Leukocytoclastic vasculitisSystemic vasculitisPurpuraReactionsType III hypersensitiCryoglobulinemiaAcuteClinicallyPrimaryDepositionForms of necrotizinBeta-lactamsKidneysTypes of vasculitisDisordersReactionGranulomatosisAutoimmuneInvolvementImmuneBiopsyPrognosisPneumonitisVesselsDiseasesHepatitisOccurSymptoms of necrotizinBlood vesselIdiopathicInfectionsSecondaryVessel VasculitisForm of vasculitisNecrotizingPolyarteritis nodosaPatientsDiagnosisNecrosisInternal organsSyndrome
Leukocytoclastic vasculitis12
- Hypersensitivity vasculitis, which is usually represented histopathologically as leukocytoclastic vasculitis (LCV), is a term commonly used to denote a small-vessel vasculitis. (medscape.com)
- Skin biopsy of the lesions reveal inflammation of the small vessels, termed leukocytoclastic vasculitis, which is most prominent in postcapillary venules. (wikidoc.org)
- A 2014 population-based study in Minnesota found the incidence of cutaneous leukocytoclastic vasculitis in adults (including IgA vasculitis as well as other types of small-vessel vasculitis) to be at 45 cases per million. (medscape.com)
- Zeiger, Roni F.. "Hypersensitivity (leukocytoclastic) Vasculitis. (unboundmedicine.com)
- Emergency Central , emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114080/all/Hypersensitivity__leukocytoclastic__vasculitis. (unboundmedicine.com)
- The etiology of this disease (a leukocytoclastic vasculitis) is still uncertain, but immune complexes of IgA and unidentified antigens seem to have a central pathogenic role. (intechopen.com)
- Henoch-Schönlein purpura, granulomatosis with polyangiitis or GPA, eosinophilic granulomatosis with polyangiitis or EGPA, previously referred to as Churg-Strauss syndrome), cutaneous leukocytoclastic vasculitis, microscopic polyangiitis). (printo.it)
- Other clinical entities that can present similarly to heparin-induced skin necrosis include calciphylaxis, pyoderma gangrenosum, disseminated intravascular coagulation (DIC), leukocytoclastic vasculitis, and other bullous disorders. (clinicaladvisor.com)
- Microscopically, both sites revealed small vascular structures, primarily capillaries, surrounded by abundant polymorphonuclear leukocytes and few eosinophils, evidence that confirmed the diagnosis of leukocytoclastic vasculitis. (consultant360.com)
- The course of leukocytoclastic vasculitis generally is benign. (consultant360.com)
- Photoclinic: leukocytoclastic vasculitis. (consultant360.com)
- The findings were reviewed by a pathologist at the University of Iowa Hospitals and Clinics and were found to be suggestive of leukocytoclastic vasculitis. (eyerounds.org)
Systemic vasculitis6
- If skin involvement is secondary to a systemic vasculitis, symptoms may also include fever, arthralgias, other organ involvement, or a combination. (msdmanuals.com)
- When using the influential classification known as the "Chapel Hill Consensus Conference", the terms "systemic vasculitis" or "primary systemic vasculitides" are commonly used. (wikipedia.org)
- Systemic vasculitis of medium and small arteries, including venules and arterioles. (wikipedia.org)
- Churg-Strauss Syndrome (CSS), now also referred to by its medically more accurate term eosinophilic granulomatosis with polyangiitis (EGPA), is a rare systemic vasculitis (inflammation in the wall of blood vessels of the body), predominantly affecting small-sized vessels. (vasculitisfoundation.org)
- Immunoglobulin A vasculitis, formerly called Henoch-Schönlein purpura (HSP), is the most common systemic vasculitis in childhood. (intechopen.com)
- Widespread (systemic) vasculitis is usually accompanied by extensive release of inflammatory molecules, causing general symptoms like fever, malaise, as well as abnormal laboratory tests detecting inflammation: erythrocyte sedimentation rate (ESR) and C- reactive protein (CRP). (printo.it)
Purpura8
- Palpable, normally painful, petechiae or purpura (skin vasculitis). (wikidoc.org)
- Henoch-Schönlein purpura (HSP), a small-vessel vasculitis characterized by deposition of immunoglobulin A (IgA) immune complexes, reportedly has an incidence of 14 cases per million people per year. (medscape.com)
- In both adults and children, Henoch-Schönlein purpura (HSP) may present in a clinically identical fashion to hypersensitivity vasculitis, and biopsy with direct immunofluorescence is typically needed to distinguish the two. (medscape.com)
- Vasculitis affecting the small vessels of the skin (eg, arterioles, capillaries, postcapillary venules) tends to cause lesions such as purpura, petechiae, and possibly shallow ulcers. (msdmanuals.com)
- Henoch-Schönlein Purpura (HSP) is the most common vasculitis in children and is usually a benign disease that completely resolves in most patients without the need for aggressive treatment. (vasculitisfoundation.org)
- Oni L, Sampath S. Childhood IgA Vasculitis (Henoch Schonlein Purpura)-Advances and Knowledge Gaps. (medscape.com)
- Palpable petechiae and purpura are a result of either perivascular inflammation (vasculitis) or infection. (wikem.org)
- A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). (embl.de)
Reactions1
- Hypersensitivity to this drug - hypersensitivity reactions have included anaphylactic reaction and angioedema (see WARNINGS, Hypersensitivity Reactions and ADVERSE REACTIONS ). (nih.gov)
Type III hypersensiti2
- Urticarial vasculitis is a type III hypersensitivity that typically presents as painful wheals that last more than 24 hours. (aafp.org)
- It is a small-vessel vasculitis mediated by type III hypersensitivity, manifested as rash accompanied by gastrointestinal (GI) symptoms, arthritis, and nephritis. (intechopen.com)
Cryoglobulinemia3
- However, when 1614 patients with hepatitis C were studied, vasculitis occurred in only 12 patients (9 with cryoglobulinemia, 3 without). (medscape.com)
- Some other types of vasculitis are also caused by immune complexes, but cryoglobulinemia is defined by a laboratory test that identifies immune complexes that fall out of solution in the cold. (vasculitisfoundation.org)
- Cryoglobulinemia vasculitis is caused by abnormal proteins in your blood, this condition cause joint pain and weakness, numbness, or tingling in in your arms or legs. (cardiology-doctors.com)
Acute3
- Hypersensitivity vasculitis may be acute and self-limited, recurrent, or chronic. (medscape.com)
- Here, we report a case of a female patient who developed hypersensitivity vasculitis a nd acute renal failure following the use of ibuprof en. (interesjournals.org)
- Some of the acute primary vasculitides are quite common paediatric diseases (e.g. (printo.it)
Clinically2
- Hypersensitivity vasculitis may present clinically as cutaneous disease only or it may be a cutaneous manifestation of systemic disease. (medscape.com)
- HA060 trade name] tablets are contraindicated in patients with previously demonstrated clinically significant hypersensitivity to any of the components of the product (API's lamivudine and zidovudine). (who.int)
Primary7
- Necrotizing vasculitis may be the primary condition such as in people with polyarteritis nodosa or granulomatosis with ANCA associated vasculitis (formerly called Wegener granulomatosis). (medlineplus.gov)
- Cutaneous vasculitis may be limited to the skin, or may be a component of a systemic primary or secondary vasculitic disorder. (msdmanuals.com)
- Any primary or secondary vasculitis can affect the skin, including that due to serum sickness, infections (eg, hepatitis C), cancers, rheumatologic or other autoimmune disorders, and hypersensitivity to drugs. (msdmanuals.com)
- The clinical spectrum of primary renal vasculitis. (medscape.com)
- Also called allergic vasculitis, its primary symptom is red spots on your lower legs. (cardiology-doctors.com)
- Primary vasculitides do not usually run in the family. (printo.it)
- We aimed to establish the applicability of these criteria in patients with primary cutaneous vasculitis (CV). (unican.es)
Deposition4
- Hypersensitivity vasculitis is thought to be mediated by immune complex deposition. (medscape.com)
- HSP is a specific small-vessel vasculitis associated with the presence of vascular IgA deposition. (medscape.com)
- Cryogloblinemia is a vasculitis of small blood vessels that is caused by deposition of immune complexes: large aggregates of antibodies and the other proteins they are bound to. (vasculitisfoundation.org)
- Another theory is that deposition of immune complexes within dermal vessels leads to vasculitis, a type III (Arthus type) hypersensitivity reaction. (clinicaladvisor.com)
Forms of necrotizin1
- Most forms of necrotizing vasculitis require long-term follow-up and treatment. (medlineplus.gov)
Beta-lactams1
- Antibiotics are the most common drugs to cause hypersensitivity vasculitis, particularly beta-lactams. (medscape.com)
Kidneys6
- The internal organs most commonly affected in hypersensitivity vasculitis are the joints, gastrointestinal tract, and kidneys. (medscape.com)
- If the vasculitis is damaging organ systems such as the kidneys, immunosuppressive agents are indicated. (wikidoc.org)
- Vasculitis can affect any part of the body, but the most common sites are the kidneys, brain, skin, and eyes. (100arthritis.com)
- Kidneys - The kidneys are often involved in hypersensitivity vasculitis, and people with the disease may experience symptoms such as kidney inflammation, pain, infections, high blood pressure and low blood pressure. (100arthritis.com)
- People with hypersensitivity vasculitis may have a more severe form of the disease, known as nephritis, in which the kidneys are seriously affected. (100arthritis.com)
- Medium vessel vasculitis typically affects arteries supplying the kidneys, bowels, brain or heart (e.g. polyarteritis nodosa, Kawasaki disease). (printo.it)
Types of vasculitis3
- The different types of vasculitis are classified according to the size and location of the blood vessels that are affected. (vasculitisfoundation.org)
- There are many types of vasculitis, each with its own symptoms. (cardiology-doctors.com)
- 2.1 What are the types of vasculitis? (printo.it)
Disorders2
- Necrotizing vasculitis is a group of disorders that involve inflammation of the blood vessel walls. (medlineplus.gov)
- It is also employed in many immune and hypersensitivity disorders like dermatitis herpetiformis, vasculitis, polyartritis nodosa etc. (longdom.org)
Reaction4
- Hypersensitivity vasculitis is inflammation of the vessel wall which is usually due to a hypersensitivity reaction to a known drug, auto-antigens or infectious agents such as bacteria. (wikidoc.org)
- Usually due to a hypersensitivity reaction to a known drug. (wikipedia.org)
- History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam). (medicines.org.uk)
- 2 EM is classified as a type III or type IV hypersensitivity reaction to certain drugs or to infections ( TABLE 2 ) including herpes, tuberculosis, Mycoplasma pneumoniae , and histoplasmosis. (uspharmacist.com)
Granulomatosis1
- Because antineutrophil cytoplasmic auto-antibodies (ANCA) can be detected in the serum (liquid and a cellular part of the blood) in up to 40% of the patients, it is also considered one of the three ANCA-associated vasculitides, along with granulomatosis with polyangiitis (Wegener's) and microscopic polyangiitis. (vasculitisfoundation.org)
Autoimmune2
- Autoimmune Disease - People with an autoimmune disease such as lupus, Hashimoto's thyroiditis, scleroderma, or rheumatoid arthritis are also at an increased risk of developing hypersensitivity vasculitis. (100arthritis.com)
- Risk factors may contribute to getting vasculitis include smoking, hepatitis B and C, and autoimmune diseases like lupus. (cardiology-doctors.com)
Involvement3
- Overall, hypersensitivity vasculitis has a favorable prognosis, particularly when no internal involvement is present. (medscape.com)
- The onset of symptoms of vasculitis, such as skin lesions, eyes, mouth and kidney involvement, can occur gradually over weeks to months. (100arthritis.com)
- Here we are reporting a rare case so called dapsone syndrome or DHS (Dapsone Hypersensitivity Syndrome), which include skin eruption (rash), fever and internal organ involvement like hepatobiliary, pulmonary, hematological and neurological and others. (longdom.org)
Immune2
- HSV occurs when the blood vessels are hypersensitive to various stimuli, which triggers a destructive immune response known as vasculitis. (100arthritis.com)
- Infectious Mononucleosis - People with infectious mononucleosis are at an increased risk of developing hypersensitivity vasculitis if they have a weakened immune system. (100arthritis.com)
Biopsy2
- At least three out of five criteria yields sensitivity and specificity of 95 and 91%: Age at onset ≥ 50 years New onset headache with localized tenderness Temporal artery tenderness or decreased pulsation Elevated ESR ≥ 50 mm/hour Westergren Temporal artery biopsy showing vasculitis with mononuclear cell infiltrate or granulomatous inflammation, usually with multinucleated giant cells These conditions are sometimes considered together with the small vessel vasculitides. (wikipedia.org)
- Patients have CNS symptoms as well as cerebral vasculitis by angiography and leptomeningeal biopsy. (wikipedia.org)
Prognosis3
- The presence of vasculitis often denotes active disease and possibly a poorer prognosis. (medscape.com)
- The prognosis of patients with cutaneous vasculitis depends on the underlying syndrome and the presence of end-organ dysfunction. (medscape.com)
- Impact of aging on phenotype and prognosis in IgA vasculitis. (medscape.com)
Pneumonitis8
- Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is an uncommon non-immunoglobulin E (IgE), T-helper cell type 1 (Th1)-mediated inflam- matory pulmonary disease with systemic symptoms resulting from repeated inhalation and subsequent sensitization to a large variety of aerosolized antigenic organic dust particles. (cdc.gov)
- The earliest forms of hypersensitivity pneumonitis were related to farming and, each year, new antigens causing occupational disease are described. (cdc.gov)
- Hypersensitivity pneumonitis was originally described in 1713 as an occupational lung disease in grain workers and later, in 1932, in farmers inhaling moldy hay contam- inated with thermophilic actinomyces, hence the term farmer's lung.1 With this recog- nition, modernization of farming methods has resulted in the reduction in farmer's lung prevalence estimated at 0.5% to 3% of exposed farmers in studies spanning from 1980 to 2003. (cdc.gov)
- Zacharisen & Fink hypersensitivity pneumonitis. (cdc.gov)
- National surveillance screening in the United Kingdom from 1992 to 2001 estimated 50 cases of hypersensitivity pneumonitis annually, rep- resenting 1.8% of all cases of work-related respiratory disease seen by chest physi- cians. (cdc.gov)
- Farmer's lung is the prototype occupational hypersensitivity pneumonitis. (cdc.gov)
- 9 Agricul- tural exposures were the most common occupation for hypersensitivity pneumonitis in the Czech Republic, with 69% of cases of farmer's lung (cattleman and dairyman), followed by malt workers and chemical workers. (cdc.gov)
- More than a dozen outbreaks of hypersensitivity pneumonitis affecting hundreds of workers exposed to contaminated airborne synthetic metalworking fluids (MWF) have been reported since the mid-1990s. (cdc.gov)
Vessels13
- Necrotizing vasculitis may affect blood vessels in any part of the body. (medlineplus.gov)
- Vasculitis is an inflammation of the blood vessels. (100arthritis.com)
- Cutaneous vasculitis refers to vasculitis affecting small- or medium-sized vessels in the skin and subcutaneous tissue but not the internal organs. (msdmanuals.com)
- Overview of Vasculitis Vasculitis is inflammation of blood vessels, often with ischemia, necrosis, and organ inflammation. (msdmanuals.com)
- Vasculitis can affect the small- or medium-sized vessels of the skin. (msdmanuals.com)
- Livedo reticularis, nodules, and deep ulcers are usually caused by vasculitis of deeper, medium or large vessels. (msdmanuals.com)
- Chronic vasculitis of both large and medium vessels, primarily affecting cranial branches of the arteries arising from the aortic arch. (wikipedia.org)
- There are several vasculitides that affect small vessels. (wikipedia.org)
- Vasculitis means inflammation of the blood vessels, arteries, veins or capillaries. (vasculitisfoundation.org)
- A result of vasculitis is that the tissues and organs supplied by affected blood vessels do not get enough blood. (vasculitisfoundation.org)
- Vasculitis refers to a group of diseases that cause the inflammation of your blood vessels or blood vessel walls. (cardiology-doctors.com)
- The classification of vasculitides depends mainly on the size and type of blood vessels involved. (printo.it)
- Leukocytoclastic, or hypersensitivity, vasculitis is a neutrophilic inflammation of small blood vessels. (consultant360.com)
Diseases4
- Collagen-vascular diseases account for 10-15% of cases of cutaneous vasculitis. (medscape.com)
- Hypersensitivity vasculitis (HSV) is a relatively new term in the world of blood vessel diseases. (100arthritis.com)
- Vasculitis is a family of rare diseases that can affect people of all ages. (vasculitisfoundation.org)
- Vasculitides include a wide group of diseases. (printo.it)
Hepatitis4
- Hepatitis C is a commonly recognized cause of vasculitis, likely secondary to the presence of cryoglobulins. (medscape.com)
- Hepatitis B has been implicated in some cases of vasculitis in the past. (medscape.com)
- In other cases, the vasculitis may occur as part of another disorder, such as systemic lupus erythematosus or hepatitis C. (medlineplus.gov)
- Hypersensitivity to thiomersal in hepatitis B vaccine. (revahb.fr)
Occur1
- Hypersensitivity vasculitis may occur at any age. (medscape.com)
Symptoms of necrotizin1
- Contact your provider if you have symptoms of necrotizing vasculitis. (medlineplus.gov)
Blood vessel4
- Central nervous system vasculitis (CNSV) is inflammation of blood vessel walls in the brain or spine. (vasculitisfoundation.org)
- Vasculitis is inflammation of the blood vessel walls. (printo.it)
- 1.4 What happens to the blood vessel in vasculitis? (printo.it)
- Vasculitis classification in children is based on the size of the blood vessel involved. (printo.it)
Idiopathic1
- CSVV sometimes refers to small-vessel vasculitis of unknown cause (also called idiopathic cutaneous small-vessel vasculitis). (msdmanuals.com)
Infections2
- [ 1 ] In this form of vasculitis, circulating antigens in the body (produced by factors such as medications, infections, and neoplasms) induce antibody formation. (medscape.com)
- Various infections may be associated with vasculitis. (medscape.com)
Secondary1
- The patient was diagnosed with hemorrhagic occlusive retinal vasculitis likely secondary to vancomycin hypersensitivity. (bvsalud.org)
Vessel Vasculitis1
- Large vessel vasculitis, like Takayasu arteritis, affects the aorta and its major branches. (printo.it)
Form of vasculitis1
- One exception is a very recently described form of vasculitis, called "DADA2", but this is very rare. (printo.it)
Necrotizing3
- Necrotizing vasculitis can be serious and life-threatening disease. (medlineplus.gov)
- Necrotizing vasculitis, also called systemic necrotizing vasculitus, is a category of vasculitis, comprising vasculitides that present with necrosis. (wikipedia.org)
- Systemic necrotizing vasculitis and aneurysm formation affecting both medium and small arteries. (wikipedia.org)
Polyarteritis nodosa1
- Methamphetamine and other sympathomimetics can cause a cerebral vasculitis alongside polyarteritis nodosa like systemic features. (wikipedia.org)
Patients1
- many patients with cryoglobulins (98%) did not have vasculitis despite an abnormal circulating paraprotein. (medscape.com)
Diagnosis1
- A diagnosis of vasculitis limited to the skin requires a complete history and physical examination. (msdmanuals.com)
Necrosis1
- More recently, biologic agents such as tumor necrosis factor (TNF)-alpha inhibitors, have been reported to cause hypersensitivity vasculitis. (medscape.com)
Internal organs1
- This term describes vasculitis that affects the skin but not the internal organs. (msdmanuals.com)
Syndrome1
- In particular, rheumatoid arthritis, Sjögren syndrome, and lupus erythematosus may have an associated hypersensitivity vasculitis. (medscape.com)