• 120ms) is commonly found in trained athletes but care is needed not to miss underlying pathology such as an atrial septal defect, brugada syndrome or arrhythmogenic right ventricular cardiomyopathy (see below) ( 1 ). (escardio.org)
  • Perform echocardiography and/or MRI, primarily to exclude arrhythmogenic right ventricular cardiomyopathy, as well as to assess for other potential causes of arrhythmias. (medscape.com)
  • Structural heart disease, such as ventricular hypertrophy, atrial septal defects (a hole between the upper chambers of the heart), arrhythmogenic right ventricular cardiomyopathy, and others refers to physical abnormalities in the heart structure. (ecgedu.com)
  • A common disease identified in boxers is arrhythmogenic right ventricular cardiomyopathy or ARVC. (pet-cardiology.com)
  • Idiopathic Ventricular Fibrillation of the Brugada Type: An Atypical Form of Arrhythmogenic Right Ventricular Cardiomyopathy? (go.jp)
  • Drugs Prolonging QT Interval and Other Arrhythmogenic Drugs. (nih.gov)
  • Category, drugs that prolong QT interval and other arrhythmogenic drugs. (aerosail.com)
  • The specialized conduction system of the heart is composed of cells that conduct electrical impulses faster than the surrounding myocardium. (medscape.com)
  • It is not clear whether this condition results from pathologically altered ventricular cells or from cells in the specialized conduction system. (britannica.com)
  • Following on last week's article reviewing the general approach to screening for inherited cardiac diseases, see here the disorder-specific approach to screening from detecting conduction and structural disorders through to arrhythmias and channelopathies. (escardio.org)
  • Therefore, avoid the use of Lamictal in people who have cardiac conduction disorders (eg, second- or third-degree heart block), ventricular arrhythmias, or cardiac disease or abnormality (eg, myocardial ischemia, heart failure, structural heart disease, Brugada syndrome, or other sodium channelopathies). (aesnet.org)
  • β-adrenergic receptor blockers increase AV conduction time and increase AV nodal refractoriness, thereby helping to terminate nodal reentrant arrhythmias. (pharmacology2000.com)
  • however, this action may induce ventricular arrhythmias (catecholamines generally are pro-arrhythmogenic). (pharmacology2000.com)
  • Among the many types of cardiac arrhythmias, ventricular tachycardia (VT) represents a potentially fatal arrhythmia in the setting of abnormal anatomical and physiological pathways of the heart. (appliedradiationoncology.com)
  • This arrhythmias may degenerate into ventricular fibrillation which is a fatal abnormal rhythm. (pet-cardiology.com)
  • Millions of people experience irregular or abnormal heartbeats, called arrhythmias, at some point in their lives. (upbeat.org)
  • Warnings and precautions (5.4) Cardiac Rhythm and Conduction Abnormalities: In vitro testing showed that Lamictal exhibits Class IB antiarrhythmic activity at therapeutically relevant concentrations [see Clinical Pharmacology (12.2)] . (aesnet.org)
  • Knowledge of the anatomy and electrophysiology of cardiac conduction system from the atrioventricular (AV) junction to the Purkinje fibers is essential to understanding the pathophysiology of right bundle branch block (RBBB). (medscape.com)
  • The cardiac conduction system develops from rings of specialized tissue found in the embryonic heart tube. (medscape.com)
  • Cardiac arrhythmia is an irregular heartbeat in which the heart beats are too fast (tachycardia), too slow (bradycardia), or in an abnormal rhythm. (holisticly.com)
  • While high levels of overall cardiac sympathetic drive are a negative prognostic indicator of mortality following MI and during heart failure, β-adrenergic receptor stimulation in the infarct border zone reduced spatially heterogeneous alternans, and prevented conduction block and propagation of extrasystoles. (frontiersin.org)
  • 13 However, no preclinical studies to date have examined electrophysiologic and histologic changes in models with aberrant conduction pathways due to intrinsic cardiac disease and, therefore, it is unknown how the latent period and tissue changes may differ from healthy models. (appliedradiationoncology.com)
  • While these studies demonstrated the feasibility of cardiac radioablation to alter electrical conduction, use in humans was limited because the arrhythmogenic pathways in the ventricular muscle needed to be mapped so a treatment volume could be appropriately delineated. (appliedradiationoncology.com)
  • This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. (justia.com)
  • The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. (justia.com)
  • More specifically, it is a circumferential ablation device assembly which is adapted to ablate a selected circumferential region of tissue along a pulmonary vein wall and thereby form a circumferential conduction block against conduction along the longitudinal axis of the pulmonary vein wall. (justia.com)
  • Since other heart disorders increase the risk of developing abnormal heart rhythms, lifestyle changes often are recommended. (upbeat.org)
  • Ectopic foci are abnormal pacemaker sites within the heart (outside of the SA node) that display automaticity. (bookriff.com)
  • Based on this activity, Lamictal (lamotrigine) could slow ventricular conduction (widen QRS) and induce proarrhythmia, including sudden death, in people with structural heart disease or myocardial ischemia. (aesnet.org)
  • Several types of proarrhythmia have been noted: (1) a change or worsening of the current arrhythmia, (2) the development of a new arrhythmia, and (3) the occurrence of a bradyarrhythmia resulting from depression of the sinus node or AV node conduction. (bookriff.com)
  • A type of atrial arrhythmia characterized by atrial rates of between 240 and 400 beats per minute and some degree of atrioventricular node conduction block. (nih.gov)
  • Understanding the mechanisms that underlie normal and abnormal rhythms of the heart at various scales, from the molecular and cellular to the whole organ. (ox.ac.uk)
  • Abnormal heart rhythms come and go so this may not be enough time for your doctor to "catch" the abnormality. (pet-cardiology.com)
  • However, some abnormal heart rhythms can be serious or even deadly. (upbeat.org)
  • Permanent junctional reciprocating tachycardia, more commonly referred to as PJRT, is a rare form of supraventricular tachycardia (SVT), or abnormal fast heartbeats, typically seen in infants and children. (pacesep.org)
  • Structural defects involve abnormal development of the fetal heart walls, valves or the blood vessels that carry blood to and from the heart. (childrenscolorado.org)
  • High-risk patients with cardiovascular or structural heart disease, history concerning for arrhythmia, abnormal electrocardiographic findings, or severe comorbidities should be admitted to the hospital for further evaluation. (aafp.org)
  • Patients with syncope and evidence of congestive heart failure or structural heart disease, abnormal electrocardiographic findings, or a family history of sudden death should be admitted to the hospital for emergent evaluation. (aafp.org)
  • We hypothesize that the border zone is most vulnerable to alternans, that β-adrenergic receptor stimulation can suppresses this, and investigate the consequences in terms of arrhythmogenic mechanisms. (frontiersin.org)
  • In this situation, slowed impulse conduction in the ventricle leads to the generation of ectopic impulses (electrical impulses derived from an area of the heart other than the sinus node) that are primarily the result of temporal dispersion of the impulse between adjacent areas of the ventricle. (britannica.com)
  • Because PVs was known to induce atrial arrhythmia through the enhancement of triggered activity, it is possible that NO may play a critical role in the PV arrhythmogenic activity. (biomedcentral.com)
  • Conduction down the left bundle branch proceeds normally, and the interventricular septum and left ventricle rapidly depolarize in the normal fashion. (medscape.com)
  • Many abnormal medical conditions in humans and other mammals have been associated with disease and other aberrations along the lining or walls which define several different body spaces. (justia.com)
  • Conduction time through AV node is increased while contractility is diminished. (pharmacology2000.com)
  • Bifascicular block or LBBB in young individuals should prompt screening of siblings and consideration of genetic testing to exclude a genetically determined progressive conduction abnormality (e.g. (escardio.org)
  • In order to treat such abnormal wall conditions of the body spaces, medical device technologies adapted for delivering specific forms of ablative energy to specific regions of targeted wall tissue from within the associated body space have been developed and disclosed. (justia.com)
  • However, animal studies have shown that oxidative stress can alter heart tissue resulting in more arrhythmogenic events. (holisticly.com)
  • These shocks may be arrhythmogenic, result in injuries, precipitate WCD discontinuation, and consume medical resources. (bvsalud.org)
  • Atherosclerosis, a vascular disease characterized by abnormal deposits upon vessel walls or thickening thereof, is an example of an abnormal wall condition. (justia.com)
  • Simulations also demonstrated that β-adrenergic receptor stimulation in this specific region reduced the formation of conduction block and the probability of premature ventricular activation propagation. (frontiersin.org)
  • A conduction block of the left branch of the bundle of His. (nih.gov)
  • Electrolyte imbalances can also affect the heart and lead to abnormal ECG patterns. (ecgedu.com)
  • Thus, the right ventricle depolarizes by means of cell-to-cell conduction that spreads from the interventricular septum and left ventricle to the right ventricle. (medscape.com)
  • This study is aimed to study the effects of nitroprusside (NO donor), on the ionic currents and arrhythmogenic activity of single cardiomyocytes from the PVs. (biomedcentral.com)
  • Either gain of function or loss of function in these ion channels, particularly when the abnormal channels are unevenly distributed, fosters abnormal electrophysiological environments. (merckmanuals.com)
  • This mechanism of ablation is fundamentally different from catheter-based approaches, which use radiofrequency energy to cauterize the arrhythmogenic circuit, over the period of days to weeks. (appliedradiationoncology.com)
  • Your veterinarian will then be sent the results if abnormal or at the end of the monitoring period if normal. (pet-cardiology.com)