Cause of acute kidney renal injury ischemia reperfusion. Medical search. Frequent questions

Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. (hindawi.com)
Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
Reduced blood flow, or ischemia, is not the only cause of acute kidney injury. (labiotech.eu)

citation needed] Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)

Several signs and symptoms include injury to the microvascular endothelium, apoptosis of kidney cells due to overstress in the endoplasmic reticulum, dysfunctions of the mitochondria, autophagy, inflammation of the kidneys, and maladaptive repair. (wikipedia.org)
In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
Exogenous administration of CFH after reperfusion caused overt AKI with creatinine increase, tubular injury, and enhanced markers of renal inflammation compared with vehicle-treated animals. (stanford.edu)
Using optical coherence tomography (OCT) we have recently shown that the retina and choroid are thinned in patients with CKD and this thinning relates to the degree of kidney dysfunction as well as inflammation and endothelial dysfunction. (ed.ac.uk)
We further discuss how injuries alter tissue environments and how this primes mononuclear phagocytes to enforce this particular environment, for example, to support host defense and pathogen clearance, to support the resolution of inflammation, to support epithelial and mesenchymal healing, and to support the resolution of fibrosis to the smallest possible scar. (hindawi.com)
Rats treated with high-salt diet (5-9 weeks after I/R) manifested progressive disease indicated by enhanced inflammation, fibrosis, and impaired renal function. (jci.org)
While complete repair of damaged tubules restores full functionality, partial or maladaptive tubule repair leads to the development of chronic kidney problems, such as chronic inflammation and renal fibrosis. (cheapebooks.org)
N-acetylcysteine is known to impair hemostasis when used for the prevention of perioperative inflammation and ischemia-reperfusion injury. (medscape.com)

Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)
A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)

At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
In rat renal tissue, pioglitazone treatment decreased the serum levels of post-renal IRI creatinine and urea nitrogen, as well as necrosis. (frontiersin.org)
After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
WBIRI leads to a significant increase in serum creatinine (SCr) and renal tubular injury by 24 h. (johnshopkins.edu)
[ 1 ] At present, serum creatinine, which is used to measure the glomerular filtration rate (GFR), is the most commonly used marker of renal function. (medscape.com)
In addition, dohongsamul-tang treatment improved renal function-related biomarkers, such as blood creatinine, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin, which were increased by TAC-induced cardiac hypertrophy. (bvsalud.org)
OJS inhibited the increase of blood urea nitrogen (BUN) and serum creatinine (SCr) levels and reduced histological changes in the kidney, like loss of brush borders, renal tubular necrosis, and cast formation. (bvsalud.org)
Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury. (biomedcentral.com)

Rapamycin, however, activated autophagy and protected against cisplatin-induced acute kidney injury. (elsevierpure.com)
Compared with wild-type littermates, these knockout mice were markedly more sensitive to cisplatin-induced acute kidney injury as indicated by renal functional loss, tissue damage, and apoptosis. (elsevierpure.com)

The mice were treated with 45 min unilateral renal ischemia and reperfusion (I/R) to induce an acute renal injury. (oncotarget.com)
Strikingly, after three weeks treatment with rotenone, we found that the unilateral I/R-induced tubular damage, tubulointerstitial fibrosis were all attenuated by rotenone as determined by the tubular injury score, Masson staining, and the levels of collagen-I, collagen-III, fibronectin, PAI-1, and TGF-β. (oncotarget.com)
Intu KO mice and wild-type littermates were subjected to unilateral renal ischemia/reperfusion injury (IRI) or unilateral ureteral obstruction. (cheapebooks.org)
Intu KO mice had less renal fibrosis during unilateral ureteral obstruction. (cheapebooks.org)
These mice developed less renal fibrosis during unilateral ureteral obstruction (UUO). (cheapebooks.org)
The subjects were divided into five groups: (A) Sham, unilateral nephrectomy, no ischemia induced. (biomedcentral.com)

Blood vessels shrink and undergo apoptosis which results in poor blood flow in the kidneys. (wikipedia.org)
Several genetic pathways that lead to apoptosis of kidney cells have been implicated in mice models and in-vitro assays. (wikipedia.org)
This shows that the Fas-pathway may play a role in the pathogenesis of the apoptosis of tubule cells during the early ischemic-reperfusion period. (wikipedia.org)
however, DAXX mediates both Fas-dependent and TGF-beta-induced apoptosis and renal induction of TGF-beta is well documented in renal ischemia studies. (wikipedia.org)
Mechanistically, Intu KO kidneys had less senescence but higher levels of cell proliferation and apoptosis during kidney repair after renal IRI. (cheapebooks.org)
Tanshinone IIA (TIIA) pre-treatment was used to alleviate renal injury induced by renal IR, and whether TIIA can attenuate renal cell apoptosis via modulating mitochondrial function through PI3K/Akt/Bad pathway in obese rats was examined. (aging-us.com)
Results: TIIA alleviated the pathohistological injury and apoptosis induced by IR. (aging-us.com)
Conclusions: Renal mitochondrial dysfunction occurs along with renal IR and can induce renal cell apoptosis. (aging-us.com)
TIIA can attenuate renal cell apoptosis via modulating mitochondrial function through PI3K/Akt/Bad pathway in obese rats. (aging-us.com)

MasR as an antagonist of AT 1 R has renoprotective effect in a number of kidney disorders, including AKI, hypertensive and diabetic nephropathy, glomerulonephritis, and tubulointerstitial fibrosis [ 14 , 15 ]. (hindawi.com)
Therefore, the study was performed to investigate whether DH, traditionally used, has effects on improving and alleviating cardiac injury and fibrosis caused by cardiac hypertrophy. (bvsalud.org)
Ablation of Intu in renal tubules delayed kidney repair and ameliorated renal fibrosis after renal IRI. (cheapebooks.org)
KO of Intu delayed kidney recovery and ameliorated renal fibrosis after ischemia/reperfusion injury (IRI). (cheapebooks.org)

Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and GFR are highlighted. (eurekaselect.com)
On the basis of recent data that T cells are important mediators of isolated renal IRI, WBIRI was evaluated in T cell-deficient nu/nu mice. (johnshopkins.edu)
Our clinical studies are supported by relevant pre-clinical models where we are investigating the roles of these microRNAs as mediators of renal and extra-renal disease. (ed.ac.uk)
Recent studies suggest that the use of antioxidants can provide renal protection, reducing parenchymal lesions and expression of inflammatory mediators, improving renal function, resulting in a better outcome. (biomedcentral.com)

In studies of mice models, a high-fat diet can induce greater injury to the kidney with renal ischemia-reperfusion as compared to mice with normal diet. (wikipedia.org)
Ischemia/ reperfusion was found to affect renal function and induce histopathological alterations. (bvsalud.org)
Grupo I/R + diacereína, inyectado por vía intraperitoneal con 50 mg de diacereína/kg i.m. 30 min antes de la operación I/R. Se encontró que la isquemia/ reperfusión afecta la función renal e induce alteraciones histopatológicas. (bvsalud.org)

Diseases such as sepsis can cause kidney ischemia too. (wikipedia.org)
8. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. (bmj.com)
In addition to ischaemic tissue damage, seen for example in renal failure, stroke or cardiovascular diseases, the mechanism may also play a central role in neurodegenerative diseases and in comorbidities of diabetes mellitus. (sciencedaily.com)
Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Nontransmissible chronic diseases, such as diabetes mellitus (DM) and nephropathy, affect a significant portion of the population, often treated due to injuries that require healing and regeneration. (scielo.br)
ER stress has emerged as a signaling platform underlying the pathogenesis of various kidney diseases. (jci.org)
This review focused on the elucidation of paracrine crosstalk between MSCs and Mφs during musculoskeletal diseases and injury. (frontiersin.org)
Additionally, adverse kidney events are directly linked with T2DM and cardiovascular diseases. (bvsalud.org)
Thanks to the evolving techniques, exRNAs, particularly those detected from urine have gained great interest in renal diseases. (biomedcentral.com)
However, most current studies on exRNA in renal diseases were derived from limited numbers of patients or in vitro data. (biomedcentral.com)
This review will provide insights into the roles of exRNA in pathogenesis, diagnosis and therapy of renal diseases. (biomedcentral.com)
Moreover, the transitivity of exRNA information between cells suggests their functional and probably therapeutic roles in renal diseases. (biomedcentral.com)
In this review, we will overview of the characterization of exRNA, summarize the current cognition about the role of exRNAs in renal diseases and compare the isolation and detection techniques. (biomedcentral.com)
Congratulations to Ying Maggie Chen, MD, PhD, Associate Professor of Medicine in the Division of Nephrology, and co-inventors, Sun-Ji Park, PhD, Yeawon Kim, and Fumihiko Urano on their patent "Compositions and methods for treating and preventing endoplasmic reticulum (ER) stress-mediated kidney diseases" that was issued on September 28, 2021. (wustl.edu)

Progressive AKI leads to acute renal failure (ARF)[ 1 ]. (biomedcentral.com)
The ischemia-reperfusion syndrome commonly seen in different clinical scenarios leads to acute renal failure and it is known that the free oxygen radicals play an important role in the pathophysiology of this injury. (biomedcentral.com)

In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
These data revealed the important role of MasR after partial kidney IR in the responses of RBF and RVR to Ang II administration in 2K1C hypertensive rats. (hindawi.com)
Thus, pioglitazone ameliorates renal IRI by inhibiting the NF-κB signaling pathway and inflammatory response in rats. (frontiersin.org)
In rats, following renal ischemia/reperfusion (I/R), there was a rapid and sustained influx of Orai1+ CD4 T cells and IL-17 expression was restricted to Orai1+ cells. (jci.org)
When kidney CD4+ cells of post-acute kidney injury (post-AKI) rats were stimulated with angiotensin II and elevated Na+ (10-7 M/170 mM) in vitro, there was an enhanced response in intracellular Ca2+ and IL-17 expression, which was blocked by SOCE inhibitors 2APB, YM58483/BTP2, or AnCoA4. (jci.org)
In addition, TIIA improved renal function, inflammatory factor, and balance of oxidation and antioxidation in obese rats after renal IR. (aging-us.com)

We address this question by pharmacologic and genetic blockade of autophagy using mouse models of cisplatin- and ischemia-reperfusion-induced acute kidney injury. (elsevierpure.com)
Chloroquine, a pharmacological inhibitor of autophagy, blocked autophagic flux and enhanced acute kidney injury in both models. (elsevierpure.com)
We also established a renal proximal tubule-specific autophagy-related gene 7-knockout mouse model shown to be defective in both basal and cisplatin-induced autophagy in kidneys. (elsevierpure.com)
Thus, our results establish a renoprotective role of tubular cell autophagy in acute kidney injury where it may interfere with cell killing mechanisms. (elsevierpure.com)

Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)
One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
Calcium oxalate (CaOx), the major constituent of most kidney stones, induces inflammatory infiltration and injures renal tubular cells. (biomedcentral.com)
In inflammatory-mediated kidney injury, a variety of T cells (γδT cells, NKT cells, regulatory T cells) infiltrate the kidney, and the number and subset composition of infiltrating T cells varies among the different forms of kidney injury [ 13 ]. (biomedcentral.com)

In addition, the knockout mice were more sensitive to renal ischemia-reperfusion injury than their wild-type littermates. (elsevierpure.com)

Therefore, in the present study, we evaluated the effect of mitochondrial complex 1 inhibition by rotenone on the chronic renal damage induced by acute ischemia-reperfusion. (oncotarget.com)

Moreover, renal ischemia can cause the delay of graft function after renal transplant and can cause rejection of the transplant. (wikipedia.org)
It is considered as a major cause of acute renal failure and the main factor in early recovery of renal graft function and long-term survival post renal transplantation. (frontiersin.org)
cardiac surgery-associated acute kidney injury and delayed graft function after kidney transplants. (labiotech.eu)

Hemodynamically mediated acute renal failure. (bmj.com)

In studies of mice models, clamping of the kidney may result in kidney ischemia. (wikipedia.org)
Upregulation of Fas and FADD protein has occurred in mice models after a 24h period of ischemic injury. (wikipedia.org)
Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
T cell-deficient mice had a significantly reduced rise in SCr and decreased tubular injury compared with wild-type mice. (johnshopkins.edu)
T cell-deficient mice had a decrease in ICAM-1 expression after WBIRI, but no decrease in renal MPO. (johnshopkins.edu)
This study describes a new, clinically relevant, model of ARF after WBIRI in mice and identifies the T cell as an important mediator of renal injury following WBIRI. (johnshopkins.edu)
After three days of I/R injury, rotenone at a dose of 200 ppm in food was administered to the mice. (oncotarget.com)
Mechanistically, these knockout mice had heightened activation of p53 and c-Jun N terminal kinase, the signaling pathways contributing to cisplatin acute kidney injury. (elsevierpure.com)

The extrinsic pathway are directly induced upon renal ischemic injury, while intrinsic pathways are dependent on mitochondrial signaling pathways. (wikipedia.org)
and the injury of mitochondrial biogenesis was assessed by decreasing PGC-1, Nrf1, and TFam. (aging-us.com)

The histopathological evaluation of renal tissue was also conducted. (frontiersin.org)
Pioglitazone also decreased the mRNA expression of TNF-α and MCP-1 in the renal tissue. (frontiersin.org)
The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
Mononuclear phagocytes contributions to tissue pathologies relate to their central roles in orchestrating all stages of host defense and wound healing, which often become maladaptive processes, especially in sterile and/or diffuse tissue injuries. (hindawi.com)
We examine tissue needs to maintain homeostasis and how to regain homeostasis upon tissue injury. (hindawi.com)
One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
Planar cell polarity (PCP), a process of coordinated alignment of cell polarity across the tissue plane, may contribute to the repair of renal tubules after kidney injury. (cheapebooks.org)
Serum and renal tissue samples were collected 24 hours after the last treatment and subjected to biochemical and histological examinations, respectively. (ac.ir)

Finally, we discuss how acute kidney injury induces permanent alterations in renal vascular structure. (eurekaselect.com)

In contrast to the negative effects of Ang II on the renal circulation, Ang1-7 as a renoprotective agent improves endothelial function, which increases RBF and decreases renal vascular resistance (RVR) [ 16 ]. (hindawi.com)
The findings imply that reactive oxygen species play a causal role in I/R-induced renal injury, and that antioxidants exert renoprotective effects, probably by radical scavenging and antioxidant activities, in this way diminishing renal function deterioration. (biomedcentral.com)

Cell-Free Hemoglobin in Acute Kidney Injury after Lung Transplantation and Experimental Renal Ischemia/Reperfusion. (stanford.edu)
Lung transplantation (LuTx) is a clinical condition with a high incidence of acute kidney injury (AKI). (stanford.edu)
My group's research focuses on the cardiovascular risk associated with the spectrum of chronic kidney disease (CKD) from early in the disease trajectory through to kidney failure requiring either dialysis or kidney transplantation. (ed.ac.uk)
Using large datasets, we are investigating the role of high-sensitivity troponin I (and other cardiovascular biomarkers) as a measure of outcome in patients with CKD and those undergoing kidney transplantation. (ed.ac.uk)
Balmes Transplantation has raised €700,000 in seed funding to run a proof-of-concept study to test its drug combination for kidney damage. (labiotech.eu)
Balmes Transplantation is a young biotech in Marseille, France, that develops combination therapies for a common complication associated with kidney transplants and heart surgery . (labiotech.eu)
Nevertheless, in most countries, priority is given to transplantation over other types of renal replacement therapies, since patients with a functioning transplant leave longer, with a better quality of life and less comorbidities. (mdmsignaling.com)

The renin-angiotensin system (RAS) and hypertension also may be influenced by renal IR injury. (hindawi.com)

What causes kidney ischemia is not entirely known, but several pathophysiology relating to this disease have been elucidated. (wikipedia.org)
Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)

More complications happen when failure of the kidney functions result in toxicity in various parts of the body which may cause septic shock, hypovolemia, and a need for surgery. (wikipedia.org)
Spectrum of acute renal failure in the intensive care unit: the PICARD experience. (bmj.com)
14. Liaño F, Pascual J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. (bmj.com)
Madrid Acute Renal Failure Study Group. (bmj.com)
Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. (bmj.com)
17. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. (bmj.com)
Apoptotic pathways in ischemic acute renal failure. (bmj.com)
More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure. (sciencedaily.com)
In the present study, the team was able to show that Liproxstatin-1 suppresses ferroptosis both in human kidney cells, Gpx4 deletion-induced acute renal failure and in a pre-clinical model of hepatic ischemia reperfusion injury. (sciencedaily.com)
Cardiovascular disease is the commonest complication of kidney disease and cardiovascular risk is greatest in those with kidney failure. (ed.ac.uk)
In population-based studies utilising high-fidelity linked healthcare data unique to Scotland, we are investigating temporal trends in the incidence and outcomes of cardiovascular disease, including rates of secondary prevention prescribing, in patients with kidney failure. (ed.ac.uk)
Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
Acute renal failure (ARF) commonly occurs after whole body ischemia. (johnshopkins.edu)
The trial had to exhibit at least one of the following results: major adverse cardiovascular events (MACE), cardiovascular death or hospitalization for heart failure, cardiovascular death, hospitalization for heart failure, renal or cardiovascular adverse events, or non-cardiovascular death. (bvsalud.org)
A temporary impairment of blood flow to the kidneys causes the death of renal cells, which can lead to kidney failure . (labiotech.eu)

Both kidney were excised, the right one homogenized for oxidative stress parameters (MDA and GSH) measurements and the left kidney fixed in formalin for histological examination. (biomedcentral.com)

Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. (eurekaselect.com)
Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. (eurekaselect.com)
Here, we assessed the metabolic alterations following subclinical focal ischemia-reperfusion injury with hyperpolarized [1- 13 C]pyruvate MRI in a porcine model. (au.dk)
There were alterations compatible with initial renal alterations, in the first 14 days, such as increased urinary density, pH alteration, presence of glucose, proteins and leukocytes, when compared to the control group. (scielo.br)
It was possible to observe morphological alterations in the kidneys submitted to I/R, regarding coloration, during surgery and after the end of the observation period, in the volume and size of the left kidney, when compared to the contralateral kidney. (scielo.br)

Acute kidney injury (AKI) is a clinical syndrome characterized by the abrupt decline of renal function, resulting from sepsis, renal ischemia/reperfusion, or exposure to nephrotoxins. (cheapebooks.org)

Herein, conditional knockout (KO) mouse models that ablate Intu specifically from kidney tubules ( Intu KO) were established. (cheapebooks.org)
Therefore, kidney repair after AKI is centered on the repair and reconstruction of renal tubules. (cheapebooks.org)
Especially, conditional knockout (KO) mouse models were established where the PCP effector Intu was ablated specifically from renal tubules. (cheapebooks.org)

Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. (mdpi.com)

Currently, his research focus is to better characterize the epidemiology of adverse perioperative outcomes such as acute kidney injury. (columbia.edu)

and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for early and accurate identification of AKI rather than secondary consequences of injury. (medscape.com)
Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)
Thus, there is an urgent need to develop ER stress biomarkers in the incipient stages of ER stress-mediated kidney disease, when a kidney biopsy is not yet clinically indicated, for early therapeutic intervention. (jci.org)

Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. (wikipedia.org)
This accounts for 60-97% of renal arterial lesions, which could lead to the occlusion of the renal artery and ischemic atrophy of the kidneys. (wikipedia.org)

Dr Chen will speak on Endoplasmic Reticulum Dyshomeostasis and Kidney Disease. (wustl.edu)
Congratulations to Ying Maggie Chen, MD, PhD, who just received an Investigator Matching Micro Grant funded by the Center for Drug Discovery (CDD) at Washington University for her proposal titled Development of a Novel Biotherapeutic Protein to Treat Endoplasmic Reticulum Stress-Mediated Kidney Disease. (wustl.edu)

Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)

Kidney disease: improving global outcomes (KDIGO) Acute Kidney Injury Work Group. (bmj.com)
Incidence and outcomes in acute kidney injury: a comprehensive population-based study. (bmj.com)

Ying Maggie Chen, MD, PhD, Associate Professor, Division of Nephrology, is the recipient of a $40K (direct costs), one year, renewable UAB-UCSD O'Brien Center Pilot Award to study therapies for acute kidney injury (AKI). (wustl.edu)

Using mouse models of ischaemia-reperfusion injury, we are investigating the cardiovascular and renal sequelae of AKI and examining new experimental medicine strategies to reduce the risks of developing these. (ed.ac.uk)

Using the American College of Surgeons National Surgical Quality Improvement Program, Dr. Kim‚Äôs work has explored variations in acute kidney injury risk among different types of general surgery procedures and the interaction effects among major surgical complications with respect to postoperative mortality. (columbia.edu)
With the rates of heart surgery and kidney transplants still high, preventative measures for complications like kidney ischemia-reperfusion injury are required. (labiotech.eu)

IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)

hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)
For the first time to our knowledge, we demonstrate that CRELD2 can serve as a sensitive urinary biomarker for detecting ER stress in podocytes or renal tubular cells in murine models of podocyte ER stress-induced nephrotic syndrome and tunicamycin- or ischemia-reperfusion-induced acute kidney injury (AKI), respectively. (jci.org)
Most importantly, urinary CRELD2 elevation occurs in patients with autosomal dominant tubulointerstitial kidney disease caused by UMOD mutations, a prototypical tubular ER stress disease. (jci.org)
Kidney stones, which primarily settle in the kidneys, are the most common disorder of the urinary tract, and their worldwide prevalence has increased over the decades [ 1 ]. (biomedcentral.com)

Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)

Renal myeloperoxidase (MPO) levels increased at 24 h after WBIRI. (johnshopkins.edu)

In addition, there is discussion of how intrinsic damage to the endothelium impairs homeostatic responses in vascular tone as well as promotes leukocyte adhesion and exacerbating the reduction in renal blood flow. (eurekaselect.com)

Balmes targets kidney ischemia-reperfusion injury , a complication that affects up to 500,000 heart surgery patients and around 45,000 kidney transplant patients in the US and Europe each year. (labiotech.eu)

We posit that the cause of the sustained impairment in kidney capillary density results from impaired endothelial growth responses and suggest that this limitation is a primary contributing feature underlying progression of chronic kidney disease. (eurekaselect.com)
We are studying the effects of apelin on systemic and renal haemodynamics and endothelial function in healthy volunteers and in patients with CKD. (ed.ac.uk)

ANCA-associated vasculitis (AAV) is a rare, autoimmune disease that commonly involves the kidney. (ed.ac.uk)

Wijeysundera et al sought to determine whether N-acetylcysteine is associated with increased blood loss and blood product transfusion in 89 patients with preexisting moderate renal insufficiency undergoing cardiac surgery. (medscape.com)

In this review, we deliver an overview of the pre-conditioning methods that are considered a strategy for improving the therapeutic efficacy of MSCs in organ failures, in particular, renal, heart, lung, and liver. (biomedcentral.com)

Acute kidney injury (AKI) has been widely recognized as an important risk factor leading to the occurrence and progression of chronic kidney disease (CKD). (oncotarget.com)

Future trials are needed to be much larger and ascertain the optimal dose and, more importantly, the time of the dose, especially in patients with decreased kidney function at baseline. (medscape.com)
Therefore, this study was performed to verify the pharmacological effect of DH on improving cardiovascular disorders and to demonstrate its mutual improvement effect on renal function. (bvsalud.org)

IPC is described as short, transient, and nonlethal ischemia periods and subsequent reperfusion which is performed before IR injury and can protect the kidney against long-term ischemia [ 6 - 8 ]. (hindawi.com)
In conclusion, CFH is a possible factor contributing to postoperative AKI after LuTx and promotes AKI in an experimental model of mild transient renal ischemia. (stanford.edu)

External validation for acute kidney injury severity scores: a multicenter retrospective study in 14 Japanese ICUs. (bmj.com)
Objective: Obesity enhances the frequency and severity of acute kidney injury (AKI) induced by renal ischemia-reperfusion (IR). (aging-us.com)

Excess myoglobin may thus cause renal tubular obstruction, direct nephrotoxicity (ischemia and tubular injury), intrarenal vasoconstriction, and acute kidney injury (AKI). (medscape.com)

Possible causes of kidney ischemia include the activation of IL-17C and hypoxia due to surgery or transplant. (wikipedia.org)

Anatomy26

Organisms11

Diseases70

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes34

Disciplines and Occupations2

Information Science4

Health Care14

Cause of acute kidney3

Predicting renal function1

Inflammation8

Bilateral renal3

Creatinine8

Cisplatin-induced acute kidney2

Unilateral6

Apoptosis9

Fibrosis4

Mediators4

Induce3

Diseases15

Leads to acute renal f2

Rats7

Autophagy4

Inflammatory4

Wild-type littermates1

Inhibition1

Graft function3

Mediated acute renal f1

Mice8

Mitochondrial2

Tissue9

Induces1

Renoprotective2

Transplantation7

Renin-angiot1

Pathophysiology2

Failure15

Oxidative1

Alterations5

Sepsis1

Tubules3

Pathways1

Perioperative1

Biomarkers3

Artery2

Endoplasmic reticulum2

Common pathophysiological1

Outcomes2

Nephrology1

Sequelae1

Complications2

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Urinary4

Clinical syndrome characterized1

Myeloperoxidase1

Intrinsic1

Complication1

Endothelial2

Commonly1

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Therapeutic1

Progression of chronic kidney1

Function2

Transient2

Severity2

Vasoconstriction1

Causes of kidney1