reye Syndrome can be achieved. (vimfay.com)
Laboratory tests play an important role in the diagnosis of Reye Syndrome. (vimfay.com)

Reye Syndrome 1990 Clinical Case Definition. (medscape.com)

While liver toxicity typically occurs in the syndrome, jaundice usually does not. (wikipedia.org)
Often, the liver is enlarged in the syndrome. (wikipedia.org)
The recovery of adults with the syndrome is generally complete, with liver and brain function returning to normal within two weeks of onset. (wikipedia.org)
Reye syndrome is characterized by sudden (acute) brain damage and liver function problems. (medlineplus.gov)
Reye syndrome is a rare but serious illness that can affect the brain and liver. (kidshealth.org)
Reye syndrome is characterized by acute noninflammatory encephalopathy and fatty degenerative liver failure. (medscape.com)
Reye syndrome is a rare condition that affects the normal chemical balance in the body, resulting in potential damage to all organs, but primarily the brain and liver. (childrenshospital.org)
Reye syndrome is a very rare but life-threatening disorder that causes inflammation and swelling of the brain and impairment and loss of function of the liver. (msdmanuals.com)
Reye's (Ryes) syndrome is a rare but serious condition that causes swelling in the liver and brain. (npsk.org)
This syndrome can cause deterioration in brain and liver function and can be life-threatening. (vimfay.com)
Reye Syndrome is a disease that usually occurs after viral infections, causing inflammation and swelling in the brain and liver. (vimfay.com)
The condition most commonly associated with fatty liver disease is metabolic syndrome. (medscape.com)
There may be a concomitant acute viral hepatitis, drug induced liver injury, Budd-Chiari syndrome or other chronic liver diseases. (bvsalud.org)

Even though it's rare, Reye syndrome should be considered if a child is vomiting a lot or shows a change in mental status or behavior, particularly after a recent viral illness. (kidshealth.org)
Reye syndrome typically occurs after a viral illness, particularly an upper respiratory tract infection, influenza , varicella , or gastroenteritis , and is associated with the use of aspirin during the illness. (medscape.com)
Studies show there is an association between the ingestion of products containing aspirin in children who have a viral illness and Reye syndrome. (childrenshospital.org)
While the exact links between Reye and aspirin are still debated, nearly all doctors will recommend not giving aspirin to children who have recently gone through a viral illness. (firstcry.com)
It has been linked to Reye syndrome, a serious illness. (healthlinkbc.ca)

As a result, the Centers for Disease Control and Prevention (CDC) and the American Academy of Pediatrics (AAP) have released warnings about the relationship between aspirin and Reye syndrome. (childrenshospital.org)
The suggestion of a defined cause-effect relationship between aspirin intake and Reye syndrome in children is not supported by sufficient facts. (qxmd.com)

This syndrome has occurred in children who were given aspirin when they had chickenpox or the flu. (medlineplus.gov)

The general recommendation to use aspirin in children was withdrawn because of Reye syndrome, with use only recommended in Kawasaki disease. (wikipedia.org)

When aspirin was withdrawn for use in children in the US and UK in the 1980s, a decrease of more than 90% in rates of Reye syndrome was seen. (wikipedia.org)
The syndrome most commonly affects children. (wikipedia.org)
A potential increased risk of developing Reye syndrome is one of the main reasons that aspirin has not been recommended for use in children and teenagers, the age group for which the risk of lasting serious effects is highest. (wikipedia.org)
citation needed] Reye syndrome occurs almost exclusively in children. (wikipedia.org)
Children with Reye syndrome get sick very suddenly. (medlineplus.gov)
Children with Reye syndrome are usually treated in a hospital. (kidshealth.org)
All children with manifestations suggestive of Reye syndrome should be tested for IEM. (medscape.com)
Less than 0.1% of children who took aspirin developed Reye syndrome, but more than 80% of patients diagnosed with Reye syndrome had taken aspirin in the past 3 weeks. (medscape.com)
[ 9 ] but recommendations by government health agencies that children not be treated with salicylates led to an immediate and dramatic decrease in the incidence of Reye syndrome. (medscape.com)
Reye syndrome usually affects children between the ages of 4 and 12, and is most common at age 6. (childrenshospital.org)
Now that aspirin use has declined and chickenpox is less common because of vaccination, only about 2 children a year in the United States develop Reye syndrome. (msdmanuals.com)
The syndrome occurs mainly in children younger than 18. (msdmanuals.com)
Doctors suspect Reye syndrome in children who suddenly develop changes in mental condition and vomiting. (msdmanuals.com)
Furthermore, in vitro studies have demonstrated that salicylates decrease beta-oxidation of the long-chain fatty acid palmitate by cultured fibroblasts from children who recovered from Reye syndrome as compared with control subjects. (medscape.com)

The pathogenesis of Reye syndrome, while not precisely elucidated, appears to involve mitochondrial injury resulting in dysfunction that disrupts oxidative phosphorylation and fatty-acid beta-oxidation in a virus-infected, sensitized host potentially with an underlying occult inborn error of fatty acid oxidation, urea cycle or mitochondrial disorder. (medscape.com)
The pathogenesis of Reye syndrome, while not precisely elucidated, appears to involve mitochondrial injury resulting in dysfunction that inhibits oxidative phosphorylation and fatty-acid beta-oxidation in a virus-infected, sensitized host. (medscape.com)

The 'rise and fall' in the incidence of Reye syndrome is still poorly understood and unexplained. (qxmd.com)

Some have suggested the term Reye syndrome or Reye-like syndrome should be used to describe clinical manifestations of diseases states regardless of etiology, while causes still without a known etiology after diagnostic workup should be referred to as Reye disease. (medscape.com)
Clinical staging in Reye syndrome. (medscape.com)

Death occurs in 20-40% of those affected with Reye syndrome, and about a third of those who survive are left with a significant degree of brain damage. (wikipedia.org)

The first detailed description of Reye syndrome was in 1963 by Australian pathologist Douglas Reye. (wikipedia.org)
The syndrome was first described in 1963 in Australia by RDK Reye and described a few months later in the United States by GM Johnson. (medscape.com)

DO NOT give aspirin to treat fever in a child younger than 19 years old because of the risk for Reye syndrome . (adam.com)

What Are The Possible Complications of Reye Syndrome? (vimfay.com)

The etiology of 'classical' Reye syndrome is unknown. (qxmd.com)

A retrospective study of 49 survivors of cases diagnosed as Reye syndrome showed that the majority of the surviving patients had various metabolic disorders, particularly a fatty-acid oxidation disorder medium-chain acyl-CoA dehydrogenase deficiency. (wikipedia.org)
Because it can be a life-threatening disorder, Reye syndrome is a medical emergency . (kidshealth.org)
With a few exceptions, there were probably no new Reye-like diseases reported during the last 10 years that could not be explained by an inherited disorder of metabolism or a misdiagnosis. (qxmd.com)

Conditions that may mimic Reye syndrome include inborn errors of metabolism (IEMs), other hepatic illnesses, neuromuscular diseases, meningitis, encephalitis, obtundation due to intussusception, adverse drug reactions, and toxic exposures to chemicals and plants that cause hepatocellular damage and encephalopathy. (medscape.com)

toxic shock syndrome is an example. (cdc.gov)

How do we diagnose Reye syndrome? (childrenshospital.org)

Early recognition and treatment of Reye and Reye-like syndromes, including presumptive treatment for possible IEM (See Inborn Errors of Metabolism ) is essential to prevent death and optimize the likelihood of recovery without neurologic impairment. (medscape.com)

Reye syndrome has become very rare. (medlineplus.gov)
Reye syndrome is an extremely rare but severe and often fatal disease. (qxmd.com)

Reye syndrome varies greatly in severity. (msdmanuals.com)

Pessoa et al reported the case of a 7-year-old child with multisystemic inflammatory syndrome associated with COVID-19, who was treated with intravenous immunoglobulin and acetylsalicylic acid and subsequently developed Reye syndrome. (medscape.com)

Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. (drugs.com)
This increases their risk for Reye syndrome. (familydoctor.org)
There is some concern that, like aspirin, it might increase the risk of developing Reye syndrome. (medlineplus.gov)
Antiparkinsonian medicines (e.g Levodopa) should not be stopped abruptly as there is a small risk of neuroleptic malignant syndrome. (bpac.org.nz)

Influenza virus types A and B and varicella-zoster virus are the pathogens most commonly associated with Reye syndrome. (medscape.com)
Congenital varicella syndrome, characterized by hypoplasia of an extremity, skin abnormalities, encephalitis, microcephaly, ocular abnormalities, mental retardation, and low birth weight, may occur among 0.4%-2.0% of infants born to women who develop varicella during the first or second trimester of pregnancy. (cdc.gov)

Hypothetically, the syndrome may result from an unusual response to the preceding viral infection, which is determined by host genetic factors but can be modified by a variety of exogenous agents. (qxmd.com)

Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs.Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic drug treatment, which patients are likely to develop the syndrome. (drugs.com)
Discontinuation syndrome appears to occur more frequently with paroxetine and venlafaxine which may partly be due to the shorter half-life of these drugs. (bpac.org.nz)

The key to medically managing Reye syndrome is early detection. (childrenshospital.org)

Reye syndrome is a rapidly worsening brain disease. (wikipedia.org)

What Are the Treatment Methods of Reye Syndrome? (vimfay.com)

Reye's Syndrome62

Symptoms16

Cases of Reye syndrome2

Diagnosis10

19901

Liver13

Illness5

Relationship between aspirin2

Chickenpox or the flu1

Aspirin in children1

Children14

Mitochondrial2

Incidence1

Clinical2

Occurs1

19632

Give aspirin1

Possible complications1

Etiology1

Disorder3

Encephalopathy1

Toxic shock sy1

Diagnose1

Inborn Errors of1

Rare2

Severity1

Acetylsalicylic1

Risk4

Varicella2

Genetic1

Drugs2

Early1

Brain1

Treatment1