GranulocytopeniaInfantile genetic agranulCongenital neutropeniaSevere neutropeniaFebrile neutropeniaSuppressionThrombocytopeniaPancytopeniaLeukopeniaDisordersDrug-inducedTransient neutropeniaCase of agranulocytosisAplasiaSymptomsInduceInfectionToxicityDuration and severityEosinophiliaBiopsyMildSeverityNeutrophil countHereditaryNeutrophils in the bRenalMegakaryocytesChronicSequestrationFeverBenignDifferentialPrecursorsAbnormalDrugsDecreaseInfectionsBloodPatients
Granulocytopenia6
- Neutropenia is sometimes called agranulocytosis or granulocytopenia because neutrophils make up about 60% of white blood cells and have granules inside their cell walls. (wordinfo.info)
- Neutropenia is sometimes called agranulocytosis or granulocytopenia because neutrophils make up about 60% of WBCs and have granules inside their cell walls. (the-medical-dictionary.com)
- Granulocytopenia causes a concurrent decrease in the number of neutrophils in the circulating blood (neutropenia). (orthopedicshealth.com)
- Therefore, the terms granulocytopenia and neutropenia are often interchangeable. (arrhythmia.center)
- 6. The method of claim 1 wherein the myelosuppression is anemia, granulocytopenia, thrombocytopenia, leukopenia, agranulocytosis or neutropenia. (patentsencyclopedia.com)
- However, the term granulocytopenia is often used synonymously with neutropenia and, in that sense, is again confined to the neutrophil lineage alone. (medscape.com)
Infantile genetic agranul6
- Also called Kostmann disease, Kostmann neutropenia, congenital neutropenia and infantile genetic agranulocytosis. (cancer.ca)
- And this week we're talking about Infantile Genetic Agranulocytosis. (coastdental.com)
- So we're talking about Infantile Genetic Agranulocytosis and this, for our listeners, is going to sound relatively similar to the previous episode where we talked about neutropenias. (coastdental.com)
- You see, an individual who has Infantile Genetic Agranulocytosis is an individual who is born, present at birth with this congenital or genetic disorder. (coastdental.com)
- So if an individual has Infantile Genetic Agranulocytosis, these are individuals who absolutely are going to be prone to infection and periodontitis, of course, is no exception. (coastdental.com)
- It absolutely means that individuals who may be experiencing oral infection associated with their Infantile Genetic Agranulocytosis are individuals who must be treated right away and then maintained consistently in order to continue to reduce the threat or vulnerability that they have to infection. (coastdental.com)
Congenital neutropenia2
- Severe congenital neutropenia syndromes are usually present in infancy. (arrhythmia.center)
- Occasionally neutrophilia may be absent in patients who are neutropenic secondary to malignancy, drugs, and congenital neutropenia. (medindiajournal.com)
Severe neutropenia4
- In severe neutropenia, the patient is likely to develop periodontal disease, oral and rectal ulcers, fever, and bacterial pneumonia. (the-medical-dictionary.com)
- High-dose and long-term therapy with β-lactam antibiotics can induce severe neutropenia, with an ANC of less than 500 cells/µL. (consultant360.com)
- We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment. (hindawi.com)
- The CAPRIE trial, which included 9.599 patients treated with clopidogrel, showed a low annual incidence (0.05%) of severe neutropenia, considered as neutrophil count below 0.45 × 10 9 /L [ 4 ]. (hindawi.com)
Febrile neutropenia5
- We describe a 70-year-old gentleman presenting with febrile neutropenia and SS. (medindiajournal.com)
- Here, we discuss a patient with febrile neutropenia, presenting with SS. (medindiajournal.com)
- In view of the persistence of fever, he was empirically treated for febrile neutropenia with cefepime and vancomycin. (medindiajournal.com)
- It is also crucial to assess the risk of serious complications in patients with febrile neutropenia, since this assessment will dictate the approach to therapy, including the need for inpatient admission, IV antibiotics, and prolonged hospitalization 2. (ukessays.com)
- The risk assessment and the diagnostic approach to patients presenting with febrile neutropenia are also discussed. (ukessays.com)
Suppression4
- Its most serious rare side effect is bone marrow suppression causing neutropenia and agranulocytosis. (wikipedia.org)
- The hematological alterations in dengue infection are in all probability the outcome of bone marrow suppression using a minor contribution of blood cell destruction by the hemophagocytosis in peripheral blood. (dot1linhibitor.com)
- Clopidogrel major adverse events are represented by marrow suppression, manifesting with aplastic anaemia, thrombocytopenia and neutropenia. (hindawi.com)
- Clopidogrel use is associated with an increased risk of bleeding and may cause haematological adverse effects, such as thrombotic thrombocytopenic purpura, haemolytic uremic syndrome, and bone-marrow suppression, manifesting with aplastic anaemia, thrombocytopenia [ 5 ], and neutropenia [ 6 , 7 ]. (hindawi.com)
Thrombocytopenia1
- Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
Pancytopenia1
- Diagnosis requires demonstration of peripheral pancytopenia and a bone marrow biopsy revealing a hypocellular marrow. (merckmanuals.com)
Leukopenia7
- Since monocytes, eosinophils, and basophils make up a relatively small proportion of the total pool of circulating leukocytes, leukopenia is almost always caused by neutropenia or lymphopenia. (arrhythmia.center)
- Primary or severe leukopenia, especially neutropenia, which is accompanied by any of the symptoms described below, causes the physician to conduct a thorough diagnosis. (arrhythmia.center)
- Leukopenia, which develops acutely, is often caused by drugs with the development of agranulocytosis, acute infections or acute leukemia. (arrhythmia.center)
- Leukopenia, which develops over a period of weeks or months, may be associated with chronic infection or a primary disease of the bone marrow. (arrhythmia.center)
- The diseases that most often provoke the development of leukopenia are hypersplenism, chronic idiopathic neutropenia in adults, rheumatoid arthritis, systemic lupus erythematosus, Wegener's granulomatosis. (arrhythmia.center)
- Like leukocytosis, which is usually due to an increase of neutrophils (neutrophilia), leukopenia usually is due to a reduction in the number of neutrophils ( neutropenia ). (britannica.com)
- Blood tests revealed severe leukopenia (white cells 1 × 10 3 / μ L) with marked neutropenia (neutrophils 3%), anaemia (haemoglobin 9.9 g/dL), and an important rise in inflammatory markers (C-reactive protein 122 mg/dL). (hindawi.com)
Disorders3
- Kostmann syndrome is associated with an increased risk of acute myelogenous leukemia (AML) or bone marrow disorders. (cancer.ca)
- Clozapine is relatively contraindicated in patients with severe cardiac or renal disorders, or a history of neutropenia, bone-marrow disorders, paralytic ileus, acute substance-induced psychosis or intoxication, circulatory collapse or epilepsy. (bpac.org.nz)
- Several cases of severe drug-induced skin disorders like agranulocytosis were reported in cocaine users. (clearbrookinc.com)
Drug-induced4
- Acquired agranulocytosis is a rare, drug-induced blood disorder that is characterized by a severe reduction in the number of white blood cells (granulocytes) in the circulating blood. (orthopedicshealth.com)
- You can also have Acquired Agranulocytosis in which an individual could be exposed to chemicals, some prescription medications, cancer medications, antipsychotic medications, for example, that will develop a form of Drug-Induced Agranulocytosis. (coastdental.com)
- 3 Acute or transient neutropenia most often is a result of cytotoxic drug therapies or idiosyncratic drug-induced reactions. (consultant360.com)
- We believe that our patient's acute neutrophil count recovery after cessation of the β-lactam agent-in this case, within one day-could be a result of myeloid maturation arrest rather than an idiosyncratic drug-induced neutropenia. (consultant360.com)
Transient neutropenia1
- The summary of product characteristics mentions that only a few cases of transient neutropenia and agranulocytosis have been reported. (bvsalud.org)
Case of agranulocytosis2
- We describe a case of agranulocytosis, a rarely described side effect that may be fatal. (bvsalud.org)
- Discussion Despite mild leucopenia typically discovered amongst patients with dengue, serious situations aren't often observed, with only one particular earlier reported case of agranulocytosis resulting from dengue infection [Insiripong, 2010]. (dot1linhibitor.com)
Aplasia1
- Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (merckmanuals.com)
Symptoms5
- Neutropenia has no specific symptoms except the severity of the patient's current infection. (the-medical-dictionary.com)
- The symptoms of this disorder come about as the result of interference in the production of granulocytes in the bone marrow. (orthopedicshealth.com)
- The first symptoms of acquired agranulocytosis are usually those associated with a bacterial infection such as general weakness, chills, fever, and/or extreme exhaustion. (orthopedicshealth.com)
- Of itself, neutropenia causes no symptoms, but persons with neutropenia of any cause may have frequent and severe bacterial infections. (britannica.com)
- Patients taking clozapine should be monitored for symptoms and signs of cardiac toxicity and neutropenia. (bpac.org.nz)
Induce3
- Other drugs that interfere with, or inhibit, granulocyte colony formation may induce agranulocytosis. (orthopedicshealth.com)
- The treatment of acquired agranulocytosis includes the identification and elimination of drugs or other agents that induce this disorder. (orthopedicshealth.com)
- e.g. concomitant use of carbamazepine and CLZ, two drugs recognized to induce neutropenia). (dot1linhibitor.com)
Infection11
- What must be viewed as when analyzing our reported circumstances, hence, is definitely the probable elevated likelihood of blood dyscrasias amongst CLZtreated patients during dengue infection, due to the occurrence of an overlap of risk for building neutropenia. (dot1linhibitor.com)
- The belief that the neutropenia was not connected to CLZ use but mainly linked to dengue infection contributed to our rechallenge decisions. (dot1linhibitor.com)
- Neutrophils play a vital role in protecting against infection, so the duration and severity of neutropenia directly correlate with the total incidence of all infections, including those that are life threatening. (medscape.com)
- Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
- [ 3 ] Major causes of acquired neutropenia are infection, drugs (through direct toxicity or immune effects), and autoimmunity. (medscape.com)
- Typically, this is diagnosed via a blood test, and it's typically managed through a combination of antibiotics, maybe even injections of a drug which are going to introduce white blood cells into the bloodstream, immunosuppressant drugs, a bone marrow transplant, and, of course, very important, the prevention of infection. (coastdental.com)
- Individuals with agranulocytosis must be very careful to avoid infection. (coastdental.com)
- Tuberculosis (see the image below) is one type of infection that may cause neutropenia. (medscape.com)
- With the increasing use of myelo-suppressive agents in the treatment of neoplastic and nonneoplastic diseases, the increased rate of infection in patients with neutropenia has been clearly established 3. (ukessays.com)
- The definition of fever as an indicator of infection in patients with neutropenia has varied. (ukessays.com)
- Neutropenia is an abnormally low level of neutrophils, which provide the primary immune defense against infection. (consultant360.com)
Toxicity2
- Case reports have described direct bone marrow toxicity causing granulomas and aplastic anemia [ 5 - 11 ]. (journalmc.org)
- The primary care team can improve safety through monitoring and management of constipation, neutropenia, metabolic effects and cardiac toxicity, and being aware of medicines which may interact with clozapine or exacerbate its adverse effects. (bpac.org.nz)
Duration and severity1
- The duration and severity of neutropenia directly correlate with the total incidence of all infections and of those infections that are life threatening. (medscape.com)
Eosinophilia2
- A bone marrow aspiration was performed showing a disappearance of the neutrophil granulocyte line and a significant eosinophilia. (bvsalud.org)
- In our case, the results of the bone marrow aspiration, the sudden drop of the neutrophil count with concomitant eosinophilia and the absence of improvement despite the dose decrease, point towards an immuno-allergic mechanism. (bvsalud.org)
Biopsy1
- In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)
Mild3
- Based upon the level of ANC, neutropenia is categorized as mild, moderate or severe. (ukessays.com)
- An absolute neutrophil count between 1000 and 1500/microL corresponds to mild neutropenia. (ukessays.com)
- An ANC of 1,000 to 1,500 cells/µL is considered to be mild neutropenia, 500 to 1,000 cells/µL is considered moderate, and below 500 cells/µL is considered severe. (consultant360.com)
Severity1
- Data about CLZ rechallenge soon after an episode of neutropenia resulting from its use show that each the danger of a brand new blood dyscrasia too as its severity are larger, with a second neutropenia with CLZ generally lasting longer and much more usually evolving into circumstances of agranulocytosis [Dunk et al. (dot1linhibitor.com)
Neutrophil count2
- While in the hospital, he had worsening neutropenia and his absolute neutrophil count hit a nadir of zero. (medindiajournal.com)
- In this case, the normalization of the patient's neutrophil count after cessation of ampicillin-sulbactam points to β-lactam-induced neutropenia. (consultant360.com)
Hereditary1
- Neutropenia has a wide range of causes, both hereditary and acquired (see Etiology ). (medscape.com)
Neutrophils in the b2
- Neutropenia is an abnormally low level of neutrophils in the blood. (the-medical-dictionary.com)
- Neutropenia is a decrease in circulating (ie, nonmarginal) neutrophils in the blood. (medscape.com)
Renal2
- In using VASOTEC consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that VASOTEC does not have a similar risk (see WARNINGS ). (rxlist.com)
- In using ACCURETIC, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. (pfizermedicalinformation.com)
Megakaryocytes1
- Thrombopoietin helps control the number of circulating platelets by stimulating the bone marrow to produce megakaryocytes. (merckmanuals.com)
Chronic1
- Chronic acquired agranulocytosis generally progresses more slowly than acquired agranulocytosis. (orthopedicshealth.com)
Sequestration1
- Causes include decreased production of neutrophils in the bone marrow, increased neutrophil destruction, sequestration of cells, adverse effects of medications, and viral infections. (consultant360.com)
Fever2
- Fever recurring every 19-30 days suggests cyclical neutropenia. (the-medical-dictionary.com)
- An overview of the concepts related to neutropenic fever, including definitions of fever and neutropenia and categories of risk are reviewed here. (ukessays.com)
Benign1
- People with acquired agranulocytosis are susceptible to a variety of bacterial infections, usually caused by otherwise benign bacteria found in the body. (orthopedicshealth.com)
Differential1
- Agranulocytosis, the complete absence of granulocytes, belongs to a specific subgroup of neutropenia, which has a unique differential diagnosis. (arrhythmia.center)
Precursors1
- A variety of drugs can cause acquired agranulocytosis and neutropenia by destroying special cells in the bone marrow that later mature and become granulocytes (precursors). (orthopedicshealth.com)
Abnormal1
- Fevers and abnormal enlargement of the spleen (splenomegaly) are characteristic features of neutropenia. (orthopedicshealth.com)
Drugs4
- Acquired agranulocytosis may be caused by a variety of drugs. (orthopedicshealth.com)
- Acquired agranulocytosis is almost invariably caused by exposure to drugs and/or chemicals. (orthopedicshealth.com)
- A complicating factor is that several commonly used anti-cancer drugs are prone to cause agranulocytosis, thus interfering with treatment. (orthopedicshealth.com)
- In rare cases of acute acquired agranulocytosis, destructive action of certain white blood cell antibodies (leukocyte isoantibodies) may be induced by certain drugs such as phenylbutazone, gold salts, sulfapyridine, aminopyrine, meralluride, and dipyrine. (orthopedicshealth.com)
Decrease3
- As neutrophil levels decrease, the susceptibility of patients with acquired agranulocytosis to bacterial infections becomes even greater. (orthopedicshealth.com)
- Neutropenia - the definition indicates a decrease in the number of neutrophils. (arrhythmia.center)
- Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4-5% of total body neutrophil stores. (medscape.com)
Infections2
- Neutropenia is a serious disorder because it makes the body vulnerable to bacterial and fungal infections. (wordinfo.info)
- If neutropenia is not treated, bacterial infections can lead to life-threatening complications such as bacterial shock or bacterial contamination of the blood (sepsis. (orthopedicshealth.com)
Blood3
- Neutrophils are white blood cells (WBCs) produced in the bone marrow that ingest bacteria. (wordinfo.info)
- Lowered production of white blood cells is the most common cause of neutropenia. (the-medical-dictionary.com)
- And yes, this will appear very similar to a neutropenia because agranulocytosis is a blood disorder in which the body is unable to make neutrophils. (coastdental.com)
Patients1
- An analysis of the FDA Adverse Event Reporting System Database highlighted a higher than expected frequency of agranulocytosis in patients treated with fosfomycin. (bvsalud.org)