DNA DamageOxidative StressReactive Oxygen SpeciesTime FactorsCells, CulturedDNA RepairComet AssayBrain Damage, ChronicUltraviolet RaysAtaxia Telangiectasia Mutated ProteinsDeoxyguanosineCell Cycle ProteinsApoptosisAntioxidantsDNA-Binding ProteinsDisease Models, AnimalTumor Suppressor Protein p53Hydrogen PeroxideGamma RaysCell SurvivalDNARadiation, IonizingDose-Response Relationship, RadiationCheckpoint Kinase 2DNA Breaks, Double-StrandedLipid PeroxidationProtein-Serine-Threonine KinasesCell CycleMutagensRats, Sprague-DawleyOxidation-ReductionMice, Inbred C57BLMethyl MethanesulfonateRats, WistarTumor Suppressor ProteinsMutationCell LineCell DeathSuperoxide DismutaseSignal TransductionMicronucleus TestsNuclear ProteinsHistonesBrainRadiation Injuries, ExperimentalDose-Response Relationship, DrugFree RadicalsDNA ReplicationGenomic InstabilityMalondialdehydeOxidantsMice, KnockoutRadiation-Protective AgentsPhosphorylationCell Line, TumorLiverDNA GlycosylasesDNA AdductsReperfusion InjuryX-RaysBiological MarkersCatalaseG2 PhaseKidneyGlutathioneDNA Repair EnzymesRadiation ToleranceMitochondriaModels, BiologicalBrain IschemiaDNA Breaks, Single-StrandedFibroblastsNeuroprotective AgentsNecrosisPoly(ADP-ribose) PolymerasesFree Radical ScavengersBlotting, WesternDNA BreaksImmunohistochemistryIn Situ Nick-End LabelingAlkylating AgentsNeuronsMicronuclei, Chromosome-DefectiveHeLa CellsProtein CarbonylationCell NucleusProtein KinasesAgingProtective AgentsMolecular Sequence DataOxygenSaccharomyces cerevisiae ProteinsGlutathione PeroxidaseCell AgingDrug-Induced Liver InjuryGene Expression Regulation